X-대역 SiGe HBT MMIC 차동형 전압 제어 발진기 개발

김보준,채규성,박민기,김창우 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

ISO 18000-6B, EPC Class-1 Gen-1, Gen-2 리더 표준에 적용되는 UHF 대역 RFID 리더용 RF 송신기를 하이브리드형 DHC로 설계 및 제작하였다. 송신기의 ASK 변조회로는 하나의 GaAs SPST스위치와 LPF로 구성하였으며, PR-ASK 변조 회로는 하나의 balua 두 개의 GaAs 통PST와 하나의 GaAs SPDT 스위치를 이용하여 link주파수 1-MHz 이상되는 변조신호에서 시간 지연이 없도록 설계하였다. LDMOS를 이용한 전력증폭기는 선형성을 위하여 8-dB back-off 상태로 동작시켜 출력전력 30-dBm을 얻었다.

CoMFA 법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석

김의기,민선영,정병호,천승훈,최보길,조원제 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-

We have performed a 3D-QSAR/ CoMFA analysis of the cytotoxiv activities of thirty-five 3-arylisoquinoline derivative against SK-OV-3 tumor cell line. The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinoline were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.841) was obtained through CoMFA.

베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례

김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

악성 갑상선 우연종의 임상상 및 초음파 소견의 진단적 가치

강한욱,김광원,이병완,강보현,김형훈,김범진,정재훈,민용기,이명식,이문규 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 최근 갑상선 초음파 검사의 빈번한 시행으로 갑상선 우연종의 발견이 증가하고 있다. 이러한 갑상선 우연종은 임상적으로 어떻게 접근하고 치료를 해야 하는지 적지 않은 문제가 되고 있다. 본 연구에서는 직경 1.5㎝ 이하의 갑상선 우연종의 유병률, 입상적 특징 및 초음파 특성, 그리고 가장 효율적인 진단적 접근에 대해 알아 봤다. 방법: 1999년 1월부터 2000년 12월까지 삼성서울병원 내과 및 일반외과로 갑상선 결절을 주소로 내원한 1457명을 대상으로 후향적 연구를 시행하였다. 우연히 발견된 직경 1.5㎝ 이하의 갑상선 결절을 가지는 환자들에서 갑상선 결절의 촉지 유무, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침 흡인세포검사, 99m^Tc 갑상선 스켄, 수술 조직검사 및 병기를 검토하였다. 결과: 분석한 갑상선 결절 1475예 중 갑상선 우연종의 유병률은 13.4%(198예)였다. 갑상선 우연종에서 악성률은 28.8%(57예)으로 나왔다. 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 결절 크기에는 의미 있는 차이는 없었다. 갑상선 스켄은 갑상선 우연종의 감별에 적합하지 않았다. 갑상선 결절의 초음파 지표 점수만이 양성 및 악석 갑상선 우연종의 감별에서 초음파 지표 점수의 민감도는 88.9%, 특이도는 74.4%, 양성 예측률은 92.4%로 나왔고 진단적 정환도는 85.5%였다. 갑상선암으로 수술을 받은 50명중 stage 1은 34명, stage 2는 6명, stage 3은 10명으로 대부분의 악성 갑상선 우연종은 낮은 TNM 병기로 나타났으나, 상당수에서는 국소 침범의 소견을 보였다. TNM 병기의 3기 환자 전부는 45세 이상이였고, 주로 갑상선암의 피막 침범에 의한 것이었다. 임파절 전이는 6명의 환자에서 나왔다. 결론: 악성 갑상선 우연종은 비교적 흔히 접할 수 있는 질환이며 양성 우연종과는 임상적으로 구별이 안 된다. 악성 갑상선 우연종은 발견 당시 대부분 낮은 병기이나, 갑상선의 피막 침범 및 임파절 전이가 상당수에서 발견되었다. 갑상선 우연종의 초음파 소견은 향후의 진단 방향을 제시하는 중요한 길잡이가 될 수 있다. 초음파 지표 점수 2점 이상의 갑상선 우연종에서만 초음파 유도 미세침 흡입검사를 권장한다. Background: High-resolution ultrasonography has made the detection of asymptomatic small thyroid possible. Recent increases in the detection of incidentalomas have created a clinical dilemma on how to properly manage such incidental nodules. We investigated the prevalence, clinical and ultrasonographic characteristics, and optimal diagnostic approach toward incidentally detected benign and malignant thyroid nodules of less than 1.5㎝ in size. Methods: A retrospective review was undertaken on the 1,475 patients who had visited Samsung Medical Center, Seoul Korea between January 1999 and December 2000. The review consisted of a physical examination of the thyroid gland, thyroid function test, antithyroid antibodies, thyroid ultrasonography, fine-needle aspiration biopsy, pathology and TNA staging of the incidentally detected thyroid nodules of less than 1.5㎝ in size. Results: The prevalence of thyroid incidentalomas was 13.4% and the malignancy rate within them was 28.8%. There were no significant differences in age, sex, thyroid function test and size between the benign and malignant incidentalomas. Ultrasonographic characteristics showed meaningful diagnostic value for the detection of malignancy in incidentalomas. Most malignant incidentalomas were of a low stage. Conclusion: Occult thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodules less than 1.5㎝; however, ultrasonographic findings can be used to decision of optimal management strategies (J Kor Soc Endocrinol 17:649∼656, 2002).

본태성 고혈압 환자의 적혈구 Na+-Li+ Countertransport 와 적혈구막 지방산 구성에 대한 연구

이영우,고경수,고재준,박경수,김원배,한은경,김성연,조보연,이홍규,고창순,민현기 한국지질학회 1991 韓國脂質學會誌 Vol.1 No.1

Since the changes of Na^+-Li^+ countertransport (SLC) Vmax in essential hypertension have been reported. it has been known that hyperlipidemia could affect SLC independently of blood pressure. To reveal the relation between SLC Vmax and RBC membrane fatty acid conposition in the hypertensive patients, we divided patients into two groups according to their levels of SLC Vmax of erythrocytes(elevated SLC Vmax: n=4, normal SLC Vamx: n=6). The results were as follows: 1) There was no difference in body mate index, waist-hip ratio, blood pressure, serum cholesterol level between two groups. Triglyceride were higher in elevated group (278.0±180.0 ㎎/㎗) than normal group (124.3±60.7 ㎎/㎗) but there was no statistical significance. HDL-cholesterol levels were significantly lower in elevated group (32.0±3.6 vs. 44.8±8.9 ㎎/㎗) and free fatty acid concentrations, intracellular (RBC) Na^+ concentrations were similar between two groups. 2) The results of oral glucose tolerance test showed no differences in the glucose and insulin area, however the incremental insulin areas of elevated group (108.8±31.3, μU. min/㎖×10²) were significantly higher compared with those of normal group (56.3±20.7 μU. min/㎖×10²). 3) In the elevated group, palmitic acid proportions of erythrocytes (22.1±0.7%) were higher than those of normal group (20.1±0.7%) and SLC Vmax showed significant correlation (r=0.81, p$lt;0.01) with palmitic acid proportion. These results suggest that the abnormal lipid metabolism may change the RBC Na^+ transport system through the alterations of RBC membrane fatty acid composition.

신장 ; 신기능에 따른 폐외결핵의 임상적 특징과 예후

최보경 ( Bo Kyung Choi ),이희선 ( Hee Sun Lee ),황인혜 ( In Hye Hwang ),신경화 ( Kyung Hwa Shin ),최문기 ( Mun Ki Choi ),최보광 ( Bo Gwang Choi ),안강희 ( Kang Hee Ahn ),남형석 ( Hyung Seok Nam ),황종민 ( Jong Min Hwang ),성은영 ( 대한내과학회 2010 대한내과학회지 Vol.79 No.4

목적: 만성 신질환 환자에서 세포성 면역기능이 감소되어 결핵에 이환될 위험성이 높으며, 특히 폐외결핵의 발생 빈도가 높은 것으로 알려져 있다. 이에 신기능에 따른 폐외결핵의 임상양상, 치료 반응, 질환과 연관된 사망률의 차이점을 비교하였다. 방법: 2003년 1월부터 2007년 12월까지 폐외결핵으로 진단된 18세 이상의 환자를 대상으로 하였고, 진단 당시의 크레아티닌 값을 이용하여 MDRD 공식으로 계산한 추정 사구체 여과율(eGFR)이 60 mL/min/1.73 m2을 기준으로 신기능 장애군(Group I)과 정상 신기능군(Group II)으로 분류하여 폐외결핵의 임상상, 치료성공률, 사망률 및 치료기간의 차이를 후향적 비교 분석하였다. 결과: 총 342명의 환자 중 Group I은 30명으로 이중 투석을 시행하고 있는 환자는 6명이었고, Group II는 312명으로, 각각의 평균 사구체 여과율은 34±19 mL/min/1.73 m2, 102±26 mL/min/1.73 m2이었다. Group I에서 고연령, 빈혈, 저알부민증이 많았으며, 고혈압, 당뇨병 및 심혈관계 질환을 동반한 경우가 많았다. 폐외결핵의 발생 부위는 두 환자군 모두 (Group I vs. Group II)에서 흉막(30.0% vs. 28.2%)이 가장 빈도가 높았고, 신경계통(23.3% vs. 16.3%)과 림프절(16.7% vs. 17.6%)의 감염이 흔하였으나, 통계학적 유의성은 없었다 (p=0.379). 모든 환자들은 표준 결핵화학요법인 HERZ, HER 및 HRZ 등을 용량 조절하여 치료하였으며, 두 환자군 모두에서 치료 실패 및 재발은 없었다. 결핵과 연관된 사망률은 Group I에서 높았으며(Group I, 22.2% vs. Group II, 2.8%, p<0.001), 연령, 혈색소 및 알부민, 당뇨병, 고혈압 및 심혈관계 질환의 유무를 보정하였을 경우에도 Group I이 사망의 위험률이 높았다(HR=11.51, 95%CI 2.512~52.741; p=0.002). 치료 중 이탈된 환자 및 사망환자를 제외하였을 경우, Group I이 치료 기간이 짧았다(278±110일 vs. 367±170일, p=0.009). 결론: 신기능 장애 환자에서 폐외결핵에 대한 치료기간이 연장되지 않았고 사망을 제외한 치료실패와 재발이 없었으나 폐외결핵으로 인한 사망률은 높았고, 신기능 저하 자체가 사망의 독립적인 위험 요소였다. 그러므로 신기능 장애 환자에서 폐외결핵에 대한 적극적인 진단 및 치료가 더 요구된다고 판단한다. Background/Aims: There is an increased risk of tuberculosis (TB) with impaired cellular immunity and extrapulmonary TB is more common in patients with chronic kidney disease. We explored the clinical features and treatment outcomes of extrapulmonary TB according to renal function. Methods: This retrospective study reviewed the medical records of patients diagnosed with extrapulmonary TB between January 2003 and December 2007. We classified the patients into two groups using the glomerular filtration rate (eGFR), estimated using the Modification of Diet in Renal Disease (MDRD) formula cut-off of 60 mL/min/1.73 m2 and evaluated their clinical features, treatment outcome and mortality (Group I vs. Group II, ≥ 60 mL/min/1.73 m2). Results: The mean eGFR of Groups I (n=30) and II (n=312) was 34±19 and 102±26 mL/min/1.73 m2, respectively. The pleura was the most frequent site of TB in both groups (Group I, 30.0% vs. Group II, 28.2%; p=0.379). There was no treatment failure or recurrence in either group. The mortality was higher in Group I (22.2% vs. 2.8%; p<0.01). In a multivariate analysis, eGFR<60 mL/min/1.73 m2 was an independent risk factor for mortality (HR=11.51, CI 2.512-52.741; p=0.002). Conclusions: Mortality related to extrapulmonary TB was higher in patients with impaired kidney function and kidney function was an independent predictor. However, there was no difference in treatment failure and recurrence according to renal function. (Korean J Med 79:387-393, 2010)

Extended local similarity analysis (eLSA) reveals unique associations between bacterial community structure and odor emission during pig carcasses decomposition

Ki, Bo-Min,Ryu, Hee Wook,Cho, Kyung-Suk Informa UK (TaylorFrancis) 2018 Journal of Environmental Science and Health. Part Vol.53 No.8

<P>Soil burial and composting methods have been widely used for the disposal of pig carcasses. The relationship between bacterial community structure and odor emission was examined using extended local similarity analysis (eLSA) during the degradation of pig carcasses in soil and compost. In soil, Hyphomicrobium, Niastella, Rhodanobacter, Polaromonas, Dokdonella and Mesorhizobium were associated with the emission of sulfur-containing odors such as hydrogen sulfide, methyl mercaptan and dimethyl disulfide. Sphingomonas, Rhodanobacter, Mesorhizobium, Dokdonella, Leucobacter and Truepera were associated with the emission of nitrogen-containing odors including ammonia and trimetylamine. In compost, however, Carnobacteriaceae, Lachnospiaceae and Clostridiales were highly correlated with the emission of sulfur-containing odors, while Rumincoccaceae was associated with the emission of nitrogen-containing odors. The emission of organic acids was closely related to Massilia, Sphaerobacter and Bradyrhizobiaceae in soil, but to Actinobacteria, Sporacetigenium, Micromonosporaceae and Solirubrobacteriales in compost. This study suggests that network analysis using eLSA is a useful strategy for exploring the mechanisms of odor emission during biodegradation of pig carcasses.</P>

An Clinical Analysis on the Dental Emergency Patients Visiting the Emergency Room of Dental Hospital of Won-Kwang University

Ki Chun Keum,Jun Young Paeng,Bo Young Choi,Jung Gu Choi,Se Ri Oh,Jun Lee,Moon Ki Choi,Kyung Hwan Kwon,Seung Hwan Oh,Seung Ki Min 大韓顎顔面成形再建外科學會 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.2S

Characterization of odor emissions and microbial community structure during degradation of pig carcasses using the soil burial-composting method

Ki, Bo-Min,Kim, Yu Mi,Jeon, Jun Min,Ryu, Hee Wook,Cho, Kyung-Suk Elsevier 2018 waste management Vol.77 No.-

<P><B>Abstract</B></P> <P>A soil burial-composting method was proposed as a hybrid disposal method for infected carcasses. This is a modified soil burial technique that involves covering carcasses with compost to achieve a final compost bed of 1.0–1.2 m during the soil burial process. To evaluate the feasibility and applicability of the soil burial-composting method, a pilot-scale system was constructed to dispose of pig carcasses and monitored its performance for 346 days. Temperature around the pig carcasses in the compost bed increased gradually, and was in the range of 35–45 °C after 200 days. Mesophilic (<I>Sporosarcina</I> and <I>Steroidobacter</I>) and thermophilic (<I>Truepera</I>) bacteria were dominant in the compost bed. Based on odor gas profiling and the morphological properties of the carcasses excavated after 346 days, it was estimated that an advanced decay stage was reached after 243 days. Considering the results of previous studies, the carcass degradation rate achieved by soil burial-composting was faster than that of soil burial, but slower than that of the composting method. Sum of odor quotient (SOQ) in the upper soil bed was lower than the SOQ in the compost bed where the carcasses were buried. This result demonstrated that the upper soil bed functioned as a biofilter to mitigate odor gases emitted during degradation of the carcasses. The soil burial-composting disposal method is preferred over soil burial because the degradation of carcasses is faster, and over composting because odor complaints and compost usage can be minimized.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Soil burial-composting is proposed as a hybrid disposal method for infected carcasses. </LI> <LI> Pig carcasses degraded more quickly using this method than the conventional soil burial method. </LI> <LI> Thermophilic bacteria as well as mesophilic bacteria were dominant in the system. </LI> <LI> The upper soil bed acted as a biofilter to mitigate cadaveric gases. </LI> <LI> Soil burial-composting can minimize compost usage and odor complaints. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>