Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

한국 어린이의 ABO혈액형 항체 생성에 대한 연구

윤영호,최효선,김덕언,박일규,김신규 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.6

Coating을 시행한 뇌동맥류 파열환자의 예후

박종혁,석종식,목진호,박관,김영백,민병국,황성남,최덕영 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.6

In rare occasions in which aneurysmal neck clipping is nearly impossible, coating is employed. During the period from 1985 to 1992, 312 patients with aneurysm underwent surgery ; aneurysmal neck clipping were performed in 284 cases while coating only in 28. The reasons that coating was required were ; wide and broad neck in 13, perforators arising from the neck in 4, neck tearing during dissection in 3, very friable neck in 2, severe adhesion with surrounding structures in 3, and small aneurysm without enough room for clipping in 3. In twenty-three cases, cotton wisp and bioglue were used as coating materials. In another five cases, the aneurysmal wall was reinforced using Surgicel or Gelfoam. Patients were followed for 24 months on average of all the patients. Four had last contact Six died(4 due to rebleeding and 2 due to pneumonia). Fourteen were good and 4 were moderately disabled. There were no rebleeding incidences during first three months' follow-up after coating. We thus concluded that coating an aneurysm offers some protection from rebleeding, particularly when the rebleeding risk period is over.

나노기술을 이용해 제작한 불소함유 접착필름의 치아우식증 예방효과

박덕용,이난영,이상호 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

필름 형태의 새로운 불소 delivery system을 개발하고 이에 대한 치아 우식증 예방효과를 기존의 전문가 불소 도포 제재인 APF gel 및 불소 바니쉬와 비교 평가해 보고자 하였다. 소의 법랑잘 시편에 APF gel (60 seconds taste^(?), 1.23% APF, PASCAL, USA)과 불소 바니쉬 (CavityShield^(?), 5% sodium fluoride, Ominii Pharmaceuticals, USA), 그리고 최근 개발된 3% 불소 함유 필름, 5% 불소 함유 필름 시제품을 도포한 후 인공 우식을 유발시켜 표면미세경도와 병소깊이를 측정하 여 다음과 같은 결과를 얻었다. 1. 실험군과 대조군의 표면미세경도의 차이는 II군, IV군, III군, I군의 순으로 컸으며, I군은 II군, III군, IV군에 비해 유의한 차이가 있었으나, II군, III군, IV군 간에는 유의한 차이가 없었다. 2. 실험군과 대조군의 병소 깊이의 차이는 II군이 가잣 컸으며(P<0.05). I군이 가장 작았다(P<0.05). III군과 IV군은 유의한 차이가 없었다. 이상의 결과로 미루어 보아 새로 개발된 불소 전달 사스템인 불소 함유 필름은 불소 젤보다 치아 우식증 예방효과가 우수한 것으로 나타났으며, 불소 바니쉬와 유사한 효과를 나타내었다. The purpose of this in vitro study was to evaluate the effect of fluoride containing adhesive film on prevention of enamel demineralization. Eighty bovine enamel blocks were divided randomly into 4 groups of 25: (1) APF gel applied ; (2) Cavityflhield™ applied; (3) 3% fluoride film applied; (4) 5% fluoride film applied: Early caries lesions were produced by placing each specimen into demineralization solution at pH 4.0 for 72 hours. Then lesion of the surface microhardness were measured by the Vicker's hardness test and the lesions depth were measured by polarizing light microscope. The results of the present study are as follows: 1. Difference of microhardness value (M±SD) between control and experimental side was the highest in group II, followed by group IV, III, I but, no significant difference was between group II, III and IV. 2. Difference of mean lesion depth (M±SD) between control and experimental side was the highest in group II, followed by group III, IV and I but no significant difference was between group III and IV. The results of the present study indicate that the fluoride film application is more effective than APF gel and is similar to fluoride varnish application for prevention of dental caries.

노년의 삶의 질에 대한 시차적 분석과 영역별 상대적 중요도

박충선,한성덕,정영숙 한국국제지역사회개발학회 1998 地域社會開發學術誌 Vol.8 No.2

The purpose of this study is to measure the level of quality of life on the basis of the time-dimension and fine the degree of influences of various elements of life domains. It is assumed that the quality of life is a finction of not only of the level of satisfaction but also of the relative influences of each element. The subject of the this study was 800 elderly people aged 60 and over, who live in the six major cities. The data were analyzed using an SPSS program. The major findings were as follows: 1) According to the time-dimensional analysis, the degree of family satisfaction is shown to be very high at the present time, and it will be maintained at the same level in the future. However, the economic satisfaction showed a little bit lower in comparion with the past, and in the future it will be expected to be better. 2) The satisfaction with the leisure domain showed a low score, and it will be exptected to be lower in the future. 3) The satisfaction with life-long education and the satisfaction with social participation showed a poor score, but it will increase a lot in the future. 4) The regression analysis indicates the relative influences of the elements, showing that the most influential domain is the domain of family. The second is the economic domain, housing as the third, the domain of the life-long education as the fourth, etc. 5) The relative influences of the elements are found to be different between the sexes, showing that the economic domain is the most important to the men, while the family domain is the most important to the women.

뇌실질내 출혈을 동반한 정맥기형

박관,석종식,최덕영 중앙대부설한국의과학연구소 1991 한국의과학 Vol.23 No.4

결핵항원에 의한 결핵환자 말초혈액 단핵구의 IL-2,IL-10 및 TNF-α mRNA 발현비교

박정규,임영재,김화중,조은경,민들레,임재현,최덕례,박성규 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

The various clinical features of tuberculosis are mediated by diverse cytokines produced by various immune cells which are initially triggered by M. tuberculosis antigens. CD4+ T cells can be classified into two subsets according to the patterns of cytokines they produce; Thl cells give rise to cell-mediated immunity and are characterized by the production of IL-2 and IFN-y, whereas Th2 cells are more efficient in mediating antibody production and secrete II-4, IL-5, IL-6 and II-10, Thl cells can control Th2 cell and vice versa. Peripheral blood mononuclear cells of healthy, cured and chronic refractory tuberculosis patients were stimulated with PPD, TSP and PHA antigen, and lymphoproliferative response and expression of II-2, IL- 10, TNF-α mRNAs were measured. Lymphoproliferative responses to PPD, TSP and PHA antigen were depressed in chronic refractory case compared with others expression of IL-2 mRNA was depressed in chronic refractory case stimulated with all antigens. Expression of IL-10 and TNF-α were depressed in cured and chronic refractory cases stimulated with PPD and TSP antigens.

개에서 피지선 과형성의 진단 및 치료 증례

박희서,손화영,정성목,송근호,조종기,이영원,신상태,김명철,김덕환,박성준 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

An eleven year old castrated male Maltese was presented to the Veterinary Medical Teaching Hospital of Chungnam National University. In physical examination, approximately 0.5 cm round mass was observed on tail base. This small elevated mass has also shown alopecic and firm configuration. It was differentially diagnosed as sebaceous adenoma and hyperplasia by fine needle aspiration. After surgical removal, the sample was diagnosed as sebaceous hyperplasia by histopathological examination. It has not yet shown any signs of recurrence and prognosis has teen good.

꽃노랑총채벌레(Frankliniella occidentalis)의 외부 미세구조의 특징

김기덕,김남성,박수진,서미자,채순용,윤영남 충남대학교 농업과학연구소 1999 농업과학연구 Vol.26 No.2

SEM을 사용하여 꽃노랑총채벌레, Franklimella occidentalis의 외부형태적 특징을 살펴보았다. 꽃노랑총채벌레의 촉각은 모두 8마디로 구성되어 있으며 길이는 0.25㎜정도이다 또한 3번째 마디와 4번째 마디는 부메랑 모양을 하고 있으며 5번째와 6번째 마디에는 길이가 7㎛정도의 감각기가 있다. 8번째마디에는 8개의 감각기가 있다. 입틀은 비교적 앞으로 튀어나온 모양을 하고 있으며 많은 감각기가 분포하고 있는데 모두 14개의 감각기가 양쪽으로 배열되어 있다. 다리의 구조는 발톱을 가지고 있지 않다. The external morphology of Frankliniella occidentalis was studied by using the scanning electron microscopy (SEM). The antenna was consisted of 8 segments and the length of antenna was 0.25mm. The 3rd segment and 4th segment were bent. The 5th segment and 6th segment had sensilla with 7㎛ long. The 8th segment had 8 sensilla. The mouthpart was protruded and distributed many sensilla on there. The leg had no claw.