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외상 후 속발된 주관절 변형에 있어서 운반각의 변화가 척골 근위부 성장에 미치는 영향
안상로,이광진,박원,오기영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2
The posttraumatic cubitus varus and valgus deformity is generally caused by malunion of supracondylar and condylar fracture of humerus in growing children. Generally it is known that carrying angle change is benign deformity causing no specific functional disabilities and the correction of the carrying angle change is performed for cosmetic reason. But after corrective osteotomy, there remained some Lasy S deformity on elbow joint. We invesgated the cause of this Lasy S deformity and found that most of deformity is caused by improper osteotomy, but we also found there developed some bowing deformity of the proximal ulnar metaphysic. So we measure the proximal ulnar bowing of 12 cases of cubitus varus and 4 cases of cubitus valgus which were operated on from 1984 to 1994. We also study the correlation between the amount and duration of the carrying angle change which the amount of the proximal ulnar bowing. The amount of carrying angle and carrying angle change correlate with the change of proximal ulnar bowing significantly. There is some correlation with duration of carrying angle change from proximal ulnar bowing.
β-CuZn 합금의 항복강도 이상거동에 미치는 변형률 속도와 온도의 영향
이기안,장영원,이종수 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.3
A series of tensile and load relaxation behaviors in B2 type β-CuZn alloy have been examined to clarify the strain rate & the temperature dependence of yield stress anomaly. It has been found in tensile tests that the region showing anomalous peak of yield stress moves to a higher stress and higher temperature region with increasing strain rate. The anomalous yielding region below peak temperature(T_p) revealed slightly positive strain rate dependence, while the region above T_p showed considerably positive strain rate dependence. The slip lines formed below peak temperatures (T_P) were clearly visible with naked eye(coarse slip lines), and became finer near T_p(fine slip lines), while they disappeared completely above T_p. Based on the different tendency of temperature and strain rate dependence of anomalous yielding as the above-mentioned results, two types of deformation modes were suggested and incorporated into the flow curve analysis, which was in accord well with the experimental results. The slightly positive strain rate dependence of yield stress anomaly indicated that the yield stress anomaly in β-CuZn alloy mainly seemed to be attributed to the vacancy hardening.
Systematic Identification of Hepatocellular Proteins Interacting with NS5A of the Hepatitis C Virus
Ahn, Ji-Won,Chung, Kyung-Sook,Kim, Dong-Uk,Won, Mi-Sun,Kim, Li-La,Kim, Kyung-Shin,Nam, Mi-Young,Choi, Shin-Jung,Kim, Hyoung-Chin,Yoon, Mi-Chung,Chae, Suhn-Kee,Hoe, Kwang-Lae Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.6
The hepatitis C virus is associated with the development of liver cirrhosis and hepatocellular carcinomas. Among the 10 polyproteins produced by the virus, no function has been clearly assigned to the non-structural 5A (NS5A) protein. This study was designed to identify the hepatocellular proteins that interact with NS5A of the HCV. Yeast two-hybrid experiments were performed with a human liver cDNA prey-library, using five different NS5A derivatives as baits, the full-length NS5A (NS5A-F, amino acid (aa) 1~447) and its four different derivatives, denoted as NS5A-A (aa 1~150), -B (aa 1~300), -C (aa 300~447) and D (aa 150~447). NS5A-F, NS5A-B and NS5A-C gave two, two and 10 candidate clones, respectively, including an AHNAK-related protein, the secreted frizzled-related protein 4 (SFRP4), the N-myc downstream regulated gene 1 (NDRG1), the cellular retinoic acid binding protein 1 (CRABP-1), ferritin heavy chain (FTH1), translokin, tumor-associated calcium signal transducer 2 (TACSTD2), phosphatidylinositol 4-kinase (PI4K) and $centaurin{\delta}$ 2 ($CENT{\delta}2$). However, NS5A-A produced no candidates and NS5A-D was not suitable as bait due to transcriptional activity. Based on an in vitro binding assay, CRABP-1, PI4K, $CENT{\delta}2$ and two unknown fusion proteins with maltose binding protein (MBP), were confirmed to interact with the glutathione S-transferase (GST)/NS5A fusion protein. Furthermore, the interactions of CRABP-1, PI4K and $CENT{\delta}2$ were not related to the PXXP motif (class II), as judged by a domain analysis. While their biological relevance is under investigation, the results contribute to a better understanding of the possible role of NS5A in hepatocellular signaling pathways.
Laparoscopic common bile duct exploration in patients with previous upper abdominal operations
Keong Won Yun,Young Joon Ahn,Hae Won Lee,In Mok Jung,Jung Kee Chung,Seung Chul Heo,Ki-Tae Hwang,Hye Seong Ahn 한국간담췌외과학회 2012 한국간담췌외과학회지 Vol.16 No.4
Backgrounds/Aims: We aimed to to evaluate the feasibility of laparoscopic common bile duct exploration (LCBDE) in patients with previous upper abdominal surgery. Methods: Retrospective analysis was performed on data from the attempted laparoscopic common bile duct exploration in 44 patients. Among them, 5 patients with previous lower abdominal operation were excluded. 39 patients were divided into two groups according to presence of previous upper abdominal operation; Group A: patients without history of abdominal operation. (n=27), Group B: patients with history of upper abdominal operation. Both groups (n=12) were compared to each other, with respect to clinical characteristics, operation time, postoperative hospital stay, open conversion rate, postoperative complication, duct clearance and mortality. Results: All of the 39 patients received laparoscopic common bile duct exploration and choledochotomy with T-tube drainage (n=38 [97.4%]) or with primary closure (n=1). These two groups were not statistically different in gender, mean age and presence of co-morbidity, mean operation time (164.5±63.1 min in group A and 134.8±45.2 min in group B, ρ=0.18) and postoperative hospital stay (12.6±5.7 days in group A and 9.8±2.9 days in group B, ρ=0.158). Duct clearance and complication rates were comparable (ρ>0.05). 4 cases were converted to open in group A and 1 case in group B respectively. In group A (4 of 27 (14.8%) and 1 of 12 (8.3%) in group B, ρ=0.312) Trocar or Veress needle related complication did not occur in either group. Conclusions: LCBDE appears to be a safe and effective treatment even in the patients with previous upper abdominal operation if performed by experienced laparoscopic surgeon, and it can be the best alternative to failed endoscopic retrograde cholangiopancreatography for difficult cholelithiasis. (Korean J Hepatobiliary Pancreat Surg 2012;16:154-159)
소아 급성호흡곤란증후군에서 체외순환막장치 적용에 대한 RESP, PRESERVE, ECMOnet 점수 체계의 유용성
안원기 ( Won Kee Ahn ),한정호 ( Jung Ho Han ),김윤희 ( Yoon Hee Kim ),설인숙 ( In Suk Sol ),윤서희 ( Seo Hee Yoon ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu-earn Kim ) 대한소아알레르기호흡기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.3
Purpose: With increasing use of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) in children, development of standardized strategies for survival prediction has become crucial; however, this has not been accomplished yet. We evaluated the adult scoring systems for survival prediction used for their applicability in pediatric ARDS and validated them. Methods: A total of 11 children with ARDS receiving ECMO from 2013 to 2014 were evaluated with adult scoring systems, including the Respiratory Extracorporeal-membrane-oxygenation Survival Prediction (RESP), the PRedicting dEath for SEvere ARDS on VV-ECMO (PRESERVE), and the ECMOnet scores. We compared the scores on these scales and the clinical characteristics between survivors and nonsurvivors. Results: Eight of the 11 children died (72.7%). The PRESERVE score (survivors vs. nonsurvivors: 2 vs 5.25, P=0.048), and the ECMOnet score (4.1 vs. 5.63, P=0.048) were lower in survivors than in nonsurvivors. They correctly predicted mortality prediction. There was no significant difference in the RESP score between survivors and non-survivors (-4.33 vs -2.62, P=0.63). The parameters that showed significant differences in this study were peak inspiratory pressure, platelet, and delta neutrophil index. All children who were under immunocompromised conditions, such as those with tumors, or underwent hematopoietic stem cell transplantation died. The immunocompromised status should be considered an important factor for survival prediction in children with ARDS. Conclusion: This is the first pilot study to apply the survival prediction scoring system to pediatric ARDS with ECMO. It is necessary to establish and modify the survival prediction score system for pediatric ARDS with ECMO. (Allergy Asthma Respir Dis 2017:5:141-146)
Systematic Identification of Hepatocellular Proteins Interacting with NS5A of the Hepatitis C Virus
( Ji Won Ahn ),( Kyung Sook Chung ),( Dong Uk Kim ),( Mi Sun Won ),( Li La Kim ),( Kyung Shin Kim ),( Mi Young Nam ),( Shin Jung Choi ),( Hyoung Chin Kim ),( Mi Chung Yoon ),( Suhn Kee Chae ),( Kwang 생화학분자생물학회 2004 BMB Reports Vol.37 No.6
The hepatitis C virus is associated with the development of liver cirrhosis and hepatocellular carcinomas. Among the 10 polyproteins produced by the virus, no function has been clearly assigned to the non-structural 5A (NS5A) protein. This study was designed to identify the hepatocellular proteins that interact with NS5A of the HCV. Yeast two-hybrid experiments were performed with a human liver cDNA prey-library, using five different NS5A derivatives as baits, the full-length NS5A (NS5A-F, amino acid (aa) 1-447) and its four different derivatives, denoted as NS5A-A (aa 1-150), -B (aa 1-300), -C (aa 300-447) and D (aa 150-447). NS5A-F, NS5A-B and NS5A-C gave two, two and 10 candidate clones, respectively, including an AHNAK-related protein, the secreted frizzled-related protein 4 (SFRP4), the N-myc downstream regulated gene 1 (NDRGI), the cellular retinoic acid binding protein 1 (CRABP-1), ferritin heavy chain (FTHI), translokin, tumor-associated calcium signal transducer 2 (TACSTD2), phosphatidylinositol 4-kinase (PI4K) and centaurinδ 2 (CENTδ2). However, NS5A-A produced no candidates and NS5A-D was not suitable as bait due to transcriptional activity. Based on an in vitro binding assay, CRABP-1, PI4K, CENTδ2 and two unknown fusion proteins with maltose binding protein (MBP), were confirmed to interact with the glutathione S-transferase (GST)/NS5A fusion protein. Furthermore, the interactions of CRABP-1, PI4K and CENTδ2 were not related to the PXXP motif (class Ⅱ), as judged by a domain analysis. While their biological relevance is under investigation, the results contribute to a better understanding of the possible role of NS5A in hepatocellular signaling pathways.
조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2
Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]