大田大學校 大田韓方病院의 中風早期檢診 實態調査

염익환,송인선,유호상,손원택,오민석,송태원 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1

This study was done to investigate the distribution of disease, which belongs to the people who came to the Daejon Oriental Hospital for the examination of CVA. The results were as follows : 1. It shows the highest ratio in his 40's and in her 50's. 2. The Hypertension patient is 26% and 40's is the highest, by 35%. 3. The Obesity patient is 51% and 50's is the highest, by 57%. 4. The Diabet mellitus patient is 5% and 30's is the highest, by 9%. 5. The Hyperlipidemia patient is 44% and 60's is the highest, by 52%. 6. The Liver disease patient is 18% and 40's, 50's is the highest, by 21%. 7. Abnormal EKG patient is 39% and 60's is the highest, by 57%. 8. 16% patient have abnormalities in brain CT and 70's is the highest, by 42%. 9. 70% patient have abnormalities in C-spine series and 70's is the highest, by 85%. 10. 32% patient have abnormalities in Chest PA and 70's is the highest, by 99%. 11. Soyang type is 32%, Soyum type is 25%, Taeyum type is 43% and Taeyang type is 0%.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Molecular mapping of QTLs related to cold tolerance at seedling stage in rice

Tae Heon Kim,Yeon-Jae Hur,Saisbeul Lee,Ji-Yoon Lee,Youngbo Son,Sung Hwan Oh,Sang-Ik Han,Jun-Hyun Cho,You-Chun Song,Jong-Hee Lee,Min-Hee Nam,Dong-Soo Park,Yeong-Up Kwon,Dongjin Shin 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Rice is a staple food crop for more than half of the world population. Severe losses of rice production was caused by various environmental conditions such as cold, heat and flooding annually. Rice is a highly sensitive to low temperature below 15-20 ℃ because of originating from tropical or subtropical climates. Especially, seedling of rice is easily damaged to low temperature and result in seedling yellowing, growth retardation, reduced tillering and yield losses at last. We used a recombinant inbreeding lines (RIL) population of 384 individuals derived from a cross between Hanareum 2, a highly cold sensitive variety and Unkwang, a cold tolerant variety for molecular mapping of QTLs related to cold tolerance. Seedling discoloration of each lines and parents caused by cold response were investigated in field condition after transplanting. And leaf samples of RIL population were collected for evaluation of chlorophyll content using 80% acetone extraction. The seedling of each lines and parents was subjected to low temperate by 5~13 ℃ during 14 days. The cold recovery score (CRS) of RILs was recorded after 4 days recovery period according to standard evaluation system (SES, IRRI). Total of eight QTLs were detected on chromosome 1, 7, 8, 10, 11 and 12 using cold tolerance traits, chlorophyll content, seedling discoloration and cold recovery score in 384 RILs. The qCRS12, which detected on chromosome 12 between two flanking markers id12002113, id12002563 (1.1 Mbp) showed 25 LOD score with 26% of phenotypic variation of cold recovery score in RILs population. The positive allele contributing to cold tolerance came from the cold tolerant parent Unkwang. The result may provide useful information for a marker-assisted breeding program to improve cold tolerant in rice.

Survival rate and growth of sea cucumber (Apostichopus japonicus) seed according to the type of sea mud to be added to the feed

Tae-Ik Kim,Young-Guk Jin,Maeng-Hyun Son,Se-Hee Yang,Sun-Jo Moon,Pyoung-Joong Kim 한국수산과학회 양식분과 2016 한국수산과학회 양식분과 학술대회 Vol.2015 No.05

Effects of 12 weeks Combined exercise on Body composition, Physical fitness, BNDF and Irisin in White collar woman workers

( Ik Soo Kim ),( Tae Woo Kim ),( Jeong Min Park ),( Hyun Ji Son ),( Jin Ho Yang ),( Chang Hyun Jang ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1

Purpose: The purpose of this study is to examine on the effects of 12 weeks combined exercise on body composition, physical fitness, BNDF and Irisin in white-collar woman workers who are sedentary lifestyles. Methods: In this study, there were controlled groups and exercise group: one was composed of women who have no regular exercise program and sedentary lifestyle (n=20: age range: 37.4±8.0, height: 160.2±4.2cm, weight: 56.5±9.6kg), the other was made of white-collar women who have combined exercise, no muscular skeletal disease, same lifestyle (n=19: age range: 39.1±4.4, height: 162.3±4.3cm, weight: 61.7±5.6kg), totally 39 women are participated in this study. Combined exercises were composed of aerobic, resistance exercise, flexibility, and balance exercise: Conducting mid-level exercise with 65% of maximal oxygen uptake, 3 times a week, and 80 minutes for 12 weeks. For certifying the purpose of this study, calculate the average and standard deviation of every variant using descriptive statistics, and apply the duality-repetition-variable-analysis for interaction between groups and timing. Result: There was no significant difference of amount of muscle, body fat, and ratio of body fat between two groups after combined exercise, but show some difference between before and after exercise, regardless of groups.(p<.05; p<.05; p<.001). For considering the interaction (p<.01; p<.001), there were significant differences in amount of muscle and body fat before and after exercise for groups, but, not in ratio of body fat. There was not significant difference in physical fitness variables for groups, but differences in flexibility and ability to react instantly regardless groups have before and after exercise.(p<.05; We can see that significant value shows only in flexibility for interaction.(p<.01). p<.05) There is no significant difference in BNDF for groups and timing, but some difference in BNDF, before and after exercise, based on interaction (p<.05). On the other hand, there are some significant difference in Irisin for groups and timing, and interaction, too. In other words, some differences in Irisin for two groups, before and after exercise. Conclusion: Consequently, it shows that 12 week combined exercise make a positive effect on body composition, physical fitness, BNDF and Irisin of white collar woman workers.

Tumor Size Is Still a Useful Prognostic Factor for the Therapeutic Plan of Papillary Thyroid Carcinoma

Tae Sik Jung,Hee Kyung Kim,Hyun Won Shin,Jung Hwa Jung,Hye Won Jang,Sun Wook Kim,Man Ki Chung,Jung Han Kim,Jee Soo Kim,Young-Ik Son,정태식 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.1

Background and Objectives: Papillary thyroid microcarcinoma (PTMC) was regarded as early-stage carcinoma,but its aggressiveness has been frequently reported. We performed this study to compare the clinicopathologic characteristics of PTMC with those of papillary thyroid carcinoma (PTC) >1 cm. We evaluated the association of clinicopathologic parameters of PTMC with tumor size divided by each millimeter. Materials and Methods:We retrospectively analyzed the medical records of 1,139 patients with PTMC and 1,296 patients with PTC >1cm who underwent thyroidectomy from 1995 to 2004 at Samsung Medical Center. The aggressive variants of PTC were excluded in the subjects. Results: Multifocality, extrathyroidal invasion (ETI), lymph node invasion (LNI),and distant metastasis (DM) were significantly less frequent in PTMC than PTC >1 cm (p<0.001). Recurrence and disease-specific mortality rates for PTMC were also significantly lower than those of PTC >1 cm (recurrence 2.9% vs. 8.1%, p<0.001; mortality 0.5 % vs. 1.5%, p<0.05). Tumor size was correlated with the rates of multifocality,ETI, LNI, and DM in all PTC (p<0.01). All patients with DM had the tumor size 0.6 cm in diameter or more. Among PTMC, the rates of LNI, multifocality, and N1b significantly increased when tumor size exceeded 0.3 cm, 0.4cm, and 0.6 cm, respectively (p<0.05). Conclusion: Recurrence and mortality rates of PTMC were extremely low, although local invasion was detected on the level of subcentimeter. Tumor size was well correlated with the aggressiveness of PTC. We suggest that tumor size is still a useful prognostic factor for the therapeutic plan of PTC.

멀티 가스자동 차단 장치(도시가스, Co) 개발을 통한 사용시설 안전관리 고도화 방안 연구

김태강(Tae-Kang Kim),김동진(Dong-jin Kim),손현익(Hyun-Ik Son) 한국가스학회 2023 한국가스학회 학술대회논문집 Vol.2023 No.5

Clamping 형 guard pipe 개발

김태강(Tae-Kang Kim),이동기(Dong-Ki Lee),손현익(Hyun-Ik Son) 한국가스학회 2023 한국가스학회 학술대회논문집 Vol.2023 No.5

Determination of Target Position with BRW Stereoatic Frame in non-orthogonal CT scans

Park, Tae-Jin,Kim, Ok-Bae,Son, Eun-Ik Korean Society of Medical Physics 1992 의학물리 Vol.3 No.1

최근 두개부 종양의 방사성물질의 자입과 방사선입체조사에 의한 뇌수술이 개발되어 의료계 에 많은 관심을 끌고 있다. 또한 방사선수술등은 비관혈적인 체외조사이므로 뇌정위수술용 좌표계의 전산화단층촬영을 이용한 표적중심결정이 매우 중요하다. 현재 알려진 방법은 뇌정위수술용좌표계의 전산화단층찰영에 대한 직교성하에서 비교적 정확하게 표적의 위치를 결정하게 되나, 임상현장에서 직교성유지는 실제 어려운 실정이다. 이에 필자들은 임의의 비직교성 스켄하에서 정확한 표적좌표를 얻기위한 알고리즘을 사용하였으며, 표적오차는 평균 0.02$\pm$0.3mm를 보였다. Stereotactic implantation of intracranial lesions, and the development of stereotactic convergent irradiation, radiosurgery, techniques have to obtain the accurate coordinates of the tumor locations and that of critical organ. Computed tomography(CT) provides relatively precise imformations of tumor localization and surround the normal organs for conventional radiotherapy. This CT image use to extend for stereotactic radiosurgery procedures. Since the convergent irradiation technique in linear accelerator requires the target center coincident with gantry isocenter or radosurgery frame, the target coordinates must be described in accurately. We used the BRW stereotactic system for describing the target position in CT images This algorithm provides the coordinate conversions for orthogonal or non-orthogonal CT scan image. In this experiments, the target positions have shown the small discripancy within :to.3mm uncertanty in several known target positions in the phantom through the provided programs and it compared to that of BRW stereotactic systems.

NaI(Tl) 섬광검출기의 특성 연구

노태익,손영섭 동아대학교 교육대학원 1996 동아교육논총 Vol.22 No.-

본 연구는 감마선 스펙트럼분석을 이용하여 2″Φ×2″NaI(T1)섬광검출기의 특성을 조사하였다. 표준선원은 ^22Na, ^54MN, ^60Co, ^137Cs등을 사용하였다. 실험조건은 인가전압을 750, 800, 850 ,900, 950 volt로 하고, 증폭기의 성형시간을 0.5, 1.0, 2.0, 3.0, 6.0 ㎲로 하여 스펙트럼을 측정하였다. 측정한 스펙트럼으로 검출기의 선형성, 인가전압과 성형시간의 의존성, 에너지분해능, 검출효율등을 계산하였다. 또한 시간분해능이 가장 뛰어난 조건을 찾아내고, LET법과 CFT법을 비교해 보았다. The characteristics of 2″Φ×2″NaI(T1) scintillation detector were investigated using gamma-ray spectrum analyses. The gamma-ray pulse height spectra were obtained from several sources, ^22Na, ^54MN, ^60Co, ^137Cs for various high voltage(750, 800, 850, 900, and 950volts) and shaping time(0.5, 1.0, 2.0, 3.0, and 6.0㎲). The pulse height spectra were checked for linearity, dependence of applied high voltage, of pulse shaping time, energy resolution, and intrinsic efficiency of the detector. The time resolution of detector were checked for the dependence of pulse shaping time, and Gate channel-range by measuring time spectra.