특수 언어발달 장애 환아의 임상 및음향음성학적 특성연구

김연희,박세훈,신용일,김찬양,김현기,김정수 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

지속형 항응고성 살서제 중독에 기인한 뇌실질출형 1예

양충용,이진훈,이서울,정복희,노상균,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

저자들은 brodifacoum성분의 지속형 효과를 갖은 항응고제인 쿠마린계 살서제를 정확한 용량을 추정할 수는 없지만 다회의 약물 복용 17일 후 뇌실질출혈이 발생한 증례를 문헌 고찰과 함께 보고하는 바이다. 지금껏 쿠마린계의 지속형 항응고성 살서제의 약물 중독이 알려져 있다. 이러한 약물은 vitamin K₁ 2,3-epoxide 환원효소를 억제하여 vitamin K₁과 연속적으로 vitamin K₁ 의존성 응고인자 Ⅱ, Ⅶ, Ⅸ, Ⅹ의 합성을 억제하고 이로써 출혈 경향을 증가시킨다. 이 증례를 토대로 향후 출혈성 환자 특히 선행 질환이 없는 젊은 뇌실질출혈 환자에서 원인을 감별진단 함에 있어 환자의 약물 중독 가능성과 치료에 대한세심한 주의가 필요할 것으로 생각한다. Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.

체외순환 없이 시행한 관상동맥우회술의 조기성적

원태희,최세용,양인숙 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.1

Background : The advances in surgical techniques and stabilizing devices have made the off-pump coronary artery bypass (OPCAB) popular, and good results have been published. We analyzed the early results of OPCAB performed in our hospital. Materials and Methods : Between January 2004 and December 2004, 23 patients underwent OPCAB. There were 14males and 9 females with mean age of 62.6± 10.3years. Preoperative diagnoses were unstable angina in 13(57%), acute myocardial infarction in 9(39%), and stable angina in 1(4%). Preoperative angiographic diagnoses were three-vessel disease in 12 (52%), two-vessel disease in 8(35%), one-vessel disease in 1(4%), and left main disease in 2(9%). Results : The mean number of grafts was 2.6 ±0.9 per patient. Vessels accessed were left anterior descending artery in 23, diagonal branch in 14, obtuse marginal branch in 9, right coronary artery in 12, and posterior descending artery in 1. Left internal mammary artery were used in 22 patients and bilateral internal mammary arteries were used in 1 patient. There was no operative mortality. Postoperative complications were cerebral vascular accident in 1, postoperative bleeding which required operative management in 2, arrhythmia including atrial fibrillation in 5, and minor operative wound problem in 1. Pre-discharge graft patency was evaluated in 11 patients. One internal mammary artery graft was occluded in 11 internal mammary artery graft evaluated. The patency rate was 91%. Seventeen saphenous vein grafts were patent in 19 saphenous vein grafts and the patency rate was 89%. Conclusion : Our result of OPCAB is promising and OPCAB is suggested to be the ideal technique with less morbidity and mortality.

ROM 기반의 실시간 자바가상기계를 위한 메모리 할당기법

김세영,양희재 경성대학교 공학기술연구소 2004 공학기술연구지 Vol.11 No.-

On embedded real-time system with a single processor and no virtual memory, fixed-size memory allocation scheme is used to solve external memory fragmentation and predictability of the computation time problem. The scheme can be applied to embedded Java virtual machine with heap memory as in simpleRTJ for example. Fixed-size memory allocation scheme has an advantage that makes memory management system simple and reduces runtime overhead. We found, however, there are some problems in simpleRTJ adopting the scheme. Firstly it searches memory in linear fashion to find a free space which causes an unpredictable delay. This is a critical problem for real-time guarantee. Additionally, when array and string is allocated in the heap, it uses real size, not fixed-size. So fixed-size memory allocation scheme cannot take its advantage in this case. In this paper we have reconstructed the object, method frame and allocation scheme for the best use of the advantage of fixed-size memory allocation scheme.

한국 벤처기업의 성공요인에 관한 연구

유세준,양희순 한국생산성학회 2001 生産性論集 Vol.15 No.2

This study investigated impacts of the characteristics of entrepreneur, environment, competitive strategies, organizational characteristics, and resource capability on the performance of venture business. For empirical data for this study, 149 companies registered in KOSDAQ and 357 companies registered in Small & Medium Business Administration (SMBA) are sampled and surveyed as subjects. And the valid data of 126 venture business among them are collected by direct interview and mail survey. The statistical techniques that are used to test hypothesis were factor analysis, cluster analysis, multiple regression analysis, one-way ANOVA, and T-test. The results of this study indicate that the performance of venture business is determined by characteristics of entrepreneur (need for achievement, age and academy background of entrepreneur), environmental characteristics(the degree of competition and the growth rate of the industry), competitive strategies, organizational characteristics(task autonomy), and resource capability(capital capability and technical capability), In addition, the Fitness between the growth rate of the industry and competitive strategies, the Fitness between organizational structure and competitive strategies, and the growth step of venture business influences over the performance of venture business

주의력결핍/과다활동장애(ADHD) 아동에 대한 약물-부모훈련 병합치료의 효과

김세실,이양희,안동현 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 주의력결핍/과다활동장애 아동의 문제 행동, 어머니의 양육태도 및 양육스트레스에 대한 약물 및 부모 훈련 병합치료의 효과를 검증하고자 한다. 대상 및 방법 : 한양대학교병원에서 주의력결핍/과다활동장애로 진단받은 24명의 아동(만 5∼11세)과 어머니를 대상으로 하였다. 세 군으로 나누었는데, 약물단독치료군(N=6), 약물 및 부모훈련 병합치료군(N=6), 병합치료 대기군(N=6)으로 구분하였다. 약물치료는 메칠페니데이트를 0.5∼0.7㎎/㎏/day를 투여하였다. 부모훈련은 주 1회, 9주간 실시하였고, 4주후 추후모임을 가졌다. 평가는 약물치료군(N=12)과 병합치료군(N=12)에서 각각 치료 전후에 비교하였으며, 병합치료군에서는 장기 효과를 보기 위하여 6개월후에 재평가하였다. 평가는 아동변인(아동행동조사표, 코너스부모용평정척도, 가정상황질문지), 어머니변인(어머니양육태도검사도구, 부모양육스트레스목록표, 결혼적응척도), 프로그램변인(부모사용자만족도 질문지)을 각각 조사하였다. 결 과 : 어머니의 양육태도 및 양육스트레스, 아동의 문제 행동에서 약물 단독치료군에 비해 약물-부모훈련 병합치료군에서 월등히 좋은 결과를 얻었다. 또한 이 효과는 6개월후의 추적조사에서도 대부분 유지되었고, 어머니들의 프로그램에 대한 만족도도 매우 높았다. 결 론 : 주의력결핍/과다활동장애 아동의 치료에 있어서 약물단독보다는 약물-부모훈련병합치료가 매우 우수한 치료 효과를 갖는다. Objective : We attempted to confirm the effects of the combined treatment of medication and parent training on the behavioral problems of referred ADHD chidren, the maternal behavior and the parenting stress of their mothers. Methods : Twenty-four children between the ages of 5 to 11 and their mothers were selected as subjected from Child Psychiatric Clinics of Hanyang University Hospital. Three groups were organized : combined treatment group of medication and parent training(N=6) ; wating list group(N=6) ; and medication only group(N=6). Methylphenidate(0.5-0.7㎎/㎏/day) was prescribed for children. Mothers of the combined treatment group of medication and parent training and the wating list group attended the parent training once a week for nine weeks and a booster session 4 weeks later. Treatment outcomes were evaluated by comparing both treatment groups at pre- and post-treatment using the various rating scales. Especially the combined treatment group was followed up after 6 months to evaluate the stability of treatment effects. Results : This study showed greater effectiveness of the combined treatment of medication and parent training relative to the medication only in decreasing the overall behavioral problems of ADHD children and the parenting stress of mothers as well as in increasing the desirable maternal behavior. In addition, these improvements were maintained at 6 month follow-up. Conclusion : The combined treatment of medication and parent training facilitated the behavioral improvement of referred ADHD children in several aspects.

청소년의 주거가치 및 주거선호 경향과 관련변인에 관한 연구

황경희,양세화 울산대학교 2000 생활과학논문집 Vol.2 No.1

본 연구의 목적은 울산시 소재 중 · 고등학교에 재학중인 청소년들의 주거가치와 주거선호 경향을 파악하고 이에 영향을 미치는 변인을 규명하기 위한 것이다. 이를 위한 자료는 설문조사를 통해 수집되었으며 최종적으로 597부가 분석에 사용되었다. 수집된 자료는 빈도, 백분율 등을 포함하는 기술통계와 다중회귀분석을 이용하여 분석하였으며 주요 연구결과는 다음과 같다. 첫째, 주거가치를 프라이버시 및 안전성, 편리성, 입지 및 근린환경, 개성 및 사회적 지위, 경제성의 5개 특성으로 나누어 그 경향을 조사한 결과, 그 중 프라이버시 및 안전성, 편리성, 입지 및 근린환경의 3개 특성에 대해 다소 높은 가치를 부여하는 것으로 나타났다. 둘째, 주거선호는 기본 편의시설, 근린시설 및 공동생활, 개인생활, 첨단시설 및 자기과시 등 4개 특성으로 나누어 조사하였으며, 그 중 기본 편의시설에 대한 선호도가 가장 높았다 셋째, 주거선호를 이루는 4개 특성을 종속변인으로 한 회귀모델은 모두 유의적인 것으로 나타났으나, 주거가치에서는 개성 및 사회적 지위, 입지 및 근린환경에 대한 가치를 종속변인으로 한 두 모델만 유의적인 것으로 나타났다. This study attempts to explore the housing values and preferences of adolescents in Ulsan. The sample for this study consisted of 597 middle and high school students living in Ulsan, and the probability sampling method was utilized. The data were analyzed by descriptive statistics and multiple regression analysis. The major findings are summarized as follows: (1) It was found that the adolescents are more likely to have high values on privacy & security, followed by convenience, and neighborhood environment, while low values on individuality & social status, and economy of housing. (2) The adolescents have the highest preferences for basic facilities, followed by high-style facilities & show-off, neighborhood & community life, and Personal life. (3) Among the five aspects of housing values, the two regression models of individuality & social status and neighborhood enironment are significant, while all of the models of four aspects of housing preferences are significant.

자살 시도에 영향을 미치는 정신사회적 요인

허지원,최광연,이분희,심세훈,양종철,김용구 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objectives : A lots of studies have investigated the psychosocial characteristics of suicidal attempters in order to find eff-cient coping strategy and treatment intervention. The purpose of this study was to examine the psychosocial factors affecting the suicide attempt in psychiatric patients. Methods : Two hundred eighty patients who attempted suicide and admitted in the emergency room in 3 university hospitals from December 2003 to May 2006 were recruited in this study. The patients were interviewed using Structured Clinical Inter-view for DSM-IV Axis I disorder (SCID-RV), Lethality of Suicide Attempt Ratings Scale (LSARS) and Risk-Rescue Rating system (RRR). Results : The suicide attempters have psychosocial characteristics of female preponderance, age 20-39, high school in educational level, married in marriage condition, inoccupation, house makers in occupation. Most of attempters used the non-severe methods such as drug ingestion or wrist cutting, and selected home as the place of attempt. The delay until discovery was less than 4 hours for most suicide attempters, and the rate of asking for help directly or dropping clues were high. Major depressive disorder was the most common psychiatric illness among attempters. Conclusions : The present study would be the early stage to explore the risk factor and protect factor of suicidal attempt. This study suggests that the closed observation to potential-suicidal attempter in daily life is critical to protect against the fatal results due to suicidal attempts.

Isolation and Characterization of an Antifungal and Plant Growth-Promoting Microbe

( Se Won Park ),( Hee-jong Yang ),( Ji Won Seo ),( Jinwon Kim ),( Su-ji Jeong ),( Gwangsu Ha ),( Myeong Seon Ryu ),( Hee Gun Yang ),( Do-youn Jeong ),( Hyang Burm Lee ) 한국균학회 2021 韓國菌學會誌 Vol.49 No.4

Fungal diseases including anthracnose, stem rot, blight, wilting, and root rot of crops are caused by phytopathogens such as Colletotrichum species, Sclerotinia sclerotiorum, Phytophthora species, and Fusarium oxysporum and F. solani which threaten the production of chili pepper. In this study, to identify biological control agents (BCAs) of phytopathogenic fungi, potentially useful Bacillus species were isolated from the field soils. We screened out five Bacillus strains with antagonistic capacity that are efficiently inhibiting the growth of phytopathogenic fungi. Bacillus species were characterized by the production of extracellular enzymes, siderophores, and indole-3-acetic acid (IAA). Furthermore, the influence of bacterial strains on the plant growth promoting activity and seedling vigor index were assessed using Brassica juncea as a model plant. Inoculation with Bacillus subtilis SRCM 121379 significantly increased the length of B. juncea shoots and roots by 45.6% and 52.0%, respectively. Among the bacterial isolates, Bacillus subtilis SRCM 121379 showed the superior enzyme activities, antagonistic capacity and plant growth promoting effects. Based on the experimental results, Bacillus subtilis SRCM 121379 (GenBank accession no. NR027552) was finally selected as a BCA candidate.

NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase Signaling

Yang, Se-Ran,Kim, Sun-Jung,Byun, Kyoung-Hee,Hutchinson, Brian,Lee, Bong-Hee,Michikawa, Makoto,Lee, Yong-Soon,Kang, Kyung-Sun Wiley (John WileySons) 2006 Stem cells Vol.24 No.2

<P>Neural stem cells (NSCs) are capable of giving rise to neurons, glia, and astrocytes. Although self-renewal and differentiation in NSCs are regulated by many genes, such as Notch and Numb, little is known about the role of defective genes on the self-renewal and differentiation of NSCs from developing brain. The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative disease caused by a mutation of the NPC1 gene that affects the function of the NPC1 protein. The ability of NSC self-renewal and differentiation was investigated using a model of NPC1 disease. The NPC1 disorder significantly affected the self-renewal ability of NSCs, as well as the differentiation. NSCs from NPC1-/- mice showed impaired self-renewal ability compared with the NPC1+/+ mice. These alterations were accompanied by the enhanced activity of p38 mitogen-activated protein kinases (MAPKs). Further, the specific p38 MAPK inhibitor SB202190 improved the self-renewal ability of NSCs from NPC-/- mice. This indicated that the NPC1 deficiency can lead to lack of self-renewal and altered differentiation of NSCs mediated by the activation of p38 MAPK, impairing the generation of neurospheres from NPC1-/- Thus, the NPC1 gene may play a crucial role in NSC self-renewal associated with p38 MAPK.</P>