한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

건축형태에서 임의성과 재현성 발현 관계에 대한 연구

이수진(Lee, Su-Jin),이민정(Lee, Min-Jung),이동언(Lee, Dong-Eon) 대한건축학회 2015 대한건축학회 학술발표대회 논문집 Vol.35 No.1

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

위선암에 병발된 혈액학적 합병증 1예 : 백적아구증, 파종성 혈관내 응고, 미세 맥관성 용혈성 빈혈

정혜경,김희진,이선영,최진혁,이순남,이홍수,정화순,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.2

Among the hematologic complications of solid tumors, leukoerythroblastosis, DIO and MAHA have been known to be clinically significant According to the recent increasing incidence of cancer, these hematologic complications have been reported frequently. However, the simutaneous developement of such manifestations is rare. Recently, we have experienced a patient with gastric adenocarcinoma in which case severe bleeding tendency were observed and laboratory studies including bone marrow examination demonstrated the findings of leukoerythroblastosis, DIC and MAHA. She died of upper gastrointestinal bleeding despite the supportive care such as vlood transfusions. We should give attention to the findings of peripheral golld smear for the patient with malignancy and it is mandatory for therapeutic plan to perform bone marrow examination if the above mentioned hemorrhagic complications are suspected.

부분 무치악 환자에서 마그네슘 이온주입 임플란트의 성공률에 대한 전향적 임상연구

최수정,유정호,이규복,김진욱 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: This study examined the clinical success rate of Mg titanate implants (M Implant system, Shinhung, Korea), which employ a Mg coating method, by evaluating the marginal bone loss and implant stability using radiographs and Osstell, over a 1 year. Materials and methods: The locations of the implants placement were divided into 4 areas; the maxillary and mandibular premolars and molars. In the maxilla, 8 and 9 implants were inserted in the premolar and molar areas, respectively. In the mandible, 11 and 51 implants were inserted in the premolar and molar areas. Marginal bone loss and ISQ of all implants (79) were measured after insertion, mounting the prosthetic appliance, and 1, 3, 6, and 12 months after loading. The marginal bone loss was measured from the radiograph using XCP bite, which was customized, and the implant stability measured using Osstell. Fisher's exact test (α=.05) was used to compare the success rates of each region. Results: The mean marginal bone loss for the upper and lower jaws were 1.537 mm and 1.172 mm. The mobility showed a non-significant reduction or increase according with time. The success rates were accounted for 94.12% and 98.39% in the upper and lower jaws; the premolars and molars were accounted for 100% and 96.67%. The two cases of early failure resulted from failure of primary stability during implant insertion. The late failures were not observed for 1 year after adding a loading to the implants. Conclusion: The Mg titanate implant showed good primary stability and good clinical results in both healing and function. 연구 목적: 부분 무치악 환자에서 Mg titanate implant (M Implant system, Shinhung, Korea)의 보철후 1년간의 방사선사진을 이용한 변연골 흡수량과 Osstell을 이용한 임플란트 안정성 평가 결과를 분석하여 임상적인 성공률에 대해 알아보고자 한다. 연구 재료 및 방법: 38명의 환자에 79개의 임플란트를 식립하여 보철 후 1년 동안 변연골 흡수량, 임플란트의 동요도, 임플란트 식립 위치에 따른 분포 및 성공률, 보철 전후에 따른 성공률을 분석했다. 결과: 변연골의 흡수량은 보철물 장착 후 1년간의 평가에서 상악에서는 평균 1.537 mm, 하악에서는 평균 1.172 mm의 변연골 흡수가 관찰되었으며, 전체적인 상하악의 평균 변연골 흡수량은 1.255 mm로 관찰되었다. 수술 후 시간이 경과함에 따라 ISQ값은 미약하게 감소하였다가 증가하는 경향을 보였으나, 상악과 하악 모두에서 식립 당일 이후 예비 인상일, 최종 보철물의 장착일과 주기적인 평가 기간 동안 ISQ값의 큰 증가나 감소를 나타내지는 않았다. 성공률은 상악에서의 94.12%였고, 하악에서의 98.39%였다. 결론: 본 실험의 결과로 미루어 Mg titanate implant는 임상적으로 양호한 결과를 보여주었다.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

고속액체크로마토그래피에 의한 나프록센 광학이성질체의 분리 및 품질관리

정수진,진전성,이은주,이은실,강종성 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

Enantiomeric separation of naproxen is necessary in drug evaluation processes as the pharmacological activity of naproxen resides mainly in the (S)-enantiomer, The enantioseparation of naproxen was carried out with three different stationary phases. The methods were validated with the terms of linearity, intraday and interday precision, accuracy, selectivity and recovery. Among the selected stationary phases, ChiroSil DMB column with hexane : t-butylmethylether : acetic acid (60:40:0.1, v/v/v) as mobile phase showed the best enantioseparation of the naproxen in the commercial preparations. The wavelength for detection was 270 nm and flow rate was 2.0 mL/min. The contents of (S)-naproxen in the commercial preparations were 92.7 - 98.3%, indicating that all tested preparations were satisfactory to current regulation. However, the contents of (R)-naproxen as impurity in the commercial preparations were varied from 0.08% to 1.08%.

경마 투자의 정당성 확보와 저변확대를 위한 발전방안

권기정 김진수 이미정 청주대학교 사회과학연구소 2005 한국사회과학연구 Vol.27 No.2

The purpose of this study is to demonstrate that horse racing is not gambling but investment. To demonstrate this, we used two methods. the first is logical reasoning three standards; information usage degree, benefit promotion degree, expected revenue degree is used. The second method is questionaire research of university student and professional group. The result of logical reasoning shows horse racing is not gambling but rational investment and the result of questionaire research is general public has blind prejudice that horse racing is a gambling. On the base of these result , this study suggested three step plans to improve and gain public favor in horse racing investment. the first step plan is marketing and education strategy to building human infrastructure in the short term. The second step plan is offering rational and unbiased horse racing investment infomation in the middle term, The last step plan is establish horse racing university to improve and gain scientific reasonableness. 본 연구에서는 투자와 도박을 판단히는 세 가지 기준인 정보의 이용정도, 효익 증대의 정도, 기대수익의 정도를 이용하여 경마가 도박이 아닌 '투자’ 라는 사실을 이론적이고 논리적으로 증명하였다. 또한 전문가와 일반인들의 경마에 대한 인식현황 파악을 위해 이론적 연구와 더불어 전문가 집단과 일반 학생 집단에 대해 간이설문조사를 실시하였다. 설문조사의 결과 대부분의 사람들이 투자와 도박에 대한 일정한 판단기준 없이 단지 ‘선입관’이나 ‘편견’에 따라 경마를 도박으로 보고 있었다. 이러한 이론적이고 논리적인 토대를 바탕으로 본 연구에서는 경마투자의 정당성 확보와 저변 확대를 위한 발전 방안을 3가지 제시하였다. 첫째, 본 연구에서는 단기적으로 인적 인프라를 구축할 수 있는 대 · 내외적인 홍보전략과 교육전략을 제시하였다. 둘째, 중기적으로 투명하고 공정한 경마정보의 제공방안을 정보의 신뢰성, 정보의 공유성, 정보의 차별성, 정보의 통제성, 정보의 적시성 측면에서 상세하게 제시하였다. 셋째, 본 연구에서는 장기적으로 학술장려 및 연구지원을 통해 경마를 새로운 사회과학이리는 학문영역(예, 경마투자론,경마투자학 등)으로 자리잡을 수 있는 방안을 제시하였다. 또한 최종적으로는 경마의 모든 분야를 포함할 수 있는 경마종합대학을 설립함으로써 일반인들에게 정당성과 타당성을 자연스럽게 인정받을 수 있는 학문적인 체계를 구축할 수 있도록 하였다.

볶은 보리 및 참깨의 갈색도와 돌연변이 유발성

정희진,이서래 이화여자대학교 생명과학연구소 1991 생명과학연구논문집 Vol.2 No.-

본 연구는 현재 국내에서 사용되고 있는 보리차용 보리와 참깨의 볶음정도와 아울러 Salmonella typhimurium TA98과 TA100균주를 이용한 Ames test에 의한 돌연변이 유발성 여부를 실험하엿따. 시판용 보리차는 갈색도로 보아 볶음정도가 다양함 을 알 수 있었고 업소용 보리차는 가정용 보리차에 비해 5배 정도로, 참기름용 참깨는 깨소금용 참깨보다 4배 정도 더 볶아진 것으로 평가되었다. 볶은 보리와 볶은 참깨의 수용성, 에탄올 용해성 및 에테르 용해성 성분에 대한 Ames test 결과는 모두 최고의 시험농도에서 돌연변이 유발능이 있다고 단정하기는 어려웠다. This study was undertaken to measure the degree of browning and mutagenicity by Ames test using Salmonella typhimurium TA 98 and TA 100 strains for roasted barley and sesame seeds used as food materials. The degree of browing of roasted barley for barley tea on the market showed a wide variation; barley for restaurant-use was heavily roasted (5 times) in comparison with home-use barley. Sesame seeds for oil extraction were more roasted (4 times) than those for seasoning. Water-, ethanol-and ether-soluble fractions from roasted barley and sesame seeds did not show any signs of mutagenicity, even at the extremely high concentrations of the extracts.