한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

소아 확장성 심근증의 임상적 고찰

이성환,김준식,박근수,김명성,권태찬,김천수,이상락 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1

A Clinical assessment of the 25 patients with dilated cardiomyopathy who were admitted to the Department of Pediatrics, Keimyung University Dong San Hospital from January, 1982 to June, 1993 was performed. The result were as follows: 1) Among 25 patients with dilated cardiomyopathy. 8(32%) were younger than 1 year of age at the time of admission. 2) Adriamycin toxicity was the only encountered etiologic factor in 1 patient. 3) On admission, hepatomegaly and tachycardia were noted in almost all patients. 4) The Chest X-rays showed cardiomegalies in all 25 patients, pulmonary vein congestions in 15(60%) and pleural effusion in 2(8%). 5) The electrocardiography showed left ventricular hypertrophy in 72% and supraventricular tachycardia in 32%. 6) The echocardiographic examination showed left ventricular dilatations in all patients and left atrial dilatations in 20(80%). 7) Of 18 patients who had followed mean period of 2.9 years, 10 patients died within 9 months after the diagnosis.

다중 중합효소 연쇄반응을 이용한 반코마이신 내성 장구균의 신속 검출

박성언,박수진,엄용빈,김종배,송혜원,박상욱,김양수,김근희 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

일반적으로 임상검사실에서 vancomycin resistant enterococci(VRE)를 검출하는 일은 어렵고, 시간이 많이 들며, 검체처리 비용도 많이 든다. 따라서 본 실험은 임상검체에서 분리된 세균으로부터 VRE를 신속하게 확인하고, 진단하기 위한 방법으로서 다중 중합효소 연쇄반응을 확립하였다. 본 실험에 사용된 primer는 장구균에 특이한 유전자인 vanA, vanB, vanC-1, vanC-2/3각각의 염기서열을 기초로 primer를 제작하고, 다중 중합효소 연쇄반응을 실시하여 임상검체로부터 분리된 VRE 유전자의 type 및 분포율을 조사하고자 하였다. 국내에서 분리된 75주의 장구균을 대상으로 다중 중합효소 연쇄반응을 실시한 결과 36주의 분리균주에서 vancomycin에 대해 높은 저항성을 보이는 vanA 유전자를 가진 것으로 나타났다. 그리고 18주에서는 vancomycin에 낮은 저항성을 내성을 보이는 vanC-1또는 vanC-2/3유전자를 보유한 것으로 나타났다. 따라서 본 실험에서 확립한 다중 중합효소 연쇄반응 기법은 신속한 VRE 진단 방법으로 이용할 수 있을 것이다. It is generally difficult, time-consuming, and expensive for the clinical laboratory to detect vancomycin resistant enterococci (VRE). The aim of this study was to develop and evaluate the multiplex polymerase chain reaction (PCR) assay system as a diagnostic tool for the rapid detection of VRE from clinical samples and/or for the identification of VRE from the bacterial strains isolated from clinical specimens. Specific primers, designed from the nucleotide sequences respectively encoding the vanA, vanB, vanC-1, vanC-2/3 genes in enterococci, were coupled in a multiplex PCR assay system. With this multiplex PCR assay system, we investigated the incidence rates and types of VRE isolated from clinical samples. A total of 75 strains of enterococci were isolated in 3 general hospitals in Korea. Of these isolates, 36 strains showed a pattern of highlevel vancomycin resistance which associated with vanA gene, whereas 18 strains showed lowlevel vancomycin resistance associated with vanC-1 or vanC-2/3 gene. Thus, multiplex PCR assay method established in this study could be applied for the rapid detection of VRE.

VP-16으로 성공적으로 치료된 위 Kaposi 육종 1예

양웅석,송근암,조몽,이재승,송철수,김형욱,김영민,이수봉,김태오,이성훈 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

The skin is an uncommon site of distant metastasis from any internal malignancy, and the incidence of metastatic skin lesions as the first symptom of disease is only 0.8% in patients with all systemic malignancies. Furthermore, cutaneous metastasis from adenocarcinoma of the stomach has been found to be extremely rare. A 35-year-old female patient was admitted due to multiple cutaneous nodules in her chest, abdomen, and back. A gastroendoscopic examination and biopsy was made according to the results of skin pathologic findings. Stomach and skin biopsy results revealed a signet ring cell type of adenocarcinoma. A case of gastric adenocarcinoma in which metastatic skin nodules appeared as the first sign of disease, is here in reported with a review of related literature.

2종의 Ferrite가 혼합된 페라이트/ 고무 복합형 전파흡수체의 전파흡수특성

김한근,이수호,손무헌,박정학,사공 건 東亞大學校 1997 東亞論叢 Vol.34 No.-

In this study, the ferrite/rubber composite microwave absorbers mixed Ni-Zn ferrite and Ni₂Y ferroxplanna were prepared in order to control matching condition. The variation of the material constants(ε*, μ*) and microwave absorbing characteristics were investigated with various ferrite mixing ratio. The material constants of ferrite/rubber composite microwave absorber could be controlled by variation ferrite mixing ratio.

방사선 조사에 의한 흰주 난포의 퇴축과 난포세포의 방사선 감수성

김수일,한승로,조근자,허대영,이영호,조문준,김무강,김원식 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

The aim of this study were to investigate radiation-induced atresia and radiation susceptibility in the rat ovary morphologically. Female rats (Sprague Dawley strain) of 4 weeks old were irradiated with dose of 4 Gy and 8 Gy, and sacrificed at hour 6, 12, and 24 after radiation. The H & E stain, the TUNEL method (ApopTag kit) and transmission electron microscopy (TEM) were used. In light microscopic observation, the number of atresia of ovarian follicles were increased significantly at 6h after irradiation (p<0.01). There was no significant difference between 4 Gy and 8 Gy irradiated groups. In TEM observation, granulosa cells in radio-sensitive follicles were characterized by several structural features including condensation of nuclear chromatin granules, nuclear fragmentation and apoptotic body formation. An apoptotic cell is observed to have been phagocytosed by a normal granulosa cell. Granulosa cells in radio-resistant follicles were characterized by several structural features including nuclear indentation, partial condensation of chromatin granules, mitochondrial swelling, dilatation of RER cisterns, accumulation of dense irregular masses, accumulation of lipid droplets, and increased lysosomal bodies. Number of gap junctions between granulosa cells were decreased, and intercellular space were widen than that of control animals. These findings were prominent at 6h after irradiation and were diminished at 12h and 24h after irradiation. With these results, it was concluded that radiation-induced follicular cell apoptosis and ovarian follicular atresia in rat ovary increased considerably at 6h after irradiation. Further studies are needed to reveal the more extensive differences between radiosensitive and radioresistant follicular granulosa cells.

남성 근로자의 고혈압 유무에 따른 열량 영양소 및 지질 섭취 상태 비교

김연정,김수근,백윤미,김미경 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

목적: 본 연구에서는 정상 근로자와 고혈압인 근로자간의 식이섭취 실태의 차이를 파악하여 효과적인 사업장 고혈압 관리 방안에 대한 기초 자료를 얻고자 하였다. 방법: 연구 대상은 임의 추출한 발전소 근무자 427명을 대상으로 하였으며, 신장, 체중과 혈압을 측정하고, 생활습관 및 식품섭취빈도조사를 실시하여 자료가 완전한 338명을 분석하였다. 대상자를 정상, 경계 고혈압과 고혈압군으로 분류하여 각 군 간 연령, 신장, 체중, 체질량지수, 혈압 등 인체계측 결과와 흡연, 음주, 운동 등 생활습관 및 열량 영양소 섭취 상태, 지질 성취상태의 결과를 비교하였다. 결과: 연령과 신장은 세 군 간 차이가 없었으나 체중과 체질량지수는 고혈압 군과 다른 두 군 간에 유의한 차이를 보였다(p<0.05). 세 군 모두 흡연율은 40.0% 미만으로 차이가 없었으나 흡연량은 경계 고혈압과 고혈압군이 정상군보다 유의하게 더 많았다(p<0.05). 음주 습관에서 음주 빈도와 음주량은 경계 고혈압군이 다른 두 군보다 더 높았으며, 음주량만 통계적으로 유의한 차이가 있었다(p<0.05). 운동 빈도는 주3회 이상 하는 경우가 정상군에서 높았으나 세 군 간에 차이가 없었다. 총 열량 섭취량은 세 군 간 차이가 없었으나, 탄수화물, 단백질, 지방 섭취량과 3대 영양소의 에너지 섭취 비율은 세 군 간에 유의한 차이가 있었으며, 고혈압 군이 다른 군 보다 탄수화물의 섭취는 많고, 지방 섭취는 적었다(p<0.05). 정상군에 비해 경계 고혈압과 고혈압군이 콜레스테롤 섭취량이 상대적으로 적었으나, 유의한 차이가 없었다. P / M /S비도 세 군 간에 유의한 차이가 없었다. 경계 고혈압군은 총 열량, 단백질, 지방 과잉 섭취자의 비율이 높았고, 고혈압군은 탄수화물, 지방 과잉섭취자의 비율이 높았으나 통계적으로 유의하지는 않았다. 결론: 본 연구에서 정상 근로자와 고혈압 환자 간에 탄수화물 섭취에 유의한 차이가 있었으며, 경계 고혈압과 고혈압군에서 열량 영양소 섭취와 지방산 섭취가 상대적으로 불균형하였다. 이러한 연구결과에 따라 고혈압뿐만 아니라 경계 고혈압단계에 있는 근로자를 조기에 발견하여 식습관을 포함한 생활습관을 개선하도록 관리할 필요가 있다. Objectives: The purpose of this study was to investigate the difference in nutrient intake between normotensive workers and hypertensive workers to obtain basic data for developing a program of effective hypertension care at work. Methods: The subjects were 338 male workers. We measured physical data by medical examination and collected lifestyle data by questionnaire survey. Dietary intakes were collected using a food frequency questionnaire. We classified the subjects into normal, prehypertension, and hypertension groups, and compared the results of age, body mass index (BMI), blood pressure (BP), lifestyles and energy nutrients and lipids intake. Results: There were significant differences in both weight and BMI between the hypertension group and the other two groups (p<0.05). The smoking levels of the prehypertension group and hypertension group were significantly higher than that of the normal group (p<0.05). The three groups also showed significant differences in drinking amount (p<0.05). There were significant differences in carbohydrate and protein intakes and the ratio of carbohydrate, protein, and fat intake (p<0.05). Conclusion: In this study, there was a significant difference in carbohydrate intake between normotensive and hypertensive workers, and the intake of energy nutrients and fatty acids in the prehypertension group and hypertension groups was unbalanced. Therefore, early diagnosis of workers with hypertension and prehypertension is necessary to improve lifestyles particularly food habit.

랫드에서 법제유황과 비법제유황의 독성비교

김근수, 정유리, 이남진, 홍성희, 유종훈, 정재황, 강종구 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

[논문]지반공학 분야에서의 신뢰성해석기법의 현황과 전망

김진만,김근수,김성진 釜山大學校生産技術硏究所 2007 生産技術硏究所論文集 Vol.66 No.-

지반구조물을 설계할 때 대상 지반의 불확실성을 극복하기 위해 여러 가지 셜계법이 사용되고 있다. 지반공학분야에서 사용되어온 기폰의 허용응력설계법은 구조물의 리스크를 효율적으로 관리하지 못한다. 그래서 통계확률 기법에 기초한 신뢰성 해석과 하중저항계수설계법이 제안되었다. 본 논문에서는 이들의 설계개념과 현황 및 향후 전망을 다루어보았다.

Surface Properties of Amphoteric Copolymers : contact angle and ARXPS

김재원,하종욱,박인준,이수복,오성근 한국공업화학회 2004 응용화학 Vol.8 No.2

The environmental response of the fluorine-contanining amphoteric copolymer in water and air has been investigated. The polymers were coated on slide glass by spincoater. The surface composition was determined by Angle Resolved X-ray Photoelectron Spectroscopy(ARXPS). Sessile-drop and captive-bubble techniques were used for contact angle measurements. Advancing contact angle was increased by increment of fluorine content. Octane contact angle in water increased with decreasing advancing contact angle in air. Octane contact angle in water was strongly affected by dispersion term in surface free energy.