정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Radiocobalt의 體內 汚染에 對한 除染效果

정인용,정현우,김태환,진수일,윤택구 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.1

국내 原子力 産業의 施設增大로 放射線核種汚染의 가능성이 날로 증가되고 있음에도 불구하고 종사자 및 인근주민에 대한 診療對策에 관한 연구가 전무한 실정에 있어 이에 대한 기초자려마련의 일환인 應急處置方案을 수립코자 58CoCl2 1μCi를 마우스 (NIH-(GP))의 腹腔內에 投與한 후 CoNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, saline 5ml등을 각각 投與하였으며, cobalt의 全身殘存量, 體內分布 및 尿內 含有된 量을 測定하기 위해 投與 後 4, 8, 12, 48시간, 그리고 7일에 MCA의 Ge-detector로 放射能을 計測하였고, 또한 각 實質臟器內 殘存된 cobalt의 放射能을 測定하기 위하여 각 group당 6마리의 마우스를 屠殺解體하여 測定하였던바 다음과 같은 결론을 얻었다. CoNa3 DTPA 處置群에서는 汚染된 放射性 cobalt의 全身殘存率의 減少 및 排泄率 增加에 유효한 效果가 있었으며, system contamination에 대한 방어효과는 CoNa3 DTPA, CoNa3 DTPA 그리고 saline 順으로 유효하였다. 결론적으로 본 실험결과로 볼 때 放射性 cobalt의 體內汚染에 대한 緊扱措置는 CoNa3 DTPA와 다량의 물을 동시에 投與함으로써 體內汚染된 放射性 cobalt의 排泄을 促進시킬 것으로 사료된다. In case of the acute intake of radionuclide, an early medical treatment may be necessary, but the little is established the procedures to decontaminate the victims of internal contamination in Korea. The purpose of the present investigation is to study chemical agents to remove radiocobalt from the victims and to provide a more reliable procedure for the treatment. The removals of radiocobalt from the NIH-(GP)mice injected intraperitoneally with lμCi of 58Co as CoCl2 were investigated with doses of either CaNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, or saline 5ml. The radioactivity was determined by MCA and Ge-detector on 4, 8, 12, 48 hours and 7 days for the whole body, organ distribution and urine excretion. Six mice per each group were sacrificed for the measurement of cobalt retention in the parenchymal tissue. The cobalt trisodium chelate had a pronounced effect on reducing the whole body retention and increasing the excretion rate. Regarding to the systemic protective effects, CoNa3 DTPA, CaNa3 DTPA and saline were effected significantly in order. In conclusion, the extrapolations from these results to human were suggested that the rapid administration of cobalt trisodium chelate and an amount of saline to the contaminated person after internal contamination of radiocobalt were markedly increasing the decontamination effects.

진화 알고리듬을 위한 객체지향 모델링과 클래스 라이브러리 구현

정호연,이수연,곽재승,김용주,박기태,현철주 한국경영과학회 2000 經營 科學 Vol.17 No.2

In evolutionary algorithm, there exist various models for the evolution of the population with respect to schemes and strategies for reproduction, in the application of the algorithm to a specific problem, one model suitable to the problem is to be properly chosen and a program expert or a software is needed to help implement and test a designed algorithm. In this study, object oriented modeling and the class library for simple evolutionary algorithms(SEA) with one population is developed. The library proposed here can be used as a generalized tool for solving problems in a wide range of domains.

기계구조용강의 첨가제에 따른 Tribology 특성

서영백,이충엽,박흥식,전태옥 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

This paper was undertaken to do tribology characteristics on oiliness agent adn extreme pressure agent. The lubricating wear test was performed under different experimental conditions using the wear test device was made in our laboratory and wear specimens of the pin on disk type was rubbed on paraffine series base oil by materials, varying applied load, sliding distance, oil additives such as stearine acid, DBDS, TCP, DBDS and TCP have a role of extreme pressure agent but a role of absorbed film of stearic acid decrease in high load. As applied load increase, in no additive lubricating oil, friction coefficient of three test piece is decreased by decrease in oil film thickness and viscous damping. But friction coefficient in STS304 has bigger value than SM45C and STB2 for work hardening in austenite.

기업도산예측에 관한 연구 : 산업별 비교 Comparison between Industry

정준수,김태수,김태오 釜山 大學校 經營 經濟 硏究所 2000 經營 經濟 硏究 Vol.19 No.1

The perpose of this paper is examine the incremental information contents of non-accounting information in predicting business failure. Also, This paper investigates inter-industry differences in the predictors of bankruptcy. We analyzed listed firms which were included in the database developed by Korea Information Service(KIS). We estimated the bankruptcy prediction model for the period 1981~1997 using the data of one-years, two-years and three-years before the year of bankruptcy. The major results of this paper can be summarized as follows : First, non-accounting information variables were not useful in predicting the bankruptcy over and above the information contained in financial statements. Second, because there are inter-industry differences in the predictors of bankruptcy. the different predictors need to be used in estimating the bankruptcy prediction model in different industries.

國恥 直後의 新韓村과 韓民學校 硏究(1910~1914)

鄭泰秀 대진대학교 1993 大眞論叢 Vol.1 No.-

In the history of Korean independence movement from Japanese rule, the five years from 1910, when the Yi Dynasty fell by the invasion of Japanese Army, to 1914, the year shortly before the end of the First World War, had been a first transition period from the struggle of righteous army to that of independence movement. During the five years, Vladivostok, a Russian port located in the Far East, formed a base for the movement. Some Koreans established a residential quarters, Shinhan Village, there, and organized an assembly called "Shinhan Village Association" and a corps of independence movement called "Kwonuphoe". These organizations established "Hanmin School", which inspired the spirt of the independence movement. This paper aims, firstly, to survey the processes of deportation of Koreans in Vladivostok from "Kaechukni" to a new residence which Russian government provided. Secondly, we look at the procession of organization of Shinhan Village Association, the first assembly of the migrants, and the regulations of the board and its decision. Then we consider the organization of "Kwonuphoe", its board, regulations and activities. Lastly, we examine the first newspapers and cultural activities in Shinhan Village. Most of the paper is dedicated to the background of Hanmin School as an educational institution for Korean immigrants to teach their children their native language, history and culture. It will be considered with regard to the Russian policy of Russianizing Korean on the one hand, and fervent national education on the other. We describe in detail the leading founders of Hanmin School, the managerial states of the School and its curriculum. In an appendix, nine pieces of "chang-ga (vocal music)" such as the national anthem and "Keongukka (the national foundation song)" are recorded which were taught at School to inspire the spirit of national independence. In addition, the list of 501 anti-Japan Koreans in the Russian territory of the Far East and their activities are printed, which Japanese spies of the consulate general at Vladivostok collected to report in February, 1911.

슬라브族의 「러시아 韓族」에 대한 교육정책과 民族敎育權

鄭泰秀 대진대학교 1994 大眞論叢 Vol.2 No.-

The 500,000 Russian Koreans who have lived in the old U.S.S.R. are the desendants of Koreans moved from Priamurski around Vladivostok. Although their ancestors have lived for about 130 years under the old Soviet regime, being separated from their mother land, they created their own culture combining Korean's with Soviet's. After the Stalin's policy of 1937, The Mandatory Move of Russian Koreans, 200,000 of Russian Koreans in the Farthest east of Russia had to find new places separately in the western parts where they live now and became the minority of the ethinc groups. As the old Soviet was collapsed in 1980s, they formed new ethnic groups as Russian Korean, Uzebeckstan Korean, and Kazakstan Korean. I name them Russian Korean here. Related to Russian Koreans, the followings are examind in this paper : First, The use of the educational policies that Soviet employed for Russian Koreans after 1860s ; Second , the use of the educational policy that Japanese adopted from the old colonial days of Korea ; Third, the educational policy for the ethnic group after the Revolution of 1917 ; Fourth, the suggestion of the educational policy for Russianization VS the Right of the ethnic education in future.

韓國の敎育改革と敎育制度の變遷

鄭泰秀 대진대학교 1995 大眞論叢 Vol.3 No.-

1. This year(1995) is the centennial anniversary of introducing the Western educational system and enacting the law for it, and the semi-centennial one of enacting the educational law based on democratic principles by Independence of Korea(1945). 2. The history of change of the educatonal system in korea is divided by four phases : ① the period of reforming the educational system and enacting its law in 1895 by the Western civilized thought ② the period of two educational laws: the colonial one under the Japanese occupation since 1905 and the one by the provisional government of ROK ③ the reform and legislation of education under the American military administration for three years since 1945 ④ the period of the new one by the foundation of ROK in 1948 3. The history of reform of the educational system is divided by four stage. Their characteristics in brief are as follows : ① the 1st reform in 1945 and in 1948 : the democratic and ethnic education ② the 2nd reform since 1961 : the education for the economic development ③ the 3rd reform since 1980 : the education for the social reformation ④ the 4th reform since 1995 : the education with the open-door policy

단일경사열선을 이용한 3차원 유동장의 자동측정방법

정의준,김무현,김수태 울산대학교 1992 공학연구논문집 Vol.23 No.2

퍼스널 컴퓨터 및 스텝핑 모터를 사용한 자동계측장치를 개발하였고 이러한 자동계측장치를 이용하여 단일경사열선으로 유동장의 3차원 속도성분을 측정하였다. 검정실험을 통해 얻어진 검정실험식의 사용범위를 알아보기 위해 검정실험식의 사용범위를 알아보기 위해 검정실험식으로부터 구한 속도, 스윌각 및 피치각들을 실제 측정값들과 비교 검토하였다. The 3-D velocity components were measured by single slanted hot wire. An automatic measuring system which was controlled by means of a personal computer and stepping motors was developed. Absolute velocity, swirl angle and pitch angle are calculated from the outputs of hot wire anemometer using the calibration equations. The difference between the measured and calculated values was investigated.

放射性 스트론튬의 體內汚染에 대한 應急處置劑의 效果

鄭寅容,金兌煥,陣秀一 대한방사선 방어학회 1989 방사선방어학회지 Vol.14 No.1

방사성 물질 체내 오염에 대한 진료에 필요한 기초 자료를 얻기 위하여 85SrCl₂를 NIH(GP) 마우스의 복강내 투여로 체내 오염시키고, CaNa₃DTPA 8.4mg, sodium alginate 5mg 및 saline 5ml등을 병행투여로 응급 처치한 후 경과 시간에 따라 도살 부검하여 중요 장기 및 배설물의 방사능을 측정하였다. 그 결과 방사성 스트론튬에 대한 단기간의 유효 반감기는 33시간으로 나타났으며 각 처치제의 배설효과는 CaNa₃DTPA가 4.7배, sodium alginate가 1.7배, 그리고 saline이 2.4배이었다. 스트론튬 단독 투여군의 체내 축적은 脊椎, 大腿骨, 胸骨, 肝贓의 순이었으며, 배설 경로는 尿 35.4%, 便 64.4% 및 기타 0.2%이었고, CaNa₃DTPA 및 saline 투여군은 조로 뇨, 그리고 sodium alginate 투여군은 便을 통하여 배설하였다. 이로부터 방사성 스트론튬 체내 오염에 대한 응급 처치는 CaNa₃DTPA, sodium alginate 및 saline등을 병행 투여함으로써 방사선 피폭을 경감시킬 것으로 사료되었다. To obtain the basic data for protective roles and first-aid of radiation hazard, the present studies were carried out to evaluate the decontamination of radiostrontium by the First-Aid drugs. Each mouse was administered intraperitoneally dose of sodium alginate 5mg, CaNa₃DTPA 8.4mg and saline 5ml following the internal contamination with 1 μCi of strontium as 85SrCl₂. 85Sr was determined by the radioactivity of body burden, urinary excretion, fecal excretion and organ distribution by Ge-detector and MCA. The results are summarized as follows. 1. Effective half life on whole body retention 85Sr was determined at 33 hours. 2. The decontamination effect of Fist-Aid durgs on the body 85Sr burden were increased CaNa₃DTPA(4.7 times), sodium alginate (1.7 times) and saline (2.4 times) respectively. 3. Strontium were excreted through urine (35.4%), feces(64.4%) and other (0.2%). But on the 85Sr excretion routes following First-Aid drugs treatment, strontium-85 mainly were excreted through urine after CaNa₃DTPA and saline treatment, and was excreted through feces after sodium alginate treatment. 4. The organ distribution of strontium-85 is vertebra, femur, sternum and liver in order. Finally, the extrapolations from these data to victims were suggested that the rapid administration of CaNa₃DTPA, sodium alginate and saline simultaneously were markedly increased the decontamination effects on the internal contamination of radiostrontium.