Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

급성 췌장염을 동반한 임신성 급성 지방간 1 예

강미선;박상훈;박지영 서희영;허란;김상현 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Acute fatty liver of pregnancy (AFLP) was first described as a specific clinical entity in 1940 and thought to be universally fatal. Maternal mortality in the past approached 75 percent. However early diagnosis and prompt delivery have dramatically improved the prognosis, and maternal mortality rate is now less than 18 percent. A early diagnosis, a prompt delivery, and a intensive supportive care have improved maternal and perinatal outcome. We report a 30—year—old woman at 37 weeks gestation who have multiple complications including acute pancreatitis in AFLP. She was complicated with acute renal failure, disseminated intravascular coagulation, duodenal ulcer bleeding, spontaneous bacterial peritonitis, pulmonary edema and acute pancreatitis.

콩에서 발생하는 강낭콩일반모자이크바이러스(BCMV)와 땅콩위축바이러스(PSV)의 저항성 평가

이영훈, 윤영남, 강범규, 김현영, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

It has been reported several viral diseases in soybean. The occurrence of Bean common mosaic virus and Peanut stunt virus are able to induce severe problem because the main breeding target for viral disease was focused on Soybean mosaic virus. BCMV is a spcies of the genus Potyvirus of the family Potyviridae. BCMV reduces yield by as much as 80% and also adversely affects seed quality in common bean. BCMV has a worldwide distribution because of its high rates 35% of transmission via seeds produced by plants systemically infected prior to bloom. PSV is a species of the genus Cucumovirus of the family Bromoviridae. PSV has been reported to be economically damaging on beans worldwide. Although the virus is reportedly seed transmissible at very low rates, infected plants rarely produce pods with normal viable seeds. The most satisfactory management method of viral diseases such as BCMV and PSV is the use of resistant cultivars and healthy seed. For the overcome of genetic resistance by new virus such as BCMV and PSV, virus diseases monitoring and researches need to study deeply and continually. In this study, we conducted the resistance screen on BCMV and PSV for selection of resistance cultivars. We inoculated on 128 cultivars with PSV and BCMV respectively. These cultivars were classified through pathogenic response such as resistance, necrosis and susceptibility. In addition, 99 and 66 resistant cultivars were confirmed against PSV and BCMV respectively.

1930年代 京城府 철근콘크리트조 公立 普通學校와 小學校 建築에 관한 硏究

강상훈,심우갑 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

This study aims to clarify the emerging of Modernism in Korean elementary schools which were built of reinforced concrete in 1930's through the survey and research of 49 public elementary schools which built in Seoul from 1895 to 1942. Throughout the wooden and brick building period(1985-1925), reinforced concrete elementary school buildings emerged first in 1924, reinforced concrete buildings were the most popular elementary school cuildings of 1930's. This reinforced concrete period could be divided into former period(1924-1933) and latter period(1933-1939) in which characteristics of Modernism are found. The high efficiency of reinforced concrete in heat insulation, fire resistance, durability and high density made reinforced concrete elementary school buildings which were built slightly earlier than Korean's would be model of Korean reinforced concrete school buildings. The policy on wide spreading of elementary school from 1920's and its acceleration from 1933 arouse popularization of elementary school and increasing needs for rapid and econimic construction. This made mid-1930's reinforced concrete school buildings have Modernism characteristics with existing school planning and design which to universal and rational design characteristics of Modernism.

골절 및 탈구 없는 경추손상의 치료

성경훈,김상진,강재규,도종웅 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12

The authors analized the 98 cases of cervical spine injuries without fracture or dislocation by hyperflexion/hyperextension of the neck. The peak incidence of the age was in the second to fourth decades(69.4%). There was a male preponderance with a sex ratio of 1.8:1. Sources of trauma were motor vehicle accident, object falling on and motorcycle accident in the order of frequency. The common mechanisms of injury were flexion-extension, extension and flexion injury in the order of frequency. There were 10 cases of cervical cord injury without fracture or dislocation and operative management was given in 6 cases of them. The most common preexisting desease was congenital cervical stenosis. Surgical modality such as laminectomy, laminoplasty and anterior decompressive procedure made them improved. The authors discuss the mechanism of injury and surgical management of the patients with cervical cord injury in the abscence of concomittent fracture or dislocation.

2024-T3 Al 합금의 피로거동에 미치는 인장 및 압축 과대하중의 영향에 관한 연구

강상훈 釜山工業大學校 1994 論文集 Vol.36 No.-

Tensile and/or compressive overloads are often a common accurance in service, particularly for aerospace applications, and are known to be of importance in the process of fatigue crack propagation. The present study was carried out for the purpose of investigation the effects of these overloads on the fatigue behavior, such as crack propagation, retardation, arrest and repropagation, using 2024-T3 aluminum alloy. The main results showed that the compressive overload has an acceleration effect on fatigue crack propagation due to the cyclic plastic zone, as that the tensile overload has the reardation effect due to the monotoic plastic zone.

Ⅰ급 부정교합자의 안면수직고경 및 교합평면경사도에 관한 치료전후 두부X-선 계측학적 연구

강상훈,남동석 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.1

교정치료후 안면의 수직고경변화는 교정의에게 지대한 관심을 불러 일으켜 왔다. 특히 제1소구치발치증례와 비발치증례에서 수직고경변이로 인한 악관절상의 문제도 선학들에 의해 연구되어왔다. 본 연구에서는 악골의 전후방적인 골격부조화를 배제한 Ⅰ급 부정교합환자의 수직피개정도 및 연령군에 따른 안면수직고경의 변화를 관찰하고 수직고경변화에 따른 교합평면경사의 변화양상을 비교하여 향후 치교결과의 예측, 분석에 도움을 얻고자 한다. 서울대학교병원 치과진료부 교정과에 내원하여 Ⅰ급 부정교합자로 진단되어 상하악 제1소구치를 발치하여 치료를 받은 환자 35명, 비발치로 치료를 받은 환자 30명 중 수직피개량을 기준으로 Ⅰ군(피개도<0mm), Ⅱ군(0<피개도<4mm), Ⅲ군(피개도>4mm)으로 분류하여 두부 X-선 계측사진을 계측, 비교분석하였다. 그리고 연령에 따라 성장진행군 및 성장완료군으로 분류하여 역시 비교 분석하여 다음의 결과를 얻었다. 1. 발치군과 비발치군 모두에서 치료후 전안면고경의 증가를 보였으나, 두군에서 유의한 차이는 없었다. 2. 치료전후, 성장진행군의 교합면경사도는 세군에서 유의성있는 변화를 보이지 않았으나 성장완료군에서는 각군에서 유의성 있는 차이를 보였다(p<0.05). 3. 발치군과 비발치군 모두에서 성장진행군은 전안면고경과 후안면고경의 유의성있는 증가를 보였으며 특히 성장완료군에 비해 후안면고경의 증가가 우월하였다. 4. 교정치료후 제1대구치는 모든 군에서 교합평면에 대해 유의성 있게 직립하였다(p<0.05). This study was investigated to assess the difference of facial height and occlusal plane inclination between pre- and post-treatment in Class Ⅰ malocclusion group. The subjects consisted of 35 extraction patients and 0 nonextraction patients, and was subdivided into Group Ⅰ(overbite<0mm), Group Ⅱ(0<overbite<4mm), and Group Ⅲ(overbite>4mm) in reference to overbite, and adolescent group and adult group in reference to age. Lateral cephalogram was taken with standard method, traced, and digitized for each subject. The computerized statistical analysis was carried out with SAS program. The results were as follows : 1. In both groups of extraction and nonextraction group the anterior facial height increased after orthodontic treatment, but there was no significant difference(p>0.05) between each group. 2. There was no statstical significance in change of occlusal plane inclination in adolescent group, but significant difference(p<0.05) among three subgroup in adult group. 3. In adolescent-extraction and adolescent-nonextraction group there was significant increase of anterior facial height and posterior facial height, and was superior to adult groups in posterior facial height increment. 4. In all groups upper and lower molars were uprighted to occlusal plane. This had statistically significant effect.

유리용융시 Nepheline Stone 생성에 관한 연구

강상훈,이경희,강원호 明知大學校 産業技術硏究所 1989 産業技術硏究所論文集 Vol.8 No.-

The formation of the Nepheline stone come from fusion-cast AZS Refractory and fusion-cast allumina Refractory which are use in Glass Melting Tank was investigated according to temperature variation. The results were Nephline Stone was formed easily with fused AZS Refractory in comparison with fused-cast Alumina Refractory below 1400℃ , Pendrite stone appeared with Nepheline at 1400℃ which comes from the fusion-cast AES Refractory and conrandum were found at 1500℃ comes from the fusion-cast Alumina Refractory.

전기경련치료(ECT)시 뇌파의 비선형 분석 : 단일증례 연구 A Single Case Study

강웅구,이운철,정선주,윤세창,조맹제,이상훈,김용식 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 비선형 분석을 통해 전기경련 치료(ECT)의 적절성 및 효과를 판정할 수 있는 새로운 변인을 추출해 낼 가능성을 탐색하기 위하여 한 여성 우울증 환자에서 ECT중 기록한 뇌파의 단일증례 분석을 하였다. 방 법 : 1주일 간격을 둔 두 ECT 회기에서 치료전 안정상태, 마취후-경련전상태, 경련상태, 경련후 뇌파억제상태, 치료후 안정상태의 다섯 상태에 따른 뇌파를 디지털 기록한 데이터를 분석하였다. 결 과 : 분석의 결과 1) 뇌파가 10차원 이하 저차원의 결정론적 성질을 가지고있으며 2) 뇌파는 비정상적(non-stationary)이지만 비선형 지수들이 각 상태 뇌파를 안정적으로 구분해 줄 수 있고 3) ECT 회기의 진행에 따라 경련중 뇌파의 결정론적 성질이 증가하며 4) ECT 회기의 진행에 따라 치료전후 안정상태 뇌파의 최대발산지수(PLE) 및 상관차원이 증가한다는 사실을 관찰할 수 있었다. 결 론 : 단일증례에 대한 다양한 비선형 분석의 결과는 ECT의 치료효과를 정량화할 수 있는 변인으로서 PLE, 상관차원 등 비선형 변수들이 사용될 수 있을 가능성을 제시한다. Objectives : In order to search for new parameters for the evaluation of the adequacy of electroconvulsive therapy(ECT), the authors performed a non-linear analysis of electroencephalogram(EEG) recorded during the course of electroconvulsive therapy(ECT) in a single female patient with depression. Methods : Digitized EEG recordings from two ECT sessions spaced one week were analyzed at five different stages ; pretreatment stable, postanesthetic-preictal, ictal, postical suppression and posttreatment stable stages. Results : Our analysis showed that 1) EEG signals had low dimensional(below 10 dimensions) deterministic characteristics 2) although EEG was nonstationary signal, non-linear parameters could reliably differentiate between various stages we examined. 3) the deterministic property of ictal EEG increased according to the progression of sessions and 4) the primary Lyapunov exponent(PLE) and correlation dimension of pre- and post-treatment stable stage EEG increased according to the progression of sessions. Conclusion : In this single case study, results of various non-linear analyses suggested that non-linear variables extracted from EEG recordings during ECT may have utilities as tools for the quantitative evaluation of ECT.