정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

人蔘多糖類의 理化學的 特性에 關한 硏究 : 人蔘貯藏加工中 澱粉의 理化學的 特性變化 Change of physicochemical properties of the starch during storage and heat treatment

曺哉銑,吳成基,曺羊嬉,金海中,黃明浩 경희대학교 부설 식량자원개발연구소 1985 硏究論文集 Vol.6 No.-

In order to investigate the change of physicochemical properties of ginseng root starch during storage and heat treatment. the roots were stored for 15 days at 5℃, 15℃, 30℃ and 45℃, and heated for 15 hours at 60℃, 70℃, 80℃, 90℃, respectively. The starch content was decreased from about 40% to 23-26% and sucrose content was increased from 4% to 12-16% during storage for 15 days at 5-45℃. Maltose, which was not detected in fresh samples, was increased upto 8.5% during storage or heat treatment. Granular size of the starch was decreased and some of the granules were broken during storage. Amylose content in the starch was decreased from 33% to 20%, and blue value and alkali number of the starch were increased slightly, and solubility and swelling power of the starch were decreased during storage. The higher storage temperature and the longer storage time, the starch was more susceptible to gelatinize, and the viscosity of the starch was lowered with the susceptibility of gelatinization. The susceptibility of degradation of the starch by the amylase was increased and amylolytic activities in ginseng root were, also, increased during storage.

개에 있어서 심장사상충증을 동반한 창상성 횡격막 허니아의 수술적 치료 1례

조승혁,임영환,손정민,노경완,박창식,전무형,김명철,송근호,정성목 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

A 7-month old. castrated male Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with history of depression. dyspnea. mild scale. tachypnea. exercise intolerance and severe leanness. On physical examination. cardiac arrhythmias was heard and heart worm ELISA test was positive. Microfilaria was found on the direct blood smear. Survey radiographs showed loss of diaphragmatic line and cardiac silhouette. displacement of lung fields and presence of gas filled intestines in the thoracic cavity. Rib fracture and pelvic fracture with callus formation were found incidentally. On the basis of physical examination and radiographic findings. it was diagnosed as traumatic diaphragmatic hernia and heart worm disease. Herniorrhaphy was performed. Postoperatively. it was treated for heart worm disease and scale. There is no evidence of recurrence of diaphragmatic hernia and heart worm disease over 1 year.

걷기 運動의 理論과 實際에 關한 考察

金命祚 釜山大學校 師範大學 1976 교사교육연구 Vol.3 No.2

Man's body becomes tOjfee weak and bulk small, if it is wl used. But moderate exercise of it enables man to keep health and even more to promote good health. The cause that people are indiffernt of health, in spite of knowing this aspect of health ulted in modern machanic society civilitation which reduces man's execise quantity greathm. We can not but reconsider this mordern reality of man's exercise quantitv when we see a far-sighted national polity. Walkmg Is the most fundamental one of all the excercises, therefore it is very important to promote one's health, especially whose society is where pelple walk andl at the time live. Recently according to the proposal of the people's physical strength promotion movement, the walking movement becomes the most prosperous one all over the country. To a modem man, Oxygen is apt to be insufficient owing to the lack of exercise this walking exercise a new method of promoting health. When mail is walking, he can breath oxeygen fully, consquently he can keep a good heath and keep his youngth. So, this walking movement must be extended into pan-national one,just not limited in Some special sections. Walking movement discusses worldly thought from one's mind and strengthen concentration one's attention, therefore it bas great effect in stress release; It accelerates one's mantafeolism and circulation of brood and stomach activity. At the same time, it strengthens one's fundamental activity and quickens the appetite and make life dinamic There are also longevity and relax effect in this movement So it' il be aduairable on all the people. Because waiting mayement is patice by public, it can produce propitiation and Smooth human relationship, cooperation and union.Also,it make healthy mind and body both and it is directly related to accelerating of national power production. In our country,Walking Movement spread in all over the country. Walking movement, as a public movement and a social sport, must be practiced properly and beautifully. Therefore, people can lead a healthy life.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

Virtual GIS를 이용한 산불피해지 복구 경관분석기법 개발

조명희,이명보,김준범,임주훈,김성재 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.1

우리나라의 경우 1990년대에 들어와서 산불 발생건수 및 피해지역이 지속적으로 증가하고 있으며, 산불피해지 복원기술은 주로 사방복구와 조림 등 녹화기술에 집중되어 있는 실정이다. 본 연구에서는 동해안 산불피해지를 중심으로 GIS 분석 기법을 적용하여 산불피해지의 공간 특성과 입지환경을 고려하여 내화수림대를 조성기법을 개발하고 virtual GIS의 활용을 통하여 공간정보자료가 산불피해지역 복원에 있어서의 경관생태학적 접근연구에 어떻게 활용될 수 있는 것인가에 대한 적용기법을 개발하고자 하였다. 본 연구에서는 대형산불방지를 위해 GIS 분석기법을 적용하여 내화수림대를 조성하고, 조성된 내화수림대 및 연구대상지에 3D modeling 기법을 통하여 구축된 3D수종을 적정하게 임분배치하였다. 아울러 지위지수분류곡선을 이용하여 연구대상지에 경년에 따른 산림경관을 조성하였으며, virtual GIS를 활용하여 현실세계와 가장 유사한 3차원지형을 구축하고 tracking simulation을 수행하였다. In Korea the number of forest fire occurrence and its damaged area have increased drastically and the plans for afforestation such as sound erosion control restoration and forestation have performed to restore for forest fire damaged area. In this study fire resistant forest was developed by selecting fire resistance tree species and applying GIS analysis, considering the characteristic of forest fire and location environment in forest fire damaged area along the east coast. Moreover, it showed the possibility of how spatial information technology such as virtual GIS could be applied during restoring forest fire damaged area and approaching landscape ecology researches. Especially the fire resistant forest was established by using GIS analysis against large scaled forest fires then the best forest arrangement was performed through this fire resistant forest species and 3D modeling in study area. In addition, the forest landscape was established through site index on passing years and then 3D topography and tracking simulation, which is very similar to real world, were constructed by using virtual GIS.

스포츠에 있어서 공격성 이론에 관한 고찰

金命祚,趙寅徹 釜山大學校 附設 體育科學硏究所 1986 體育科學硏究所 論文集 Vol.2 No.-

In this study, I considered the concept of aggression, the aggressive theory, and the aggression performance relationships in order to see the aggression in sport. I summarized as follows. 1) In the sport, the definition of aggression is the intention to harm another person and according to the intention is divided between hostile aggression and instrumental aggression. 2) In the instinctive theory, sport is the outlet of the aggressive drive. 3) In the frustration-aggression theory, the aggression is induced from frustration and if the aggression is appeared successively, it was cathartic effect. 4) In the social learning theory, the aggression is taught and reinforced through sport. 5) Aggression-performance relationships can't be decided positive or negative, and must be considered the variables such as the eventual specification, the team standing, the sexual difference, and the performance.

GIS와 항공정사사진을 이용한 산림정보 관리시스템 구축

김준범,조명희,권태호,김인호,조윤원,신동호 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

우리나라 산림행정 업무의 대부분은 서류 및 대장에 의존하고 있는 실정으로 신속, 정확하고 다양한 업무 처리를 위해서는 첨단의 공잔정보기술을 이용한 과학적인 산림정보 관리시스템의 개발이 시급하다. 특히 지리정보시스템(GIS)과 항공사진 활용기술의 도입은 산림이용기본계획이나 산지개발, 산림자원 관리 및 산림보호 정책 등의 의사결정지원에 효율적으로 기여할 수 있을 것이다. 본 연구에서는 GIS와 항공사진(1998년도 촬영)을 기반으로 주요 산림정보인 수치지도, 수치임상도, 임야도 및 관련 속성데이터 둥을 가공하여 DBMS(data base management system) 내에 저장하였으며, 이를 기반으로 세부 응용시스템인 지번별 임야정보 검색, 산지이용개발 정보관리, 법정제한림 정보관리, 산림자원 정보검색 등의 인터페이스를 개발함으로써 산림 관련 실무자가 산림정보의 종합적인 공간분석 및 질의 검색이 가능한 산림정보 관리시스템을 구축하였다. 본 시스템의 구축으로 산림의 효율적 관리는 물론, 경제적인 산림자원 및 임산업 육성과 쾌적한 산림환경을 조성할 수 있을 뿐만 아니라 관련 부서들 간의 표준화된 공간 자료 공유와 과학적인 정보체계의 연동으로 산림자원 관리를 위한 집약된 공간 및 전자 정보화 인프라 구축의 기반을 마련할 것으로 사료된다. Recently in order to more effectively and scientifically process forest official tasks, which have been focused on documents and inventories, they should be applied with the up-to-date spatial information technologies. Especially, the forest resource information management based on GIS (geographic information system) and aerial orthophoto is expected not only to play an important role as DSS (decision support system) for domestic forest conservation policy and forestry development industry but also to service forest resource information toward people such as the owners of a mountain rapidly. In this study, the important forest information such as digital topography map, digital forest type map, digital forest cadastral map, digital aerial photographs and attribute data were first reprocessed and constructed in DBMS (data base management system). In addition, forest officials could analyze and retrieve forest information by using detail sub-application systems such as forest cadastral retrieval, forest land development information management, reserved forest information management and forest resource information retrieval. For this, the user interface is developed by using Visual Basic 6.0 and MapObjects 2. 1 of ESRI based on CBD (component based development) technology. The result of developing this system will not only perform constructing economical forest and better environment but also be the foundation of domestic spatial technology for forest resource management.

매스미디어를 통한 社會體育 活性化 方案

金命祚,鄭容敏 釜山大學校 附設 體育科學硏究所 1989 體育科學硏究所 論文集 Vol.5 No.-

We have to depend on mass-media to publicize the sport for all which has its political, economical, cultural and educational skill and related with improvement in quality for the human living and popularization of sports, or to make use of one's leisure living according to the characteristics of modern society. The activated program for the sport for all through mass-media is as follow : 1. To ensure financial resources for this purpose, utilize sponsor. 2. Every publicity methods that available in this modernized and highly developed vehicles must be utilized. 3. The selection of model for the publicity is changeable with the honourable persons common citizen as the case may be. 4. The place of the publicity of the sport for all utilize every part of selector's living facility. 5. Maintain always correlation and intimate understanding with the persons engaged in mass-media. 6. Prepare for awarding plan of sport for all fields for workers who engaged in mass-media. 7. Special event will be held to be concerned about mass-media. 8. Display public relation campaign step by step. As described above items, we should like to emphasize the understanding of the persons who engaged in mass-media to the sport for all correlation with the leaders of physical education efforts to utilize the mass-media would enhance our korea's prospect of sport for all more brighter than ever.

釜山大 男學生의 體力 및 身體遂行 能力에 關한 硏究

金泰運,徐國雄,金命祚,趙福德,黃喆文 釜山大學校 附設 體育科學硏究所 1988 體育科學硏究所 論文集 Vol.4 No.-

The purpose of this study was measure height, weight, chest girth, sit and reach, grip strength, back strength, % body fat and VO₂max for freshman students majoring in engineering in Puasn National University. In comparison with the results of other studies, the following conclusion were drawn. A. Height(172 ±4㎝) and weight(62 ±7㎏) were increased, but chest girth(87 ±6㎝) decreased. B. VO₂max(2.4 ±0.31/min 38 ±38 ±6ml/㎏/min) and % body fat (7 ±4%) were significantly low. C. Questionaire revealed 16% of subjects exercise 4∼5 hours per week D. Questinmaire revealed that smokers and drinkers are 18%, 86% respectively.