柔軟性에 의한 제조시스템의 評價 模型

하정진,이창섭,김성희 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.2

Flexibility has become a key objectives in the design of manufacturing systems and a critical measure of total manufacturing performance. The need for flexibility is increasing due to some environmental change such a changing technical characteristics of the products and the changing nature of market demands. Most importantly, flexibility embodies competitive value for a manufacturer. Therefore, the objective of this research is to offer a definition of flexibility as well as proposing a scheme for assessing the value of flexibility, one of the performance measures of manufacturing systems.

오리고기에 關한 硏究(Ⅱ) : 오리고기 통조림의 貯藏中 罐內變化 Various Changes in the Canned Duck-meat during the Storage Period

조덕봉,김동필,성하진,장인애 광주보건대학 1978 論文集 Vol.4 No.-

Various changes, especially leaching of heavy metals, in .the canned dock-meat during the 10 months storage period were investigated. Detinning reached to 57.28 ppm level, and the leaching of Pb and Fe levels were equivalent to 3.88 and 60.00 ppm respectively in the stored 10 months cans. The changes of pH and vacuum degrees were not significant and swelled cans were not observed. . Corrosion of tin-plate was increased as the during storage period in each sample.

Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

국내 육성 포도 "두누리" 품종의 성숙 시기별 과실특성과 포도주 품질특성

장은하 ( Eun Ha Chang ),정성민 ( Sung Min Jeong ),노정호 ( Jung Ho Noh ),박교선 ( Kyo Sun Park ),임병선 ( Byung Sun Lim ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2012 한국식품저장유통학회지 Vol.19 No.6

국내 포도주 가공용 육성 품종인 ``두누리`` 포도의 양조 가능성과 고품질의 포도주 양조를 위한 적정 성숙시기를 검토하고자 성숙 시기별 과실의 품질특성과 적정 성숙시기를 판단하는 여러 가지 지표를 검토하였고, 포도주 양조후 전문가 관능평가를 통해 포도주 품질에 가장 적합한 성숙 시기를 구명하고자 하였다. ``두누리`` 포도의 과실특성을 조사한 결과 °Brix 당함량은 변색기 이후 급격히 증가하였고 성숙완료 시 17 °Brix를 나타내었으며 과숙기에는 약 20 °Brix까지 증가하였다. 산함량은 변색기 이루 급격히 감소하기 시작하여 성숙 완료 시 거의 0.66%까지 감소하였고 이후에도 서서히 감소하여 과숙기에는0.51%까지 감소하였다. 총폴리페놀과 총안토시아닌 함량은 변색기 이후 급격히 증가하는 것으로 나타났다. 특히 산함량이 0.55%정도 되었을 때 총안토시아닌 및 총폴리페놀의 함량이 최고에 도달하지만 포도가 과숙되면 오히려 함량이 감소하는 것으로 나타났다. 총안토시아닌의 축적과 당, pH, 산함량, brix/acid 비율과의 상관관계를 살펴본 결과 0.87~0.95(p<0.05)의 양 또는 음의 높은 상관관계를 나타내었다. 포도의 적정 성숙시기를 판단하는 지표인 brix×pH(2) 값과 brix/acid 비율을 적용해 본 결과 두 지표를 모두 만족시키는 성숙 시기는 산함량이 0.53~0.55 정도, 당함량이 17 °Brix일 때였다. ``두누리`` 포도주의 성숙 시기별 품질특성을 조사한 결과 산함량은 성숙 시기가 늦을수록 감소하였고, 총안토시아닌, 탄닌 함량 및 포도주의 적색도와 색의 포화도를 나타내는 a*와 C*는 증가하다가 포도가 과숙될수록 함량이 오히려 감소하는 것으로 나타났다. ``두누리`` 포도주의 관능평가를 조사한 결과 산함량은 포도 성숙 후 가장 늦게 수확하여 제조한 포도주에서 가장 안정적인 산미를 나타낸다고 평가하였지만 색, 향기, 전체적인 조화에서는 포도주의 산함량이 0.60%(포도의 산함량으로 0.53~0.55%) 정도일 때 가장 좋은 품질을 나타낸다고 평가하였다. 따라서 ``두누리``포도주를 제조할 경우 포도의 산함량이 0.55% 정도 일 대 포도의 당함량, 색 및 폴리페놀의 함량은 최고에 도달하고, 기존의 성숙시기 판단 지표인brix×pH(2) 값과 brix/acid 비율을 만족시키는 것으로 나타났다. This study was conducted to investigate several indicators of fruit maturity, and expert sensory evaluation was done to determine the most appropriate maturity time for the new Korea grape cultivar ``doonuri`` for high quality winemaking. The grape component changed dramatically during ripening, after veraison. Considerable drops in berry firmness (<0.60 kgf/cm2) and titratable acidity (<0.66%) were found at the ripening stage while the soluble solid content significantly increased in the ripening process. Most of the organic acids contained were tartaric and malic acid. The malic acid content was about twice the tartaric acid content in the fruit-growing period but was less than the tartaric acid content in the maturity period. The total anthocyanin and polyphenol contents increased sharply after veraison. In particular, the total anthocyanin and polyphenol contents reached their maximum levels when the acidity was 0.55%, and after that, there was almost no change. Correlations between anthocyanin accumulation and several factors were found in sugar 0.7811 (p<0.05), pH 0.9315 (p<0.05), and Brix/acid ratio 0.9409 (p<0.05). Brix×pH2 and brix/acid ratio were used as indicators of the proper maturation of the grapes when the acidity was 0.53 to 0.55%, and at sugar 17 Brix. When surveyed, the quality characteristics and sensory evaluation of the wine made using the latest harvested grapes showed the most reliable sourness. The color, aroma, and overall harmony of the wine, however, were evaluated to be the best when the wine acidity was about 0.60% or when the grape acidity was below 0.55%

중국 채소류 생산 관리체계 분석 -산동지역 고추, 마늘, 양파 농가 사례조사 결과-

하두종 ( Doo Jong Ha ),유창환 ( Chang Whan Yu ),최칠구 ( Chil Ku Choi ),조성주 ( Sung Ju Jo ),이종수 ( Jong Zhu Li ) 한국국제농업개발학회 2015 韓國國際農業開發學會誌 Vol.27 No.5

1. 본 연구는 중국 산동성의 평도시(平度市) 및 신강성 집단재배농장을 대상으로 주요 채소 농산물인 고추, 마늘, 양파에대하여 한국과 중국의 생산 관리체계 및 기술 수준을 비교ㆍ분석하였다. 2. 고추의 경우 한국은 묘를 구입하여 정식하는 비율이 높지만 중국은 대부분 자가 채종 후 자가 육묘를 하는 체계이다. 가장 특징적인 것은 한국은 수확을 10일 간격으로 5 ~ 6회 하지만, 중국은 일시 수확하여 수확노동력을 줄이고 있다. 고추의 경영비와 생산비 비교에서는 각각 한국이 3,975원/kg,11,686원/kg이며, 중국은 519원/kg, 1,895원/kg으로 한국의 경영비가 7.3배, 생산비는 6.2배 차이가 나는 것으로 조사되었다. 3. 중국의 마늘 파종량은 한국에 비해 3배 이상으로 밀식파종을 한다. 재배 이랑은 한국은 넓은 이랑이며, 중국은 2줄 좁은 이랑에서 재배 하고 있다. 멀칭은 한국이 기계멀칭을 64%하고 있으나 중국은 인력을 이용한 멀칭을 하고 있다 마늘의 경영비와 생산비 비교에서는 각각 한국이 1,128원/kg, 2,049원 /kg이며, 중국은 310원/kg, 686원/kg으로 경영비는 3.6배, 생산비는 3.0배 차이가 나는 것으로 분석되었다. 4. 양파는 중국이 한국보다 경지기반은 좋으나 호당 경지면 적은 0.14 ha로 매우 영세하다. 한국은 복비와 유기질 비료를 사용하고 방제를 3 ~ 5회하는 반면, 중국은 계분을 사용하고, 살균, 살충, 제초 방제는 1회만 실시하고 있다. 육묘는 중국과 한국이 모두 구입종자를 이용한 자가 육묘를 하는 동일한 생산체계이다. 양파의 경영비와 생산비 비교에서는 각각 한국이 199원/kg,334원/kg이며, 중국은 46원/kg, 98원/kg으로 한국보다 경영비는 4.3배, 생산비는 3.4배 차이가 있은 것으로 나타났다. This study was carried out to analyze the Chinese vegetable production system and to compare it with the adopted system in Korea. Farm producing pepper, garlic and onion in Sandong and Singang were surveyed. For pepper production, Korea farm purchased the planting materials while, China farm produced their own seeds and seedlings. Also, the most significant difference was the one time harvesting in China, while Korea usually harvests 5 ~ 6 times within 10 days term per year with an increase in production. The management and production cost were observed to be 3,975 won/kg, 11,686 won/kg for Korean pepper, but China has low cost by 519 won/kg, 1,895 won/kg. An amount of garlic seed in China was more than three times that of Korea. Korea covered the wide furrow with mulching plastic and used machines that raised the production rate by 64%. However, Chinese depends on the human labor and make narrow furrow to increase the productivity. The management and production cost were 1,128 won/kg, 2,049 won/kg for Korean garlic, while China has low cost by 310 won/kg, 686 won/kg respectively. To cultivate onion, the land condition of China was better than Korea having an average farm size of 0.14 ha smaller than Korea. Two nations were compared having the same seedling production system that buy the seed at the market and seedling their own land. Likewise, the management and production cost observed as 199 won/kg, 334 won/kg for Korean onion, while Chinese cost was lower by 46 won/kg, 98 won/kg. It is concluded that the good producing system of China such as pepper one-time harvesting system should be adopted to korean farm system to reduce cost.

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

수리적 간극변화를 고려한 수리적 굴착손상영역의 정의에 관한 연구

박종성,류창하,이정인,류동우,Park, Jong-Sung,Ryu, Chang-Ha,Lee, Chung-In,Ryu, Dong-Woo 한국터널지하공간학회 2007 한국터널지하공간학회논문집 Vol.9 No.2

굴착손상영역(EDZ)은 굴착으로 인해 현지 암반이 역학적으로 손상을 입게 되어 응력상태, 변위상태, 암반의 안정성, 지하수의 흐름상태 등에 변화가 일어나는 영역을 의미한다. EDZ의 역학적 특성과 관련한 많은 연구들이 수행되었지만, EDZ에서의 지하수 유동 특성에 관한 연구는 아직 부족한 수준이다. 따라서 본 연구에서는 굴착으로 인해 굴착면 주변의 수리적 간극이 늘어나는 영역을 산정하여 '수리적 굴착손상영역'이라 정의하고 이를 위해 수리-역학적 상호작용(coupling)해석을 수행하였다. 이는 개별 불연속면 망의 생성을 통한 역학적, 수리적 변화의 모사가 가능한 개별요소법(discrete element method; DEM)을 이용하여 수행하였다. 이를 통해 EDZ에서 지하수의 흐름에 영향을 미치는 각종 조건들(불연속면의 간극, 불연속면 군의 방향, 불연속면 군의 길이, 불연속면의 각도 등)의 변화와, 응력분포, 지하수의 유동 등으로 인해 수리적 간극 값이 어떻게 변화하는지를 파악하였다. 이 결과를 토대로 수리적 간극이 커지는 영역, 수리적 EDZ를 공동 주변의 불연속면 방향에 수직 방향으로 존재하는 타원형의 형태로 모델링 하였다. The excavation damaged zone (EDZ) is an area around an excavation where in situ rock mass properties, stress condition, displacement, groundwater flow conditions have been altered due to the processes induced by the excavation. Various studies have been carried out on EDZ, but most studies have focused on the mechanical bahavior of EDZ by in situ experiment. Even though the EDZ could potentially form a high permeable pathway of groundwater flow, only a few studies were performed on the analysis of groundwater flow in EDZ. In this study, the 'hydraulic EDZ' was defined as the rock zone adjacent to the excavation where the hydraulic aperture has been changed due to the excavation by using H-M coupling analysis. Fundamental principles of distinct element method (DEM) were used in the analysis. In the same groundwater level, the behavior of hydraulic aperture near the cavern was analyzed for different stress ratios, initial apertures, fracture angles and fracture spacings by using a two-dimensional DEM program. We evaluate the excavation induced hydraulic aperture change. Using the results of the study, hydraulic EDZ was defined as an elliptical shape model perpendicular to the joint.

Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors

Kim, Chan-Jin,Lee, Dong-Ik,Kim, Cheonghee,Lee, Kangtaek,Lee, Chang-Ha,Ahn, Ik-Sung American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.8

<P>Cathepsin B has been suggested to be a prognostic marker of melanoma, glioma, and a variety of cancers such as brain, breast, colon, esophageal, gastric, lung, ovarian, and thyroid cancers. Cathepsin B inhibitors have also been considered as anticancer drug candidates; hence, there has been a growing need for a probe which enables the selective and simple detection of cathepsin B and its inhibitors. For the purpose of selective assay, a cathepsin B-specific substrate, <I>N,N</I>′-diBoc-dityrosine-glycine-phenylalanine-3-(methylthio)propylamine (DBDY-Gly-Phe-MTPA) was synthesized in this study. Phe-MTPA, which was produced via cathepsin B-catalyzed hydrolysis of DBDY-Gly-Phe-MTPA, allowed aggregation of gold nanoparticles (AuNPs) leading to a color change from red to blue. When tested for cathepsins B, L, and S, this assay method exhibited AuNPs color change only in reaction to cathepsin B. The limits of detection for cathepsin B was 10 and 5 nM in the 1 and 2 h hydrolysis reactions, respectively. The efficiency of cathepsin B inhibitors such as leupeptin, antipain, and chymostatin was easily compared by the degree of color change. Moreover, IC<SUB>50</SUB> values of leupeptin, antipain, and chymostatin were found to be 0.11, 0.48, and 1.78 μM, respectively, which were similar to the results of previous studies. Therefore the colorimetric assay of cathepsin B and cathepsin B inhibitors using DBDY-Gly-Phe-MTPA and AuNPs allowed not only the selective but also the simple assay of cathepsin B and its inhibitors, which was possible with the naked eye.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2014/ancham.2014.86.issue-8/ac4039064/production/images/medium/ac-2013-039064_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac4039064'>ACS Electronic Supporting Info</A></P>

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.