A comparison of Min’s glasses and conventional occlusion therapy in the treatment of amblyopic children: a prospective study

Byung Moo Min,Seung Young Kim,Kil Hwan Ko,Seong Bok Lee 대한안과학회 2000 Korean Journal of Ophthalmology Vol.14 No.1

Min’s glasses are specially manufactured in order to enhance the satisfaction of the wearer and increase treatment effectiveness. We compared the effectiveness of Min’s glasses with that of conventional occlusion therapy in amblyopic pediatric patients. We prospectively studied 60 amblyopic patients. For four to 30 months, 24 of the patients were treated with conventional patch occlusion (patch group) and 36 of them were treated with Min’s glasses (glasses group). We compared the improvement in visual acuity and the treatment compliance between both groups, according to age (over six and less than six), sex, type of amblyopia, and the duration of treatment. Sixteen patients (66.7%) in the patch group and 32 patients (88.9%) in glasses group showed improvement in visual acuity (p=0.002). The pre-treatment average log MAR acuity was 0.56±0.25 in the patch group, and 0.59 ±0.25 in the glasses group. The average improvement in visual acuity was a 0.17 log MAR score in the patch group, and a 0.31 log MAR score in the glasses group (p=0.004). Compliance was 59.54% in the patch group and 83.44% in the glasses group (p=0.012). The pre-treatment average log MAR acuity was 0.49 ± 0.23 for children over six years of age in the patch group, and 0.58±0.28 for children over six years of age in the glasses group. For children over six years of age in the glasses group the improvement in visual acuity (0.29 log MAR score) was greater than for children over six years of age in the patch group (0.06 log MAR score) (p=0.0003). The pre-treatment average log MAR acuity was 0.55±0.22 for female patients in the patch group, and 0.60±0.25 for female patients in the glasses group. Female patients in the glasses group also showed a greater visual acuity improvement (0.29 log MAR score) than female patients in the patch group (0.14 log MAR score) (p=0.0028). However, there were no differences between the groups in patients less than six years of age and in male patients. In conclusion, Min’s glasses were more effective than conventional treatment with a patch in improving visual acuity and encouraging compliance in pediatric amblyopic patients, especially in children over six years of age and in girls.

소아약시에서 Min`s Glasses 의 처음치료와 가림치료에 실패한 후 대안치료의 효과비교

민병무(Byung Moo Min),고길환(Kil Hwan Ko),김승영(Soeng Yung Kim) 대한안과학회 1996 대한안과학회지 Vol.37 No.12

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

의·간호계 종사자 및 학생들의 죽음 인지도에 관한 연구

이길홍,김헌수,나철,권혜진,김성희,민병근 중앙대부설한국의과학연구소 1983 한국의과학 Vol.15 No.3

심인성 신체화 증상의 좌우 편재

이병욱,남궁기,민성길 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : The purpose of this study was to examine chief somatic complaints and their correlation to laterality in the body, and severity of anxiety and depression. Methods : The sixty-one patients were examined. The diagnostic criteria used was DSM-Ⅲ-R. The severity of depression and anxiety was assessed with Hamilton's depression scale and Hamilton's anxiety scale, respectively. The demographic data of the subjects were also analyzed. Results : The chief psychogenic somatic symptoms that were complained by patients occurred significantly more on the left side than on the right side(Left : Right : Both=62.3% : 19.7% : 18.0%). Headache was the most common somatic symptoms and headache and other symptoms were significantly more on the left. The demographic data did not make a difference between the left and right-sided groups. The diagnosis did not make a difference between the left and right-sided groups. The score of anxiety or depression were higher in the left-sided group than the right-sided group, but not statistically significant. conclusions : These results suggest that the laterality of psychogenic somatic symptoms seems to be more related with left hemisphere.

학생청소년의 문제행동과 가정의 심리풍토 특성과의 관계에 관한 상관분석

이길홍,김헌수,민병근 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.4

The purpose of the study was aimed to examine the relationship between the adolescent problem behaviors and their family climate among high school students in Korea, and to collect baseline data for the establishment of effective measures to prevent delinquent acting-out. In order to achieve these aims, sampling were made by three stage clustered random sampling method, and questionnaires were finally supplied to a total 1620 high school student. These data were statistically analysed by simple correlation coefficient and stepwise multiple regression analysis in order to reveal the relationship between 8 types of factor structures of male & female problem behaviors created through factor analysis of 57 problem behaviors, and 5 categories of psychological climate of family. The collected data were analysed by CDC-174 Computer of KIST, using SPSS program, and their results of the study were presented below; 1. The principal factor structures of problem behaviors among adolescent school boys and girls were classified as follows : The socialized nonaggressive, neurotic withdrawal, overt impulsive sexual, adult modelling, socialized latent sexual, school-norm avoidant, narcissistic sexual, and under-socialized latent aggressive behaviors. Among them, the socialized non-aggressive behavior and the narcissistic sexual behavior were predominantly observed in the male students, on the other hand, the socialized latent aggressive behavior and the socialized non-aggressive behavior were more common in females. From these results, we proposed that studies on causation of problem behavior and measures for guidance should be applied differently by their sex categories. 2. The defective psychological climate of family tended to affect their children's problem behaviors, and their degree of influence was more influential in male students than female students. The family stability, family member's satisfaction with home, and parent-child relation showed more significant correlation with their children's problem behavior comparing with parental child rearing practices. 3. The psychological instability of family tended to be positive correlation with their children's problem behavior. The familial tenseness, coldness, disharmony, uncooperativeness, and parental marital discord revealed significant correlation with their children's socialized latent aggressive behavior and neurotic withdrawal behavior. 4. The family member's dissatisfaction with home tended to bear significant relationships with their children's problem behavior, that is, their children's neurotic flighting behaviors including the socialized non-aggressive, neurotic withdrawal, and school-norm avoidant behavior. 5. The disharmonious parent-child relationships were positively correlated with their children's problem behavior. Particularly, parental rejection of children's opinions, children's rejection of parental opinions, alienated parent-child relationship, lesser degree of devotion, and paternal loss of affection were significantly correlated with their children's problem behaviors such as son's neurotic withdrawal behavior and daughter's socialized non-aggressive behavior. 6. The defective parental child rearing practices tended to affect their children's problem behavior. Particularly, parental mistrust to their children, parent-centered approach, authoritative approach, punishment oriented system, rigid discipline, and parental closed-mindedness were significantly correlated with their son's narcissistic sexual behavior & neurotic withdrawal behavior or daughter's school norm avoidant & undersocialized latent aggressive behavior. 7. In comparison of both parent in the degree of influence on their children's problem behavior, it was revealed that father's was more influential than mother's. Particularly, the parental child rearing practices showed more significant correlations with their son's problem behaviors comparing with their daughter's behaviors, and showed higher correlations with their same-sex children than their opposite sex children. 8. Among 7 types of parental child rearing practices, parental mistrust toward their children was most important factor. These mistrust attitude toward their children showed higher correlations with neurotic flighting types of behavior than antisocial fighting types of behavior.

청소년 정신장애에 관한 정신의학적 연구

이길홍,김헌수,나철,민병근 중앙대부설한국의과학연구소 1983 한국의과학 Vol.15 No.2

근로청소년의 산업재해와 음주양상과의 상호관계에 관한 산업정신의학적 연구

이길홍,김헌수,이규항,민병근 중앙대부설한국의과학연구소 1983 한국의과학 Vol.15 No.1