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RISS 인기검색어
- 검색키워드
- 저자 : 이규항 (검색결과 79 건)
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李奎恒,李丙允 고려대학교 의과대학 1972 고려대 의대 잡지 Vol.9 No.1
This clinical study of manic- depressive illness have revealed its incidence, prepsychotic personality, family history, age of onset, various aspects of recurrent types including their initial status, duration of their cycle and symptomatology. The 102 cases of manic-depressive illness included 57 cases of depression and 45 cases of mania. According to their recurrent types, the total cases were classified into 3 groups, which were 44 cases of depressed type, 16 cases of manic type and 42 cases of circular type. As to the types of initial attack of manic-depressive illness, there were 69 cases of depression and 33 cases of mania. The results were as following: 1. The manic-depressive were rated as 3.1% of the total 3265 patients seen in our paychiatric department from April 1, 1968 to March 31, 1971. There were 52 male patients and 50 female patients. 2. The diagnostic distribution of these total 3265 patients revealed that depressive neurosis had the highest rate and schizophrenia, psychotic depression, epilepsy, and anxiety neurosis had higher rates in this order. As to the distribution of psychotic diseases, schizophrenia and psychotic depression had the highest rates and manic-depressive illness, involutional depression and paranoid state had their rates in this order. 3. Among the various prepsychotic personality, obsessive compulsive personality and cyclothymic personality were most frequent ones, and hypomanic, depressive, schizoid and aggressive ones were also relatively frequent. 4. Family history of these manic-depressive patients revealed that 53.9% of them had suicidal cases and various psychotic disorders in their near relatives. And those of 53.9% were further classified as 36.4% of depressed patients, 81.4% of manic patients and 61.9% of circular patients. Out of these 53.9% of psychotic families, manic-depressive illness occupied 12.7% and rest of 35.3% included schizophrenics, alcoholics, drug addicts, mentally retarded, psychoneurotics and 5.9% of suicidal cases. 5. The ratio of the initially depressive patients and manic patients was 2.1 to 1. The initially depressive patients showed of milder state than the initially manic patients. 6. As to the age of onset in manic depressive illness, it was revealed that the initially depressive patients had the tendency to develop their illness between the ages of 26 to 35 and the initially manic patients had the tendency to develop their illness between the ages of 16 to 25. 7. As to the duration of cycles in manic-depressive illness, the duration of first cycle was 6.5 years, that of second cycle was 4.6 years, and that of third cycle was 2.3 years: in other words, it could be said that the more the recurrences repeated, the shorter the duration. About the duration of first cycle, the patients of depressed type had 7.5 years, the patients of manic type had 10.7 years and the patients of circular type had 4.9 years. 8. The patients with depression showed following symptoms and thought disorders in the order of their frequency: depressed mood, headache, difficulty in getting asleep, anxiousness and agitation, lack of energy and drive, awakening in the early morning, decreased psychomotor activity, many dreams during sleep, and guilt and self-blame. The patients with mania showed following symptoms in the order of their frequency: increased psychomotor activity, pressure of speech, elated mood, difficulty in getting asleep, idea of grandeur, flight of idea, verbally aggressive and destructive tendency, anxiousness and agitation, incoherence, physically aggressive and destructive tendency, many dreams during sleep, and circumstantiality. The relatively milder symptomatology of depressive state of initially depressive patients and the different figure of sex ratio of the manic-depressive of this study from that of many other reports, mostly western authors, were supposed to be the most characteistic pictures of this study.
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Pharmacological evaluation of HM41322, a novel SGLT1/2 dual inhibitor, in vitro and in vivo
이규항,이상돈,김남두,서귀현,김영훈,심상수 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.1
HM41322 is a novel oral sodium-glucose cotransporter (SGLT) 1/2 dual inhibitor. In this study, the in vitro and in vivo pharmacokinetic and pharmacologic profiles of HM41322 were compared to those of dapagliflozin. HM41322 showed a 10-fold selectivity for SGLT2 over SGLT1. HM41322 showed an inhibitory effect on SGLT2 similar to dapagliflozin, but showed a more potent inhibitory effect on SGLT1 than dapagliflozin. The maximum plasma HM41322 level after single oral doses at 0.1, 1, and 3 mg/kg were 142, 439, and 1830 ng/ml, respectively, and the T1/2 was 3.1 h. HM41322 was rapidly absorbed and reached the circulation within 15 min. HM41322 maximized urinary glucose excretion by inhibiting both SGLT1 and SGLT2 in the kidney. HM41322 3 mg/kg caused the maximum urinary glucose excretion in normoglycemic mice (19.32±1.16 mg/g) at 24 h. In normal and diabetic mice, HM41322 significantly reduced glucose excursion. Four-week administration of HM41322 in db/db mice reduced HbA1c in a dose dependent manner. Taken together, HM41322 showed a favorable preclinical profile of postprandial glucose control through dual inhibitory activities against SGLT1 and SGLT2.
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F/1.4와 30$^{\circ}$ $\sim$ 110$^{\circ}$의 시야각을 갖는 반사굴절식 LWIR 전방위 광학계의 설계 및 공차분석과 비열화 해석
이규항,강종구,조재흥,류재명 한국물리학회 2017 새물리 Vol.67 No.6
For night time security and surveillance, we designed a catadioptric long-wavelength infrared (LWIR) omnidirectional optical system with F/1.4 and a field of view of 30$^{\circ}$ $\sim$ 110$^{\circ}$ in the wavelength range from 8 $\sim$ 12 $\mu$m. The optical system is divided into a mirror part to transfer a wide angle of view into a narrow angle of view and a lens part that images the narrow angle of view obtained from the mirror part into a sensor. Firstly, we used geometric optical methods in order to calculate the radius of curvature of the primary spherical mirror for the imaging lens part. We used a patented LWIR optical system for the imaging part so as to match well with the various calculated specifications of the mirror part. From analyses of the tolerance and the athermalizaton with an auto-focusing lens, we have verified that the optical system is suitable for a LWIR omnidirectional optical system. 전방위 야간 감시 시스템을 위한 8 $\sim$ 12 $\mu$m의 파장 범위에서 F/1.4와 30$^{\circ}$ $\sim$ 110$^{\circ}$의 넓은 시야각을 갖는 반사굴절식 원적외선 (long-wavelength infrared, LWIR) 전방위 광학계를 구면거울과 구면렌즈만 사용하여 설계하였다. 이 광학계는 크게 거울부와 렌즈부로 구성되어 있으며, 거울부는 광각의 물체를 협각의 물체로 만들어 렌즈부로 전송해주는 역할을 하며, 렌즈부는 이를 받아서 촬상 소자에 결상하는 역할을 한다. 먼저 렌즈부의 사양을 고려하여 구면거울인 주경의 곡률반경을 계산하였고, 이에 적합한 기존의 LWIR 결상렌즈를 변형하여 설계하였다. 그리고 최적화 설계된 전체 광학계의 공차분석 및 마지막 렌즈를 보정렌즈군으로 선택하여 궤적이동을 한 비열화 해석 결과, 이 광학계가 LWIR 전방위광학계로 적합함을 확인하였다.
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