뇌동맥류 수술시 체성감각유발전위의 모니터링

염기훈,김국기,이기택,박종태,임영진,김태성,이봉암,임언 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

감자 養液栽培時 苗素質이 괴경형성에 미치는 영향

朴庸奉,金基澤 濟州大學校亞熱帶農業硏究所 1997 亞熱帶農業硏究 Vol.14 No.-

This study was conducted to determine the effect of potato seedling charateristics on the tuber formation and tuber rooting. The results are summarized as follows: 1) Sixty days after transplanting in Aeroponic, the Aeroponic method increased the plant height 7.4cm and the plant diameter 2.0cm more than the NFT method. 2) Ninety days after transplanting maximum stolen number of AERO, 30.4cm longer than the NFT method, and stolen per plant of NFT 10.5cm more than the Aeroponic method. 3) Tuber number Per plant was 47.1 in Aeroponic and 42.4 in NFT. However, tuber formation rate was aero : 66%, NFT : 40.3% 4) The rooting speed of a stem cutting of 1~2mm seedling was faster than 5~6mm seedlings. 5) Forty days after stem cutting, stolen increased 3~4mm and stolen length showed 5~6mm. 6) Tuber yield was 40.3 for 1~2mm seedlings, 38.3 for 3~4mm, and 27.2 for 5~6mm, was 27.2 respectively. As we said above, we can estimate that Aeroponic method was good for seed tuber formation and proper stem cutting size was 1~3mm for hydroponics.

水稻 이양전작(春播) 靑刈 옥수수의 경제성 조사

金基元,徐大振,姜奉泰 진주산업대학교 1972 論文集 Vol.9 No.-

1. The weather condition was good and the cost of producing 7,600Kg/wa of soiling corns was 3,911 Won 2. Appreciate value per Kg was 51 Won, labor-expense was 3,38won, fertilizer-expense 0,16 Won and productive quantity per invested labor-hour was 118Kg, 3. Forage quantity to purchase with the expense of soiling coiling corns sold is as follows:barley is 156,4Kg, corns are 88.3Kg, wheat bran is 165.7Kg, wheat 114.0Kg and nou-fatdrid ricebran is 23.42Kg. 4. After-farming growth and harvest quantity were not different, but the damage of disease was slightly more.

중년기 여성의 노인부양에 관한 조사연구

김기태,류기형,박병현,박봉길,장창호 부산대학교 사회복지연구소 2000 社會福祉硏究 Vol.10 No.-

菜種油의 水素添加反應에 關한 硏究 (第一報) : 요오드價, 굴절율, 융점의 變化에 따른 Kinetics The Kinetic Studies by the Changes of Iodine Value, Refractive Index and Melting Point

權泰鳳,吳成基 慶熙大學校 1983 論文集 Vol.12 No.-

Edible rapeseed oil containing about 30% erucic acid was hydrogenated using nickel catalyst under 1 atm. and other various reaction conditions. Physicochemical change of the reaction products was examined by measuring iodine value, refractive index and melting point. Also, the kinetics was studied by measuring iodine value. The results obtained are as followed: It was found that the hydrogenation of rapeseed oil at 170℃ and 0.1% catalyst level was followed the first-order kinetic, and the rate constant was calculated to be 3.9×10^-3 min^-1·Iodine value was decreased with an increase of reaction temperature, time and catalyst concentration. Refractive index and melting point were increased with a decrease of iodine value. The correlation factor between refractive index and iodine value was RI=0.00015 IV+1.4512.

靑刈用 交雜 옥수수의 生育特性 및 生産性에 關한 調査

金基元,姜奉泰,文点東,李乙熙,金哲旭 진주산업대학교 1983 論文集 Vol.21 No.-

In order to investigate the growth characteristics and yield performance oi the corn hybrid cultivated during 6 months from Mar. 1983 to Sep. the same year at fields of grass research, Dept. of Dairy Science, Jinju Agricultural & Forestry Junior Techical College. The results obtained are as follows: 1. the budding ratio was slightly low by unseasonableness of weather at the seeding day. 2. The growth of Gwang oggu hybrid was slightly superior to that of Hwang oggu at heading, tasseling and dough stage. 3. The plant length and No. leaf of Gwang oggu hybrid were superior to those of Hwang oggu by growth stage. 4. Disease resistance was generally strong, but it was necessary to control corn borer because of being well affected by it. 5. The yields of Gwang oggu hybrid and Hwang oggu are summarized as follows:

노화가 인체 중간엽 줄기세포로부터 조골세포로의 증식 및 분화에 미치는 영향

백기현,태현정,오기원,이원영,조정기,권순용,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

연구배경: 일반적으로 골다공증과 연관된 위험인자로는 연령, 폐경, 약물, 불충분한 칼슘섭취, 만성질환 및 운동부족 등이 있는데, 특히 노화가 진행할수록 골밀도가 감소하는 것은 잘 알려져 있다. 노화와 관련하여 진행되는 골소실은 조골세포 및 전구조골세포의 기능적 결핍에 의한 골형성의 감소가 주요한 요인으로 여겨지고 있다. 그 동안 연령이 조골모 세포의 양과 조골모 세포로부터 성숙조골세포로의 분화 및 증식에 미치는 영향에 대한 일부 보고들이 있었으나 아직 일치된 견해는 없는 형편이다. 방법: 다양한 연령의 사람으로부터 골수를 채취, 중간엽 줄기세포가 포함된 단핵세포를 분리한 후 조골세포로 분화하기 좋은 조건하에서 배양하였다. 대상군은다시 젊은군과 노령군으로 구분하여 다양한 변수를 비교 분석하였다. 일차배양에서는 CFU-F를 계수하여 골수내 중간엽 줄기세포의 수를 추산하였고, 칼슘측정을 통하여 기질의 무기화 정도를 비교하였다. 계대배양후 이차배양에서는 시기별로 알카리성 포스파타제 활성도를 측정하고 오스테오칼신 mRNA의 발현을 관찰하여 젊은군과 노령군 사이의 증식능 차이를 비교하였다. 또한 이차배양 시기별로 MTT 측정을 하여 양군간에 증식능 차이가 있는지 알아보았다. 결과: 1. 일차배양 15일째에 평균 CFU-F의 수는 젊은군에서 유의하게 많았다(젊은군 148.3±28.9, 노령군 54.3±9.1, p=0.02). CFU-F의 평균면적은 젊은군에서 넓은 경향을 보였으나 통계적으로 유의하지는 않았다. 2. 일차배양 17일 경과 후 양군간에 기질 칼슘 침착정도는 유의한 차이를 보이지 않았다(젊은군 103.6±50.6, 노령군: 114.0±56.5, p=NS). 3. 이차배양 10일째에 젊은군에서 알카리성 포스파타제 활성도가 고령군에 비해 유의하게 높았다(젊은군: 935.5±115.0 U/mg, 노령군: 578.4±115.7U/mg,p.0.05). 고령군에서는 시간 경과에 따른 변화가 미약했으며 전반적으로 알카리성 포스파타제의 활성도가 젊은군에 비해 낮았다. 4. 이차배양도중 오스테오칼신 mRNA의 발현은 배양시기별로 젊은군에 비해 고령군에서 더 낮은 경향을 관찰할 수 있었다. 5. 이차배양 10일과 15일에 젊은군에서 노령군보다세포증식이 유의하게 증가된 양상을 보였다(10앓 젊은군 0.73±0.05, 노령군 0.58±0.04, p=0.05, 15일; 젊은군 0.80±0.05, 노령군 0.70±0.03, p=0.05).결론: 이상의 연구에서 저자들은 노령군에서 젊은군보다 골수 내 중간엽줄기세포의 수가 적고, 노령군에서 유래한 전구조골세포의 성숙조골세포로의 증식 및 분화가 젊은군 보다 감소해 있는 것을 관찰할 수 있었다. Background: Osteoblasts originate from osteoprogenitor cells in bone marrow stroma, termed mesenchymal stem cells (MSCs) or bone marrow stromal cells. Each MSC forms colonies (colony forming units-fibroblasts [CFL-Fs]) when cultured ex vivo. There are some reports about the age-related changes of the number and osteogenic potential of osteoprogenitor cells, but any relationship has not been clearly established in humans. In this study, we counted MSCs using CFU-Fs count and examined the proliferative capacity and differentiation potential of osteoprogenitor cells. Finally, we analyzed how these parameters varied with donor age. Methods: Bone marrow was obtained from the iliac crest of young (n=6, 27.2±8.6 years old) and old (n= 10, 57.4k6.7 years old) healthy donors. Mononuclear cells, including MSCs, were isolated and cultured in osteogenic medium. In primary culture, we compared the colony-forming efficiency of MSCs between the two groups and determined the matrix calcification. When primary culture showed near confluence, the cells were subcultured. Alkaline phosphatase activity, osteocalcin expression by RT-PCR and proliferative potential by MTT assay were examined by the time course of secondary culture. Results: At the 15th day of primary culture, the mean number of CFU-Fs was significantly higher in the younger donors (young: 148.3±28.9, old: 54.3±9.1, p=0.02) and the mean size of CFL-Fs was also larger in the younger donors than the older donors. However, matrix calcification was not different between the two groups (young: 103.6±50.6, old: 114.0±56.5, p=NS). In secondary culture, alkaline phosphatase activities were significantly lower in the older donors. The younger donors showed peak alkaline phosphatase activity at day 10, while the older donors didn't showed a remarkable peak (young: 935.5±115.OU/mg, old: 578.4±115.7U/mg, p<0.05). Total cell number as a proliferative index increased progressively during the secondary culture and a significantly greater cell number was noted in the younger donors. Osteocalcin expression was generally upregulated in the younger donors, but this was not statistically significant. Conclusion: Our study shows that the number of osteoprogenitor cells is decreased during aging and that the proliferative capacity and differentiation potential of osteoprogenitor cells seem to be reduced during aging (J Kor SOC Endocrinol 18:296-305, 2003).

韓國産 大豆油의 抗酸化에 關한 硏究(第一報) : 大豆油에 있어서 tocopherol과 phospholipid의 抗酸化 相乘效果에 關하여 Synergistic Antioxidation Effect of Tocopherol and Phospholipid

權泰鳳,吳成基 慶熙大學校 1985 論文集 Vol.14 No.-

The synergistic antioxidation effect of α-tocopherol and soybean phospholipid was examined by measuring peroxide value at 100℃, 150℃ and 200℃ with time. Various concentrations of tocopherol and phospholipid were added to the edible soybean oil respectively. When phospholipid was not added the antioxidation effect of tocopherol was more found at 0.01% addition level than 0.05% or 0.1% additional level. In the case of phospholipid was added the antioxidation effect was more significantly found than phospholipid not added and, when the addition level of tocopherol was increased the antioxidation effect of phospholipid was found at higher phospholipid addition level. But at the low addition level of tocopherol, the high phospholipid addition level was decreased antioxidation effect. When the 0.05% tocopherol and 0.1% phospholipid was added to the edible sobean oil at 100℃, the antioxidation effect was exhibited to maximum and also, 0.05% tocopherol and 0.05% phospholipid at 150℃ too. The antioxidation effect was increased with an increase phospholipid addition level at 100℃ but at the low addition level of topherol, the antioxidation effect was decreased with an increase phospholipid concentrations at 150℃. The antioxidation effect was not significantly different from phospholipid and tocopherol at 200℃

축하중과 첨가질량이 작용하는 적층복합판의 진동해석

이봉학,김경진,원치문,성기태 江原大學校 産業技術硏究所 1995 産業技術硏究 Vol.15 No.-

A method of calculating the natural frequency corresponding to the first mode of vibration of beams and tower structures, with irregular cross-sections and with arbitrary boundary conditions was developed and reported by D. H. Kim in 1974. IN this paper, hte result of application of this method to the laminated plates with axial forces and with attached point mass/masses is presented. Both N? and N? forces are considered. The solution for the laminated plates with arbitrary boundary conditions and irregular section can be obtained by simply obtaining the deflection influence coefficients by any method. The effect of neglecting the mass of the plates on the natural frequency, as the ratio of the point mass/masses to the plate mass increases, is thoroughly studied. The influence of N? and N? is also carefully investigated.