정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

마우스 골수세포 배양시 수종 국소조절인자가 파골-유사세포 형성에 미치는 영향

채한정,채수완,김형룡 한국노화학회 1998 한국노화학회지 Vol.8 No.3

가족성 고콜레스테롤혈증 유병자에서 HMG Co-A Reductasen Inhibitor 및 Bile Acid Resin의 투여로 인한 아킬레스건 황색종의 감소

채인호,한기훈,박영배,조주희,김효수,손대원,김철호,오병희,이명묵,최윤식,서정돈,이영우 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

기저귀 사용실태와 피부자극도 조사 : Cost, Environment, and Skin Irritability

한정석,김동건,신현숙,정예리,정태석,채선미 한국모자보건학회 2000 한국모자보건학회지 Vol.4 No.1

치과용 자성 어태치먼트 재료의 안정성 개선에 관한 연구 : II.질화티타늄 코팅이 치과용 자성재의 내식성에 미치는 영향 Ⅱ.Effect of TiN Coating on Corrosion Resistance of Dental Magnetic Materials

최한철,고영무,정재헌,신종연,김일선,최성욱,정효수 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.4

Dental magnetic materials have been applied to removable prosthetic appliances, maxillofacial prostheses, obturator and dental implant but they still have some problems such as low corrosion resistance in oral environments. To increase the corrosion resistance of dental magnetic materials, surfaces of Sm-Co and Nd-Fe-B based magnetic materials were plated with TiN and then electrochemical corrosion test were performed in 4 kinds of electrolyte solutions(0.9% NaCl. 1% lactic acid, 0.05% HCl and modified Fusayama's artificial saliva). From this study, corrosion behavior, amount of elements released, mean average surface roughness values and the changing of mean surface microhardness values were measured comparing with control group of non-sputtered plating magnetic materials. The results were as follows: 1. TiN layer coated on magnet grows into preferred direction with lamellar structure and its thickness is 3.0㎛. 2. Sm-Co base magnetic materials coated with TiN have good corrosion resistance in 1% lactic acid and their pitting corrosion can not be seen. 3. Nd-Fe-B base magnetic materials coated with TiN showed good tendency of corrosion resistance in 0.05% HCl solution. 4. The amount of elements released from both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were more significantly decreased than that of uncoated magnetic materials. 5. The mean surface roughness values of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were smooth than that of uncoated magnetic materials after corrosion test. 6. The decreasing rate of microhardness of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were lower than that of uncoated magnetic materials after corrosion test. 7. Dental magnetic materials coated with TiN produced various corrosion products such as TiO, TiO₂, Ti₂O₃on the surface and resulted in better corrosion resistance than uncoated magnetic materials. In conclusion, it is considered that the corrosion problem of dental magnetic materials could be solved to some extent by EB-PVD with TiN on the surface of dental magnetic materials.

전신장기의 호산구 침윤을 동반한 급성 심내막염과 심근염 : An Autopsy Case 부검증례

이상한,이숙희,임재원,곽정식,채종민 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

We experienced an autopsy case of acute endocarditis and myocarditis with systemic organic eosinophilic infiltration probably due to Clonorchis sinensis infection. Localized hypersensitivity reaction due to parasitic infection is common. Systemic eosinophilic infiltration is generally noted in idiopathic hypereosinophilic syndrome, drug induced reaction and parasitic infection.

고등어(Scomber japonicus)의 염장, 동결, 해동 및 가열에 의한 조직학적 변화에 관한 연구

윤정의,이수한,채수규 서울보건대학 1998 서울보건대학 부설 한국보건과학연구소 논문집 Vol.5 No.1

어류의 가공, 저장에 따른 재료의 구조 및 변화를 밝힐 목적으로 고등어를 시료로 사용하여 염장, 가열, 동결, 해동, 동결과 해동의 반복에 다른 근육구조의 변화를 식품 조직학적 방법으로 관찰하여 다음과 같은 결과를 얻었다. 1. 고등어는 피하지방 조직이 잘 발달하여 있고, 근육조직의 근초에 지방이 많이 분포되어 있으며, 근세포는 비정형이다. 2. 염장에 의한 식염의 삼투와 자가소화에 의하여 근세포에 공동과 균열이 현저하다. 3. 가열에 의하여 지방조직은 용해된 상태이며, 근세포는 파괴되어 근형질의 이탈과 수축현상을 보인다. 4. 염장과 가열처리에 의하여 근핵의 감소현상을 보인다. 5. 동결에 의하여 세포 내외에 크고 많은 빙결정이 생성되며, 해동에 의하여 근세포의 파괴, 수축현상과 근초의 간격이 넓어진다. 6. 결합조직은 염장, 가열, 동결 후 해동에 의하여 loose하게 풀어지는 opening-up 현상을 보이며, 통조림 가열과 해동에 의해서 염색성이 저하된다. The histological changes of the muscle tissue of pacific mackerel by the process of salting, heating, freezing, thawing and repeat in freezing and thawing were investigated. The subcutaneous fat tissue of pacific mackerel was developed well, fat was distributed plentifully in the sarcolemma of it's muscle tissue and the muscle cell was amorphous. By the heating, fat tissue was liquefied, muscle cell was destroyed and the separation and contraction of cytoplasm was occurred. By the process of salting or heating the number of nuclei was decreased. By the freezing, a lot of big ice crystal were formed in the inside and outside of the muscle cell. By the thawing, the destruction and contraction of the muscle cell was occurred and the intervals of sarcolemma were extended. The connective tissue was loosed and opening up by the process of salting, heating and thawing. The dyeing quality of the tissue was fallen by the process of canning and thawing.

액상소결법에 의한 SiC 세라믹스의 파괴인성 평가

윤한기,정헌채,김부안 동의대학교 산업기술개발연구소 2005 産業技術硏究誌 Vol.19 No.-

Monolithic Liquid Phase Sintered SiC (LPS-SiC) was fabricated by hot pressing method under 20 MPa using sintering additives at different temperature such as 1760 ℃, 1780 ℃, 1800 ℃ and 1820 ℃. The starting powder was high purity 13-SiC nano-powder with an average particle size of 30 nm. Compositionsof sintering additives were Al_(2)O_(3) Y_(2)O_(3) = 60.7 and 1.5 (wt%). Monolithic LPS-SiC was evaluated in terms of sintering density, hardness and fracture toughness through indentation fracture method by the Vickers hardness tester. Sintered density, hardness and fracture toughness of fabricated LPS-SiC increased with increasing the sintering temperature. It is higher value than that of fabricated SiC by the chemical vapor deposition method.

하지 분절 각도에 따른 수의 등척성 수축(MVIC)시 근전도 비교

김정자,이민형,김연정,채원식,한윤수,권선옥 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

J. J. KIM, M. H. LEE, Y. J. KIM, W. S. CHAE, Y. S. HAN, O. KWON. Comparison of the maximum EMG levels recorded in maximum effort isometric contractions at five different knee flexion angles. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 197-206, 2005. The purpose of this study was to quantify the maximum EMG levels and determine if there are differences in these EMG levels with respect to different knee flexion angles. Eight university students with no known musculoskeletal disorders were recruited as the participants. The maximum voluntary isometric knee extensions and flexions were taken from each participant sat on the isokinetic exercise machine (Cybex 340) at five different knee flexion angles (10?30?50?70? 90?. After surface electrodes were attached to rectus femoris, vastus medialis, vastus laterlis, biceps femoris, and semitendinosus, maximum EMG levels at five different knee flexion angles were measured. The results showed that there was no significant difference in maximum EMG levels among five different knee flexion angles. Although there was no significant difference in EMG levels and were some variations among different knee flexion angles, the EMG signals of quadriceps in extension and biceps femoris in flexion were the greatest at 30? It seems that different joint angles or relative locations of body segments might affect the magnitude of EMG levels. Because the maximum EMG levels could change with a different knee flexion angle, an attempt should be made to more accurately measure these values. If then, %MVIC measure provides more reliable data and is most appropriate for EMG normalization.

Lidocaine에 의한 경련이 뇌조직에서 c-fos 발현에 미치는 영향

조성범,채한정,강장숙,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.1

Recently, a variety of stimuli including convulsion, ischemia and noxious stimuli have been shown to induce the expression of c-fos mRNA in central nervous system (CNS). In this study, c-fos expression in both mRNA and protein (Fos) levels is examined up to 72 hr in brain regions, including hippocampus, piriform cortex, neostriatum, amygdala, dentate gyrus, cerebral cortex, and thalamus during lidocaine-inducced convulsion. Intraperitoneal administration of lidocaine (120 mg/kg) induces generalized convulsion of rats within 10 min and subsequent increase of c-fos expression in both mRNA and Fos protein levels in dentate gyrus, piriform cortex, amygdala, neostriatum, cerebral cortex, hippocampus, and thalamus. A prominent induction of c-fos mRNA and Fos protein in dentate gyrus suggests that dentate gyrus plays an important role in the process of lidocaine-induced convulsion. These results suggest that c-fos may participate in plastic changes of central nervous system associated with stimuli such as seizure activity.