Regulatory Effect of Matcha Green Tea on Fine Dust-Exposed Cytotoxicity in Respiratory System

Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

This study was performed to evaluate the protective effect of matcha green tea on particulate matter (PM)2.5-indued nasal and pulmonary cytotoxicity. The matcha green tea increased the cell viability and inhibited the ROS production in PM2.5-induced cytotoxicity in nasal RPMI2650 and pulmonary A549 cells. The matcha green tea regulated the expression of apoptosis, such as p-Akt, BCl-2, caspase-3, caspase-1 and HO-1, and inflammation, such as TLR4, TLR4 and Nrf2, in PM2.5-indued RPMI2650 cells. In addition, the matcha green tea showed regulatory effect of the apoptosis and inflammatory effect by increasing the BCl-2 and suppressing the caspase-3, TLR4, TNF-α and COX-2 in A549 cells. In addition, the matcha green tea suppressed antioxidant deficits by regulating the reduced GSH contents, SOD activities and MDA levels, and ameliorated the mitochondrial dysfunction by regulating the mitochondrial ROS production, mitochondrial membrane potential and ATP contents in pulmonary tissue. Ultimately, consumption of matcha green tea down-regulated the inflammatory proteins such as TNF-α, p-JNK, p-IκB-α, p-NF-κB and COX-2 in lung tissue.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

치과 임플랜트를 이용한 보철수복시 자연지대치와의 연결형태에 따른 응력의 광탄성학적 분석

林鍾和,李文嶺,曺仁鎬 단국대학교 치의학연구소 1992 논문집 Vol.4 No.-

The connection between natural tooth abutment and implant has been studied with various methods. This study compared the stress distribution during the function of four prosthesis with variant connection modalities design between natural tooth abutment and implant fixture. The four connection types are rigid, non-rigid, telescopic crown and free standing. Each specimen was examined and taken the photograph with 30Kg force. the results were as follows. 1. Generally, the implant fixture has more stress concentration than the natural tooth abutment. 2. The specimens using the free standing type and the telescopic crown connection showed less stress concentration than the other specimen. 3. Although maximum fringe order was not equal, stress distribution of the specimen using rigid connector was similar with that of used telescopic connection. But of the showed even stress distribution at the natural tooth abutment and implant fixture. 4. In the specimen using non-rigid connector, more and wide stress distribution was seen around implant fixture comparing with the other specimen. 5. In case of connecting the implant and natural tooth abutment, using the telescopic crown connection is adventageous in stress distribution, and manintenance of prothesis because of easy removal and reinsertion.

노인의 게이트볼 활동 참여정도에 따른 자아개념인지에 관한 연구

임종호 대전대학교 기초과학연구소 2003 自然科學 Vol.14 No.1

본 연구는 노인의 게이트볼 활동 참여정도에 따른 자아개념 인지에 대해 알아보기 위하여 천안 지역의 게이트볼 활동 참여 노인 총 258명을 대상으로 하여 게이트볼 활동 참여정도(기간, 빈도, 강도)에 따라 자아개념이 어떻게 나타나는지를 분석하였는데 그 주요 결론은 다음과 같다. 첫째, 노인의 게이트볼 활동 참여기간에 따른 자아개념은 사회체육활동 참여기간에 따라 자아개념에 차이가 있었으며 참여 기간이 길면 자아개념이 높은 것으로 나타났다. 둘째, 노인의 게이트볼 활동 참여빈도에 따른 자아개념은 사회체육활동 참여빈도에 따라 자아개념에 차이가 있으며 참여빈도가 많아지면 자아개념이 높은 것으로 나타났다. 셋째, 노인의 게이트볼 활동의 참여강도에 따른 각 요인별 자아개념에 대한 평균과 표준편차를 살펴보면 요인별 별 차이가 없는 것으로 나타났으며 통계적으로도 유의한 차이를 보이지 않았다. 이러한 결과는 게이트볼 활동의 참여강도는 자아에 큰 영향을 미치고 있지 않음 나타내 준다. The study analyzed how the seniors to react in self-concept based on frequency of participation in the gateball activity. (period, frequency, strength) through the survey research of 258 seniors who participate in the gateball activity in Cheonahn area in order to find out how a gateball activity influence to seniors' self-concept. Hereunder are the major results in the research. 1. Seniors' self-concept based on the period of gateball activity shows differences by the period of participation in the social physical activity. The result shows that longer period of participation gives higher self-concept. 2. Seniors' self-concept based on the frequency of participation in gateball activity shows difference by the frequency of participation in the social physical activiy. The result shows that more frequent participation gives higher self-concept. 3. As the average and the standard deviation of seniors' self-concept based on each kind of cause from strength in playing the gateball activity were shown, the differences were scarcely found by the kinds of cause. And difference also could hardly be found in the statistical research. Thus, the result shows that strength in playing a gateball activity does not influence much to seniors' self-concept.

CaO-SiO₂, CaO-SiO-CaF₂계 슬래그의 질소용해도에 관한 열역학적 연구

임종호,이승원 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.1

The nitrogen solubility and nitride capacity of CaO-SiO₂ and CaO-SiO₂-CaF₂ slag systems were measured using gas-liquid equilibration. The nitrogen solubility in CaO-SiO₂ slag system is affected as following factors; (1) the structure and species of polysilicate ions (2) the number of the bonds between nitrogen and polysilicate ions. The detection of Si-N bond in this slag system by XPS analysis proves nitrogen in the slag substitute oxygen ion in polysilicate. With CaF₂ containing slag system nitrogen solubility decreases with increasing CO partial pressure with the liner relationship between nitrogen contents and oxygen partial pressure of -3/4. And the nitrogen solubility first decreases to reach a minimum value and then increases with the increase of CaO contents. This behavior indicates that there are two types of nitrogen dissolution mechanisms, one with an acidic component and the other with a basic component. With low basicity, the addition of CaF₂ is effective on denitogenization, but with high basicity, it's not.

연속식 오존처리공정을 이용한 낙동강 상수원수의 정수처리 효과

임영성,강관호,이홍재,서동철,박문수,허종수,조주식 한국환경농학회 2002 한국환경농학회지 Vol.21 No.3

낙동강 상수원수를 대상으로 연속적 오존처리에서 오존주업농도에 따른 유기물 분해 특성을 조사하기 위하여 오존처리에 의한 DOC성분변화, UV254/DOC의 변화와 소비오존에 따른 DOC 제거효율을 조사한 결과는 다음과 같다. 유입원수의 수질변화에 따라 다소 차이는 있었으나 전반적으로 오존주입농도가 증가할수록 DOC 처리효율도 증가되었다. 오존처리에 따른 DOC 성분변화는 전오존을 3 mg/L농도로 처리시 TDOC, ADOC, A&BDOC 및 NRDOC는 각각0.6, 0.2, 0.1 및 1.0 mg/L 정도 오존처리에 의하여 감소되었으나 BDOC는 0.8 mg/L 증가하였다. UV254/DOC의 분율은 오존주입농도를 1, 3 및 5 mg/L 처리하였을 때 전오존의 경우는 각각 0.048, 0.044 및 0.037 이였고, 후오존의 경우는 각각 0.018, 0.015 및 0.012로 나타나 오존주입농도가 증가할수록 감소하는 경향을 보였다. 초기 DOC mg당 소비되는 오존량에 대한 DOC 제거율은 전오존과 후오존처리의 초기 DOC에 대한 소비오존량이 각각 약 1.5와 2.3일 때 각자 25%와 32%로서 최대의 DOC 처리효율을 나타내었다. 낙동강 상수원수에 전오존을 처리할 경우 오존주입량은 초기 DOC mg당 소비된 오존이 1.5 mg 이내의 농도가 되도록 주입하고, 후오존은 유입수인 모래여과수의 초기 DOC mg당 소비된 오존이 2.3 mg이내의 농도가 되도록 조절하여 주입하면 적당할 것으로 생각되었다. This study was carried out to evaluate the pollutant removal efficiencies of the advanced drinking water treatment using ozonation process. For raw water. Nakdong River was used. By conducting continuous ozonation experiments, the following results were obtained. Efficiency of water treatment was enhanced with increase in ozone dosage. When ozone dosage of 3 mg/L was used, preozonation of raw water reduced TDOC, ADOC, A&BDOC and NRDOC as much as 0.6 mg/L, 0.2 mg/L, 0.1 mg/L and 1.0 mg/L, respectively. On the other hand, content of BDOC Increased at the level of 0.8 mg/L. Ratio of UV254 absorbance to DOC content by the preozonation with 1, 3 and 5 mg/L dosage were 0.048, 0.044 and 0.037, respectively. In case of postozonation, it were 0.018, 0.015 and 0.012, respectively. When the ratios of consumpted ozone content to 1 mg of initial DOC were 1.5 and 2.3 in preozonation and postozonation treatment, respectively, the highest DOC removal rates of 25% and 32% were obtained by the continuous ozonation.

피치제어를 이용한 풍력발전시스템의 출력제어

임종환,최민호,허종철,김건훈 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.1

This paper derives a modeling of a wind turbine and generator. and presents a power control algorithm for a full pitch-controlled wind turbine system. The design of a controller. in general. is performed by linearizing the torque in the vicinity of a operating point assuming the tip speed ratio is constant. For power control. however. the tip speed ratio is no longer a constant. In this study. a reference pitch model is derived in terms of a wind speed. angular velocity. and pitch angle. which makes it possible to design a controller without linearizing the non-linear torque model of the blade. The validity of the algorithm is demonstrated with the results produced through sets of simulation.

고교투기종목 코치의 리더십이 지도만족 및 지도 효율성에 미치는 영향

임종호,김진표,김윤태 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.2

이 연구는 투기종목 지도자의 변화적 리더십과 상통적 리더십이 지도만족 및 지도 효율성에 미치는 영향과 상대적 기여도를 규명하는데 목적이 있다. 연구대상은 투기종목(유도, 태권도, 레슬링, 복싱)의 고등학교 258명을 대상으로 리더십, 지도만족, 지도 효율성을 조사하였다. 수집된 자료는 윈도우용 SPSSV. 9.0을 사용하여 분석하였으며, 변환적 리더십 ? 상통적 리더십, 지도만족 및 지도 효율성의 하위척도에 대하여 다중회귀분석(maltiple regression)을 이용한 경로분석(path analysis)을 실시하였다. 그 결과 다음과 같은 결론을 도출하였다. 1. 변환적 리더십과 상통적 리더십이 내재적 만족을 설명하는 능력은 37.3%이고, 외재적 만족을 설명하는 능력은 57.8%이었다. 그리고 리더십과 지도만족이 지도효율성을 설명하는 능력은 42.5%이었다. 2. 경로도형에서 내재적 만족에 대하여는 카리스마, 개별적 배려, 조건적 보상, 예외적 관리가 유효하고, 외재적 만족에 대하여는 카리스마와 예외적 관리가 유효하며, 지도 효율성에 대하여는 카리스마, 개별적 배려, 조건적 보상, 내재적 만족이 유효하였다. The purpose of this study is to analyze the effects of coaches' leadership styles on players' satisfaction with leadershp and coaching effectiveness. To this end, 258 high school combat sports players were sampled to be surveyed. The collected data were analyzed using SPSS for Windows V 9.0 program to verify the differences of subcategories between schools with the independent determine the causes with the multiple regression analysis. The results of this study are as follows: Two leadership styles' explanatory power of student players' internal satisfaction with leadership was 37.3%, while that of external satisfaction with leadership was 57.8% And leadership styles and satisfaction with leadership explained 42.5% of the coaching effectiveness. On the other hand, as far as internal satisfaction was concerned, "charisma", "personal consideration", "conditional compensation" and "special management" were found significant. And as far as external satisfaction was concerned, such subcategories as "charisma", "personal considerationN, "intellectual stimulation" and "special management" were found significant For coaching effectiveness, such subcategories as "charisma", "personal consideration", "conditional compensation" and "external satisfaction" were found significant.

피치제어를 이용한 풍력발전시스템의 출력제어

임종환,최민호,허종철,김건훈 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.2

This paper derives a modeling of a wind turbine and generator, and presents a power control algorithm for a full pitch-controlled wind turbine system. The design of a controller, in general, is Performed by linearizing the torque in the vicinity of a operating point assuming the tip speed ratio is constant. For power control, however, the tip speed ratio is no longer a constant. In this study, a reference pitch model is derived in terms of a wind speed, angular velocity, and pitch angle, which makes it possible to design a controller without linearizing the non-linear torque model of the blade. The validity of the algorithm is demonstrated with the results produced through sets of simulation.

AGNPS 모델을 이용한 담수호 유입 오염부하량 산정

임경호,김종오 7개 국립대학교 환경연구 논문집 공동발행 위원회 2001 환경연구논문집 Vol.1 No.1

The monthly pollutants loads from nonpoint sources were estimated in Susan A·B watershed using a distributed watershed model, AGNPS(agricultural nonpoint sources) and unit load method. It was estimated that about 66∼84% of annual nonpoint source load would be discharged during 4 months from June to September, when a rainy reason in Korea. Especially during August and September with the highest monthly rainfall, about 44∼73% of nonpoint source load would be discharged into lakes. This study indicates that present annual average approach should not be adequate to estimate the waste loads from the nonpoint sources in Korea due to the high seasonal variation of rainfall. Therefore, it is suggested that the temporal nonpoint loads should be estimated based on the amount of rainfall for the pollution load allocation analysis in Korea.