서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Dong-Chun Lecture : Cell-based High Content Screening (HCS) for action modes of drug targets by using systematic deletion mutants of Schizosaccharomyces pombe

( Dong Uk Kim ),( Im Seon Woo ),( Mi Sun Won ),( Young Joo Jang ),( Kyung Sook Chung ),( Han Oh Park ),( Hyang Sook Yoo ),( Kwang Lae Hoe ),( Doo Sik Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

Ⅴ. 속담(俗談)ㆍ수수께끼편

임동권(Im Dong-Kwon),박현국(Park Hyun-Kook),김정원(Kim Jung-Won),장정순(Jang Jong-Soon) 중앙대학교 한국문화유산연구소 1995 중앙민속학 Vol.- No.7

The Relationship between Mitochondrial ROS and ER Stress in Allergic Airway Diseases

( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Mi Ran Kang ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Hee Jung Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Mitochondria and the Nox family of NADPH oxidase are the two major sources of reactive oxygen species (ROS) that are induced by external stimuli, and the mitochondria respiratory chain is considered as an important site of ROS production within most cells. Recent evidence has demonstrated that various biological stimuli increase accumulation of unfolded or mis-folded proteins in ER lumen, which is referred to as "ER stress". Moreover, these various pathologic stimuli have been reported to provoke oxidative stress as well as ER stress. In this study, we used the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice) for elucidation of the relationship between mitochondrial ROS and ER stress in bronchial asthma. The OVALPS-OVA mice showed that the expression of ER stress markers and the protein levels of un-folded-protein response (UPR)-related marker in lung tissues were significantly increased after OVA challenge. In addition, we visualized the localization of mitochondrial ROS in BAL cells isolated from OVALPS-OVA mice using confocal microscopy; the significant increase in mitochondrial ROS in BAL cells was observed after OVA challenge. Our results also showed that Necrox-5 or 4-PBA significantly reduced the increases in ER stress, mitochondrial ROS, inflammatory cytokines, airway in-flammation, and bronchial hyperresponsiveness. These findings suggest that mitochondrial ROS and ER stress plays an im-portant role in the induction and maintaining allergic airway diseases synergistically.

Mito-Tempo Can Protect Against the Allergic Airway Inflammation through Reducing Mitochondrial ROS Generation

( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.

Mini-implant를 이용한 III급 부정교합 환자의 협진 치료 : 문제중심의 교정치료

임동혁,김영신,조민아,김기성,양성은 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.4

체형별 승용차 구매 평가기준의 차이 : 경영혁신의 체형별 성공요인 Sucess Factors with Body Types in Business Innovations

김임곤,김수동 한국정보전략학회 2001 한국정보전략학회지 Vol.4 No.1

It is supposed that if consumers' purchasing behaviors are different according to body types, these difference could be utilized for the sales policy of products. The purpose of this research is to analyze, with body types, whether there are any difference in a degree of values of the purchasing evaluation criteria, when they purchase automobiles. Weight and height of men from 25 year-old to 29 year-old are measured and then how to evaluate the 10 purchasing evaluation criteria of automobiles presented in questionaires are investigated. And body types are classified as lean, slightly lean, normal, slightly obese, and obese type with measured weight and height, The founding of this analysis is that there are significant difference in a degree of values of each purchasing evaluation criteria. This result shows that lean type and obese type are considerably different from the other body types, and also the types are different from each other in a degree of values of the criteria. Obese type highly evaluate factors related to comfort, lean type highly evaluate related to design and dignity, but slightly lean type and slightly obese type lowly evaluate factors related to comfort and design. Improved some problems and carried out more concrete researches, the result of the research could be better utilized for establishing automobile sales-production policies and strategies.

복부대동맥류를 동반한 환자의 위아전절제술 마취경험

임의재,이동준,김문철,이상준,김명화 인제대학교 2009 仁濟醫學 Vol.30 No.-

Abdominal aortic aneurysms rarely occur with cancerous lesion but occasionally with gastrointestinal malignancy, and need absolute blood pressure control to prevent rupture. A 71 year old male who complained dizzness and hematochezia. He has been managed for hypertension, stable angina and abdominal aortic aneurysm which diagnosed 2months ago. He was diagnosed as advanced gastric adenocarcinoma and subtotal gastrectomy was performed. General anesthesia was scheduled and epidural catheterization was performed to controll intraand post operative pain and minimize hemodynamic change to prevent aneurysmal rupture 37.5mg of Ropivacaine was injected through epidural catheter before anesthesia and infusion of remifentanyl and propofol was performed during general anesthesia. The blood pressure was maintained between 95/50 and 145/95 and did not significantly increased. The general-epidural combined method was successfully performed and we are report this case with a brief review of the literature.

서울대학교 치과병원 교정과에 내원한 부정교합 환자의 최근 경향

임동혁,김태우,남동석,장영일 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.1

최근 치의학이 눈부시게 발전하고, 소득이 증가하면서 이에 따라 일반인의 의식이 점차 변하면서 외모에 대한 관심도도 점차 높아지고 있다. 본 연구는 내원환자의 부정교합의 유형, 치료방법의 변화를 파악하여 내원환자와 보다 적절한 의사소통을 위한 정보를 제공하고, 교정치료 요구의 특성을 파악하여 부정교합의 역학적 자료를 제공하고자 본 연구를 시행하였다. 이를 위해 2002년 상반기와 1992년 상반기에 서울대학교 치과병원 교정과에 내원한 환자중 진료기록부가 잘 보존된 676명을 대상으로 하여 부정교합의 유형과 내원 환자의 지역분포 및 주소의 변화, 치료방법의 변화를 조사 연구한 결과 다음과 같은 결론을 얻었다. 1. 내원 환자의 남녀 비율은 1992년 1:2.1에서 2002년 1:1.5로 남자환자가 많이 증가했음을 알 수 있다. 2. 연령별 내원 환자의 분포에서 2002년에는 7세에서 12세군이 32.0%로 가장 높게 나타났으며, 그 다음으로는 19세에서 24세군이 24.0%, 13세에서 18세군이 21.6%, 25세 이상군이 14.2%, 4세에서 6세군이 5.8%, 0세에서 3세군이 2.4%로 가장 낮았다. 1992년도 내원 환자의 연령 분포와 비교시 성인 환자의 비중이 증가하였다. 3. Angle 분류법에 의한 내원환자의 분포에서 2002년에는 Ⅲ급 부정교합이 48.1%로 가장 높게 나타났으며, Ⅰ급 부정교합이 25.0%, Ⅱ급 1류 부정교합이 20.9%, Ⅱ급 2류 부정교합이 3.4%로 나타났다. 4. 내원환자의 지역별 분포에서 서울 북동지역의 환자가 37.0%, 서울 남동지역이 13.2%, 서울 남서지역이 12.3%, 서울북서지역의 환자가 6.5%로 나타났다. 1992년도와 비교시 서울 북동지역환자의 내원 비율이 증가하고 그 외 지역내원 환자의 비율은 감소한 것으로 나타났다. 5. 주소(chief complaint)별 내원 환자의 분포는 2002년에 하악 전돌이 17.5%로 가장 높게 나타났으며, 크라우딩이 14.2%, 안면 비대칭이 11.8%로 나타났다. 1992년의 주소별 내원 비율과 비교시 안면 비대칭을 주소로 내원한 환자의 비율이 유의하게 증가하였고, 내원 동기가 매우 다양해졌다. 6. 2002년도 내원 환자의 치료방법은 고정식 장치가 38.0%, 악교정 수술이 25.0%, 성장 관찰이 13.0%로 나타났다. 1992년도와 비교시 chin cap의 사용이 줄었으며, 상대적으로 악교정 수술과 성장관찰을 요하는 환자의 비중이 유의할 만하게 증가하였다. Over the past decades, the number of patients seeking orthodontic treatment has increased markedly with socioeconomic development and change of recognition on appearance. The purpose of this study was to provide an epidemiologic data base related to the orthodontic treatment need. We could take an adequate information regarding the characteristics of orthodontic patients, and the changing trends about treatment mordality. Distrubution and treands were investigated in 676 patients who had been examined and diagnosed at Departnent of orthodontics, Dental Hospital, Seoul National University from January to June in 1992 and 2002. 1. Sex distribution of patients changed from 1:2.1 to 1:1.5(male:female). 2. In 2002, age distribution had shown 7∼12 vear-old group being the largest (32.0%) and percentage of 19∼24, 13∼18, over 25, 4∼6, 0∼3 year-old group were 24.0%, 21.6%, 14.2%, 5.8%, 2.4% respctively. Compared with data in 1992, the number of adult patients highly increased. 3. With regard to angle classification, each percentage of ClassⅠ, Class Ⅱ div 1, Class Ⅱdiv 2, and Class Ⅲ malocclusion were 25.0%, 20.9%, 3.4%, and 48.1% respectively in 2002. 4. Geographic distribution showed that most of the patients visited (37.0%) lived in northeast of Seoul in 2002. 5. Mandibular prognathism showed the highest percentage in chief complaints. The percentages of crowding and facial asymmetry were 14.2% and 11.8% in 2002. Patients with facial asymmetry increased significantly. 6. Percentages of patients treated with fixed appliance and orthognathic surgery were 38.0% and 25.0% in 2002. Patients needed to observe the growth pattern comprised 13.0% with increasing trends. The use of chin cap reduced and the percentage of orthognathic surgery and growth observation increased significantly.

반코마이신 내성 장내구균 분리 환자에서 황색포도알균의 내성

김동욱,신선혜,김혜진,류선,이선희,장철훈,김영대,곽임수 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : Vancomycin-resistant enterococci (VRE)로부터 S. aureus로의 vacomycin 내성 유전자의 전파는 오래전부터 예견되어져 왔으며 큰 걱정거리로 남아있다. 최근에 vanA 유전자를 가지고 있는 vancomycin-resistant S. aureus 2주가 미국에서 분리되었다. 이 연구의 목적은 VRE를 보균하고 있는 환자들에서 S. aureus 보균양상과 항균제 내성을 알아보는데 그 목적이 있다. 재료 및 방법 : 2001년 1월부터 2001년 12월까지 부산대학교병원에 입원하였던 환자들 중 임상검체에서 VRE가 분리된 환자 7명과 2001년 9월부터 12월까지 외과 중 환자실에 입원하였던 환자들 중 VRE 감시배양을 시행하였던 20명의 환자들을 대상으로 하였다. 환자들은 전비공, 액와부, 회음부, 직장에서 매주 면봉으로 검체를 채취하였다. 선별배지에서 검체를 배양하여 S. aureus를 분리하였고 원판 확산법을 이용하여 methicillin 감수성을 측정하였다. Broth microdilution 법으로 vancomycin MIC를 측정하였다. 결과 : 총 27명에서 73회의 방문과 292회의 배양이 시행되었으며 총 67주의 S. aureus가 분리되었다. 이중 64주(95.5%)가 methicillin 내성이었다. 전비공 MRSA 보균율은 VRE를 보균하고 있었던 환자는 19명 중 11명(58%)에서, VRE를 보균하지 않았던 환자는 8명 중 3명(37.5%)으로 VRE 보균자에서 보균율이 더 높았다. 총 64주의 MRSA의 vancomycin MIC의 분포는 0.5-2㎍/mL였으며 2㎍/mL를 초과하는 균주는 발견되지 않았다. 64주 중 vancomycin MIC가 1㎍/mL인 균주가 54주(84.4%)로 가장 많았으며 2㎍/mL 6주(9.4%), 0.5㎍/mL 4주(6.3%)의 순이었다. 결론 : VRE 환자에서 S. aureus의 보균율은 비보균자 보다 높았으며 분리된 균주들은 대부분 MRSA였다. VRSA 균주는 발견되지 않았다. Background : The transfer of vancomycin resistance from vancomycin-resistant enterococci (VRE) to Staphylococcus aureus has been predicted. The purpose of this study is to determine the prevalence and antibiotics resistance of S. aureus among patients colonized with VRE. Methods : Between January 2001 and December 2001, a prospective study was performed at Pusan National University Hospital on 27 patients. Surveillance swabs from nasal cavity, axilla, perineum, and rectum were obtained at weekly intervals. Methicillin susceptability of S. aureus was determined by oxacillin disk diffusion test and minimum inhibitory concentration (MIC) for vancomycin by microdilution broth test. Results : Total of 292 swab cultures were performed and 67 S. aureus isolates were collected. 64 isolates (95.5%) were resistant to methicillin. The prevalence of nasal MRSA carrier in 19 patients colonized with VRE was higher than that in 8 patients not colonized with VRE (58% vs. 37.5%). In 64 MRSA isolates, MIC (㎍/mL) for vancomycin ranged from 0.5 to 2. No isolates with MIC >2 ㎍/mL were observed. MIC of 1 ㎍/mL was shown (observed) in 54 isolates, 2 ㎍/mL in 6 isolates, and 0.5 ㎍/mL in 4 isolates. Conclusion : The prevalence of S. aureus with colonization of VRE is higher than that without colonization of VRE. Most of S. aureus isolates were resistant to methicillin. VRSA isolates were not observed.