위선암에서 p53 단백의 과발현과 임상 및 병리학적 예후인자와의 상관관계

서병조,유항종,이주호,주미,이혜경,김진복 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumor progression. Wild-type p53 negatively regulates the cell cycle; a loss of function by mutation might be expected to result in enhanced proliferating activity and tumor progression. A large number of immunohistochemical studies have confirmed p53 accumulation to be a very common feature of human malignancy. The aim of the present study was to determine whether p53 status in gastric cancer is correlated statistically with various histopathological indicators or not. Methods and Materials: A total of 197 surgically resected gastric adenocarcinomas were examined to determine whether a correlation exited between immunohistochemical expressions of the p53 protein and other histopathological factors. Results: p53 overexpression was observed in 46.2% of the gastric cancers. Overexpression of p53 was correlated with vascular invasion of gastric cancer(p=0.004). In early gastric cancer, the p53 overexpression rate was 42.3%, and of them, a correlation was found between the intestinal type of the Lauren classifcation(p=0.013) and histologically differentiated gastric cancer(p=0.014). Conclusion: p53 overexpression was significantly correlated with vascular invasion of gastric cancer. In cases of early gastric cancer, p53 overexpression was correlated with Lauren classification and differentiation. These results suggest that p53 mutation plays an important role in carcinogenesis in gastric adenocarcinomas. Further study in needed to determine the correlation between p53 overexpression and the prognosis for the gastric cancer patient.

비대칭 정현아치의 자유진동 해석

서주석,이병구,오상진 圓光大學校 1990 論文集 Vol.24 No.2

아치가 진동할 때 아치의 미소요소에 작용하는 합응력과 관성력에 대한 동적평형방정식을 이용하여 회전관성을 고려한 일반적인 변화곡률을 갖는 비대칭 아치의 평면내 자유진동을 지배하는 무차원 미분방정식을 유도하였다. 이 무차원 미분방정식을 정현아치에 적용시키고, 시행착오적 고유치문제와 Runge-Kutta method를 이용하여 비대칭 정현아치의 자유진동을 해석할 수 있는 알고리즘을 개발하였다. 본 연구의 수치해석 결과와 SAP80의 결과를 비교하여 본 연구에서 유도한 무차원 미분방정식과 수치해석방법의 타당성을 입증하였다. 수치해석 예에서는 각종제원의 아치에 대한 제1고유진동수를 계산하였으며, 힌지-힌지, 고정-고정, 고정-힌지, 힌지-고정의 단부조건을 갖는 아치에 대하여 회전관성이 제1유진동수에 미치는 영향, 제1고유진동수와 아치의 높이의 대한 지간길이의 비, 세장비 및 정규화된 비대칭아치의 지간길이의 관계를 고찰하였다. The governing differential equations for the free vibration of the unsymmetric arch with variable curvature are derived as the nondimensional forms including the effect of rotatory inertia. These differential equations are applied to the sinusoidal arches and the numerical methods are developed to solve these equations. A trial eigenvalue method is used for determining the lowest frequency, and the Runge-Kutta method is used in this method to perform the intergration of the differential equations. As the numerical results, the lowest dimensionless frequencies are calculated. The effects of the rotatory inertia on the lowest dimensionless frequencies are studied. The relations between the lowest dimensionless frequency and the dimensionless rise, the slenderness ratio and the dimensionless span length are presented in figures.

정신보건 관련 시설의 재원 기간 및 관련 요인에 대한 연구

조성진,이병조,조맹제,김용익,서동우,정인과 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Object : This study was aimed to find the contributing factors that influence the length of stay in mental health related facilities and to present future direction for the mental health policy. Methods : The 1,875 patients who are aged between eighteen and sixty-five are chosen by the stratified random sampling from ten psychiatric hospitals, six psychiatric nursing facilities and five homeless asylums. We investigate about length of stay of all subjects by sociodemographic characteristics, socioeconomic status, functional status, disease related characteristics and analyse contributing factors. Results : From total subjects, average length of stay was 1,906 days, and facilities, where subjects are institutionalized, explains 40% of length of stay. Other related factors are female, old age, single, lack of supportive system before admission and after discharge, medical assistance type I, unavailable of public transportation and utility, long duration of illness, and psychotic disorder. Conclusion : For lowering the rate of long-term hospitalization, evaluation of appropriateness is needed for admission to nursing facility and homeless asylum and make up for the medical payment system and the supportive system from family and community.

13,135예의 위암의 최신치료요법 : 면역화학수술요법

김진복,서병조 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1S

■ Objectives The purpose of this study is to analyze the clinicopathologic characteristics of gastric cancer patients and to evaluate the survival and prognostic factors and effect of immunochemosurgery for gastric cancer patients. ■ Methods and materials The clinicopathologic characteristics were analyzed for 13,135 consecutive patients who underwent operation for gastric cancer from 1970 to 2001. We also evaluated the survival and prognostic factors for 9,262 consecutive patients from 1981 to 1996. The prognostic significance of treatment modality [surgery alone, surgery + chemotherapy, surgery + immunotherapy + chemo-the apy (immunochemosurgery)] were evaluated in stage Ⅲ gastric cancer. ■ Results The 5-year survival rate (5-YSR) of overall patients was 55.8%, and that of patients who received curative resection was 64.8%. The 5-YSRs according to TNM stage were 92.9% for Ⅰa, 84.2% for Ⅰb, 69.3% for Ⅱ, 45.8% for Ⅲa, 29.6% for Ⅲb and 9.2% for Ⅳ. Regarding adjuvant treatment modality, significant survival difference was observed in stage Ⅲ patients. The 5-year survival rates were 44.3% for immunochemosurgery group, 36.8% for surgery + chemotherapy group and 27.2% for surgery alone group. Curative resection, depth of invasion and lymph node metastasis were the most significant prognostic factors in gastric cancer. ■ Conclusions Consequently, early detection and curative resection with radical lymph node dissection, followed by immunochemotherapy especially in patients with stage Ⅲ gastric cancer should be recommended as a standard treatment principle for patients with gastric cancer.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Crystal Packing of Two Different Tetranuclear Iron(III) Clusters, [(tacn)₄Fe₄O₂(OH)₄]₂.8Br.9H₂O (tacn = 1,4,7-triazacyclononane)

Jin, Mi-Kyung,Kim, Yoo-Jin,Jung, Duk-Young,Heu, Min,Yoon, Seok-Won,Suh, Byoung-Jin Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.2

[$(tacn)_4Fe_4O_2(OH)_4]_2{\cdot}8Br{\cdot}9H_2O$ (tacn = 1,4,7-triazacyclononane), a tetranuclear iron(III) complex was synthesized by the hydrolysis of (tacn)FeCl3 and crystallizes in the orthorhombic space group, Pca2(1), with cell parameters, a = 37.574(3) $\AA$, b = 16.9245(12) $\AA$, c = 14.2830(11) $\AA$, V = 9082.9(12) ${\AA}^3$. [$(tacn)_4Fe_4O_2(OH)_4]^{4+}$ cations approach S4 point symmetry containing an adamantane skeleton. Four Fe(III) atoms have distorted octahedral environments with two hydroxo and an oxo bridges. Two [$(tacn)_4Fe_4O_2(OH)_4]^{4+}$ clusters having different Fe…Fe distances are connected to each other by the networked hydrogen bonds. The electrochemical behavior reveals irreversible three cathodic and two anodic peaks. Magnetic properties are characterized by antiferromagnetic (AF) interactions between Fe(III) ion spins. However, the low-lying states are still magnetic and exhibit a blocking behavior and a magnetic hysteresis at low temperatures.

1H NMR and Magnetization Measurements in a Trinuclear Spin System {Mn3}

Byoung Jin Suh 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.2

We present new results of dc magnetization and nuclear magnetic resonance measurements in a trinuclear manganese compound {Mn3} consisting of two Mn(III) (S = 2) and one Mn(II) (S = 5=2). The magnetic properties are characterized by two antiferromagnetic (AFM) coupling constants, J = -22:9 K between Mn(II) and Mn(III) ion spins and J0 = -16:0 K between two Mn(III) ion spins. The 1H nuclear spin-lattice relaxation rate, 1=T1, shows a strong enhancement at low temperatures with a peak that depends on the external field, which is discussed in the light of the universal scaling behavior commonly observed in antiferromagnetically coupled rings or clusters. We present new results of dc magnetization and nuclear magnetic resonance measurements in a trinuclear manganese compound {Mn3} consisting of two Mn(III) (S = 2) and one Mn(II) (S = 5=2). The magnetic properties are characterized by two antiferromagnetic (AFM) coupling constants, J = -22:9 K between Mn(II) and Mn(III) ion spins and J0 = -16:0 K between two Mn(III) ion spins. The 1H nuclear spin-lattice relaxation rate, 1=T1, shows a strong enhancement at low temperatures with a peak that depends on the external field, which is discussed in the light of the universal scaling behavior commonly observed in antiferromagnetically coupled rings or clusters.

Prognostic Value of Dual-Energy CT-Based Iodine Quantification versus Conventional CT in Acute Pulmonary Embolism: A Propensity-Match Analysis

Im Dong Jin,Hur Jin,Han Kyunghwa,Suh Young Joo,Hong Yoo Jin,Lee Hye-Jeong,Kim Young Jin,Choi Byoung Wook 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.9

Objective: The present study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters offer an incremental risk stratification benefit over the CT ventricular diameter ratio in patients with acute pulmonary embolism (PE) by using propensity score analysis. Materials and Methods: This study was conducted on 480 patients with acute PE who underwent CT pulmonary angiography (CTPA) or DECT pulmonary angiography (DE CT-PA). This propensity-matched study population included 240 patients with acute PE each in the CTPA and DECT groups. Altogether, 260 (54.1%) patients were men, and the mean age was 64.9 years (64.9 ± 13.5 years). The primary endpoint was all-cause death within 30 days. The Cox proportional hazards regression model was used to identify associations between CT parameters and outcomes and to identify potential predictors. Concordance (C) statistics were used to compare the prognoses between the two groups. Results: In both CTPA and DECT groups, right to left ventricle diameter ratio ≥ 1 was associated with an increased risk of allcause death within 30 days (hazard ratio: 3.707, p < 0.001 and 5.573, p < 0.001, respectively). However, C-statistics showed no statistically significant difference between the CTPA and DECT groups for predicting death within 30 days (C-statistics: 0.759 vs. 0.819, p = 0.117). Conclusion: Quantitative measurement of lung perfusion defect volume by DECT had no added benefit over CT ventricular diameter ratio for predicting all-cause death within 30 days.

Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma

Hong, Sae Rom,Hur, Jin,Moon, Yong Wha,Han, Kyunghwa,Chang, Suyon,Kim, Jin Young,Im, Dong Jin,Suh, Young Joo,Hong, Yoo Jin,Lee, Hye-Jeong,Kim, Young Jin,Choi, Byoung Wook Elsevier 2018 European journal of radiology Vol.101 No.-

<P>Conclusions: Dual-energy CT using a quantitative analytic method based on iodine concentration measurements can be used to predict the effects of chemotherapy in patients with advanced adenocarcinoma.</P>

Myocardial T1 and T2 Mapping: Techniques and Clinical Applications

Kim, Pan Ki,Hong, Yoo Jin,Im, Dong Jin,Suh, Young Joo,Park, Chul Hwan,Kim, Jin Young,Chang, Suyon,Lee, Hye-Jeong,Hur, Jin,Kim, Young Jin,Choi, Byoung Wook The Korean Society of Radiology 2017 KOREAN JOURNAL OF RADIOLOGY Vol.18 No.1

<P>Cardiac magnetic resonance (CMR) imaging is widely used in various medical fields related to cardiovascular diseases. Rapid technological innovations in magnetic resonance imaging in recent times have resulted in the development of new techniques for CMR imaging. T1 and T2 image mapping sequences enable the direct quantification of T1, T2, and extracellular volume fraction (ECV) values of the myocardium, leading to the progressive integration of these sequences into routine CMR settings. Currently, T1, T2, and ECV values are being recognized as not only robust biomarkers for diagnosis of cardiomyopathies, but also predictive factors for treatment monitoring and prognosis. In this study, we have reviewed various T1 and T2 mapping sequence techniques and their clinical applications.</P>