젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

후천성 면역 결핍증 환자의 혀에 발생한 거대세포바이러스(CMV : cytomegalovirus) 감염

송노헌,이종호,정필훈,김명진,김수경,남일우,김종원,백세미,홍삼표 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

다형성교아세포종을 동반한 Von Recklinghausen氏 병 1예

이현개,이종수,백민우,이승재,박효일,지제근 인제대학교 1981 仁濟醫學 Vol.2 No.4

가족성으로 신경섬유종증에 동반되는 중추신경계의 종양으로 수막종, 신경교종, 신경초종 등이 있으며 이들은 드물지 않게 보고되었다. 그러나 신경교세포에 생기는 종양 중 신경섬유종증에 동반되어 대뇌에 생긴 다형성교아세포종은 매우 드물다. 본 교실에서 가족성으로 발생한 신경섬유종증의 환자에 동반된 다형성교아세포종을 경험하였으며 가족중 부친은 von Recklinghausen씨 병을, 또 두 자녀는 다발성 cafe´ au lait spots를 가지고 있었다. The tumors of the central nervous system associated with familial neurofibromatosis are meningioma, glioma, and neurilemmoma, which are not uncommon. Of the glial tumors of the central nervous system, the association of cerebral glioblastoma multiforme with neurofibro matosis is very rare. We have experienced the unusual coincidence of neurofibromatosis and glioblastoma multiforme in a 33 year old man, whose father was afflicted with von Recklinghausen's disease and whose son and daughter had also multiple cafe´ au lait spots on their bodies.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

The Sewol Ferry Accident and Early Mental Health Care Response by Volunteer Activities of Korean Disaster Mental Health Committee and Members of Korean Neuropsychiatric Association

Jong- Woo Paik,Hyun- Soo Kim,Minyoung Sim,Hae- Kook Lee,Young Sup Woo,Chanseung Chung,Sang- Hyuk Lee Jeong- Ho Seok,Hong Jin Jeon,Sang- Min Lee,Soo- Young Bang,Kyoung- Sae Na,Boung Chul Lee,Myung- Soo 대한신경정신의학회 2015 신경정신의학 Vol.54 No.1

On 16 April 2014, the Sewol ferry, carrying 476 people, sank in the ocean off the south coast of South Korea. Two hundred and ninety five are confirmed dead and 9 remain missing. The Korean Neuropsychiatric Association (KNPA) set up a Disaster Mental Health Committee (KDMHC) for out- reach services and to provide general strategies for promoting mental health and resilience. Mem bers of KDMHC and Volunteering Psychiatrists of the KNPA had participated in disaster mental health services organized by Gyeonggi- Ansan disaster mental health support team. Their activities were composed of psychoeducation, supportive individual and familial counseling and referring service to professional institutes. This report has described the outline of the initial and acute mental health care responses by KDMHC and volunteers among KNPA members.

A Study on the Long and Mid-term Policy for Korean Neuropsychiatric Association

Jong-Woo Paik,Hae Kook Lee,Seung Yup Lee,Kyoung-Sae Na,Kang Joon Lee,Won-Seok Choi,Han-Yong Jung 대한신경정신의학회 2015 신경정신의학 Vol.54 No.1

As the official organization of psychiatrists in South Korea since 1945, the Korean Neuropsychiatric Association (KNPA) has played important contribution in academic and mental health development. It is time to plan long-term policy for future strategy. Thus, the authors tried to perform brainstorming in members of a special task force team and survey for internal specialists in the KNPA and external professionals. Based on the above major issues and results of the survey, the authors suggest the overall direction of the long and mid-term policy for KNPA.

B-KNO₃ 점화제의 가속노화 시험에 따른 특성연구

백종규(Jong Gyu Paik),류병태(Byung Tae Rhu),권미라(Mira Kweon),이철우(Cheol Woo Lee),양지우(Jee Woo Yang) 한국추진공학회 2013 한국추진공학회 학술대회논문집 Vol.2013 No.12

B-KNO₃의 노화에 대한 원인을 규명하기위해 B-KNO₃ 점화제의 가속화 시험을 통한 노화특성을 해석하였다. 본 점화제는 미사일 고체 추진제에 사용되는 효과적인 점화제 중 하나로 저압 점화가 용이하고 연소 속도가 비교적 빠르고 안정되며 최대 압력 형성이 균일하다는 장점을 지니고 있다. 그러나 이들 점화제는 보관 방법이나 보관기간에 따라 점화 효율이 저하되는 경향이 있으며 안정된 사용을 위해서는 이에 대한 명확한 이해가 필요하다. 이를위해 미세구조와 결정구조 및 열분석을 통해 환경시험 조건에서 발생되는 변화를 이해하고 이들이 점화 특성에 끼치는 영향성을 규명하였다. 따라서 미세구조와 결정구조 및 열분석을 통해 환경시험 조건에서 발생되는 변화를 이해하고 이들이 점화 특성에 끼치는 영향성을 규명하고자 하였다. 특히 산화제로 첨가된 KNO₃의 내부 구조 변화를 심층 분석함으로써 점화제 노화에 끼치는 산화제 영향을 해석하였다. Aging effects on the B-KNO₃ mixture were investigated by analyzing the results of the accelerated environmental aging tests. The B-KNO₃ system is one of the most effective ignitor which could be applicable for solid rocket propellants of missiles. There are many good properties in B-KNO₃ system for the ignitor such as easy ignition at low pressure, high speed and stable combustion, and uniform formation of maximum pressure. However those ignitor systems showed the degradation in ignition properties depending on the method and period of storage. It should be found out the cause of the degradation. The main cause of the degradation was analyzed by microstructure analysis, XRD analysis and thermal properties analysis using DSC. It was found out that the lattice parameters of the KNO₃ as the oxidizer in the ignition system was changed into original value as the aging time increased. From this study the change of the crystal structure of oxidizer during the storage could be related to the aging properties of ignitor system.

과민성 장증후군의 정신과적 접근

백종우 ( Jong Woo Paik ) 경희대학교 경희의료원 2007 慶熙醫學 Vol.23 No.2

Effect of laser beam energy density on the structural and electrical properties of TiO₂-doped Bi₅Nb₃O₁₅ thin film grown by pulsed laser deposition

Sun, Jong-Woo,Kang, Lee-Seung,Kim, Jin-Seong,Paik, Dong-Soo,Nahm, Sahn,Seong, Tae-Geun,Kang, Chong-Yun,Kim, Jong-Hee Institute of Physics [etc.] 2010 Journal of Physics. D, Applied Physics Vol.43 No.30

<P>With the addition of TiO<SUB>2</SUB>, the dielectric constant (ϵ<SUB>r</SUB>) of a Bi<SUB>5</SUB>Nb<SUB>3</SUB>O<SUB>15</SUB>(B<SUB>5</SUB>N<SUB>3</SUB>) film was slightly increased and the leakage current decreased, probably due to the increased dipole moment and the decreased number of free electrons in the film, respectively. The energy density of the laser beam considerably influenced the structure and electrical properties of the 1.0 mol% TiO<SUB>2</SUB>-doped B<SUB>5</SUB>N<SUB>3</SUB> (TBN) films. At low beam energy densities (⩽2.0 J cm<SUP>−2</SUP>), Bi<SUB>3</SUB>NbO<SUB>7</SUB> and Bi<SUB>8</SUB>Nb<SUB>18</SUB>O<SUB>57</SUB> phases with a porous microstructure were formed and a poor interface was also formed between the film and the electrode. However, for the TBN film grown at 200 °C at a high beam energy density of 4.0 J cm<SUP>−2</SUP>, a dense Bi<SUB>3</SUB>NbO<SUB>7</SUB> phase was formed with a sharp interface. The ϵ<SUB>r</SUB> value of this TBN film was very high, approximately 115, with a low leakage current density of 1.4 × 10<SUP>−8</SUP> A cm<SUP>−2</SUP> at 0.5 MV cm<SUP>−1</SUP> and a high breakdown field of 0.55 MV cm<SUP>−1</SUP>. This improvement in the ϵ<SUB>r</SUB> value and the electrical properties was explained by the formation of a dense Bi<SUB>3</SUB>NbO<SUB>7</SUB> phase with a (1 1 1) preferred orientation, Ti doping and a sharp interface, indicating that the TBN film is a good candidate material for embedded capacitors.</P>

SUM 선택신호 발생 방식을 이용한 64-bit 가산기의 설계

백우현(woo-Hyun Paik),서범수(Bun-Soo Suh),기훈재(Hoon-Jae Ki),한우종(Woo-Jong Han),김수원(Soo-Won Kim) 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.6