정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

파뢰기의 열화진단 전문가 시스템 개발에 관한 연구

길경석,김명진,한주섭 한국해양대학교 산업기술연구소 2002 연구논문집 Vol.19 No.-

This paper describes with an effect of a single- and a quadruple- lightning impulse currents on electrical characteristics of ZnO blocks, and an expert system to diagnose deterioration of arresters. In this study, an accelerated deterioration test is carried out to deduce the parameters needed for diagnosing arrester deterioration, and leakage current components are measured. Also, wave height distribution of the leakage current with the progress of arrester deterioration is analyzed. From the experimental results, the wave height distribution of the leakage current showed a conspicuous difference even in an immaterial leakage current increase. The use of wave height distribution of the leakage current in deterioration diagnostic technique makes more accurate diagnosis than the conventional method using only a leakage current value. Finally, the expert system based on the experimental reslts is developed, and the effectiveness of the system is estimated in a 18[kV] lightning arrester.

Denis-Browne Technique에 의한 34예 Hypospadia의 외과적 치료

김홍명,박길용 大韓成形外科學會 1976 Archives of Plastic Surgery Vol.3 No.1

Clinical observation were made for 34 cases of Hypospadia who were operated by Denis Browne technique the Dept. of General Surgery, National Medical Center for ten years from 1960 to 1970. 1) For age incidence, 16 cases among them were between 5 and 10 years old. 2) Among the 34 cases, another anormalies were detected in 15 cases as 9 of them combined Cryptochidism, 3 of them bifid scrotum and one of each inguinal hernia, fennel chest and congential heart disease. 3) The type of hypospadia, 9 cases of them were penile, 18 cases were penoscrotal, 3 cases were scrotal and perineal type in 4 cases. 4) As for the average of hospitarization, 13 days for the first stage, 15 days for the second stage and 17v days for the all stage. 5) Among the 34 cases, 6 cases of them were not performed the first stage procedure, 7 cases of them were not performed second stage procedure, 12 of them were performed first revision and 4 cases of them had to be performed second revision of repair fistula. 6) The postoperative complications, 4 cases of them showed stricture, 13 cases fistula, 5 cases infection and one of each complete disruption, and leaking of urine from the site of urethrostomy. 7) For the follow-up observation, 4 cases of them persisted fistula, 3 cases stenosis and one showed complete failure.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

應答比에 의한 R.C 슬래브교의 耐荷力 算定

김영인,박길현,양승현,김재명 朝鮮大學校 建設技術硏究所 2001 建設技術硏究 Vol.21 No.1

It is very hard to do that exactly safety-degree criticism of practical bridges as would be not agree for inspection method, judgment of engineer, who operates inspection for bridges. So, It must be operated the study to apply to criticize Loading Carrying Capacity of bridges owing to the criticism through data rational and simply, and gather them. It must be adjusted a rule rational and objective as to be anxious a loss of maintenance of bridges for minding their safety excessively according to the judgment of inspector in deciding Loading Carrying Capacity of them as chiefly purpose of safety-inspection. This study suggest that Improvement should be proper which calculates Loading Carrying Capacity from respondent-ratio, produced from displacement practical and that computed by the program(SAP 2000) in ordinary as Compressive strength is obtained for dug core of bridges, mixed Schmidt Hammer and Pulse Velocity, through Concrete and use Schmidt Hammer on bridges that were already performed safety-inspection.

Socrates의 철학이 체육사상에 미치는 영향

김명미,김융길 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study is to examine the interrelation between Socrates' life and physical education. In the history of physical education, physical idea was discussed widely whether objective aspects or subjective aspects through the process of human society. Socrates thought that although soul man's master, body is his servant, this is based on the theory of Socrates idea which is soul and body are one Socrates insisted that the whole person formed through physical training is very valuable because he could gain happy and satisfaction from biological and physiological development. Socrates shows his concept of individual human perfection and relates it of social and mental perfection in his Greek period. Socrates discards all the dogmas of revealed formation which represent luxury and extravagance and believes only that people will have health when they are fully mature between soul and body. Therefore his concept of perfection is the harmony of soul and body in order to approach his concept, Socrates already talks with young men and is wondering without shows. In the end Socrates recognized goodness on the basis of intellectual reliance and finally reached to the true self identity through the insight and reflection According to "know yourself" which is the matter of Socrates life, Socrates awakes himself all the time.

CURRENT CONVEYOR에 의한 전류측정 프로우브 및 비접지 인닥턴스의 실현

金明起,金斗泳,金吉重 동아대학교 공과대학 부설 한국자원개발연구소 1980 硏究報告 Vol.4 No.2

Current conveyors as relatively newer active building blocks have been introduced by Smith and Sedra, and many possible applications have been explored during the past few years. The operation of the current conveyors is based on the principle of conveying equal currents at its output and input ports at different admittance levels. In this paper, a second generation current conveyor (CC-Ⅱ) with negative sign is applied to the design of a simple current measuring probe and to the synthesis of the floating inductance. Experiments were performed by using the CC-Ⅱ consisting of operational amplifiers realized by M. Sharif Bakhtiar and P. Aronhime. Experimental results agreed well with the theoretical values, and confirmed that the frequency limitation was confined by the frequency response of CC.-Ⅱ. If operational amplifiers with high frequency capability were used to realize the CC-Ⅱ, the frequency limitation could be improved.

공황장애(Panic Disorder) 환자의 MMPI 및 Rorschach 반응특성 : On the Characteristics of the Responses of MMPI and Rorschach Test in Patients with Panic Disorder

민성길,이호영,김명선 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

As the diagnastic criteria of DSM-Ⅲ was newly established, a lot of studies have been conducted on the biological and psychological aspects of Panic Disorder, but studies using psychological tests are few. Chambless insists that the patients in this diagnostic criteria have hysterical cognitive style. Therefore, in this study, we attempted to examine the characteristics of MMPI and Rorschach of 13 Panic Disorder patients and whether these characteristics support the hysterical cognitive style. The results are as follows; a. The group mean profile of MMPI is Hs-D-Hy-Pt type (1-2-3-7 type) and the frequency of Hy type (3-type) has got the highest points. b. For Rorschach Test, the patients showed M〈ΣC and FC〈C+CF in EB, which is the major indicator of hysteria. These results suggest that our subjects of Panic Disorder patients showed typically hysterical feature.

인체 체액내 황색포도상구균의 증식과 철 획득 기전

신성희,이강길,이명희,양남웅,임용,김진호 대한감염학회 2000 감염 Vol.32 No.5

세팔로스포린 3′-퀴놀론의 합성 및 항균작용

나성범,정명희,김완주,지웅길 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

To a suspension of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-{3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl}-4-oxo-3-quinoline carboxylic acid(C1) in sodium hydroxide solution and water is added dropwise with stirring carbon disulfide. [6R][6α, 7β(Z)]]-7-[[[(2-Amino-4-thiazoly)methoxyimino]-acetyl]amino]-3-[[[[7-(3-carboxy-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-guinolonyl)-3,7-diazabicyclo[3.3.0 ]act-1(5)-en-3-yl]thioxomethyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (DACD) was synthesized from 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[7-(mercapto)thioxomethyl-{3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl}]-4-oxo-3-quinoline carboxylic acid disodium salt(C2) and cefotaxime. The in vitro activity of novel dual-action cephalosporin, DACD, was compared with the in vitro activities of CENO(cefotaxime 3'-norfloxacin dithiocarbamate), cefotaxime, and norfloxacin against a variety of bacterial species. In vitro activity of DACD was superior to that of norfloxacin against Streptococcus pyogenes. Against Gram-positive and Gram-negative bacteria, its activity was almost equal to that of CENO.