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Kim, Kyeong Seok,Yang, Hun Yong,Song, Hosup,Kang, Ye Rim,Kwon, JiHoon,An, JiHye,Son, Ji Yeon,Kwack, Seung Jun,Kim, Young-Mi,Bae, Ok-Nam,Ahn, Mee-Young,Lee, Jaewon,Yoon, Sungpil,Lee, Byung μ,Kim, Hyung TAYLOR & FRANCIS 2017 Journal of Toxicology and Environmental Health Vol.80 No.9
<P>Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i.p.) and sacrificed at 1, 3, or 5 days after treatment. Ischemia was achieved by bilaterally occluding both kidneys with a microvascular clamp for 45 min and verified visually by a change in tissue color. After post-reperfusion, urine samples were collected at 9, 24, and 48 hr intervals. Urinary excretion of protein-based biomarkers was measured by Western blot analysis. In cisplatin-treated rats, mild histopathologic alterations were noted at day 1 which became severe at day 3. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at day 3. Levels of urinary excretion of SBP1, neutrophil gelatinase-associated lipocalin (NGAL), and a tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly elevated at day 3 and 5 following drug treatment. In the vehicle-treated I/R group, serum levels of BUN and SCr and AST activity were significantly increased compared to sham. Urinary excretion of SBP1 and NGAL rose markedly following I/R. The urinary levels of SBP1, NGAL, TIMP-1, and KIM-1 proteins excreted by AKI patients and normal subjects were compared. Among these proteins, a marked rise in SBP1 was observed in urine of patients with AKI compared to normal subjects. Based upon receiver-operator curves (ROC), SBP1 displayed a higher area under the curve (AUC) scores than levels of SCr, BUN, total protein, and glucose. In particular, SBP1 protein was readily detected in small amounts of urine without purification. Data thus indicate that urinary excretion of SBP1 may be useful as a reliable biomarker for early diagnosis of AKI in patients.</P>
김곤섭,Eung-goo Lee,Yong-hwan Kim,정태성,Yong-seung Shin,Gee-wook Shin,Hui-guen Cha,Mi-rim Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Map of Soluble Proteins from Salmonella enterica Serovar Enteritidis byTwo-Dimensional ElectrophoresisMi-rim Park, Eung-goo Lee, Yong-hwan Kim, Tae-sung Jung, Yong-seung Shin, Gee-wook Shin, Hui-guen Cha and Gon-sup Kim*Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, KoreaReceived May 17, 2003 / Accepted July 23, 2003J. Vet. Sci. (2003), 4(2), 143-149JOURNAL OFVeterinaryScience*Corresponding author: Gon-sup Kim Laboratory of Veterinary Biochemistry, Collage of Veterinary Medicine, Gyeongsang National University, 900 Gazwa, Jinju 660-701 Korea Tel: +82-55-751-5823, Fax: +82-55-751-5803 E-mail: gonskim@nongae.gsnu.ac.kr
김유진,박미경,박이랑,이보람,이혜림,전선미,양난영,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38
The results of this Study are as follows:33.6% of all participants have insomnia; 22.5% of those who have insomnia are DIS(difficulty in initiating sleep), 17.3% are DMS(difficulty returning to sleep once awakened) and 7.0% awakened too early. 3 4.8% experience sleepiness during daytime. Type 1, experiencing insomnia and sleepi ness during daytime together, is 12.0%, Type 2, with insomnia only, is 21.6%, Type 3, with sleepiness during daytime only, is 22.8% and 43.5% experience no sleeping disturbances. After studying only those with 3 types of sleeping disturbances, it is found that the most common cause of such disturbance is stress 88.4%, anxiety 56.0%, no apparent reason 33.8%, anxiety/fear/terror 29.3%, hurry 23.6%, alcohol/caffeine 16.9%, bedroom tem perature 11.1%, urination during nighttime and persons living together 10.7%, noise from inside 8.9%, illumination 8.0%, and pain/itch 5.8%. The one group revealed significant differences in residential environment(p=0.003). Sex, age, education level, medicine, monthly earning revealed no meaningful differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), whether taking enough sleep(p=0.029), whether taking regular sleep(p=0.005) showed significant differences depending on whether or not having insomnia, and mean duration of sleep time, time to sleep, time of rising, whether taking naps did not reveal significant differences. Of sleep behavior, time to sleep(p=0.000), whether taking naps(p=0.000), indicated significant differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), and whether taking enough sleep(p=0.000), time of going to bed (p=0.002), whether or not taking nap(p=0.000), whether or not taking regular sleep(p=0.010) indicated significant differences among the sleeping disturbance types.
아동의 사회적 문제해결능력과 어머니의 대화형태와의 관계연구
김재림,백은주,신유림,심미경,이혜경 연세대학교 생활과학대학 1985 婦學 Vol.18 No.-
The present study investigated the relationship between the social problem solving ability of children and the language patterns of their mothers. The subjects included 193 nine yearolds (185 girls, 108 boys), and 230 twelve yearolds (115 girls, 115 boys). The instruments used were a language patterns test for the mother and IPA (Interpersonal Problem Solving Ability Test) for children. Major finding from this study were: ⑴ the correlation between the social problem solving ability of children and the language patterns of their mothers was not statistically significant, ⑵ the language patterns of the mothers were significantly different by child's sex; for boys, mother used more ordered language patterns and for girls, mothers used more ordered language patterns and for girls, mothers used more humanoriented language patterns, ⑶ the social problem solving ability of children were significantly different by child's age; 12yearolds exhibited higher ability than 9yearolds.
김경회, 정미림 김천대학교 2016 김천대학교 논문집 Vol.18 No.-
Nowadays, "dual career family" has appeared because of an increase of working mothers. In case of dual career family. the family members are to experience certain strains and stresses(pressure). Especialy in Korea - lack of institutional and administrative support for dual career family-"child care is one of the biggest problems they have to meet. In other words, parents have experienced difficulty in caregiving because moth-ers should take a big role not only in social works but also in family works, and their role-taking of householding and caregiving between father and mother is not in clearance. To solve this kind of problems that dual career family are involved in, administrative support is needed. So we have designed parent education program to support them.
오감각적 자극과 감성 브랜드 프로모션 공간 연출 디자인에 관한 연구 -마임 건강식품 알로주스 프로모션 연출을 중심으로-
김은애,김예은,정채림,진산,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 최근 감성중심의 디자인 환경에서 화두되고 있는 ‘오감’을 활용하여 브랜드 프로모션 공간을 연출하는 일련의 프로세스를 제안하는데 목적이 있다. 본 연구 범위는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출디자인> 수업에서 진행된 수업의 결과물로서 4개 팀 중 1개 팀의 작업물이다. 연구방법은 오감에 대한 문헌 연구와 융합연출 디자인 조사 정리한 사례 연구로 한다. 그 결과 본 연구는 산업체 <마임>과 연계하여 오감을 융합하는 쇼케이스 프로젝트부터 실제 브랜드 프로모션 공간 연출에 이르기까지 건강식품에 대한 브랜드의 일관성과 감성, 스토리성을 제시하였다. 끝으로 본 연구는 오감 을 활용한 공간 연출 디자인으로, 브랜드와 실질적으로 융합하여 브랜드를 프로모션함에 있어서 감성적인 접근방안을 제시 한 것에 의의가 있다. 또한 향후 본 연구는 이와 관련된 공감각, 오감을 담은 브랜드커뮤니케이션 디자인과 브랜드이미지, 브랜드 공간 연출개발에 있어서 기초 자료로 활용될 것으로 기대된다.
김훈,임재석,최성원,김호겸,권종진,최미숙,김성문 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1
There are various defects caused by trauma or resection of maignant tumor in the orofacial region, which can be reconstructed with various regional and pararegional flaps. Among these defects, it is very difficult to reconstruct palatal and midfacial defects after maxillectomy and patients have problems in speaking and swallowing of food. Therefore it is very important for surgeons to reconstruct these defects functionally and esthetically and to return the patients to the normal social activity. These defects are usually obturated with prosthodontic appliances to assist the phonation and swallowing. But nowadays surgical reconstruction by various flaps was considered and performed for better rehabilitation. For this purpose the forehead flap, the nasolabial flap, the tongue flap, the sternocleidomastoideous flap, the temporal flap, the latissimus dorsi flap, the scapular flap etc. are used. We reconstructed small-sized plalatal defects with tongue flap, medium-sized palatal and maxillary defects after maxillectomy with temporal myofascial flap and large midfacial defects including eyeball exenteration with latissimus dorsi myocutaneous flaps. Here we are to report 5 cases of these flaps used for the reconstruction of palatal and midfacial defects and consider the versatility, reliability and limitation in use of these flaps.
박물관 브랜드 마케팅 및 공간 프로모션 전략 -숙명여자대학교 내 정영양자수박물관 C·E·M 공간디자인을 중심으로-
김은애,김예은,정채림,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 정영양자수박물관의 콘텐츠를 활용한 통합 브랜드를 개발함에 있어 브랜드·디자인 ·마케팅을 융합한 시점에서 바라보고 그래픽아이덴티티, 제품아이덴티티, 공간아이덴티티 통합브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구는 기존의 박물관 방문자들과 20-30대 여성을 대상으로, 디자인과 마케팅의 융합된 측면에서 도출된 ‘C·E·M’을 物, 事, 人, 場가 융합된 문화로 한정한다. 그 결과, ‘C·E·M’은 디자인과 마케팅 전략을 융합하여 로고 및 사인물의 그래픽디자인부터 제품디자인, 공간디자인에 이르기까지 일관성과 객관성, 스토리성을 도출한다. 끝으로 본 연구는 브랜드가 디자인과 마케팅을 융합하여 더 체계화된 G·I, P·I, S·I의 통합 브랜드 매뉴얼을 만든 것에 의의가 있다. 아울러 향후 이와 관련된 통합브랜드 디자인 개발에 있어서 기초 자료로 활용될 것으로 기대된다