자색 당근 분말을 첨가한 스펀지케이크의 관능적 품질 특성

정채림,윤혜현 (사)한국조리학회 2022 한국조리학회지 Vol.28 No.3

Purple carrot has high fiber and provitamin A, and received great attention because of its anthocyanin. In this study, sponge cakes were prepared by adding with 0%, 4%, 8%, 12%, 16% and 20% of purple carrot powder and its quality properties and sensory characteristics were analyzed. The specific gravity and baking loss rate were increased, while volume, specific volume, the moisture content and pH were decreased. The L and b values of crumb were decreased but a value was increased and L, a, and b values of crust were all decreased. The hardness, gumminess, and chewiness were increased but springiness was decreased. According to attribute differences PC4 showed highest in greeness, and PC20 had hightest purpleness. The caramel and chocolate flavor showed the highest score in PC20 and CON had highest score of egg and raw flour flavor. The texture test results showed all categories were increased except springiness. After taste of sweetness and chocolate taste had highest score in PC20. The sensory attribute difference test results indicated PC4 and PC8 showed the highest scores. Based on the results between 4% to 8% addition would be suitable to improve the quality characteristics and its preferences.

Clinical Usefulness of Real-time PCR and Amplicor MTB PCRAssays for Diagnosis of Tuberculosis

정채림,김미경,서동춘,이미애 대한임상미생물학회 2008 Annals of clinical microbiology Vol.11 No.1

Background: PCR assay has provided a mean of more rapid and sensitive detection of Mycobacterium tuberculosis (MTB) complex than conventional acidfast bacilli (AFB) smears and MTB cultures. Using the recently developed AdvanSure TB/NTM kit (LG Life Science Diagnostic Division, Korea), which could differentiate nontuberculous mycobacteria (NTM) from MTB, this study compared clinical usefulness of real- time PCR assay and Amplicor MTB PCR assay (Roche Molecular Systems, USA) for diagnosis of tuberculosis. Methods: A total of 213 specimens (148 respiratory and 65 nonrespiratory specimens) were tested by using real-time PCR, Amplicor MTB PCR, AFB smear, and MTB culture. The sensitivity and specificity of four methods were evaluated according to clinical diagnosis. Results: Of six NTM grown in culture, four (67%) were detected by real-time PCR. The overall agreement of real-time and Amplicor MTB PCR was 92% (191/207). The overall sensitivity and specificity were 91% and 87%, respectively, for real-time PCR, and 86% and 93% for Amplicor MTB PCR. In nonrespiratory specimens, the sensitivities of real-time PCR, Amplicor MTB PCR, AFB smear, and MTB culture were 67%, 60%, 13%, and 40%, respectively, and the specificity of the four methods were all 100%. Conclusion: For diagnosis of tuberculosis, the sensitivity and specificity of the real-time PCR assay using AdvanSure TB/NTM kit and Amplicor MTB PCR were similar, and the former could differentiate NTM from MTB. The PCR assay can be considered as a more sensitive technique for the detection of MTB than the conventional AFB smear and culture.

국내 프로바이오틱스 제품 현황 분석 및 향후 발전 방안

정채림,신해욱,양정우,김수정 한국식품저장유통학회 2020 식품저장과 가공산업 Vol.19 No.2

투석 중인 만성신부전 환자에서 Cardiac Troponin T 증가의 평가

정채림,홍기숙 이화여자대학교 의과학연구소 2010 EMJ (Ewha medical journal) Vol.33 No.2

Objectives:Cardiac troponin T(cTnT) levels are elevated in patients with chronic renal failure(CRF) with dialysis which represent myocardial damage. But the cut-off levels were different in laboratories and clinical physicians. We conducted a study to find out the cut-off levels of acute myocardial infarction(AMI), ischemic heart disease(IHD), and cardiovascular disease (CVD) in CRF patients with dialysis and prognostic aspect according to cTnT levels. Methods:Cardiac troponin T(cTnT) of total 98 patients(men 43, women 55, mean age 60.4±13.0 years) was reviewed the diagnosis and progress for 3 years by the medical records. Serum cTnT by Elecsys 2010(Roche diagnostics, Germany), the 4th generation assay was performed. Results:Mean cTnT level of total 98 patients was 0.26ng/mL and the patients with CVD were 59(60.2%) and their cTnT level was 0.41 ng/mL. The mean levels of cTnT in AMI, IHD, and CVD were 1.10, 0.52, and 0.41 ng/mL, respectively. cTnT, CK, CK-MB, and glucose were increased according to severity of cardiovascular disease. The cut-off levels of cTnT in AMI, IHD, and CVD was 0.10, 0.07 and 0.06 ng/mL. The sensitivity and specificity of AMI, IHD, and CVD in each cut-off level were 88.2/71.6%, 76.2/71.4%, and 81.4/71.8%, respectively. The survival rate above cTnT 0.1 ng/mL during 3 years was significantly decreased(p<0.001) than less than 0.1 ng/mL. Conclusion:The degree of cTnT elevation in CRF patients with dialysis represents severity of cardiovascular disease and poor survival rate. 배 경 투석중인 만성신부전 환자에서 cardiac troponin T(cTnT) 증가는 심근손상을 알려주는 표지자이다. 그러나 투석중인 신부전 환자에서의 심근손상에 있어서의 cTnT의 결정치는 다양하게 해석 되고 있다. 본 연구에서는 투석을 받고 있는 만성신부전 환자에서 cardiac troponin T(cTnT)의 증가 원인을 확인하고 심근경색, 허혈성 심질환, 심혈관질환 진단의 결정치를 구하고 생존율과의 관계를 평가하고자 한다. 방 법 신부전으로 투석을 받고 있는 환자로서 cTnT 검사를 시행한 98명(남자 43명, 여자55명, 평균 연령 60.4±13.0세)을 대상으로 하였다. 질병의 진단 및 진행상황은 진료기록을 참조하였고 관찰기간은 3년간이었다. cTnT는 4세대 검사법인 Elecsys 2010(Roche diagnostics, Germany)으로 측정하였다. 결 과 투석중인 신부전환자 98명의 cTnT의 평균치는 0.26ng/mL이었다. 그 중 심혈관질환이 있는 환자는 59명(60.2%)이었고 cTnT의 평균치는 0.41 ng/mL이었고 심혈관질환이 없는 군에서는 0.04 ng/mL이었다. 심근경색, 허혈성 심질환, 심혈관질환에서 cTnT 평균치는 각 1.10, 0.52, 0.41 ng/mL이었다. CK, CK-MB 및 glucose는 심혈관질환의 심한 정도에 따라 증가하였다. 그 외 LD, NT-proBNP, BUN, Creatinine, eGFR, triglyce-ride, cholesterol 및 albumin치는 질환의 정도에 따른 차이가 없었다. 허혈성 심질환이 있는 군에서 없는 군보다 cTnT, NT-proBNP 및 glucose치가 유의하게 높았다. 심근경색, 허혈성 심질환, 심혈관질환의 결정치는 cTnT 0.1, 0.07, 및 0.06 ng/mL이었고, 각각의 민감도와 특이도는 88.2/71.6%, 76.2/71.4% 및 81.4/71.8%이었다. 3년간의 생존율은 cTnT 0.1 ng/mL 이상 군에서 0.1 미만 군보다 유의하게 낮았다. 결 론 투석 중인 만성신부전 환자에서의 cTnT증가의 정도는 심혈관질환의 심한 정도와 낮은 생존율을 나타내었다.

건강보험 약국 급여비 분석과 약국 유형화 연구

정채림,최상은,이화영,김진이 대한약학회 2013 약학회지 Vol.57 No.1

The objectives of the study are to investigate pharmacy remuneration levels stratified by the number of pre- scriptions dispensing and the type of nearby medical facilities using the Korean National Health Insurance (NHI) database,and to classify community pharmacies based on the characteristics. Claims data of all community pharmacies were extractedfrom the Korean NHI database from January 1 to June 30, 2010. A total of 14,985 pharmacies were included for the analysis.The remuneration amounts per pharmacist were directly associated with the number of prescription dispensing, and variedby the type of nearby medical facilities where more than 90% of prescriptions dispensed at the pharmacy are issued from.We classified pharmacies to six groups according to the number of prescription dispensing and the type of nearby medicalfacilities; (1) pharmacies with equal to or less than 200 prescriptions per month per pharmacist, (2) pharmacies near a gen-eral hospital, (3) pharmacies near a regular hospital, (4) pharmacies near a clinic, (5) pharmacies near multi clinics, and (6)pharmacies that do not belong to the above types. Compared to pharmacies near a clinic or multi clinics, pharmacies neara general hospital showed a lower number of prescription dispensing per pharmacist, but the income from dispensing fees was higher (p<0.05). The new taxonomy of community pharmacies can be a useful basis for further policy development in pharmacy remuneration system.

Cardiac Troponin I 경도 증가의 임상적 의의

정채림,조성은,홍기숙 대한진단검사의학회 2008 Annals of Laboratory Medicine Vol.28 No.5

Background : Cardiac troponin I (cTnI) is known as a sensitive and specific marker for myocardial ischemia. The purposes of this study are to establish cut-off values of cTnI for acute myocardial infarction (AMI) and to analyze clinical significance of minor elevation of cTnI. Methods : Two hundred and four patients from whom cTnI was measured at Ewha Womans University Dongdaemun hospital from January to March, 2006 were enrolled in the study. cTnI was measured using Dimension RxL (Dade Behring, USA). The lower limit of detection (LLD), 10% CV value, 99th percentile of healthy individuals, and cut-off value for AMI by ROC curve analysis were determined. Results : LLD, 10% CV value, and 99th percentile of cTnI were 0.00 ng/mL, 0.10 ng/mL, and 0.07 ng/mL, respectively. The cut-off value of peak cTnI for AMI by ROC curve analysis was 0.13 ng/mL with the sensitivity, specificity, and AUC of 90.9%, 87.7%, and 0.921, respectively. The peak value of cTnI of patients with ischemic heart disease (IHD) was higher than that of the patients without IHD (P<0.05). According to the above reference and cut-off values of the initial cTnI, patients were categorized into four groups; ≤0.05 ng/mL (group 1), 0.06-0.09 ng/mL (group 2), 0.10-0.59 ng/mL (group 3), ≥0.60 ng/mL (group 4), and compared frequencies of AMI, IHD, cardio vascular disease (CVD) and death after 1 month among groups. Frequencies of AMI, IHD, CVD, and death after 1 month were significantly increased as the cTnI concentrations were increased (P<0.05). Conclusions : Minor elevation of cTnI value, even in group 3 was significantly associated with high incidence of AMI, IHD, CVD, and death rate after 1 month. (Korean J Lab Med 2008;28:339-45)

서울시 가구의 과부담의료비 지출 발생 및 반복적 발생의 영향요인

정채림,이태진 한국보건행정학회 2012 보건행정학회지 Vol.22 No.2

The public health insurance system in Korea is characterized as relatively high out-of-pocket payments, which are the principal source of catastrophic health expenditure (CHE). The objectives of this study are to estimate the incidence of household CHE and to clarify the characteristics that affect the occurrence and recurrence of household CHE using the Seoul Welfare Panel Survey database for 2008 and 2010. Thresholds to estimate CHE were 10% and 20% of the total house income (T/X), and 25% and 40% of the income excluding food share (T/Y). Determinants of the occurrence and recurrence of CHE at the threshold of T/X=10% were analysed using multiple logistic regression models. Out of the 3,665 households that responded in 2008 survey, households with CHE were 12.07% (T/X≥10%), 5.34% (T/X≥20%), 6.84% (T/Y≥25%), and 4.44% (T/Y≥40%). Risk factors associated with household CHE included living with a spouse, non-Medicaid beneficiary, householder unemployment, low household income, the number of the disabled, poor subjective health, and the number of chronic diseases. A total of 41.78% of households with CHE in 2008 repeatedly experienced CHE in 2010. Risk factors of CHE recurrence included decreased household income and an increase in chronic diseases over the two time periods, the number of members with disability or chronic diseases, and the presence of cancer patients in 2008. Households with lower socioeconomic and health status had a higher financial burden on health care than do their counterpart households. There is a need to enhance society-wide financial protection in health spending among vulnerable citizens in Seoul, particularly, households with low income, disabled members or cancer patients.

인구고령화가 의료비 증가에 미치는 영향 - 연령대별 사망 전 의료비의 변화를 중심으로 -

정채림,이태진 한국보건경제정책학회 2017 보건경제와 정책연구 Vol.23 No.4

Future health care expenditures (HCE) are projected based on expected mortality and age-specific death related costs which are relatively low among the oldest old, assuming healthy ageing. This study examined the impact of age and death on individual HCE and the change of the impact over time in order to explore the influence of population ageing on future HCE. We used a nationally representative medical and pharmacy claims data of the Korean National Health Insurance from 2002 to 2013. We used two part models with the interaction term of death, age and year to explore the change in death related costs among the elderly over time. A total of 123,127 elders were included, of whom 26,387 were deceased in the study period. Younger decedents consumed higher death related costs than those who died later. HCE among the oldest old increased faster than that of the younger old. The difference in death related costs between the oldest decedents and the younger decedents decreased over time. We suggest that future HCE projections should count on (1) the changes in population structure, (2) death related costs by age group, and (3) the increasing trend of death related costs among the oldest old.

A Case of IgM Deficiency with B Cell Deficiency Detected by ABO Discrepancy in a Patient with Acute Osteomyelitis

정채림,차미경,준병혁,홍기숙 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.3

ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here,we describe a case of IgM deficiency discovered during the evaluation of an ABO discrepancy in a 16-yr-old Korean boy. ABO blood grouping showed that while his cell type was O+, serum typing detected only anti-A (3+). Anti-B was not detectable at room temperature but was graded at 1+ at 4˚C. ABO genotyping revealed an O/O genotype. His serum IgG, IgA, and IgM concentrations were 770 mg/dL (reference range: 800-1,700 mg/dL),244 mg/dL (reference range: 100-490 mg/dL), and 13.5 mg/dL (reference range: 50-320mg/dL), respectively. He was diagnosed with acute osteomyelitis on the basis of clinical presentation and imaging studies. The symptoms gradually improved within 3 weeks of treatment. However, the ABO discrepancy and IgM deficiency persisted even 6 months after recovery and lymphocyte subset analysis revealed CD19+ B cell deficiency. To the best of our knowledge, IgM deficiency detected by ABO discrepancy in a patient with acute osteomyelitis has not been reported before.

Prognostic Implications of Elevated Cardiac Troponin T in Patients with Acute Ischemic Stroke

정채림,정태동,홍기숙 대한진단검사의학회 2017 Laboratory Medicine Online Vol.7 No.1

Background: Elevated cardiac troponin T (cTnT) levels have been reported in patients with acute ischemic stroke, however, the prognostic relevance is not well established. We evaluated the association between cTnT elevation and prognosis in patients with acute ischemic stroke. Methods: The 182 consecutive patients enrolled had new-onset acute ischemic stroke. Their clinical and laboratory findings were collected retrospectively. Stroke severity and prognosis were determined using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) scores, as well as 30-day all-cause mortality. The patients were divided into two groups according to their cTnT levels: ≤14 and >14 ng/L. Cox proportional hazards regression analysis was performed to determine the associations between clinical or laboratory variables and 30-day all-cause mortality. The Kaplan–Meier method was used to compare the overall survival rate in patients with elevated and normal cTnT levels. Results: The cTnT level was elevated in 14.8% of the patients. Age, NIHSS and mRS scores, creatinine kinase-MB, and 30-day all-cause mortality were significantly higher in patients with elevated cTnT levels than in those with normal cTnT levels. The hazard ratio of the elevated vs. normal cTnT group for 30-day all-cause mortality was 8.06 (95% confidence interval: 1.13–57.25, P=0.037). A Kaplan–Meier survival analysis revealed a significantly higher survival rate in patients with normal cTnT levels compared to those with elevated cTnT levels (P<0.0001). Conclusions: An elevated cTnT level is significantly associated with poor short-term outcomes in patients with acute ischemic stroke.