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윤경호,유남진,김남호,정진원,박현영,이상재,오석규,박도심 한국심초음파학회 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4
Background: It is still unknown whether increased cardiac adiposity is related to the risk factors of coronary artery disease (CAD). We measured epicaridal adopose tissue (EAT) and mediastinal adipose tissue (MAT) using echocardiography and examined their correlations with CAD and serum adiponectin. Methods: One hundred fifty three patients who underwent elective coronary angiography for chest pain were measured cardiac adiposity by transthoracic echocardiography. The correlations of cardiac adipose tissue with the presence and severity of CAD and the serum adiponectin level were examined. Results: EAT was thicker in patients with CAD (1.8±1.4 vs. 3.8±1.9 mm, p<0.001), but MAT was not different according to the presence of CAD (2.9±2.8 vs. 3.5±2.5 mm, p=0.121). EAT showed a significant positive correlation with age (r=0.225, p=0.005), homocystein (r=0.289, p=0.001), fasting glucose (r=0.167, p=0.042), and fibrinogen (r=0.218, p=0.009), and a significant negative correlation with serum adiponectin (r=-0.194, p=0.016). EAT thickness (OR 11.53, 95% CI; 3.61-36.84, p<0.001) and low serum adiponectin (OR 2.88, 95% CI; 1.02-8.15, p=0.046) were independent predictors of obstructive CAD. However, MAT thickness was not associated with CAD. Conclusion: EAT was associated with the severity and risk factors of CAD and correlated with serum adiponectin level. In contrast with EAT, MAT was not associated with CAD and adiponectin. Background: It is still unknown whether increased cardiac adiposity is related to the risk factors of coronary artery disease (CAD). We measured epicaridal adopose tissue (EAT) and mediastinal adipose tissue (MAT) using echocardiography and examined their correlations with CAD and serum adiponectin. Methods: One hundred fifty three patients who underwent elective coronary angiography for chest pain were measured cardiac adiposity by transthoracic echocardiography. The correlations of cardiac adipose tissue with the presence and severity of CAD and the serum adiponectin level were examined. Results: EAT was thicker in patients with CAD (1.8±1.4 vs. 3.8±1.9 mm, p<0.001), but MAT was not different according to the presence of CAD (2.9±2.8 vs. 3.5±2.5 mm, p=0.121). EAT showed a significant positive correlation with age (r=0.225, p=0.005), homocystein (r=0.289, p=0.001), fasting glucose (r=0.167, p=0.042), and fibrinogen (r=0.218, p=0.009), and a significant negative correlation with serum adiponectin (r=-0.194, p=0.016). EAT thickness (OR 11.53, 95% CI; 3.61-36.84, p<0.001) and low serum adiponectin (OR 2.88, 95% CI; 1.02-8.15, p=0.046) were independent predictors of obstructive CAD. However, MAT thickness was not associated with CAD. Conclusion: EAT was associated with the severity and risk factors of CAD and correlated with serum adiponectin level. In contrast with EAT, MAT was not associated with CAD and adiponectin.
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정상 관동맥 조영소견을 보인 흉통 환자의 원인 질환과 임상적 특성
윤경호,유남진,이명수,김남호,김태현,오석규,정진원 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1
Background : The obvious clinical differentiation of the histories between vasospastic angina and esophageal disorder is not still clear. The aim of this study is to describe clinical characteristics and incidence of patient with angina-like chest pain and nonspecific findings in coronary angiogram. Methods : From March 1998 to March 2000, 76 consecutive patient with normal or insignificant coronary arteriographic findings were included. Ergonovine provocation test was performed in all the patients, and for the patients that coronary spasm was not induced, esophago-gastro-duodenoscopy, esophageal manometry, Bernstein test, 24 hour esophageal pH monitor, measurement of esophageal pressure, esophageal pH monitoring under treadmill test were done. To evaluate of clinical features, one physician ascertained history by administered questionnaire. Results : 1. Of 237 patients that coronary angiography was performed, 76 cases(32%) showed normal or insignificant angiographic findings. Of this patients, 32 cases(42%) revealed vasospastic angina, 22 cases(29%) gastroesophageal reflux, 8 cases(11%) Nutcracker esophagus, and 3 cases(4%) nonspecific esophageal motility disorder. 2. Risk factors of vasospastic angina were male sex and smoking. Vasospastic angina were induced by moderate physical activity rather than exercise and alcohol, especially morning next to alcohol drinking. The chest pain presented early in the morning and in evening, and at night made frequent awakening due to pain. Belching occurred in 38% of patients, and thereafter soon the pain subside. In addition, cold sweat(in 88% of the patients), syncope(19%), nausea(38%), vomiting(22%), and general weakness(38%) were accompanied. 3. Gastroesophageal reflux was more complained in female. It referred to the back in 23% of the patients. The symptom was exacerbated during exercise and improved after taking water or antacid. 72% of the patients had a chronic duration of more than a year, and the pain usually presented in the afternoon. Gastrointestinal symptom revealed in 50% of the patients, but that was not related with chest pain. 4. The incidence of esophageal motility disorder was nearly same in male and female. The pain was radiated to the back in 36% of the patients. The prevalence period was short, and the symptom duration was more than 1 hour in 45% of the patients. Conclusion : There were some distinguishable characteristics between vasospastic angina and esophageal disorder. Full medical history taking may provide important clues to make diagnosis. We noticed that, belching or liquor is very important history to suggest vasospastic angina. Even though the mechanism was not fully determined, we expect that there would be the specific findings, which different aspects of the medical history, of vasospastic angina and esophageal disorders, respectively.
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윤경호,Youngyu Lee,이필승 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.4
In this paper, we propose a continuum mechanics based 3-D beam finite element with crosssectional discretization allowing for warping displacements. The beam element is directly derived from the assemblage of 3-D solid elements, and this approach results in inherently advanced modeling capabilities of the beam element. In the beam formulation, warping is fully coupled with bending, shearing, and stretching. Consequently, the proposed beam elements can consider free and constrained warping conditions, eccentricities, curved geometries, varying sections, as well as arbitrary cross-sections (including thin/thick-walled, open/closed, and single/multi-cell cross-sections). We then study the modeling and predictive capabilities of the beam elements in twisting beam problems according to geometries, boundary conditions, and cross-sectional meshes. The results are compared with reference solutions obtained by analytical methods and solid and shell finite element models. Excellent modeling capabilities and solution accuracy of the proposed beam element are observed.
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윤경호,박근호 대한슬관절학회 2014 대한슬관절학회지 Vol.26 No.2
The meniscus has several important roles, such as transmission of the load, absorption of the shock in the knee joint, acting as a secondary anteroposterior stabilizer of the knee joint, and contributing to proprioception of the knee joint. Degenerative changes of the knee joint develop in the long-term follow-up even after partial meniscectomy. Thus, there has been growing interest in meniscal repair. In addition, with increased understanding of the important roles of the meniscal root and advancement of diagnostic methods, efforts have been made to ensure preservation of the meniscal roots. In this review article, we will discuss operative techniques and clinical outcomes of arthroscopic repair of the meniscus and the meniscal root and postoperative rehabilitation and complications as well.
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윤경호,임재홍,황교범,우선호,정진우,김용철,조대열,고점석,이상재,이은미,오석규 대한심장학회 2014 Korean Circulation Journal Vol.44 No.5
Background and Objectives: Contrast-induced nephropathy (CIN) is associated with increased morbidity and mortality. This observational, non-randomized study evaluated the effect of rosuvastatin loading before percutaneous coronary intervention (PCI) on the incidence of CIN in patients with acute coronary syndrome (ACS). Subjects and Methods: A total of 824 patients who underwent PCI for ACS were studied (408 patients in the statin group=40 mg rosuvastatin loading before PCI; 416 patients of control group=no statin pretreatment). Serum creatinine concentrations were measured before and 24 and 48 hours after PCI. The primary endpoint was development of CIN defined as an increase in serum creatinine concentration of ≥0.5 mg/dL or ≥25% above baseline within 72 hours after PCI. Results: The incidence of CIN was significantly lower in the statin group than that in the control group (18.8% vs. 13.5%, p=0.040). The maximum percent changes in serum creatinine and estimated glomerular filtration rate in the statin group within 48 hours were significantly lower than those in the control group (5.84±22.59% vs. 2.43±24.49%, p=0.038; -11.44±14.00 vs. -9.51±13.89, p=0.048, respectively). The effect of rosuvastatin on preventing CIN was greater in the subgroups of patients with diabetes, high-dose contrast medium, multivessel stents, high baseline C-reactive protein, and myocardial infarction. A multivariate analysis revealed that rosuvastatin loading was independently associated with a decreased risk for CIN (odds ratio, 0.64; 95% confidence interval, 0.43–0.95, p=0.026). Conclusion: High-dose rosuvastatin loading before PCI was associated with a significantly lower incidence of CIN in patients with ACS.
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