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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
Adrenal Medullary Hyperplasia with Coexisting Adrenal Cortical Adenoma
Jung Whan Chun,M.D.,Seong Woo Hong,M.D.,Yun Kyung Kang,M.D.<SUP>1<.SUP>,Woo Yong Lee,M.D.,Yeo Gu Jang,M.D. and Byungmo Lee,M.D. 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.3
Adrenal medullary hyperplasia is an increase in the mass of the adrenal medullary cells. We report a case of a 38-year-old man presenting with pheochromocytoma-like symptoms who was preoperatively misdiagnosed with pheochromocytoma. Hypertension was associated with an intracranial hemorrhage evident in a brain computed tomography scan, in which no obvious pituitary gland enlargement was detected. An abdominopelvic CT revealed a solitary tumor in the right adrenal gland with no obvious enlargement of the contralateral adrenal gland or sympathetic chains. Lab results showed increased levels of urinary metanephrines. Based on clinical data, the patient underwent a laparoscopic right adrenalectomy bases on a diagnosis of pheochromocytoma. The patient was finally diagnosed with adrenal medullary hyperplasia with coexisting ipsilateral non-functioning adrenal cortical adenoma. Postoperatively, blood pressure and lab results were maintained in the normal range and the patient was symptomatically free during the follow-up period. (Korean J Endocrine Surg 2011;11: 182-185)
The utility of CD44 and D2-40 as a prognostic predictor in invasive carcinomas of the breast
Jung Whan Chun,Yeo Goo Chang,Seong Woo Hong,Woo Yong Lee,Byungmo Lee,Hye Kyung Lee 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.1
Purpose: Local recurrence and distant metastasis are major prognostic factors associated with breast cancer. Lymphovascular invasion is an important pathway of metastatic spread. CD44 and D2-40 are assumed to be related with invasion of malignant cells to the adjacent lymphatic or vascular structures by different mechanisms. This study was conducted to examine whether CD44 and D2-40 expression together have prognostic value in invasive carcinoma of the breast. Methods: A total of 46 surgically resected tissue samples of invasive carcinoma of the breast were analyzed for immunohistochemical expression of CD44 and D2-40, along with other clinicopathologic factors. Association between patient related factors and disease free survival was evaluated by statistical analysis. Results: Disease free survival was shorter in CD44-positive patients (median, 66.5 months) than in CD44-negative patients (median, 112.6 months; P<0.001). All of 17 patients with recurrence showed D2-40 positivity. When both markers were positive, disease free survival was considerably shorter (63.3 months) than when at least one marker was negative (112.9 months, P<0.001). Conclusion: We concluded that expression of CD44 and D2-40 is associated with unfavorable prognosis. Concurrent positivity of both markers may be useful in predicting malignant relapse following surgical resection with shorter disease free survival in patients with invasive carcinoma of the breast.
부신피질종양에서 신호전달체계에 연관된 Oncogenes발현에 관한 연구 : Gs alpha, Gi alpha, CREB 단백의 변이에 대하여
정은경,이현숙,신동환,박형천,허갑범,이현철,임승길,이은직,김경래,정우희,윤영대 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.4
Functioning adrenal cortical tumors are originated form a distinct zone(zonna glomerulosa, zonna fasciculata or zonna reticularis) or the transitonal zone of adrenal gland. Each zone of the gland is regulated by their specific hormons or cytokines, and their signal transduction systems are different. The oncogenes of many endocrine tumors were mutated proteins involved in signal transduction, however gip is the only reported oncogene in adrenal cortical tumors. Therefore we decided to reevaluate whether gsp might be detected as an oncogene in several different functioning adrenal tumors, and we also tested whether CREB protein is a tentative oncogene or not. In our study, gsp was not detected in 13 patients, however gip was not also detected unexpectedly. There were no mutations in the phosporylation site of CREB("P" box) in adrenal cushing syndrome. We concluded that gip was not a oncogene detected frequently in adrenal cortical tumor, and CREB protein was not considered as a tentative oncogen, because there might be no amplification of the signals due to its extreme distal component of PKA or PKC system(J Kor Soc Endocrinol 9: 350-357, 1994).
LTD induction suppresses LTP-induced hippocampal adult neurogenesis
Chun, Sung Kun,Sun, Woong,Jung, Min Whan Lippincott Williams Wilkins, Inc. 2009 NEUROREPORT - Vol.20 No.14
Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.
이정환,이상우,최재현,이성준,이홍식,김창덕,진윤태,류호상,전훈재,송치욱,현진해,허병원 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.1
Background/Aims : Sharp impacted esophageal foreign bodies can be very difficult to manage. When attempting to remove such objects inappropriately, life threatening complications, such as perforation can occur. Terefore, surgical intervention generally affords a safer approach. The aim of this study was to evaluate the safety and efficacy of endoscopic remval of sharp impacted esophageal foreign bodies using a dilatation method with an oral side balloon. Methods : A total of 17 patients (7 Male, 10 Female)with sharp impacted esophageal foreign bodies underwent endoscopic Extraction. The following technique was successfully performed; an oral side balloon (Top Co., Japan) for esophageal variceal sclerotherapy was attached on the distal part of the endoscope. Under local anesthesia, the endoscope was inserted near the proximal part of the esophageal foreign body. Then, the oral side balloon was gradually dilated. Dilataion of the proximal part of the esophagus made it possible to release the sharp impacted foreign body from the esophageal wall. Results : The types of foreign bodies were fish bones (6 cases), press-through packages (6 ases), chichen bones (3 cases), dentures (1 case), and a watch (1case). Endoscopic removal was successful in all 17 cases without complications such as perforation. Conclusions : This method of using an oral side balloon is safe and effective in removing sharp impacted esophageal foreign bodies, preventing, surgery and possible perforation.