무증상 갑상선기능저하증 환자에서 Thyroxine 치료에 따른 혈청 지질 및 아포지단백의 변화

조보연,신찬수,김원배,고창순,김성연,박혜영,박건상,이홍규,박형규,김숙경 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1

Background: Subclinical hypothyroidism(SCH) is a common biochemical abnormality which can be found in routine screening tests of thyroid function. We are increasingly faced with the question of whether its an indication for thyroxine replacement therapy. The effect of thyroxine replacement on lipid profile in SCH has aroused a great interest because of an association of overt hypothyroidism(OVH) with hyperlipidemia and increased risk of coronary artery disease. Method: We prospectively evaluated the changes in lipids and apoproteins before and after thyroxine replacement therapy in 23 patients with SCH and in 37 patients with OVH. We measured serum total cholesterol and triglyceride using autoanalyzer, high density lipoprotein(HDL) chole-sterol by dextran sulfate method, Apo A1 and Apo B by immunonephelometric assay. Results: Thyroxine replacement therapy significantly decreased total cholesterol, low density lipoprotein(LDL) cholesterol and apo B levels, but did not affect the level of triglyceride, HDL cholesterol or apo AI in patients with OVH. In SCH, thyroxine replacement therapy with the doses to normalize serum TSH concentrations also decreased significantly the level of cholesterol and LDL cholesterol albeit apo B levels did not change. Moreover, in most of patients with OVH (11 of 12) and in all of patients with SCH(5 of 5) who had had hyperchlesterolemia before treatment, thyroxine replament normalized their cholesterol and LDL cholesterol levels. Conclusion: In regard to the beneficial changes in blood lipid levels, patients with SCH should be treated, especially in cases who have other risk factors for the development of atherosclerosis. If thyroxine replacement only will reduce the incidence of coronary artery disease in SCH remains to be elucidated by long-term prospective studies(J Kor Soc Endocrinol 11:41-51, 1996).

난치성 만성정신분열증 환자의 생활의 질에 미치는 정신사회치료 프로그램의 효과에 대한 예비연구

송동호,배민진,이종호,이홍식,김선경,서호석,김찬형,전지용 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : Recent studies of psychosocial adjustment after hospitalization have found that the combination of maintenance antipsychotic drug treatment and psychosocial treatment including psychoeducational program are highly predictive of social rehabilitation and reduction of subsequent relapse. Two groups of patients with refractory chronic schizophrenia were preliminarily compared to determine the effect of a psychosocial treatment program on the quality of life in refractory chronic schizophrenics in an open comparative trial. Methods : One group(N=11) was assigned to approximately six months of the psychosocial treatment program(including psychoeducation program and activity program such as interpersonal relationship program, social skill training, self management program, outings, etc), in a group format, twice a week and a fixed maintenance dosage of clozapine ; while scale(QLS) was used to provide an objective measure of changes in patient's psychosocial functioning and a general assessment of psychopathology was made using the Brief Psychiatric Rating Scale(BPRS). Results : Both BPRS total positive score and the QLS total score, especially in the intrapsychic foundation factor of the scale showed a statistically significant improvement in the psychosocial treatment group. But there was no significant change in both BPRS and QLS scores over a 6-month period in the non-psychosocial treatment group. A significant negative correlation was found between the negative symptom and changes of QLS total, instrumental role and common object and activities scores respectively after receiving a 6-month of the psychosocial treatment program. Conclusion : These results suggest that a psychosocial treatment program including the integration of psychoeducation and a skill training oriented activity program serve as an outpatient treatment modality to improve the quality of the life in refractory chronic schizophrenia. To further clarify the effect of psychosocial treatment in chronic schizophrenia, a randomized trial should be done.

울형성 심부전증에서 심혈관계 보상기전의 지표로서 저나트륨혈증의 의의에 관한 연구

김경환,김미경,이우형,홍사석,신길자,장일중 대한내과학회 1986 대한내과학회지 Vol.31 No.3

In patient with congestive heart failure, it is well known that the sympatho-adrenal system and the renin angiotensin system are activated to compensate for the reduction of cardiac output and the redistribution of blood flow. Although Lilly, et al. (1984) and Francis, et al. (1985) have insisted that the induction of these circulatory compensation mechanism by pastura1 changes is closely related to the concentration of plama sodium in congestive heart failure, it is still controversial. Thus, in an effort to clarify this hypothesis, present study was designed to determine the relationship between the existing sodium concentration in plasma and the changes of the plasma catecholamine concentration and renin activity during postural alterations in patients with congestive heart fai1ure and normal subjects. Ten patients with congestive heart failure who had been admitted to the Ewha Womans University Hospital from May, 1985 to July, 1985 and five normal volunteers were chosen. Patients with more than one year history of congestive heart failure belonging to class 3 or 4 as the criteria set by the New York Heart Association have been selected for this study. Among these ten patients, 5(3 males and 2 females) had low plasma sodium concentration(below 135mEq/l) and 5(3 males and 2 females) had normal plasma sodium concentration(above 135mEq/l). The observed results are as follows: 1) In the normal subjects, the observed plasma renin activity was 1,2±0.4ng/ml/hr and the concentrations of norepinephrine and epinephrine were 177.5±27 and 150.0±8pg/ml, respectively, at supine position. However, these values were increased by about 2 times by changing to upright position. 2) In patients with hyponatremic congestive heart failure, the values of plasma renin activity and catecholamine levels were significantly higher than those patients having normonatremia. 3) The increase in the plasma renin activity and catecholamin levels induced by upright position were minimal in patients with congestive heart failure having normonatremia. 4) However, in patients with hyponatremic congestive heart failure, the plasma renin activity and the levels of plasma catecholamines were not altered, or rather decreased, by the same postural changes. Based on the results, the levels of plasma sodium concentration in patients with congestive heart failure could provide an index for the induction of circulatory compensation mechaniams and may have important significance in determining the severity and prognosis of the disease. Particularly in the congestive heart failure patients with hyponatremia, as the circulatory compensation mechanism appear to be operating at maximum already, they would not be able to utilize the reflex compensation mechanism inducible with the changes of body position.

합성섬유를 혼입한 콘크리트의 강도 및 내구특성

홍창우,정영화,이주형,이정호 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

Concrete structures has been deteriorated by poor environment. This study was conducted to evaluate durability of concrete which are increasingly demanded recently. Therefore, the research of durability must be executed for application of Polypropylene fiber reinforced concrete real structures. Concrete durability properties incorporating Polypropylene fiber was performed with the variable of Fiber contents, Fiber type and Target strength, specimens were made and subjected to durability and strength tests. The results show that strength of concrete is increased the Fiber content increase, Mono-Filament fiber and Polypropylene fiber reinforced concrete makes improved durability properties.

연립 주택 화재시 유독가스 방출 특성과 Rats를 이용한 독성평가

김홍,강영구,김동현,정기창,이창섭,김운형 한국화재소방학회 2002 한국화재소방학회논문지 Vol.16 No.3

화재에 의한 독성가스의 노출은 인간에게 있어서 화재시 생명에 아주 위험한 요소일 것이다. 다양한 화재에 의한 독성가스의 노출 중 본 논문에서는 경기도 안산시 재개발지구에서 한 연립주택을 이용하여 실제화재와 같은 조건으로 화재 시험을 하였다. 화재시 발생하는 가스 CO, CO_2, O_2, SO_2, NO 및 NO_2등을 측정하였으며, 발생하는 가스를 실험동물인 백서(S.D)에 노출시켜 2분간격으로 혈액을 체취하였다. 독성평가를 위하여 백서의 혈액과 혈청 중 Glucose, AST(GOT), ALT(GPT), CBC Count 및 CO(carboxy)-Hb를 분석하였다. 폭로되는 CO의 농도와 백서의 혈액중 CO-Hb 농도사이에 양-반응 관계(dose-response relationship)를 보였다. It has long been recognized that exposure to fire-induced toxic gases is a fatal hazard confronting people in fires. In this study, an indoor fire experiment was conducted in an unoccupied residential building located in An-san city, Kyoung-gi province, and the composition of effluent gases, which include CO, CO_2, O_2, SO_2, NO and NO_2, were measured by a gas analyzer A group of lab rats were exposed to the toxic gases released from fire, and the blood samples of the rats were gathered every 2 minutes. A toxicity evaluation was conducted by analyzing the concentrations of Glucose, AST(GOT), ALT(GPT), CBC Count and CO(carboxy)-Hb in the blood samples. Shown from the analysis is the does-response relationship between the CO concentration that rats were exposed to and the CO-Hb concentration in rat blood.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

제주시 지역 빗물의 특성 및 분석 데이타의 정밀도에 관한 연구

강창희,홍상범,강영철,김원형,허철구 濟州大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.10 No.1

The precipitation samples were collected at a site in Cheju National University and investigated for the major ion components of them during the period of October, 1996 to May, 1997. During this period, the volume-weighted average value of pH was 5.09 and that of electric conductivity was 16.61μS/㎝, and the concentrations of ions were shown in the order of SO₄²?> Cl?> NO₃?>Na?> NH₄?> Ca²?> K?> Mg²?. For the precision of the analytical data, the correlation coefficient between the sum of the cation equivalent concentrations and that of the anion equivalent concentrations showed r²=0.8745 (r=0.940), and the correlation coefficient between the measured conductivity and the calculated conductivity was r²=0.9898, showing quite satisfactory agreement each other. Also, the correlation coefficient between the acid fraction from the equivalent concentrations of each ion and that from the measured pH and electric conductivity showed r²=0.9107. In the investigations of sea-salt effect, the enrichment factor of SO₄²?, Ca²?, K? was 9.1, 12.8, and 8.2, respectively, showing that most of these were coming to the air by the other factors rather than from seawater. On the other hand, it was found that the Cl? and Mg²? were mostly due to the origin of seawater. In the case of the effect of soil particulates, the enrichment factors of SO₄²?, Cl?, NO₃?, and NH₄? showed quite high values indicating suspending in the air through the other factors, however, some of Na?? and Mg²? and most of K? were found mainly due to the soil particulates. Moreover, for the effect on the pH of rainwater, the calculated neutralization factors of NH₄?, Ca²?, and Mg²? were 0.415, 0.274, and 0.101, respectively. It has shown that the hydrogen ions in the rain of Cheju city were neutralized about 52% by NH₃, and the Ca²? and Mg²? have neutralized them about 35%, and 13% respectively.

전신성 홍반성 루프스에서 고용량 경정맥 당질코르티이드로 치료된 단백질 소실성 장질환 1예

이규형,권창모,김현도,윤대영,이재웅,홍여훈,이충기 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Generalizes edema and hypoalbuminemia are relatively common presenting manifestations in many clinical situations. The differential diagnosis of hypoalbuminemia include; Kwashiorkor, synthetic dysfunction of the liver, and excessive protein loss as in nephrotic syndrome. In systemic lupus erythematosus (SLE), hypoalbuminemia and generalized edema are most commonly due to protein loss associated with lupus nephritis; gastrointestinal involvement is uncommon, and therefore protein loss through the gastrointestinal tract is quite rare. We report a case of a protein losing enteropathy (PLE) associated with SLE. The patient was referred to out hospital for generalized edema, arthralgia and facial rash. After clinical evaluation, the patient met the criteria for the SLE diagnosis; hypoalbuminemia with general edema was consistent with a protein losing enteropathy. After two weeks of therapy with parenteral high dose glucocorticoid, the patients was improved in laboratory findings as well as clinical symptoms.

제주도 한라산 1100 고지 대기 에어로졸의 조성 및 특성

김원형,강창희,신찬성,고선영,홍민선 濟州大學校 基礎科學硏究所 2003 基礎科學硏究 Vol.16 No.1

The atmospheric aerosols collected at the 1100 site located in Mt. Halla have been analyzed to investigate their compositions and chemical characteristics. The average concentrations of water-soluble cautions were in the order of NH_(4)^(+)>Ca^(2+)>Na^(+)>K^(+)>Mg^(2+) during the spring, showing high increase of Ca^(2+) concentration with the value of 0.60㎍/㎥, and NH_(4)^(+)>Na^(+)>K^(+)>Ca^(2+)>Mg^(2+) during the other seasons. The average concentrations of anions have shown in the order of SO_(4)^(2-)>NO_(3)^(-)>Cl^(-) for all seasons, and SO_(4)^(2-) and NO_(3)^(-) had higher concentrations in spring with the values of 4.84㎍/㎥ and 1.08㎍/㎥, respectively. From the analytical data of size-segregated particles by cascade impactor sampling, the components of NH_(4)^(+), SO_(4)^(2-), NO_(3)^(-) and K^(+) were distributed mainly in fine particles, but Ca^(2+), Na^(+), Mg^(2+) and Cl^(-) were included mostly in coarse particles. The correlation coefficients of nss-SO_(4)^(2-)/NH_(4)^(+), nss-SO_(4)^(2-)/K^(+) and NO_(3)/nss-Ca^(2+) showed quite high values with 0.871, 0.857 and 0.654, respectively. Based on the study of enrichment factors, it is considered that Na^(+), Mg^(2+), Cl^(-) and Ca^(2+) components were delivered from oceanic and soil sources, but SO_(4)^(2-), NO_(3)^(-) and NH_(4)^(+) might have other source origins. The factor analysis study showed the aerosol at the 1100 site was influenced mainly by anthropogenic factors, followed by oceanic and soil factors.

씨름샅바抵抗이 手掌骨에 미치는 影響

蔡鴻遠,李敏炯,張海植 慶北大學校 師範大學 體育學硏究會 1992 體育學會誌 Vol.20 No.-

The purpose of this study is to analyze the ossa manus in high school serum players. Addition, this study is to compare the skeletal developments of right and left hand in players. There selected players are 14 high-school serum players, Who are the second best in national athletic meeting. This study is to investingate pathological, Histological and morphological peculiarities in nature of ossifcation of the damaged region on the hand bone through the observation of X-ray films of regions concerned. Examination is used for the analysis of date from roentogen graphic and cross sectional method. The results are as follows: The films show no sign of pathological and histological peculiarity but the hypertrophic of ossa digitorum manus is more significant for right hand as 42.9% and 28.6% increases in which hands. The width of ossa carpi is more significant for left hand than right hand(P<.05). The average rate of increases is 0.07mm(0.2%) 0.57mm(1.3%) in left hand. The length of ossa digitorum manus is more significant for right hand than left hand(P<.05). The average rate of increase is 1.14mm(1.1%), 0.28(0.2%), -0.54mm(-0.3%), 1.0mm(0.7%), 1.25mm(1.0%)in right hand. The thickness of ossa digitorum manus is more significant for right hand than left hand(P<.05, P<.01). The average rate of increases is 0.54mm(3.2%), 0.47mm(3.7%), 0.25mm(3.5%) at caput of ossa carpi, 0.57mm(3.7%), 0.18mm(1.1%), 0.36mm(2.8%) at basis of ossa carpi.