프로세스 분석

권도영,김예슬 한국지능정보시스템학회 2012 한국지능정보시스템학회 학술대회논문집 Vol.2012 No.5

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson’s Disease NATION Study Group

권도영,고성범,이재혁,박희경,김한준,신혜원,윤진영,박건우,최선아,김상진,최성민,박지운,전범석,김지영,정선주,이정식,박정호,안태범,김원찬,김현숙,천상명,김희태,이지영,김지선,김은주,김종민,이광수,김중석,김민정,백종삼,박기종,김희진,박미영,강지훈,송숙근,김용덕,윤지영,이호원,오형근,조진환,송인욱,손영호,이필휴,김재우 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4

Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for as¬sessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather ex¬ert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strate¬gies is warranted to improve the HrQoL in PD patients.

한약이 류마티스 관절염 환자의 골다공증에 미치는 영향: 체계적 문헌 고찰 및 메타분석을 위한 프로토콜

권도영,구지향,이은정 한방재활의학과학회 2022 한방재활의학과학회지 Vol.32 No.3

Objectives This study is designed to identify the effectiveness of herbal medicine for osteoporosis in rheumatoid arthritis. Methods We will investigate 10 databases, 4 Korean databases (KoreaMed, KMBASE, Koreanstudies Information Service System [KISS], ScienceOn) and 6 of abroad (PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure [CNKI], WanFang, Citation Information by NII [CiNii]) without publication date, language limitation for clinical study of herbal medicine for osteoporosis in rheumatoid arthritis. Type, dose, duration, frequency of herb medicine will be analyzed. Results Randomized controlled trials about herbal medicine or herb extract for osteoporosis in rheumatoid arthritis should be included in the study. Cochrane's risk of bias tools will be used to assess quality of the study. Mean differences or standardized mean differences of 95% confidence intervals will calculated and data synthesis will be conducted using Review Manager (RevMan, ver.5.3; The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). Conclusions It is expected to provide basic data for the active use of herb medicine by systematically synthesizing and analyzing the actual situation, effectiveness, and safety of herb medicine for osteoporosis in rheumatoid arthritis.

Acute pulmonary toxicity and inflammation induced by the mixtures of household chemicals in rats

권도영,김현미,권정택,김은지,임연미,김필제,최경희 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.2

MMSS 자기서사 진단 사례 연구

권도영 강원대학교 인문과학연구소 2022 인문과학연구 Vol.- No.72

This paper is a case study of diagnosis using the MMSS self-narrative diagnostic test tool. In November 2021, the manual was officially distributed through the workshop, “MMSS Magic Mirror for the Story-in-depth of Self V.1.1 for the general public to spread the story of life in a healthy and happy way.” The results of self-narrative diagnosis and diagnostic counseling were analyzed for three middle-aged women in their 50s and 60s. The effects that could be confirmed through the MMSS self-narrative diagnosis can be stated through clarification, dimensionalization, and self therapy. First, clarification is that the diagnosis results are expressed by paying attention to the characters in the story so that the characteristics of the self-narrative can be understood contextually within the framework of existence and relationship. Second, dimensionalization was able to comprehensively identify the characteristic features of the self-narrative through the analysis of the correlation between each work and each item. Third, it was confirmed that the self therapy has the effect of objective reflection on the participant itself through diagnostic counseling. Based on the theory of literary therapy, MMSS self-narrative diagnosis can be an effective tool for diagnosing and describing the characteristics of the participant’s self-narrative by identifying the narratives that the participant accesses well and those that are not, and analyzing the characteristics of the narrative. 본 논문은 MMSS 자기서사 진단 검사도구를 활용한 진단 사례 연구이다. 2021년 11월에 워크숍을 통해 공식적으로 매뉴얼이 배포된 「인생이라는 스토리를 건강하고 행복하게 펼쳐가기 위한 MMSS 자기서사 진단지(Magic Mirror for the Story-in-depth of Self) 일반인용 V.1.1」을 활용하여 50, 60대 중년 여성 3명을 대상으로 자기서사 진단과 진단상담을 실시한 결과를 분석하였다. MMSS 자기서사 진단을 통해 확인할 수 있었던 효과는 명료화, 입체화, 자가치료로 나타낼 수 있다. 첫째, 명료화는 진단 결과를 이야기 속의 캐릭터에 주목하여 진술함으로써 자기서사의 특성을 존재성과 관계성의 틀 속에서 맥락적으로 이해할 수 있도록 하였다는 것이다. 둘째, 입체화는 각 작품들 간, 각 문항 간 연관성에 대한 분석을 통해 자기서사의 특징적인 모습을 종합적으로 확인할 수 있었다는 것이다. 셋째, 자가치료는 진단상담을 통해 참여자 스스로도 객관적인 성찰의 효과를 가짐을 확인할 수 있었다. MMSS 자기서사 진단은 문학치료학의 이론을 바탕으로 하여 참여자가 잘 접속하는 서사와 그렇지 못한 서사를 확인하고 그 서사의 특성을 분석함으로써 참여자의 자기서사의 특성을 진단하고 서술하는 데 효과적인 도구가 될 수 있다.

판소리 서사의 재맥락화를 통한 공감서사의 창작-뮤지컬 <인당수 사랑가>를 중심으로-

권도영 판소리학회 2019 판소리연구 Vol.47 No.-

In the modern age, the Pansori narrative has been disseminated by works of popular culture such as movies and musicals. Among them is Indang's Blues, a musical production comprised of two separate tales: Chunhyangga and Simchungga. Analysis of Indang's Blues’ narrative composition can be a meaningful endeavor for recontextualization of the Pansori narrative. By focusing on Pansori's notion of self-identity, Pansori stories can combine with the narratives of existing works. Such integration, which gives present-day meaning to these narratives, can be an effective recontextualization method. In analyzing the structure of Indang's Blues based on compositional narrative principles, it is clear that cross-connective features are applied both to narrative and semantic aspects. Additionally, the intentions of the epigraphic union were analyzed. In this newly-formed narrative, created through synthesis of two separate narratives, the meaning of the existing Chunhyangga and Simchungga changes. Romantic love between Byeonhakdo and Chunhyang(who resists the authority of the existing world), is emphasized. Due to this, a new plot can be created which provides empathy to young, modern audiences facing the same life problems as the work’s protagonist. Thus, it is necessary not only to preserve the existing works in full (remaining mindful of their traditions and creation), but also to revive their unique values in order to reinvigorate Pansori. Pansori's intrinsic values of healthy problem solving and worrying about life’s concerns can be understood as its self-identity. In light of this, the new piece created by recontextualizing the existing works’ plots can provide a modern significance to sympathy narratives. 판소리 서사는 현대에도 화나 뮤지컬 등의 대중문화 작품으로 창작되어 대중들에게 사랑을 받고 있다. 그 중 본고에서 주목하는 <인당수 사랑가>는 <춘향가>와 <심청가>를 결합하여 구성한 뮤지컬 작품이다. 이 작품의 서사 구성 방식을 분석하는 일은 판소리 서사의 재맥락화와 관련하여 의미 있는 작업이 될 수 있다. 판소리의 자기동일성 개념에 주목했을 때 판소리 서사가 현대에도 유효한 의미를 가질 수 있도록 하는 데에 기존에 존재하던 작품들의 서사를 결합시키는 방식이 효과적인 재맥락화의 방법이 될 수 있기 때문이다. <인당수 사랑가>의 서사 구조에 대해서 복합서사 구성 원리에 근거하여 분석 해 보았을 때, 서사 결합의 형태적 측면에서는 교차연결형 결합 방식이 적용되었 다고 보았고, 의미적 측면에서는 재맥락화를 통해서 기존 서사와는 다른 방향으 로 진행되도록 한 서사 결합의 의도를 분석할 수 있었다. 이렇게 서사 결합을 통해 새로 형성된 서사에서는 기존의 <춘향가>나 <심청가>가 갖고 있던 의미에 변화가 일어나, 변학도의 낭만적 사랑이 강조되기도 하고, 기존 세상의 권위에 저항하는 춘향에게 부모 또한 넘어야 할 벽으로 제시되었다. 이를 통해 작품의 주인공이 맞닥뜨리는 것과 비슷한 삶의 문제에 놓여 있는 현대의 젊은 관객들에 게 충분한 공감을 주는 서사로서 창작될 수 있었다. 이 사례를 통해 판소리의 전승 및 창작과 관련하여 기존 작품을 온전하게 보존하는 일뿐만 아니라 판소리의 생명력을 살리는 데에는 기존 작품이 가지고 있는 고유한 가치관을 현대에 살려내는 데에도 관심을 가질 필요가 있음을 주장하고자 하다. 삶의 문제에 대해 치열하게 고민하고 건강한 방식으로 문제 를 풀어가고자 했던 판소리의 고유한 가치관은 판소리의 자기동일성으로 이해 될 수 있다. 이러한 관점을 바탕으로 하여 기존의 작품이 갖고 있던 서사들을 결합시키면서 재맥락화하는 작업을 통해 창작된 작품은 공감서사로서 의의를 가질 수 있다.

Translation and Validation of the Korean Version of the 39-Item Parkinson’s Disease Questionnaire

권도영,김재우,마효일,안태범,조진환,이필휴,정선주,김중석,백종삼,고성범 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.1

Background and Purpose The importance of health-related quality of life (HrQoL) has been increasingly emphasized when assessing and providing treatment to patients with chronic,progressive, degenerative disorders. The 39-item Parkinson’s disease questionnaire (PDQ-39)is the most widely used patient-reporting scale to assess HrQoL in Parkinson’s disease (PD). This study evaluated the validity and reliability of the translated Korean version of the PDQ-39(K-PDQ-39). Methods One hundred and two participants with PD from 10 movement disorder clinics at university-affiliated hospitals in South Korea completed the K-PDQ-39. All of the participants were also tested using the Unified Parkinson’s Disease Rating Scale (UPDRS), Korean version of the Mini-Mental State Examination (K-MMSE), Korean version of the Montgomery-Asberg Depression Scale (K-MADS), Epworth Sleepiness Scale (ESS) and non-motor symptoms scale (NMSS). Retests of the K-PDQ-39 were performed over time intervals from 10 to 14 days in order to assess test-retest reliability. Results Each K-PDQ-39 domain showed correlations with the summary index scores (rS=0.559-0.793, p<0.001). Six out of eight domains met the acceptable standard of reliability (Cronbach’s αcoefficient ≥0.70). The Guttman split-half coefficient value of the K-PDQ-39summary index, which is an indicator of test-retest reliability, was 0.919 (p<0.001). All of the clinical variables examined except for age, comprising disease duration, levodopa equivalent dose, modified Hoehn and Yahr stage (H&Y stage), UPDRS part I, II and III, mood status (KMADS), cognition (K-MMSE), daytime sleepiness (ESS) and (NMSS) showed strong correlations with the K-PDQ-39 summary index (p<0.01). Conclusions The K-PDQ-39 has been validated for use in the Korean-speaking PD population. The questionnaire is a valid and reliable assessment tool for assessing the HrQoL of Korean PD patients.

복수하는 여성 원혼의 서사적 정체성

권도영 한국여성문학학회 2023 여성문학연구 Vol.59 No.-

한국구비설화에서 여성이 남성으로부터 버림받음으로 인해 원혼이 되어 상대 남성에게 가해하는 서사를 발견할 수 있다. 본고에서는 대표적으로 〈첫날밤 소박맞은 신부〉, 〈조월천과 상사뱀〉, 〈신립장군과 원귀〉 세 유형의 자료에 주목하여 원인사건과 복수사건으로 이루어지는 복수서사의 구조를 확인하고, 각 시퀀스 안에서 여성 주체의 존재적 속성과 관계적 속성이 달라지는 양상을 확인하였다. 여성 원혼의 복수서사는 서사적 정체성의 개념을 통해 분석했을 때 고정된 본질적속성으로서의 여성이라는 존재적 속성 때문에 발생한 문제에 대해서 관계 맺음의 과정에서 그 존재적 속성 자체를 원혼으로 변화시킴으로써 새로운 관계적 속성을 형성하고 이로써 문제 해결을 시도하는 서사로 볼 수 있다. 여성 원혼의 복수서사는 원혼 형상을 갖춘 후에야 복수 행위를 시도할 수 있었고 그 되갚음의행위가 상대 남성의 사회적 지위를 무력화시키는 방향이었다는 점에 주목하여그 성정치적 의미를 설명할 수 있다. In Korean traditional narratives, one can find a narrative pattern where a woman, rejected by a man, becomes a vengeful spirit and inflicts harm upon the male counterpart. In this paper, the focus is on three representative narratives: 〈첫날밤 소박맞은 신부〉(The Bride Who Was Beaten on the First Night), 〈조월천과 상사뱀〉(Jo Wolcheon and Sangsa Snake), and 〈신립장군과 원귀〉(General Shin Rip and the Vengeful Ghost). By examining these narratives, the paper investigates the structure of revenge narratives consisting of causal and retaliatory events. It also explores how the existential and relational attributes of the female protagonist change within each sequence. The revenge narratives of female spirits can be understood as an attempt to address problems that arise due to the existential attribute of “woman” as a fixed and essential characteristic. Through the concept of narrative identity, the paper argues that these narratives transform the very essence of this existential attribute into a vengeful spirit, thereby forming a new relational attribute and attempting to resolve the issue through the process of forming new relationships. The revenge narratives of female spirits highlight that revenge actions could only be attempted after taking on the form of spirits, and the acts of repayment were aimed at neutralizing the social status of the male counterpart, emphasizing the sexual political significance.

Ethylene glycol potentiated didecyldimethylammonium chloride toxicity in human bronchial epithelial cells

권도영,Eunji Kim,Jung-Taek Kwon,Doo-Hee Lee,Sun-Young Park,Hyun-Mi Kim,Pilje Kim,Kyunghee Choi 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.2

Didecyldimethylammonium chloride (DDAC) is an antimicrobial agent used as a preservative in household products. DDAC is toxic in human lung cells and in mouse lung. Aerosol products that contain DDAC often include ethylene glycol (EG) as a solvent; no safety information is available for respiratory toxicity of this combination (DDAC and EG). Human bronchial epithelial cells (BEAS-2B) were exposed (24 h) to DDAC and EG, separately or together. DDAC showed concentration-dependent cytotoxicity. EG did not affect cell viability. Compared to DDAC alone, EG and DDAC together enhanced mitochondrial damage and cell membrane disruption. Increased reactive oxygen species and decreased glutathione levels were seen in cells treated with the combination. Intracellular DDAC concentrations were elevated in the presence of EG. EG potentiated DDAC toxicity in lung cells by inducing oxidative stress through enhanced cellular uptake of DDAC. The use of these chemicals together in spray-type products should be carefully considered.

Comparison of Peroxyl Radical Scavenging Capacity of Commonly Consumed Beverages

권도영,최권회,김선주,최달웅,김영식,김영철 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2

The antioxidant potential of commercial beverages against peroxyl radical was determined using the Total Oxyradical Scavenging Capacity (TOSC) assay. Peroxyl radicals generated from thermal homolysis of 2,2’-azobis-amidinopropane oxidize α-keto-γ-methiolbutyric acid to ethylene, which is monitored by gas chromatography. The TOSC of each beverage is quantified from its ability to inhibit ethylene generation relative to a control reaction. Nine different beverages (green tea, jasmine tea, black tea, instant coffee, brewed coffee, cocoa mix, oolong tea, prune juice, and grape juice) were selected for this study. Their antioxidant capacities per a cup-serving (125 mL) were measured and compared to peroxyl radical scavenging capacity provided by a recommended daily dose of ascorbic acid (90 mg) dissolved in the same volume of water. The greatest antioxidant capacity was found in brewed coffee, which was followed, in decreasing order, by prune juice, instant coffee, green tea, cocoa mix, grape juice, jasmine tea, black tea, oolong tea, and ascorbic acid. There was an almost 7-fold difference in the TOSC between brewed coffee and ascorbic acid. The data suggest a potential role for commonly consumed beverages in lowering the risk of pathophysiologies associated with peroxyl radical-mediated events.