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응급실 내원 외상환자에 대한 TRISS Method 와 ASCOT Method의 비교분석
홍성화,이상목,이기형,윤충,김정호,고영관 대한외상학회 1994 大韓外傷學會誌 Vol.7 No.2
TRISS Method has been used for means of case identification of trauma patients. This method combines three variables associated with injury severity-Injury Serverity Score (ISS), Trauma Score (TS), and Age. But this method has limitations. So in recent years ASCOT was developed by Champion et al. To adress known limitation to TRISS and ASCOT method provides a more precise description of patients physiologic status and injury number, location, and severity than TRISS. From September 1993 to February 1992, 192 patients with traumatic injury via Emergency Room, Kyang Hee University Hospital were collected and compared the results between TRISS Method and ASCOT Method using probability of survivals, and disparity, sensitivity, specificity, Z-statistics. The results were as follows l. Average probability of survival by TRISS and ASCOT was 0. 9800 and 0. 9830 respectively. 2. Disparity using TRISS and ASCOT was 0. 3268 and 0. 3087 respectively. 3. Sensitivity using TRISS and ASCOT was 33.3% and 33.3% respectively. 4. Specificity using TRISS and ASCOT was 98.9% and 99.4% respectively. 5. Z-statics using TRISS and ASCOT was +1. 3329 and +l. 295 respectively. The authors concluded that there was relatively small gain in predictive accuracy by ASCOT over TRISS but no significant difference and we should develop future models that include additional variables, stratify patients by several injury cause and use decision rules to select variables and variable weights.
Antioxidative and Hepatoprotective Effects of Magnolol on Acetaminophen-induced Liver Damage in Rats
Yung-Hsiang Chen,Feng-Yen Lin,Po-Len Liu,Yi-Tsau Huang,Jen-Hwey Chiu,Yi-Chun Chang,Kee-Ming Man,Chuang-Ye Hong,Yen-Yi Ho,Ming-Tsung Lai 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Acute liver failure (ALF), an often fatal condition characterized by massive hepatocyte necrosis, is frequently caused by drug poisoning, particularly with acetaminophen (N-acetyl-p-aminophenol/APAP). Hepatocyte necrosis is consecutive to glutathione (GSH) depletion and mitochondrial damage caused by reactive oxygen species (ROS) overproduction. Magnolol, one major phenolic constituent of Magnolia officinalis, have been known to exhibit potent antioxidative activity. In this study, the anti-hepatotoxic activity of magnolol on APAP-induced toxicity in the Sprague-Dawley rat liver was examined. After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 μg/kg). Histological changes around the hepatic central vein, lipid peroxidation (thiobarbituric acid-reactive substance/TBARS), and GSH depletion in liver tissue induced by APAP were also recovered by magnolol treatment. The data show that oxidative stress followed by lipid peroxidation may play a very important role in the pathogenesis of APAP-induced hepatic injury; treatment with lipid-soluble antioxidant, magnolol, exerts anti-hepatotoxic activity. Our study points out the potential interest of magnolol in the treatment of toxic ALF.
박용관,박치영,조은택,조기섭,박찬국,송창훈,이미자,기근홍 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2
Hepatocellular carcinoma frequently metastasizes through direct extension, lymphatic, and hematogenous routes. The most common sites of metastasis are the lungs and the lymph nodes, glands, bones, spleen, kidneys, colon, and pleura are the sites of metastasis in decreasing order of frequency. But metastasis to the ovary is very rare. It is thought that metastasize to the ovary occurs through infiltration or dissemination. However, we observed ovarian metastasis of primary hepatic tumor in a 34-year old female who suffered from lower abdominal pain. At first, it was diagnosed as a primary ovarian tumor. But histologically, it presented sinusoidal pattern surrounded by the tumor cells and contained rounded by the tumor cells and contained round hyaline globules in minority of the cytoplasm. Then, the histologic features of percutaneous, sono-guided liver biopsy speecimen of the liver mass are similar to those of resected ovarian tissues. Therefore, we concluded that ovarian tumor was originated from hepatocellular carcinoma. In summary, this report examines a case of hepatocellular carcinoma with ovarian metastasis in a female and reviews the literature.