국가 대장암검진사업에서 면역화학분변잠혈검사의 역할

박동일 ( Dong Il Park ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2

Mongolian gerbil에서 Helicobacter pylori 감염 후 발생되는 Microsatellite Instability에 관한 연구

박동일 ( Dong Il Park ),김민경 ( Min Kyung Kim ),김재준 ( Jae J. Kim ),유태우 ( Tae Woo Yoo ),박정호 ( Jung Ho Park ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),손정일 ( Chung Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( Byung 대한내과학회 2006 대한내과학회지 Vol.71 No.1

목적: H. pylori (HP) 감염성 위염에서 HP는 DNA 손상복구기능에 장애를 유발하여 위 상피세포의 유전자에 발생하는 돌연변이를 축적시켜 위암의 발생 위험을 증가시킬 수 있다. 본 연구는 Mongolian gerbil (MG)animal model을 이용한 in vivo 실험에서 만성적인 HP감염이 위 점막의 MSI를 발생시키는 지 알아보고자 하였다. 방법: 7주된 수컷 MG에 HP CA20 균주를 감염시킨 후 일정한 시점마다 동물을 희생시켜 위를 절제하였다. 위염부위의 위 상피를 미세박리하여 DNA를 추출한 후 Fam이나 Hex로 표지시킨 다섯 가지 gerbil MSI marker를 이용하여 중합효소연쇄반응을 실시한 후 310 genetic analyzer를 이용하여 MSI 분석을 시행하였다. 결과: MSI는 정상부위(식도)에서는 관찰되지 않았고, 위염이 없는 부위에 비해 위염부위에서 빈번히 관찰되었다(p<0.05). 위염부위 중 6예에서는 low level MSI를 1예에서는 high level MSI를 관찰하였다(p<0.05). 결론: 본 연구로 MG에서 만성적인 HP 감염이 MSI유발에 관여함을 입증하였다. 이와 같이 HP는 위상피세포내의 DNA mismatch repair 단백 발현을 저하시켜 위상피세포 유전자에 발생하는 돌연변이의 축적을 유발할 수 있을 것으로 생각한다. Background: During Helicobacter pylori (HP) gastritis, the organisms cause an impairment of DNA repair that results in accumulation of mutations in the genome of epithelial cells and an increased risk of gastric carcinoma. The aim of this study was to determine whether microsatellite instability (MSI) could be induced by chronic HP infection in the Mongolian gerbil model. Methods: Seven-weeks old, specific pathogen-free male Mongolian gerbils were infected with the HP strain CA20. They were sacrificed at the each time points (1, 2, 3, 6, 9, 12 months). Areas of gastritis were carefully microdissected. DNA from tissues was analyzed for the presence of MSI by genomic DNA amplification with five gerbil microsatellite markers per sample. Gerbil markers labelled with Fam or Hex were obtained to perform MSI analysis using the 310 Genetic Analyzer. Results: MSI was more frequent in the area of gastritis than in that of normal (p<0.05). Six showed MSI-low and one showed MSI-high within the area of gastritis (p<0.05). Conclusions: This study shows that chronic HP infection in the Mongolian gerbil induces MSI. This finding indicates that HP infection causes a decrease in DNA MMR proteins in epithelial cells of the stomach that may reach critically low levels, allowing for the accumulation of mutations such as those seen in microsatellite regions.(Korean J Med 71:17-23, 2006)

초등학생의 신체능력평가 컴퓨터 프로그램 개발

박동일(Park Dong-Il),안양옥(Aun Yang-Ok),이병근(Lee Byung-Kun) 한국체육과학회 2001 한국체육과학회지 Vol.10 No.2

The purpose of this study is to develop physical capacity evaluation program used the data of physical constitution, physique and physical fitness test for elementary school students, and to use the programs for effective managing of the physical capacity. The subject were elementary school S and 6 grade. This study was carried out from 1999 September to 2000 March, The program was made by Visual basic 6.0 and Crystal report 7.0 for Window 95/98. The development process were divided 3 stage; planning, design and development. The planning was included the draw out plan and the adaptation of plan. The design was included the draw out of design and the adaption of design. The physical capacity evaluation program and exercise guideline program were developed used by physical test data, The physical test data were included the physical constitution test(5 items), physique(5 items) and physical fitness test(5 items). The physical capacity evaluation program were development test data is provide normal and abnormal, fitness level, obesity level, percentage of fitness by the physical test data. The exercise guideline program is provide exercise item according to the fitness level of muscle power, cardiovascular endurance, flexibility, speed and the guide about the intensity, frequency, duration of exercise. This program can print the output about the evaluation of fitness. The physical capacity evaluation reports are printed out from the physical capacity evaluation program. The reports are included normal and abnormal, obesity level, fitness level, the percentage of fitness by the physical test data. This program would be useful thing on elementary school students by the elevation of functions and the effective exchange with the health reports program.

혈관침범이 의심되는 췌장암 환자에서 절제 가능성과 생존율 분석

박동일(Dong Il Park),이종균(Jong Kyun Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),이규택(Kyu Taek Lee),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이종철(Jong Chul Rhee),최규완(Kyoo 대한내과학회 2000 대한내과학회지 Vol.58 No.6

N/A Background : One of the major limitations of curative resection in pancreatic cancer patients is local tumor extension to the mesenteric vessels. Thus, the purposes of our study were (1) to assess the clinical value of contrast enhanced spiral CT in predicting the resectability and survival of pancreatic cancer patients with suspicious vascular invasion and (2) to assess the influence of curative resection on survival in these patients.Methods : Forty cases of the pancreatic cancer patients who were suspected of having involvement of adjacent large vessels and subsequently underwent operation with curative intent were enrolled in this study. Resectability and survival were correlated with CT findings such as segment length, degree of encasement, type and number of vessel involved. Survival rate was compared between curative and palliative resection groups. And survival was also compared between resected and non-resected groups. Results : Of the 40 patients with adenocarcinoma of the pancreas, 14 patients had curative resections, and 26 patients had palliative resections. The probability of curative resection was higher in patients with segment length less than 2 cm, compared with those with more than 2 cm. However, there was no difference in survival between two groups. There were no differences of resectability and survival according to the degree of encasement, type and number of vessel involved. There were no difference in survival between curative and palliative resection groups, and between resected and non-resected groups. Conclusion : A survival benefit is not achieved by curative resection in pancreatic cancer patients with vascular invasion. So other non-operative treatments should be considered as effective tools prior to resection in these patients.(Korean J Med 58:651-656, 2000)

蘇子導痰降氣湯이 SO₂에 의한 흰쥐의 呼吸器損傷에 미치는 影響

朴東一(Park Dong-il),金奉載(Kim Bong-jae) 대한한의학회 1997 대한한의학회지 Vol.18 No.1

계단등반을 위한 가변형 단일 트랙 메커니즘 해석

박동일(Dong Il Park),임성균(Sung-Kyun Lim),곽윤근(Yoon Keun Kwak) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

There have been many researches about the driving mechanism for off-road mobility and the various utilities of rescue robot constantly. In this paper, a new type of driving mechanism for rescue robot which has a variable geometry single-track is introduced to achieve such objectives as surveillance, reconnaissance and rescue activity. It was designed to improve the performance of overcoming stairs and energy efficiency and to minimize its weight and size. We analyzed the design parameters for several steps of climbing stairs and confirm the possibility of realization of presented driving mechanism from various experiments.

19세기 남명학파의 동향 일고찰 -월촌(月村) 하달홍(河達弘)의 삶과 교유활동을 중심으로-

박동일 ( Dong Il Park ) 경상대학교 남명학연구소 2014 남명학연구 Vol.44 No.-

月村 河達弘은 19세기 강우지역에서 활동했던 학자이다. 그는 실용 을 중시하는 학문경향을 가지고 南冥 曺植과 謙齋 河弘度를 존숭하며 慕寒齋에서 강학활동을 전개하였다. 이로써 인근의 학자들을 운집시키 고 그들에게 남명학파로서의 의식을 고취시켰다. 이때 月皐 趙性家ㆍ 溪南 崔琡民ㆍ東寮 河載文ㆍ克齋 河憲鎭ㆍ斗山 姜柄周ㆍ尼谷 河應魯 등이 그의 문하에서 종유하였다. 이후 조성가와 최숙민은 하달홍의 인도 아래 보다 체계적인 학문을 위해 노사학단에 나아가 奇正鎭에게 수학하였다. 한편 하재문과 하헌 진은 본거지로 돌아가 寒州 李震相과 교유하였고, 강병주와 하응로는 性齋 許傳에게 나아가 집지하였다. 조성가와 최숙민이 노사학단의 핵심인물로 자리매김한 것에 비해 하재문이 한주학단에서나 강병주가 성재학단에서 차지하는 비중은 그 리 크지 않다. 그러나 이들 모두는 남명을 존숭하고 학문의 실천성을중시하는 남명학파로서의 정체성을 가지고 있었다. 이를 통해 두 가지 사실을 알 수 있는데, 하나는 하달홍의 모한재 강학이 남명학파의 정체성을 확립하는데 큰 역할을 했다는 것과, 다른 하나는 하달홍이 노사학파와 친밀성이 깊다는 점이다. 다시 말해 하달홍은 19세기 하동과 인근 강우지역의 문인들에게 남 명의 학문과 사상을 계승하고 보다 큰 학문을 접할 수 있도록 발판의 역할을 해 주었으며, 이를 통해 그 문인들은 남명학파로서의 정체성을 가지고 각자의 학문을 발전시켜 나갔던 것이다. Ha Dal-hong(河達弘, 1809~1877) was a scholar who worked in the Rainfall Area. He respected Nammyeong(南冥) Jo-Sik(曺植)ㆍ Kyumjae(謙齋) Ha Hongdo(河弘度) besides had a practical academic tendency. And gatherd the young scholars around as inspired the Nam-myoung school``s consciousness. Especially scholars such as Wolko(月皐) Cho Sung-ga(趙性家), Gyenam(溪南) Choi Suk-Min(崔琡民) gatherd there When he was studying at Ha Hongdo``s school Mohanjae(慕寒齋). Since then, Cho Sung-ga and Choi Suk-Min enterd the Nosa School of Ki Jung-jin(奇正鎭) for systematic studying under his leadership. Other scholars enterd the Han-ju School of Yi jin-sang or Sung Jae School of Heo Jeon. Even though they said they had a different academic orientation emphasized the practical academic tendency. And they had a identity as Nam-myoung school``s scholar. So Ha Dal-hong had a great influence in that Rainfall Area``s people had a identity as Nam-myoung school``s scholar, Through this, he receives a rating that succeed to the Ha Hongdo``s learning.

좌측 신주위 ( Perirenal Space ) 에 생긴 췌장가성낭포

박동일(Dong Il Park),오민구(Min Gu Oh) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5

Extrapancreatic fluid collection is well known comp1ication of pancreatitis. Involvernent of the left perirenal space is extremely rare and it is often difficult to differentiate from the cystic disease of renal and ureteral origin. We present 1 case of pancreatic pseudocyst which is located at the left perirenal space. We did distal pancreatectomy with splenectomy to disconnect the communicating duct frorn the cyst and the huge cyst was drained externally.

원발성 담즙성 경변증 16예의 임상상 : 단일 센터 경험

박동일(Dong Il Park),고광철(Kwang Cheol Koh),이준혁(Jun Hyek Lee),최문석(Moon Seok Choi),강태욱(Tae Wook Kang),문원(Won Moon),류민규(Min Kyoo Ryu),이용욱(Yong Wook Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),장재권(Jae Kwon Jang) 대한내과학회 2000 대한내과학회지 Vol.59 No.6

N/A Background : Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. The disease is relatively common in western countries, but so far, only about 20 cases have been reported in Korea. Thus, the purpose of our prospective study was to evaluate the clinical characteristics of PBC in Korea. Methods : Between October 1994 and February 1999, 16 patients diagnosed as PBC at our department were enrolled in this study. We analyzed these patients for the distribution of age and sex, initial symptoms and signs, associated disorders, laboratory, endoscopic, and radiologic and histologic findings. Results : Of the 16 patients, the ratio of male to female was 1:7 and the average age was 57.5 years. Pruritus (37.5%) was the most frequent presenting symptom followed by xerostomia and xerophthalmia (12.5%), jaundice (6.3%), chronic fatigue (6.3%), melena (6.3%). Associated disorders were Sj gren's syndrome (25%), arthropathy (12.5%), Raynaud's phenomenon (6.3%) and diabetes (6.3%). Abnormalities of liver function were found frequently. Antimitochondrial antibody (100%), antinuclear antibody (31.25%) and rheumatoid factor (31.25%) were found. Long-term administration of UDCA improved both clinical and biochemical signs in most patients, however, 2 patients experienced exacerbation during UDCA therapy. Conclusions : We experienced 16 cases of PBC within a short period. It is expected that we can find these patients more frequently if we suspect this disease in patients with pruritus and unexplained obstructive pattern of liver function abnormality.(Korean. J. Med 59:634-640, 2000)

수배관 시스템 최적화를 통한 데이터센터 냉각 에너지절약 설계방안

박동일(Dong Il Park),조진균(Jinkyun Cho) 대한설비공학회 2021 대한설비공학회 학술발표대회논문집 Vol.2019 No.-