대한동의생리학회 50년: 회고와 반성

이충열 한의병리학회 2025 동의생리병리학회지 Vol.39 No.6

The Physiological Society of Korean Medicine (大韓東醫生理學會, PSKM) was established on November 28, 1975. For the following 50 years, the Society stood at the forefront of the development of the Physiology of Korean Medicine (韓醫生理學, PKM). The academic foundations for PKM were laid by Yoon Gil-Young, and Kim Wan-Hee subsequently developed into a physiology based on the Neo Medicine Discourse(第3醫學論) and Analogical Function System(類機能體系). From the 1950s to the 1970s, the efforts of these two scholars enabled the field of PKM to play a pioneering role within the Korean medicine community, leading the discourse on the development of Korean Medicine. However, the 'scientific and modernized PKM’ advocated by these two scholars faded during the 1980s and 1990s. This paper reviews the current state of PKM as PSKM marks its 50th anniversary, and considers the direction the Society should take. It emphasizes the need to continue the academic lineage of the 'scientific and modernized PKM', which faded after Yoon Gil-Young and Kim Wan-Hee, and advocates for changes in PKM to meet contemporary demands. Furthermore, it argues that this work should be centered around the Society.

상황버섯이 인간 백혈병 세포주인 HL-60 세포의 분화유도 및 증식에 미치는 영향

최은영(Eun Young Choi),주성민(Seong Min Ju),박진모(Jin Mo Park),박준호(Jun Ho Park),한동민(Dong Min Han),전병훈(Byung Hun Jeon),김원신(Won Sin Kim) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

We have examined the effect of water extract of Phellinus linteus, a raw material of Korean traditional herbal medicine, on the induction of HL-60 cell differentiation. The proliferation of HL-60 cell was inhibited dose-dependently by treatment with various doses of P. linteus extract. It also caused a significant change in NBT reduction (7.5 times). The expression of CD11b and CD14 was increased in the cells treated with the extract, especially in those arrested at G0/G1 stage, which suggested that some components in P. Linteus extract induced HL-60 cell differentiation to granulocytic and monocyte lineages. Moreover, the expression levels of p21WAF1/CIP and p27KIP were up-regulated during HL-60 cell differentiation induced by P. Linteus extract. These results together suggest that P. Linteus extract contains potential HL-60 cell differentiation agents.

小菟絲子丸이 ob/ob mouse의 혈당, 고지혈증, Polyol Pathway 및 항산화작용에 미치는 영향

박성호(Seong Ho Park),정지천(Ji Cheon Jeong) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

Effects of Sotosaja hwan on Blood Glucose, Hyperlipidemia, Polyol Pathway and Antioxidative Mechanism in ob/ob Mouse Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might play a major role. Therefore, many efforts have been tried to regulate free oxygen radicals for treating diabetes and its complications. Sotosaja-hwan has been known to be effective for the antiaging and composed of four crude herbs. In male ob/ob mouse in severe obesity, hyperinsulinemia and hyperlipidemia, which are features of NIDDM, the hyperglycemic activites and mechanisms of Sotosaja-hwan were examined. Mice were grouped and treated for 5 weeks as follows. Both the lean (C57/BL6J black mice) and diabetic (ob/ob mice) control groups received standard chow. The experimental groups were fed with a diet of chow supplemented with 30 and 90 mg Sotosaja-hwan per 1 kg of body weight for 14 days. The effects of Sotosaja-hwan extract on the ob/ob mice were observed by measuring the serum levels of glucose, insulin, lipid components, and the kidney levels of superoxide anion radical (·O₂⁻), MDA+HAE, GSH/GSSG ratio, and also the enzyme activities involved in polyol pathway. Sotosaja-hwan lowered the levels of serum glucose and insulin in a dose dependent manner. Total cholesterol, triglyceride and free fatty acid levels were decreased, while the HDL-cholesterol level was increased, in Sotosaja-hwan treated groups. Renal aldose reductase and sorbitol dehydrogenase activities were increased in the ob/ob mice, whereas those were inhibited in the Sotosaja-hwan-administered groups. Sotosaja-hwan inhibited the generation of ·O₂⁻ in the kidney. Finally, MDA+HAE levels was increased and GSH/GSSG ratio was decreased in the ob/ob mice, whereas those were improved in the Sotosaja-hwan-administered groups. Sotosaja-hwan showed the antidiabetic and antihyperlipidemic activities by regulating the activities of polyol pathway enzymes, scavenging reactive oxygen species and reducing the MDA+HAE levels in the ob/ob mice.

봉독약침이 Monosodium Iodoacetate로 유발된 흰쥐의 골관절염에 미치는 영향

김용문(Yong Mun Kim),김순중(Soon Joong Kim),서일복(Il Bok Seo) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

This study was to investigate the effects of Bee-venom Treatment on the monosodium iodoacetate(MIA)- induced osteoarthritis in rats. Arthritis was induced by injection of MIA(0.5 mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was injected with normal saline once a day for 20 days, while treated group was injected with Bee-venom extract once a day for same duration. Body weights were measured at 0, 5, 10, 15, 20 days after injection. At the end of experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan contents of articular cartilages were analysed by safranine O staining method. The contents of TNF-α, IL-1β and IL-6 in synovial fluids were analysed by ELISA method. And also, COX-2 and iNOS immunohistochemical examination on the knee joints were performed. Body weights of the treated group were increased compared with control group at 20 days after injection. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control group. PG contents in articular cartilages of the treated group were significantly increased compared with control group. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control group. TNF-α contents in synovial fluids of the treated group were decreased compared with control group. Positive reactions of COX-2 in chondrocytes and synovial membranes of the treated group were decreased compared with the control group. On the basis of these results, we concluded that Bee-venom treatment has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it's effects were related with reduced secretion of TNF-α and COX-2 from osteoarthritic chondrocytes and synovial membranes.

백질려 추출물이 Streptococcus mutans에 대한 항치아우식에 미치는 영향

이다홍(Da Hong Lee),유현희(Hyeon Hee Yu),정수영(Su Young Jung),문해닮아(Hae Dalma Moon),김수민(Su Min Kim),전병훈(Byung Hun Jeon),유용욱(Yong Ouk You) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

Streptococcus mutans is considered one of the primary etiologic agents of dental caries. we studied the effect of the ethanol extracts of Tribuli fructus (T. fructus) on the growth, biofilm formation, acid production, adhesion and insoluble glucan synthesis of S. mutans. The ethanol extracts of T. fructus showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition at the concentration of 0.025, 0.05, 0.1, 0.2, 0.3, 0.5 mg/ml compared to the control group. In the biofilm assay, the ethanol extracts of T. fructus inhibited formation of biofilm synthesized by S. mutans at the concentration of 0.05 mg/ml. The extracts markedly inhibited S. mutans adherence to HA treated with saliva, and cell adherence was repressed by more than 50% at the concentration 0.05 mg/ml. On the activity of glucosyltransferase which synthesizes water insoluble glucan form sucrose, ethanol extract of T. fructus showed more than 10% inhibition over the concentration of 0.025 mg/ml. Hence, we conclude that T. fructus might be a candidate of anticaries agent. Further studies are necessary to clarify the active constituents of T. fructus responsible for such biomolecular activities.

2천년대의 한의학

안규석(Ahn Kyoo Seok) 한의병리학회 1988 동의생리병리학회지 Vol.3 No.-

싸리꽃 추출물의 tyrosinase 활성 및 멜라닌합성 억제효과

유인식(In Sik Ryu),박시준(Si Jun Park),문연자(Yeun Ja Mun),고준석(Joon Suk Ko),신기돈(Ki Don Shin),이장천(Jang Cheon Lee),우원홍(Won Hong Woo),임규상(Kyu Sang Lim) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

絲瓜絡의 항산화효과 및 3T3-L1분화 시 Cytokine류에 미치는 영향

윤용관(Yong Kwan Yoon),차윤엽(Yun Yeop Cha) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.5

In recent year, We are concerned in anti-aging, disease-protection, long-life, many method are used in solving this problem. Recently, We heard that Luffae Fructus Retinervus(LFR) has effect of anti-aging, disease-protection, long-life. So I let made a experiment for this result. The purpose of this study is to; 1) the anti-oxidant effect of Luffae Fructus Retinervus(LFR) used for 3 methods, those are DPPH radical scavenging activity, Nitric oxide(NO) radical scavenging activity, Superoxide anion radical scavenging activity, 2) cultivation 3T3-L1 Preadipocytes and Protein chip used for ProteoPlexTM 16-Well Murine Cytokine Array Kit. We measured level of DPPH radical scavenging activity. And we experienced that the ability of DPPH radical's elimination was increased by rising concentration of LFR. When the concentration of LFR was 5 mg/ml, the ability of DPPH radical's elimination was Maximum. We measured level of Nitric oxide(NO) radical scavenging activity. And we founded that the ability of NO radical's elimination was significant when concentration of LFR was from 1.25 mg/ml to 2.5 mg/ml. We measured level of Superoxide anion radical scavenging activity. And we founded that the ability of Superoxide anion radical's elimination was maximum when concentration of LFR was 0.3125 mg. When we inspected Antioxidative Effects with BSA, we experienced that ability of defense was increased by rising concentration of LFR. We known the immunity of LFR about 3T3-L1 Preadipocytes and gained the increase of Cytokines(IL-2, IL-4, GM-CSF) without IL-12p70, INF-γ, TNF-α. So I guess that Luffae Fructus Retinervus(LFR) has effects of anti-aging, disease-protection, long-life, etc.

白屈菜 추출물의 피지생성 억제효과

최두호(Doo Ho Choi),박시준(Si Jun Park),김호민(Ho Min Kim),노성택(Seong Taek No),유일수(Il Soo Yoo),문연자(Yeun Ja Mun),임규상(Kyu Sang Lim),우원홍(Won Hong Woo) 한의병리학회 2006 동의생리병리학회지 Vol.20 No.6

Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Androgens have profound effects on the physiology of the sebaceous gland. Using the human sebocyte cell line SZ95, we investigated the inhibitory effect of Chelidonii Harba (CH) on the subum production. Our results showed that numerous cytoplasmic lipid droplets were examined by Oil red staining and lipid droplets were increased markedly by testosterone. Cell viability was dose-dependently decreased by CH as compared with untreated cells, while total lipid content and cholesterol slightly were increased by CH. Testosterone significantly stimulated the synthesis of total lipid and the synthesis of specific sebaceous lipids such as cholesterol and triglyceride. Combined treatment with CH and testosterone resulted in a lower lipid synthesis than with testosterone alone. Especially cholesteol content was reduced by combined treatment with CH and testosterone. These results indicate that CH inhibits the testosterone-induced lipid synthesis in SZ95 cells and acts antagonistically to androgen at the cellular level.

갈근 메탄올분획의 과산화수소에 의해 유도된 지질과산화와 카드뮴에 대한 독성억제효과 (Ⅲ)

임진아(Jin A Lim),김연하(Yun Ha Kim),백승화(Seung Hwa Baek) 한의병리학회 2006 동의생리병리학회지 Vol.20 No.6

The effects of the methanol subfraction from Pueraria Radix on hydrogen peroxide-induced lipid peroxidation and cadmium-induced cytotoxicity were investigated in NIH 3T3 fibroblast cells. After the methanol subfraction treatment, the content of MDA induced by 600 μM H₂O₂ significantly decreased in proportion to the subfraction concentrations as well as 50 μM CdCl₂-induced cytotoxicity. Especially, 200 μg/mL concentration of methanol subfraction was strongly shown inhibition of lipid peroxidation and detoxification of cadmium. These results suggest that the methanol subfraction from Pueraria Radix retains a potential antioxidant and protective effect against cadmium.