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김유진,박미경,박이랑,이보람,이혜림,전선미,양난영,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38
The results of this Study are as follows:33.6% of all participants have insomnia; 22.5% of those who have insomnia are DIS(difficulty in initiating sleep), 17.3% are DMS(difficulty returning to sleep once awakened) and 7.0% awakened too early. 3 4.8% experience sleepiness during daytime. Type 1, experiencing insomnia and sleepi ness during daytime together, is 12.0%, Type 2, with insomnia only, is 21.6%, Type 3, with sleepiness during daytime only, is 22.8% and 43.5% experience no sleeping disturbances. After studying only those with 3 types of sleeping disturbances, it is found that the most common cause of such disturbance is stress 88.4%, anxiety 56.0%, no apparent reason 33.8%, anxiety/fear/terror 29.3%, hurry 23.6%, alcohol/caffeine 16.9%, bedroom tem perature 11.1%, urination during nighttime and persons living together 10.7%, noise from inside 8.9%, illumination 8.0%, and pain/itch 5.8%. The one group revealed significant differences in residential environment(p=0.003). Sex, age, education level, medicine, monthly earning revealed no meaningful differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), whether taking enough sleep(p=0.029), whether taking regular sleep(p=0.005) showed significant differences depending on whether or not having insomnia, and mean duration of sleep time, time to sleep, time of rising, whether taking naps did not reveal significant differences. Of sleep behavior, time to sleep(p=0.000), whether taking naps(p=0.000), indicated significant differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), and whether taking enough sleep(p=0.000), time of going to bed (p=0.002), whether or not taking nap(p=0.000), whether or not taking regular sleep(p=0.010) indicated significant differences among the sleeping disturbance types.
Lee, Yu-Jin,Kang, Yeong-Rim,Lee, So Young,Jin, Yena,Han, Dong Cho,Kwon, Byoung-Mog Lychnia 2017 International journal of oncology Vol.51 No.4
<P>Ginkgetin has been reported to display antitumor activity. However, the relevant pathway integrating cell cycle regulation and signaling pathways involved in growth inhibition in CRC cells remains to be identified. In this study, ginkgetin-treated HCT116 CRC cells exhibited significant dose-dependent growth inhibition with a GI(50) value of 4.0 mu M for 48-h treatment, together with apoptosis, via G(2)-phase cell cycle arrest. When HCT116 cells were treated with 10 mu M ginkgetin for 48 h, the percentage of cells in G(2)/M phase increased by 2.2-fold (43.25%) versus the untreated control (19.69%). Ginkgetin regulated the expression of genes that are critically involved in G(2) phase arrest cells, such as b-Myb, CDC2 and cyclin B1. Furthermore, we found that the suppression of b-Myb expression by ginkgetin was rescued similar to 5.1-fold by treatment with a miR-34a inhibitor (500 nM) and b-Myb was downregulated by >80% by 100 nM miR-34a mimic. These data suggest that the miRNA34a/b-Myb/cyclin B1 cascade plays a critical role in ginkgetin-induced G(2) cell cycle arrest, as well as in the inhibition of HCT116 cell proliferation. Moreover, the administration of ginkgetin (10 mg/kg) reduced tumor volumes by 36.5% and tumor weight by 37.6% in the mice xenografted with HCT116 cells relative to their vehicle-treated counterparts. Therefore, ginkgetin is the first compound shown to regulate b-Myb by modulating miR-34a, and we suggest the use of ginkgetin as an inducer of G(2) arrest for the treatment of CRC.</P>
( Yu Rim Lee ),( Kyunghwa Kim ),( Se Young Jang ),( Won Young Tak ),( Young Oh Kweon ),( Bina Jung ),( Gyoun Eun Kang ),( Sang Kyung Seo ),( Jung Gil Park ),( Hye Won Lee ),( Young Seok Han ),( Jae Mi 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Long interspersed nuclear element-1 (LINE-1) hypomethylation, representing global DNA methylation level, is associated with prognosis via activation of oncogenic functions of genes. This experiment was performed to evaluate prognostic implication of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) and the possible mechanisms related to oncogene activation. Methods: Ninety-six HCC patients between October 2014 and September 2015 at Kyungpook National University Hospital, Daegu, South Korea were enrolled for this prospective study. Quantitative pyrosequencing was performed to quantify the methylation level of for CpG sites in the LINE-1 promotor. The expression of CD133 and ST18 were measured by immunohistochemistry and their correlation with LINE-1 methylation levels were analyzed. Results: LINE-1 was significantly hypomethylated in tumor tissues compared with nontumor tissues (64.0 ±11.6% vs. 75.6 ±4.0%, respectively, P<0.0001). In this study population, LINE-1 hypomethylation group had a large proportion of female gender, smaller tumor size, and nonexistence of ascites (P< 0.05). Contrary to previous reports, LINE-1 hypomethylation was not an independent risk factor for overall survival and disease progression (all P >0.05). A total of 81 (84.4%) patients had demethylation of LINE-1 (ΔMI<0), and 15 (15.6%) patients had hypermethylation of LINE-1 (ΔMI≥0). HCC with demethylation of LINE-1 (ΔMI<0) had higher CD 133 expression than HCC with hypermethylation of LINE-1 (ΔMI≥0) (P=0.011). Moreover, when patients divided into two groups based on the mean value of tumor line-1 methylation, ST18 showed borderline significance in distinguishing the LINE-1 hypomethylation group than the other (P=0.053). Conclusions: LINE-1 demethylation is associated with expression of CD133 and ST18 in Hepatocellular carcinoma. In this study, LINE-1 hypomethylation was not related to overall survival and disease progression, this is probably due to the enrollment of HCC patients with various tumor stages and liver function.
Impact of Existing Liver Disease on Clinical Outcomes of COVID-19: A Multicenter Study
( Yu Rim Lee ),( Min Kyu Kang ),( Jeong Eun Song ),( Hyun Jung Kim ),( Young Oh Kweon ),( Won Young Tak ),( Se Young Jang ),( Jung Gil Park ),( Changhyeong Lee ),( Jae Seok Hwang ),( Byoung Kuk Jang ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. Methods: A total of 1,005 patients who had laboratory-confirmed COVID-19 admitted to five tertiary hospitals in South Korea were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease and predictors of disease severity and mortality in COVID-19 were assessed. Results: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe diseases (4.5% vs. 0.9%, P=0.006). Compared to patients without advanced liver fibrosis, a higher proportion of patients with significant fibrosis (presence of liver cirrhosis or FIB-4 >3.25) needed oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, acute kidney injury; succumbed to death (P<0.05). Presence of liver cirrhosis and higher FIB-4 value were found to be independent predictors of severe disease (OR 4.52, 95% CI 1.20-17.02, P=0.026; OR 6.09, 95% CI 3.76-9.86, P<0.001) and death (HR 2.86, 95% CI 1.04-9.30, P=0.042; HR 4.30, 95% CI 2.56-7.23, P<0.001) in COVID-19, along with old age and diabetes. FIB-4 index showed a high predictive power for disease severity and mortality of COVID-19 (AUROC=0.858, AUROC=0.870, respectively). Conclusions: This study suggests advanced liver fibrosis is a significant risk factor of COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients.
Quality Characteristics and Antioxidant Activity of Malt Made with domestic Oats
Yu-Rim Lee,Seung-Hyun Sim,Da-Bin Kim,Kang-Hyun Chung,Jeung Hee An 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was conducted to investigate the quality characteristics and antioxidant activity of malt made from oats. The moisture content of the oat malt was contained 7.33%. The pH, total sugar content, and soluble solid of the oat malt was at 6.05, 119.95 mg/g, and 2°Brix, respectively. The color values of the malt were 56.37 at the L(lightness) value, 2.27 at a(redness) value, and 18.08 at the b(yellowness) value. The protein contents of oat were contained 13.83%. Also, the oat malts higher increased to 14.95% than the barley. The diastatic power was showed at oat malt (163.39 W.K), and higher increased than other malts. The domestic oat malt showed the highest total polyphenol, flavonoid content, and tannic acid. In addition, in the DPPH and ABTS radical-scavenging activity of domestic oat malt extract was increased in a dose-dependent manner and it showed a higher content than other malts. The domestic oat malt contained a higher reducing power than ascorbic acid at 700∼1000 μg/mL concentration. Therefore, these results suggest that domestic malts can be used effectively as functional foods with antioxidant activity or free radical scavenging activity.