기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

HPLC-ICP/MS 와 ICP/MS를 이용한 FAPAS 07187 쌀의 총비소, 무기비소, 카드뮴 측정

노현명 ( Hyun Myung Noh ),김지영 ( Ji Young Kim ),김원일 ( Won Il Kim ),( Anitha Kunhikrishnan ),김민지 ( Min Ji Kim12 ),김경진 ( Gyeong Jin Kim ),박기문 ( Ki Moon Park ),류지혁 ( Ji Hyock Yoo ),김두호 ( Doo Ho Kim ),이영자 ( Y 한국환경농학회 2013 한국환경농학회 학술대회집 Vol.2013 No.-

Metal (loid)s such as environmental contaminants affect food safety. Metal (loid)s exist trace extremely in agriculture products. Therefore it is important to analyze accurately about trace these metals. High resolution techniques and quality controls are needed to analyze these materials. In order to achieve quality results, standardized methods and techniques are required. So ISO(International Organization for Standardization) of laboratory proficiency testing is determination of laboratory testing performance by means of inter-laboratory comparison. The values have been derived as a consensus of a number of laboratories using a variety of methods. Proficiency tests were applied to analyze the metal(loid)s [inorganic arsenic (As), total As and cadmium (Cd)] in powdered rice FAPAS 07187 (Food Analysis Performance Assessment Scheme; February-April 2013). The rice powder sample was extracted with 1% HNO3 for inorganic As for microwave-assisted extraction using water at 95℃ for 90 min and their analysis by HPLC/ICPMS. Also, HNO3 for total As and Cd using microwave-assisted extraction using at 200℃ for 50 mins and analysis by ICP/MS. Validation check was performed for accuracy using CRM (NMIJ CRM 7503-a) for inorganic As, and CRM (IRMM-Rice CRM) for total arsenic and cadmium. The result were satisfactory. FAPAS 07187 the z-scores of inorganic As, total As and Cd in powdered rice were-1.8,-0.9 and 0.2(lzl<2, respectively).

정신분열병 환자의 인지 기능 장애와 연성 신경학적 징후

김재경,이상익,홍경수,안소연,김지혜,김이영 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 정신분열병 환자는 인지 기능의 장애와 연성 신경학적 징후의 이상 소견을 보이며, 이는 병태 생리 과정에서 중추신경계의 기질적 이상을 시사하는 소견으로 받아들여져 왔다. 본 연구는 인지 기능 장애와 연성 신경학적 징후가 정신분열병 환자에서 임상 상태나 치료 약물과는 독립적인 질병특성 표지자로서 나타나는지를 확인하고자 하였다. 또한 인지 기능 장애와 연성 신경학적 징후가 고위 인지 기능의 조정곤란 현상으로 상관관계가 있는지의 여부를 검증하고자 하였다. 방 법 : 정신병적 증상을 나타내고 있는 20명의 정신분열병 환자를 대상으로, 항정신병 약물 치료 전과3주 이상 치료 후 각각 Trail Making A, B, Stroop Test, Word Fluency Test로 인지 기능을 평가하고, Cambridge Neurological Inventory(Part 2)를 이용하여 연성 신경학적 징후를 측정하였다. 임상 증상은 Positive and Negative Syndrome Scale(PANSS)과 Clinical Global Impression(CGI)으로, 추체외로계 부작용은 Extrapyramidal Symtoms Rating Scale로 평가하였다. 대조군으로는 환자와 성별, 연령, 학력 및 지능 수준이 같은 정상인 20명을 선정하여 환자군에서와 같은 방법으로 인지 기능 및 연성 신경학적 징후를 평가하였다. 결 과 : 정신분열병 환자군은 치료 전 평가 결과, 인지 기능검사에서는 Trail Making A, B, Stroop Test, Word Fluency Test 모든 항목에서 대조군에 비해 유의하게 낮은 성적을 나타내었다. 연성 신경학적 징후 평가에서는 Grasp reflex, Go/no-go, Finger thumb opposition, Rhythm tapping, Finger agnosia, Fist-edge-palm, Left-right orientation, Extinction의 8가지 항목에서 대조군에 비해 유의한 장애를 나타내었다. 환자군에서 임상 증상은 치료 전후에 유의한 호전을 보였으나 인지 기능에서는 모든 항목에서 유의한 차이를 보이지 않았으며, 연성 신경학적 징후에서도 치료 전 대조군과 차이를 보였던 8개 항목 중에 Go/no-go, Finger agnosia 항목을 제외한 6개 항목에서 유의한 차이를 보이지 않았다. 연성 신경학적 징후 중 Rhythm tapping이 치료 전후로 인지 기능과 유의한 상관관계를 나타내었다. 결 론 : 연성 신경학적 징후와 인지적 조정곤란은 정신분열병에서 임상 증상 및 약물에 의해 영향을 받지 않는 질병특성 표지자임이 시사되었다. Rhythm tapping에서 이들 두 가지 결함의 관련성이 시사되었다. Objectives : Clinical studies have shown cognitive dysfunctions and soft neurological signs in schizophrenic patients and these findings have been suggested as evidence of organic bases in the pathophysiology of schizophrenia. This study was intended to investigate the characteristics of cognitive deficits and soft neurological signs in schizophrenia and, to determine whether any abnormality in these functions can be regarded as a trait marker of the illness which is independent of antipsychotic treatment and clinical improvement. We also investigated the correlation between cognitive deficits and soft neurological signs reflecting cognitive dysmetria, respectively. Methods : Twenty schizophrenic patients were assessed for the soft neurological signs and cognitive functions before and after neuroleptic treatment. The patients had been medicated for at least 3 weeks with one of the atypical neuroleptics. Cognitive functions were evaluated by Trail making A, B, Stroop test and Word fluency test. Soft neurological signs were assessed by Cambridge Neurological Inventory(Part 2). Positive and Negative Syndrome Scale(PANSS) and Clinical Global Impression(CGI) were used to assess the clinical severity and Extrapyramidal Symtoms Rating Scale was used to estimate the extrapyramidal symptoms. Cognitive functions and soft neurological signs of twenty normal controls were assessed with the same scale. Results : Before treatment, schizophrenic patients showed significant impairments on cognitive function tests(Trail Making A, B, Stroop Test) and soft neurological sign tests(8 items : Grasp reflex, Go/no-go, Finger thumb opposition, Rhythm tapping, Finger agnosia, Fist-edge-palm, Left-right orientation, Extinction). Although significant clinical improvements were observed after the treatment, there were no significant changes in cognitive functions and soft neurolo-gical signs(except for Go/no-go test and Finger agnosia). Among the soft neurological signs of the patients, abnormality in Rhythm tapping was significantly correlated with cognitive deficits. Conclusion : Schizophrenic patients showed characteristic cognitive deficits and soft neurological signs which were independent of medication and clinical symptoms. And these two characteristics were partly correlated with each other.

간호조직에서의 리더십에 관한 논문 고찰

김인아,박영주,서문경애,임지영 대한간호학회 간호행정학회 2006 간호행정학회지 Vol.12 No.2

Purpose: The objective of this literature review study was to identify patterns and trends of studies on leadership among nurse managers in nursing organization and suggest the direction of future researches. Methods: Research Studies on the leadership were selected from thesis and related journals, which had been conducted from 1975 to 2006.5. Search Terminologies were used "leadership". The Total number of the collected studies were 69. Results: The number of studies on leadership has been increased rapidly since 1990's. In research design, Quantitative studies were 68 except for a Qualitative study. Correlation research were 45(65.2%) among quantitative studies. Conceptual frameworks, research questions and hypotheses were involved 31.9%, 98.6%, 31.9%. In subject, General nurse is 46.4%, Head nurse and General nurse was 23.2% and Head nurse is 2.9%. All the studies used questionnaire in data collection method. Measurement tools were used 50% for Bass' MLQ(MLQ-5X). For the statistical analysis, Correlation, ANOVA, t-test were used for 20.3%, 17.4%, 10.5% respectively. The number of leadership related variables were work-related, organization-related, personal recognition or attitude, empowerment, personality. The sub-variables were used for 31 Job satisfaction. Further studies were suggested the develop of leadership program, measurement for the effect of leadership, repeated studies on leadership, the development of measurement about leadership. Conclusion: These results will be used to provide the basic data for developing leadership theory on nursing organization.

공동주택의 자연환기 성능 개선에 관한 연구

魯志雄,金庚連 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-

This paper aims for evaluating the wind-driven ventilation in basement parking lots of apartment. Wind tunnel tests coupled with tracer gas method were conducted, and classified by wind directions and opening types. The test results showed that, as for wind-driven ventilation, stack type openings were more successful than scuttle vent. Additionally, the rates of air amount change by wind directions for base type(no openings) were presented in the order of W > E > SW/NE > SE/NE > S/N. Finally, according to Weibull distribution in Seoul, yearly averaged wind-driven ventilation rate was calculated.

전문간호사를 위한 임상 전문실습교육프로그램 요구

유호신,오복자,임지영,강희선,양승희,서문경애,김애경,함옥경,추상희 대한간호행정학회 2007 간호행정학회지 Vol.13 No.4

Purpose: This study aimed to assess needs of training programs for APN practice courses and continuing education programs for APNs to provide baseline data to improve APN education and practice. Methods: A total of 98 questionnaires were distributed to professors in 38 nursing institutions and 64 (65.3%) were returned. Data collection was performed in November and December, 2007 through email. Results: Professors in charge of geriatric and home care nurse practitioner programs constituted 43.7% of the study participants. Forty-one percent answered that they were satisfied with the practice programs they currently have operated, while 36.5% responded to have difficulty in appointment of institutions for practice programs and 56.3% had problems in assignment of preceptorship. In case of developing training programs for APN practice courses, 58.7% answered that they are willing to participate, and 90.6% felt needs for development of continuing education programs for APNs. Regarding liability insurance for APN students, only 11.5% provided insurance policy. Conclusion: The study results indicated that standardized training programs are needed to assure quality of APN education, and continuing education programs are required to provide opportunities for APNs to improve competencies.

[PE-0014] Data analysis and utilization through imaging of CNDH and SNDH

Ji-Hun Kim(Ji-Hun Kim),Jae-Ryoung Park(Jae-Ryoung Park),Yoon-Hee Jang(Yoon-Hee Jang),Eun-Gyeong Kim(Eun-Gyeong Kim),Kyung-Min Kim(Kyung-Min Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Evaluation of Real-time PCR for the Detection of Vibrio parahaemolyticus in Inoculated Seafood Products

Hae-Ji Kim,Do Gyun Kim,Young Il Kim,Su-Ok Kim,Jin-Hee Kim,Moon-Hee Lee,Eun-Ji Lee,Ho-Yong Lee,Chi-Yeun Cheung,Mi-Gyeong Kim,Sang-Yub Kim,Soon Ho Lee,Hyo-Seon Kwak,Woo-Sung Kim 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

All-cause and cause-specific mortality risks among patients with hidradenitis suppurativa: A Korean nationwide population-based cohort study

( Ji Hae Lee ),( Hyun Jeong Ju ),( Ji Yoon Kim ),( Seo Gyeong Lee ),( Soo Hyung Kim ),( Solam Lee ),( Gyong Moon Kim ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms : A Multicenter Study in Korea

Kim, Seon Gyeong,Hong, Ji Man,Kim, Hahn Young,Lee, Jun,Chung, Pil-Wook,Park, Kwang-Yeol,Kim, Gyeong-Moon,Lee, Kwang Ho,Chung, Chin-Sang,Bang, Oh Young Ovid Technologies Wolters Kluwer -American Heart A 2010 Stroke Vol.41 No.4