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만성 두부외상 환자에서 99mTc - HMPAO Brain SPECT의 임상적 유용성
서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),정진일(Jin Ill Chung),김영수(Young Soo Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
N/A Minima1 deterioration of cerebral perfusion or microanatomical changes were undetectable on conventional Brain CT or MRI. So evaluation of focal functional changes of the brain parenchyme is essential in chronic head injury patients, who did not show focal anatomical changes on these radiological studies. However, the patients who had longstanding neurologic sequelae following head injury, there had been no available imaging modalities for evaluating these patients precisely. Therefore we tried to detect the focal functional changes on the brain parenchyme using Tc-99m-HMPAO Brain SPECT on the patients of chronic head injuries. Twenty three patients who had suffered from headache, memory dysfunction, personality change and insomnia lasting more than six months following head injury were included in our cases, which showed no anatomical abnormalities on Brain CT or MRI. At first they underwent psychological test whether the symptoms were organic or not. Also we were able to evaluate the cerebral perfusion changes with Tc-99m-HMPAO Brain SPECT in 22 patients among the 23, which five patients were focal and 17 patients were nonfocally diffuse perfusion changes. Thus we can predict the perfusion changes such as local vascular deterioration or functional defects using Tc-99m-HMPAO Brain SPECT in the patients who had suffered from post-traumatic sequelae, which changes were undetectable on Brain CT or MRI.
만성 신부전증 환자의 중증 고혈당에 따른 의식변화 결핍에 대한 연구
박은주,강성귀,한상웅,김호중,이창범,임천규,박성광,윤경택,위형중,안유헌 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.6
In diabetic patients who were being treated with hemodialysis, coma and other neurological deficits did not occur in spite of extremely elevated serum glucose levels. In this report, we compared diabetic patients with renal failure in severe hyperglycemia with nonketotic hyperosmolar coma patients with normal renal function to know what affect mental changes. Mental changes were not present in diabetic patients with renal failure. These patients with renal failure showed more severe hyperglycemia, but corrected serum sodium concentration and calculated effective serum osmolality were low. So it is suggested that corrected serum sodium concentration and effective serum osmolality are more important factor affecting mental changes than high blood glucose levels in diabetic patients with renal failure, due to absence of osmotic diuresis.
Park, Dong Yoon,Chang, Seongju SAGE Publications 2014 Indoor and Built Environment Vol.23 No.7
<P>This study analyses the performance characteristics of combined variable ceiling and floor-based air distribution systems in an office room using a numerical method to optimize the level of thermal comfort and indoor air quality. To validate the computational fluid dynamics simulations, temperature, air velocity and CO<SUB>2</SUB> concentration were measured and compared. The simulation results of various combinations of ceiling and floor-based air distribution systems show that the exhaust should be located above the occupant and the window in summer; due to the large thermal plume as heat sources that could be generated by the window and the occupant. Whereas in winter, the supply should be located on the ceiling far from the window and the exhaust should be positioned on the floor near the occupant; as the downward airflow around the cold window surface would become more dominant when compared to the upward airflow associated with any other heat sources. The results have indicated that having both ceiling and floor-based air conditioning systems would allow the flexibility to change supply and exhaust air diffuser locations to optimize thermal and ventilation performance more efficiently in countries that are subject to distinct seasonal changes.</P>
점증적 최대부하 운동이 호흡순환계 및 젖산변화에 미치는 영향
박순진,윤종대,권창기,김귀성 용인대학교 무도연구소 2000 武道硏究所誌 Vol.11 No.1
This study was to investigate a cardiorespiratory response and the chang of blood lactate concentration between untrained men and judo fellows after maximal exercise. The result of this study was as follows: All of the variables(HR, VE, and VO2max) were non significant as well as RER in a cardiorespiratory response. In addition, both between groups and interaction were non significant the change of a blood lactate concentration. However, not only VO2 was sigpificant(p<.05) in the comparison of between groups in a cardiorespiratory response but the chang blood lactate concentration was significant(p<.01) in measuring time. As a result of this study, the study of a cardiorespiratory variables and the reduction of blood lactate concentration related to recovery on fourties subjects after maximal exercise didn't get particular result but it is showed the condition of health of middle aged men indirectly as well as the difference of between untrained men and judo fellows. Therefore, it is showed that both untrained men and judo fellows need a exorcise, which is suggested a objective and scientific the method and the need of motivation for health.
전립선암의 조기진단을 위한 염색체 이상에 관한 연구 : Fluorescence In Situ Hybridizatioan법을 중심으로
박종윤,박정덕,홍연표,장임원 중앙대학교 의과대학 의과학연구소 1994 中央醫大誌 Vol.19 No.1
To detect the numerical changes of the chromosome 13 and 17, containing tumor suppressor genes (retinoblastoma gene and p53) in normal tissue, intraepithelial neoplasm and carcinoma of the prostate, the Fluorescence In Situ Hybridization technique with paraffin embedded tissue was done. Materials observed in this study consisted of 14 cases of lacalized carcinoma(TB1NOMO) and 1 case of locally infiltrating cancer(TC1NOMO)> The chromosomal number changes were counted at normal tissue, intraepithelial neoplasm and neoplastic gland at the same radical prostatectomy specimen. From the 4 patients, studied prospectively, fresh cancer tissue and peripheral whole blood were collected for the primary culture of the cancer cells and lymphocytic culture. There cultured cells were used fro karyotyping. The results were as follows : 1. There were no significant chromosomal number changes between 13 and 17 in each group. 2. The normal non-neoplastice duct, intraepithelial neoplasm and neoplastic gland of experimental group showed no significant difference in chromosomal change. 3. There were significant changes more than 30% in chromosomal numbers between control Y chromosome and experimental chromosome 13 and 17 in each group. 4. The karyotyping on primary cultured prostate cancer cells and lymphocyte showed significant difference in chromosomal number in spite of the same host, representing local chromosomal changes.
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice
Yoon, Hye Eun,Kim, Eun Nim,Kim, Min Young,Lim, Ji Hee,Jang, In-Ae,Ban, Tae Hyun,Shin, Seok Joon,Park, Cheol Whee,Chang, Yoon Sik,Choi, Bum Soon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-
<P><I>Background</I>. This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.<I> Methods</I>. Histologic changes and expressions of transforming growth factor-<I>β</I> (TGF-<I>β</I>), collagen IV,<I> fibronectin</I>, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG),<I> 3-nitrotyrosine</I>, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.<I> Results</I>. Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-<I>β</I>, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice. The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age. The expressions of phosphorylated serine<SUP>1177</SUP>-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age. The expression of Nox2 significantly increased with age, but that of Nox4 did not change.<I> Conclusions</I>. The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice. </P>
제올라이트 분말도와 치환율에 따른 시멘트모르타르의 활성도 지수 평가에 관한 실험적 연구
윤창복 ( Yoon Chang Bok ),박장현 ( Park Jang Hyun ),이한승 ( Lee Han Seung ) 한국구조물진단유지관리공학회 2019 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.23 No.1
This research and development analysis provides numerical analysis techniques that can be used conveniently to determining the safety of the current state and to predict the stability in the future. It also seeks to present algorithms of back analysis to develop unified management system for control, prediction, coordination, and information modeling that can reasonably handle appropriate responses to structural behavior at project sites and design changes.