만성 호중구성 백혈병 1례

기장도,박치영,류보열,김태종,모성환,곽재정,문철호,박근홍,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood (PB), hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid. serun viatmin B 12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or underlying infection or disease sufficient to mimic a leukemoid reaction. We have experienced a 34-years-old male patient with atypical chronic neutrophilic leukemia. On admission, the leukocyte count was 56,860/uL. severe neutrophic leukocytosis with 76% neutrophils and rare immature forms on PB smear. Many neutrophils had toxic granules, and vacuoloes. Leukocyte alkaline phosphatase score was decreased. The cytogenetic study showed Philadelphia chromosome negative with normal karyotype.

Benz(a)anthracene이 마우스태자 간조직 세포의 소핵출현에 미치는 경태반효과

成耆天,張聖薰,車喆煥 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.1

In order to adduce the cytogenic effect of Benz(a)anthracene(B(a)A) in pregnant mice through placental barrier to fetus, 125㎎/㎏, 250㎎/㎏, 500㎎/㎏, of B(a)A were administrated to groups of mice 16th pregnancy day About 20 hrs later, freauency of micronuclei in polychromatophilic normoblasts of liver tissues extracted from fetus was measured At the same time, 200 ㎎/㎏ and 400 ㎎/㎏ of Benzo(a) pyrene(B(a)P) were administered with same procedure to compare the frequencies between in cases of B(a)A and B(a)P administration. Especially incase of B(a)A administration, frequencies of their appearances in bone marrows of mother mice and livers of fetuses were compared. On the other hand, pathological changes of fetus liver caused by B(a)A and B(a)P in mothers were observed through microscopic examination in order to reconfirm and compare their transplacental effects. As the results, cytogenic toxicity for feture caused of B(a)A was confirmed. It means that some amount of B(a)A which was administered to pregnant mice could be transmitted to fetus through placental barriers Mutagenicity caused of B(a)A was higher in fetus than mother mouse. The cytogenic toxicity caused of B(a)A both for mother mouse and fetus was lower than that of B(a)p.

약·강성축 및 브레이싱을 고려한 3차원 강뼈대구조물의 최적설계

성창환,김진규,김기욱 영남이공대학 산업기술연구소 2001 産業技術硏究 Vol.13 No.-

There are many studies of steel frame structures, however the optimum designs taking account of the effect of the major and minor axes are inefficient. This study implements the 3-dimensional steel frame optimum design which takes many types of the major and minor axes. A discrete optimum design algorithm and a computer program for three dimensional steel frame structures considered the major and minor axes is used in this study. For analysis of three dimensional steel frame structure, finite element method is adopted. In the optimization formulation, objective function is the total weight of steel members. AISC steel sections are used in the discrete optimization. Design constraints were derived from the provisions of AISC-ASD, AISC-LRFD, BS5950, CISC, and EUROCODE specipications. The result of this study indicates that the optimal design based on the axes arrangement is more economic than that of not considering axes arrangements.

태풍 Vera 통과시 남해에서의 파랑추정

전기천,강시환,박광순,김상익 경남대학교 환경문제연구소 1990 환경연구 Vol.12 No.-

최근 한반도를 통과했던 태풍 중 그 규모가 커서 海上에서 발생된 颱風波浪에 의해 특히 남해안 지역에 큰 재해를 준 1986년 태풍 Vera(8613)호 통과시에 南海의 거문도와 거제도 海上에서 동시에 태풍파랑을 관측하였다. 관측된 태풍파랑의 재현을 위하여 유럽의 북해를 대상으로 최근 연구개발된 Hybrid Parametric Wave Model(HYPA)을 적용하여 Vera 통과시의 파랑분포를 수치적으로 계산하였으며, 그 계산결과를 관측치와 비교하였다. 또한 태풍파랑의 추정에 주로 사용되어온 Wilson모델의 결과와도 비교하여으며, HYPA모델의 결과가 Wilson모델에 비해 훨씬 관측된 파랑자료에 근접함을 보였다. 따라서 본 연구를 통해서 한반도 근해상에서 발생되는 태풍파랑의 예측과 추정에 있어 HYPA모델에 매우 정확함을 보여주었다. During the passage of Typhoon Vera(8613) which causes the heavy natural disasters, especially, on the southern coast of Korea, waves were simultaneously measured at two different locations of the South Sea, that is, near to the Geomun and the Geoje Islands. In order to reproduce the measured typhoen-waves, Hybrid Parameteric Wave Model(HYPA) which has been developed for the North Sea was adopted to calculate numerically the waves generated by the Typhoon Vera. The model results were jilter-compared with the measured waves, and also with the results of Wilson model which has been widely used for the hindcast of typhoon-waves. HYPA's results show in the closer ageement with the measured waves than those of Wilson's. Based on these comparisons, HYPA model can be used for more accurate forecast and hindcast of typhoon-waves in Korean Seas.

Paraquat중독 사망한 한국인의 혈액 농도

이상기,인상환,정영호,구기서 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

To elucidate the fatal blood concentration of paraquat(Gramoxone), a contact herbicide, we investigated blood concentration of paraquat in 91 cases of paraquat intoxication. The blood paraquat concentration of 91 cases due to ingestion of paraquat was 0.9 ㎍/ml -1023.5 ㎍/ml and has been subdivided according to survival time. 48 of 91 cases were identified survival time. In 34 of 48 cases died within a day after ingestion of paraquat, blood paraquat concentration was ranged from 2.3~ 636. 6 ㎍/ml, and in 12 of 48 cases died 1~4 days after ingestion of paraquat, blood paraquat concentration was ranged from 0.9~25.1㎍/ml.

탈지 환원유에서 Bifidobacterium longum의 호기성 고농도 배양에 관한 연구

구동환,하상우,조수현,박기문,김동운,강국희 성균관대학교 생명과학자원연구소 1997 生命資源科學硏究 Vol.4 No.1

The objectives of this study were to investigate the optimal condition for growth and highly concenterated culture of Bifidobacterium longum (Bif longum). The effects of additives were compared with titratable acidity and viable cell counts, and 10% reconstituted skim milk (no additive) was used as a control. Correlation coefficient for the growth of Bif. longun between CO_2 anaerobic jar method and overalaid medium method was R=0.99. When 1% Bif. longurn was inoculated on 12%, 14%, and 16% reconstituted skim-milk, viable cell counts were 8.60, 8.89, and 8.93 Log CFU/ml, respectively. When Lactose, Glucose, Glucosamine, Fructose, Peptone, N-acethyl-D-glucosamine, D-galactose, and liver extract were added to 16% reconstituted skim-milk, the viable cell counts were 8.61, 9.05, 9.15, 9.24, 8.82, 9.75, 9.17, and 9.64 Log CFU/ml, respectively. Therefore, D-galactose, liver extract, and N-acethyl-D-glucosamine were selected as final additives. When Bif longum was inoculated on Fermentor-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), Fermentor-II (16% reconstituted skim milk containing 0.190% yeast extract, 0.590% N-acethyl-D-glucosamine and 0.5% liver extract), Batch culture-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), and Batch culture-II (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% N-acethyl-D-glucosamine and 0.5% liver extract), viable cell counts were 10.46, 9.37, 9.03, and 8.83 Log CFU/ml, respectively. Although liver extract was the important additive for the highly concentrated culture of Bif. longum in this study, it caused serious off-flavor when liver extract-1 (contained cell mass) was added to Fermentor culture. However, flavor was improved when liver extract-2 which was removed cell mass, was used instead of liver extract-1. Addition of 2% liver extract-II and 1% D-galactose had the similar effect with addition of 0.5% Liver extract-I and 0.5% D-galactose on the growth of Bif. longum.

견인 골 신장술을 이용한 하악 정중부 확대 치험례

태기출,오승환,민승기 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.5

하악골 횡적 성장결핍에 의한 하악 전치부의 총생을 치료하는데 성인의 경우 발치가 종종 요구된다. 그러나 발치에 의한 안모 변화가 바람직하지 않을 때 견인골 신장술을 시행하여 하악 정중부의 확장은 횡적 공간을 확보하여 빠른 교정치료 및 안정성을 확보할 수 있는 방법으로 고려된다. 하악 정중부 견인골 신장술을 시행한 후 tooth-borne type과 tooth & bone-borne type distractor를 사용하여 latency, distraction, consolidation period를 거쳐 하악 정중부 횡적확장을 시행하여 전치부 총생을 빠르게 치료할 수 있었으며, 두가지 방법에 의한 치유과정을 비교한 결과 치주적인 요소와 골 형성과정은 유사하였으며 악관절 부위의 퇴행적 증상변화는 관찰되지 않았다. Transverse skeletal deficiency is a common clincal problem associated with narrow basal and dentoalveolar bone. The clinical characteristics of transverse deficiency presents with anterior crowding and posterior buccal crossbite. Orthodontic expansion, using lip bumper and functional devices, was recommanded for younger ages. However, expansion of lower anterior area in older patients is unstable and tends to relapse toward the original dimension. Distraction osteogenesis is a unique from of clincal tissue engineering and biologic process of new bone formation between bone segments that are gradually separately by incremental traction. Distraction osteogenesis was considered that great potential for correcting transverse mandibular deficiencies. In this paper, a case of treated transverse deficiency patients with distraction osteogenesis using tooth-borne and tooth & bone-borne distractor is presented.

인체 지방 및 간장조직 중 유기염소제류의 확인 및 정량기법 체계화

이상기,양자열,인상환,김기욱,이수연,오승민,김미영,정규혁 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

비용ㆍ편익 분석을 중심으로 한 중수도 시설의 처리방법별 적정규모선정

노상환,민동기,송영일,박태욱,박주양 한양대학교 환경공학연구소 2000 環境科學論文集 Vol.21 No.-

미래의 안정적인 수자원 확보를 위한 수요관리방안인 중수도 시설 설치 시 발생하는 비용과 편익의 현재가치를 이용하여 처리방식별로 중수도 시설의 경제성 분석을 하였다. 사회적 편익을 고려하였을 경우 중수도 시설규모가 300㎥이상의 1일 처리용량의 경우 경제성이 있는 것으로 나타났다. 그러나 사적편익을 고려하였을 경우에는 사회적 편익에서 고려된 환경비용절감등의 여러 외부 편익이 포함되지 않아 중수도 시설에 의한 편익이 작아지게 된다. 따라서 사적편익만을 고려할 경우에는 대체로 경제성이 있는 중수도 시설의 규모는 사회적 비용을 고려하였을 경우 보다 커진다. Water reuse is a control method of water demand to steadily assure water resources in the future. Economical efficiency of wastewater reuse plants with various treatment processes was studied using the present value of cost-benefit. When social benefits are considered, the capacity of 300㎥/ day was found to be economically effiecient. However, when private benefits are considered, the social benefit of wastewater treatment plant decreases because the private benefits do not include environmental expenses and other benefits which are included in social benefits. Therefore, when the private benefits are only considered, the economically efficient capacity of the wastewater reuse plant will be higher than that considering social expenses.

마늘이 白鼠의 카드뮴中毒에 미치는 影響 : Alkaline phosphatase 活性度, 臟器內 카드뮴濃度, 臟器의 病理組織學的 變化를 中心으로

金成基,裵恩相,車喆煥 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

Garlic contains some allylsulfide(e.g., diallyldisulfide, propylallyldisulfide, and diallyltrisulfide), 12 kinds of aminoacids(e.g., cystine, and cysteine), thiolactic acid, glutathione, witamin C, vitamin B and etc. It also contains allicin, responsible for the unique smell, which is formed by alliinase from diallyldisulfide. Owing to its contents, that is, allyldisulfide and SH compounds. Garlic has been expected to be involved in the detoxication of heavy metal poisonings by forming thiochelate compounds when reaction with heavy metals in living bodies. To examine this hypothesis more closely, rats were selected as experimental animals and divided into six groups: one which was given only 100 ppm cadmium; one with 3.35% garlic only; three groups given 1.7%, 3.35% and 6.7% garlic(which were represented 50, 100 and 200 ppm by allicin, respectively) in addition to 100 ppm cadmium, and a control. Cadmium dissolved in water was used, and the garlic was mixed with feed. After rearing the selected rats for 11 weeks, weight changes, alkaline phosphatase activities in the blood, and cadmium content in both the liver and the kidney were measured. Additionally, pathological changes in the liver, kidney and chondrocytes of the articular cartilage of the femur which are target organs of cadmium poisoning, were observed. The results were as follows: 1. For weight changes, the control group had gained 61% of its original weight by the first day of examination, while the group given only cadmium gained 47%. On the other hand, the one with 6.70% garlic showed an nearly the same rate increase in weight as the control group. 2. Change in alkaline phosphatase activities was observed in the group with only 3.35% of garlic as being 109.25%(p<0.05) change on the basis of the control group being 100%. This indicates that garlic strengthens activities of alkaline phosphatase. But in the case of the group with cadmium and 3.35% of garlic, the change was lower than in the control group by 4%(96.31%), while higher than in the group with only cadmium by 7.6%. In the group with cadmium and 6.70% of garlic, the change was higher than the one with only cadmium by 20.3%, and higher than the control group(81.33±9.83u/1) by over 75%(87.56±14.22u/1). 3. Cadmium contents accumulated in the liver and kidney were measured. As for the cadmium content in the liver, the control group contained 0.09±0.05㎍/g and the group with only cadmium and 3.35% of garlic showed a decrease in content, 29.02±5.16, and the one with cadmium and 6.70% garlic showed a further decrease, 25.28±4.05㎍/g. Like the phenomena in liver, the cadmium content in the kindneys of the group with cadmium and 3.35% garlic showed a significant decrease; the group with only cadmium contained 33.93±2.65㎍/g of cadmium, while the one with cadmium and 6.70% of garlic contained 29.19±5.16㎍/g. 4. Histopathological changes were observed in the liver, kidney and chondrocytes of the articular cartilage. The group with only garlic showed no change like the control group. But the one with only cadmium clearly showed a big swelling in glomeruli, a cludy swelling in renal tubules, necrosis of hepatic cells at peripheral zone of hepatic lobule as well as numeral decrease and atrophy of chondrocytes of the articular cartrilage. Compared with the one with only cadmium, the group with cadmium and garlic 6.70% showed no histopathological changes. But the group with cadmium and 3.35% garlic showed a little convalescent change in liver, kidney and chondrocytes of articular cartilage. Though the group with cadmium and 6.70% of garlic showed a cloudy swelling in renal tubles, the renal corpuscles, hepatic cell cords, sinusoids of liver and chondrocytes in lacunae of articular cartilages maintained their normal architectures.