내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

전해질로 나피온을 사용한 Ti/IrO_2 전극상에서 유기물의 양극산화 반응

강태구,윤영재,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This paper describes the anodic oxidation od various alphathic alcohols in pure water using Nafion cation exchange membrane as solid polymer electrolyte. The oxidation has been carried out on an IrO_2 anode under conditions of simultaneous oxygen evolution. The experimental results for the anodic oxidation of four different alcohols are in good agreement with the theoretical model presented in a previous paper. Finally a simple experimental method is described for the determination of the relative reactivity of organics oxidation on IrO_2 anodes.

마이크로파에 의한 WC의 합성 및 특성에 관한 연구

강성구,정윤중 明知大學校 産業技術硏究所 2005 産業技術硏究所論文集 Vol.24 No.-

Tungsten carbide(WC) powders were synthesized by self-propagating high temperature synthesis(SHS) chemical furnace that microwave heating system. Attempt to find the optimal condition for synthesis of tungsten carbide(WC), the effects of molar ratio between carbon and tungsten, compaction pressure, pellet thickness and heating time of microwave on synthesis were investigated. Powder was synthesized in Ar atmosphere. Chemical fuel was Ti-C mixed powder. Compositional and structural characterization of these powders was carried out by scanning electron microscope(SEM) and x-ray diffraction(XRD). Powder characterization was carried out by the measurement of particle size distribution with laser-particle size analyzer. Tungsten carbide(WC) obtained by microwave depend very much on the mole ratio between carbon and tungsten and heating time of microwave given in a product, i.e. Optimum molar ratio of synthesized powder was tungsten : carbide = 1 : 1.5, pellet thickness 10㎜, compaction pressure l500Psi and microwave heating time was 60sec after propagation to best condition powder. By optimizing the synthesis conditions, it is possible to fabricate tungsten carbide(WC) powders which have little secondary phases.

영어 이중목적어 구문 구사 시 한국 고등학교 영어 교사들의 담화원칙 적용 양태

강상구 淸州大學校 韓國文化硏究所 2023 人文科學論集 Vol.66 No.-

In this paper, Korean high school English teachers’ use of English dative constructions is compared with that of English native speakers, especially focusing on how the given-before-new(GN) discourse principle is applied. A written elicited production task with six dative verbs presented in each of the given-theme and ivenrecipient conditions was provided to the participants in order to probe how the two objects are aligned in English dative constructions. The results showed that Korean teachers tend to instantiate the GN order more in prepositional datives than in double object datives. This result suggests that besides their knowledge about the GN discourse principle, other factors such as the difference of difficulty in acquiring the prepositional datives and double object datives might be in play. A more in-depth research with more Korean participants at varying different English proficiency levels is required to investigate how the GN discourse principle might be instantiated by Korean learners of English.

Sol-Gel방법에 의해서 성장시킨PbTiO₃박막의 결정화와 물리적 성질

구영진,강민진,정원태,김태현,김상수 昌原大學校 基礎科學硏究所 2000 基礎科學硏究所論文集 Vol.12 No.-

Ferroelectric PbTiO3 thin films coated on SiO2/Si(100) and ITO glass substrates were prepared by sol-gel processing of metal alkoxide solutions and solvents. The use of sol-gel method for preparing various functional films makes it possible for the homogeneous distribution of elements at the molecular level, precise composition control, lower temperature synthesis, large surface coating and high optical quality. First of all, the XRD investigation shows that perovskite phase of polycrystalline PbTiO3 was formed by four times coating of the concentrated solution and by the heat treatment over 500, 600℃(O2 gas and air) and over 10, 20, 30 min. Surfaces of thin films were crack-free and uniform and the average grain size investigated by SEM was 0.25∼1.00 ㎛. Dielectric constant of PbTiO3/ITO glass thin film were 380 ∼ 5.25 in the region of 1 kHz∼ 10 MHz at room temperature(30℃), respectively. From the hysteresis loop of PbTiO3/ITO glass thin film, a remnant polarization of 0.382 μC/cm2 and a coercive filed of 23.85 kV/cm were obtained. At the frequency(5 kHz), C-V measurements of films in MFIS and MFM configurations showed well-behaved C-V characteristics and an injection type hysteresis. The capacitance of flat band(CFB) was 60 pF. The band gap energies of the thin films depend on the assumption of direct or indirect transition. Using one layer structure model, we calculated refractive index, extinction coefficient, absorption coefficient and band gap energy of thin film in the wavelength range of 300 to 800 nm. The band gap energy, refractive index and extinction coefficient at λ = 6325 Å of the PbTiO3 thin film were 3.7 eV, 1.96 and 0.1 respectively.

생활도우미활동이 장애학생에 대한 일반학생의 또래관계에 미치는 영향

강성구 국립특수교육원 2005 특수교육연구 Vol.12 No.2

이 연구는 일반중학교에서 장애학생의 학급생활을 돕기 우해 활용되어지고 있는 생활도우미 활동이 장애 학생에 대한 일반학생의 또래관계에 미치는 영향에 대해 알아보고자 하는 데 목적이 있다. 이를 위해 통합교육을 실시하고 있는 일반중학교 1개교(208명)를 대상으로 학급배치요인(장애학생과 같은 반/다른 반)과 또래관계개입요인(개입 유/무)을 기준으로 집단을 구분하고, 또래관계 질문지를 통해 또래관계를 전체 점수와 하위 점수(공유활동, 친사회적행동, 친밀감, 애착ㆍ자존심ㆍ고양, 신의, 갈등)로 환산하여 각 집단 간 차이를 분석하였다. 연구 결과는 1. 학급배치요인(physical proximity)은 일반학생과 장애학생의 친밀감을 감소시키지만 갈등도 감소시켰다. 그 효과는 미미하다. 2. 또래관계개입요인(peer-relationship intervention)은 일반학생과 장애학생의 또래관계에서 갈등을 제외한 대부분 영역에서 또래관계 점수를 높여주었다. 3. 또래관계점수는 학년에 영향을 받았고, 상호작용효과는 학년과 학급배치요인 간에 두드러졌다. 그러나 또래관계 점수는 성별에는 영향 받지 않았다. 따라서 통합교육환경에서 단순히 학급배치만을 고려하는 것은 장애학생과 일반학생의 또래관계개선에 큰 도움이 되지 못했다. 그렇지만 생활도우미활동을 실시했을 때 또래관계개입을 함께 고려하면 또래관계를 개선하는데 큰 도움이 된다는 결론을 내릴 수 있었다. The objects of this study is to find the effects of Peer helper activity which are related with the non-disable student's peer relationship with disable student. I took sampling 208 students who went to N School which progress peer-helper activity, surveying and analyzing it according to proximity, peer relationship intervention, grade, sex. The peer-helper activity effects remarkably on non-disable student's peer relationship with disable student. However, there is some question in building up the in creasing non-disable student's peer relationship with disable student which is only peer-relationship intervention. The remarkably peer-helper activity's effects is peer-relationship intervention and a chance which interact with disable students. and The grade interacts significantly with Physical proximity and has main effects but, The sex does not interact significantly with any ones and does not have main effects. Come to the Conclusion that activity which is only refer to proximity is not helpful to non-disable student's peer relationship with disable student but that activity which is refer to both Physical proximity and peer-relationship intervention is helpful to non-disable student's peer relationship with disable student.

한국 대학생들의 영어능력과 어휘 반응 속도 간의 상관관계

강상구 청주대학교 인문과학연구소 2017 人文科學論集 Vol.54 No.-

This study utilized a body-part picture naming task (HALA - Hawaii Assessment of Language Access) to assess the proficiencies and dominance of Korean and English from 20 Korean college students. Their accuracy and response time were gauged to show the correlation between language proficiency and vocabulary response time. The results of this study suggest that lexical accessibility can be used as a legitimate reflection of a speaker's overall language proficiency and thus, the potential of utilizing the HALA project as a simple and convenient tool for future related research should be seriously considered.

호르텐스극구흡충에서 Alkaline Phosphatase 및 Acid Phosphatase의 특성

강성구,양용석,박주연,임지애,김인식 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY 1999 Journal of biomedical laboratory sciences Vol.5 No.1

호르텐스극구흡충 성충 (adult worm)을 재료로 하여 acid phosphatase (Acp)와 alkaline phosphatase (Alp)의 조직 세포에 대한 분포 및 동위효소의 특성을 규명하기 위하여 Gomori lead nitrate 및 Gomori calcium 방법 그리고 전기영동법 등을 시행하였다. 조직 내의 Acp 및 Alp의 분포는 충체의 소장 (intestine)과 난황선 (vitellaria) 그리고 인두 (pharynx)에서 강한 반응을 나타냈다. 동위효소 유형은 Acp에서 179.5 및 209.4 kDa 두 개의 분획이 분리되었고, Alp은 145.9, 207.5 및 220.8 kDa의 세 개의 분획이 분리되었다. 열에 대한 안정도는 Alp가 90℃에서 12초 경과 후에 완전히 불활성화 되었으며, Alp의 최적 온도 및 pH는 40℃와 pH 9이었고 Acp의 최적 pH는 5였다. 그리고 Acp 및 Alp의 최대활성도 (unit)는 Acp가 71 범위였고, Alp는 189의 범위에 있었다. 이상에서와 같이 호르텐스극구흡충은 phosphatase가 소화관과 난황선에서 주로 분포하고 있었으며 숙주 체내에서 소화관을 중심으로 대사가 활발하게 이루어지고 있음을 알 수 있었다. This study was aimed to investigate the enzyme-histochemical localization and characteristics of alkaline and acid phosphatase extracted from adult of Echinostoma hortense. Using the Gomori calcium stain and the Gomori lead nitrate satin method, we found that the alkaline and acid phosphatases were localized mostly in the intestine, vitellaria and pharynx of Echinostoma hortense. The three isozymes of alkaline phosphatase and two isozymes of acid phosphatase were separated from Echinostoma hortense by electrophoresis. The isozymes of alkaline phosphatase were 145.9, 207.5, 220.8 kDa and the isozymes of acid phosphatase were 175.9 and 209.4 kDa. The activity of alkaline phosphatase was denatured completely after heating at 90℃ for 12 seconds. The optimum pH and temperature for activity of alkaline phosphatase were about pH 9 and 40℃, while the optimum pH for activity of acid phosphatase was about pH 5. The maximum activity of alkaline phosphatase was at 189 unit, but maximum activity of acid phosphatase was at 71 unit. As the result from above, we observed that alkaline and acid phosphatases funtion mainly in the alimentary tract and vitellaria. Echinostoma hortense performs the parasitism in the intestine of host by using proper isozyme of phosphatase.

탈지 환원유에서 Bifidobacterium longum의 호기성 고농도 배양에 관한 연구

구동환,하상우,조수현,박기문,김동운,강국희 성균관대학교 생명과학자원연구소 1997 生命資源科學硏究 Vol.4 No.1

The objectives of this study were to investigate the optimal condition for growth and highly concenterated culture of Bifidobacterium longum (Bif longum). The effects of additives were compared with titratable acidity and viable cell counts, and 10% reconstituted skim milk (no additive) was used as a control. Correlation coefficient for the growth of Bif. longun between CO_2 anaerobic jar method and overalaid medium method was R=0.99. When 1% Bif. longurn was inoculated on 12%, 14%, and 16% reconstituted skim-milk, viable cell counts were 8.60, 8.89, and 8.93 Log CFU/ml, respectively. When Lactose, Glucose, Glucosamine, Fructose, Peptone, N-acethyl-D-glucosamine, D-galactose, and liver extract were added to 16% reconstituted skim-milk, the viable cell counts were 8.61, 9.05, 9.15, 9.24, 8.82, 9.75, 9.17, and 9.64 Log CFU/ml, respectively. Therefore, D-galactose, liver extract, and N-acethyl-D-glucosamine were selected as final additives. When Bif longum was inoculated on Fermentor-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), Fermentor-II (16% reconstituted skim milk containing 0.190% yeast extract, 0.590% N-acethyl-D-glucosamine and 0.5% liver extract), Batch culture-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), and Batch culture-II (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% N-acethyl-D-glucosamine and 0.5% liver extract), viable cell counts were 10.46, 9.37, 9.03, and 8.83 Log CFU/ml, respectively. Although liver extract was the important additive for the highly concentrated culture of Bif. longum in this study, it caused serious off-flavor when liver extract-1 (contained cell mass) was added to Fermentor culture. However, flavor was improved when liver extract-2 which was removed cell mass, was used instead of liver extract-1. Addition of 2% liver extract-II and 1% D-galactose had the similar effect with addition of 0.5% Liver extract-I and 0.5% D-galactose on the growth of Bif. longum.

비외상성 두개내 출혈 환자에서 심근손상의 발생과 예후에 미치는 영향

강구현,황성호,이강현,조준휘,김성환,문중범,박해상,이서영,이성수,김헌주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Objective: The aim of this study was to investigate the clinical significance of myocardial injuries in patients with nontraumatic intracranial hemorrhage by identifying the occurrence of myocardial injury and defining its correlation with subsequent cardiovascular events. Subjects and methods: One hundred twenty-four patients with nontraumatic intracraninal hemorrhage presented to the emergency department within six hours from onset of symptoms were enrolled. Brain CT, serial electrocardiography, and echocardiography were done at the emergency center. Blood samples for troponin I and creatine kinase(CK)-MB were drawn immediately and eight hours after admission, Troponin I and CK-MB were measured using a chemiluminescent immunoassay, respectively. Results: Electrocardiographic and echocardiography abnormalities were found in 65 cases(52.4%) and 21 cases(17%), respectively. Serum troponin I and creative kinase-MB were increased in 35 cases (28.2%) and in 58 cases(46.8%), respectively. Abnormal findings of echocardiography and ECG, as well as elevated levels of serum troponin I and creative kinase-MB, were associated with an increased risk of cardiovascular event and survival. Logistic regression analysis revealed that an abnormal echcocardiographic finding and elevation of serum troponin I were factors associated with the occurrence an adverse cardiovascular event and that electrocardiographic abnormalities and initial mental status were factors associated with poor prognosis. Conclusion: This study reveals that actual myocardial injury develops in a significant proportion of patients with nontraumatic intracranial hemorrhage and that the development of the myocardial injury is associated with an adverse cardiovascular event that occurs during admission.