심실보조장치 이식의 새로운 수술기법-Korea University Technique-

선경,박성영,오혜정,신재승,이혜원,심환주,김형묵 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

고려대학교 흉부외과에서는 심실보조장치 이식에서 흉골 재절개(re-sternotomy)에 따른 합병증과 사망률을 감소시키기 위하여 우측 개흉을 이용한 독자적인 수술법을 개발하였다 (KU technique). 다양한 동물모델과 사체실험 및 임상적용을 통해 안정성과 유용성을 확인하였으며, 향후 좌심 및 양심보조장치 이식에서 표준기법의 하나로 제안하고자 한다. We have developed a new surgical technique (KU technique) of right thoracotomy for cannulation of ventricular assist devices, which can lessen potential morbidity and morta1ity from re-sternotomy. The technique has been proved to be safe and efficient in various animal models, preclinical cadaver fitting test, and human application. We would like suggest KU technique as a part of standard in implantation of left ventricular or hi-ventricular assist devices.

組合回路에 對한 檢査性 測定法의 比較 硏究

김명선,김신택,민형복 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.2

Fault coverage evaluated by fault simulators is accurate. However, fault simulation is not only memory consuming but also time consuming, and fault simulation time is propotional to, at least, square of circuit size. These limitations become more serious because of increased circuit densities. Recently, several algorithms for testability measures have been published. In this paper, three algorithms, STAFAN, COP, and PREDICT, are compared each other with respect to accuracy and execution time, in order to provide a useful guideline for those who plan to design a new digital circuit.

DNA chip을 사용한 myeloid cell의 유전자 발현분석

박형선,신길상,이미영 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

Total RNAs were extracted from promyeloid cell(HL60)and myeloid cell(U937). Reverse-transcriptions of the RNAs were performed by using AMV-reverse transcriptase. The RNAs of promyeloid cell and myeloid cell were labelled with fluorescent dye of Cy5-dUTP and Cy3-dUTP, respectively. The reverse-transcribed and labelled RNA was hybridized to a DNA chip containing 384 human cDNAs. Comparative analyses of the gene expression profiles for promyeloid cell and myeloid cell were monitored by gene pie plot or scatter plot, and the gene expression ratios of promyeloid cell/myeloid cell were determined. The expression ratios for thymosin beta-10 gene, immunophilin homolog ARA9/HBV-X associated protein gene, Bcl-w/KIAA0271 actin beta gene and heat shock protein86 gene were determined to be 31%/69%, 26%/74%, 11%/89%, 51%/49% and 79%/2l%, respectively.

한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).

팩시밀리의 主機板에 對한 技能的 試驗機의 設計 및 具現

김신택,이재훈,김명선,김한상,민형복 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

본 연구는 팩시밀리의 주기판(main board)을 기능적으로 테스트하기 위해 구현한 FFTS(Functional Facsimile Test System)에 대한 기술이다. 본 연구의 목적은, 테스트시 수반되는 모든 작업을 자동화하고, 테스트 수행중 발생하는 여러가지 상태들을 자료화하는 것이다. 아울러 주기판에 대한 입출력 신호들의 종류와 그 특성들이 변경될 경우라도 소프트웨어의 수정만으로 그 것에 대처한 후 계속적으로 테스트를 수행할 수 있도록 한다. FFTS는 주기판에 접속되는 여러가지 장치들을 하드웨어적으로 에물레이션하며, 테스트용 전용언어, 그리고 그것에 대한 컴파일러를 포함한다. FFTS로 테스트를 수행하는 방법에는 대화식 모드(IAT)와 대화식 테스트에서 수행할 수 있는 모든 과정을 테스트용 언어로 저장한 후 그것을 반복하여 사용하는 배치 모드(Batch mode) 등이 있다. FFTS의 유용성을 실증하기 위해 여러 종류의 팩시밀리에 대하여 실험을 실시하였다. FFTS (Functional Facsimile Test System) is designed and implemented. It is possible to eliminate repeated test work and to analyze the data obtained through test. If the specification of the signals from/to main board of facsmile is changed, it is possible to cope with the change by modification of FFTS software. FFTS emulates the devices connected to the main board. FFTS is designed to test the main board either by using interactive(IAT) mode with graphic user interface or by using noninteractive(NIAT) mode with test command file which is coded manually or created from IAT mode. The operation of the FITS is verified for several types of main board of G3 class facsmiles.

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

척추손상 쥐의 지방유래 줄기세포와 미노사이클린의 운동기능 회복효과

장재혁,고현윤,차영선,박형욱,신용범,손현주 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

수술 전 관상피내암으로 진단되었던 환자에서 침윤성 유방암이 발견될 위험 인자

신선형(Sun Hyoung Shin),김병천(Byung Chun Kim),송영주(Young Ju Song),윤현철(Hyun Chul Yoon),조진성(Jin Seong Cho),박민호(Min Ho Park),윤정한(Jung Han Yoon),제갈영종(Young Jong Jegal) 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.2

Purpose: Ductal carcinoma in situ (DCIS), unlike invasive ductal carcinoma, does not require sentinel lymph node biopsy or axillary lymph node dissection because the possibility of axillary lymph node metastasis is low. However, occasionally, despite preoperative diagnosis of DCIS, invasive ductal carcinoma can be diagnosed by postoperative biopsy. Therefore, a study of the associated risk factors is necessary. Methods: 198 patients with an initial diagnosis of DCIS, treated between February 2005 and December 2009, were retrospectively analyzed. Associations between clinical and pathologic factors were analyzed for significance using univariate and multivariate analyses. Results: Of the 198 patients, 57 (28.8%) were found to have invasive disease on final pathology. Multivariate analysis revealed 4 independent predictors of invasive cancer upon final pathology: diagnosis by needle biopsy (OR, 3.165; P=0.008), positive p53 on preoperative biopsy (OR, 2.494; P=0.019) DCIS size (>2 ㎝) on microscopic finding (OR, 2.683; P=0.014), and relatively young age (OR, 0.958, P=0.046). Of the 13 patients with positive axillary lymph nodes, 11 (84.6%) were shown to have invasive cancer on final pathology (P<0.001). Conclusion: In cases of preoperative diagnosis based on needle biopsy, positive p53, large tumor, and relatively young age, an SLNB procedure can be considered because in almost 30% of the patients an invasive carcinoma is found after surgery.

A Case of Nephrogenic Diabetes Inspidus in Type 2 Diabetes Mellitus Patient

Jae Hyoung Sun,Doo Young Lee,Jae Hyoung Sun,Jin Suk Park,Jun Gwang Son,Hong Ju Sun,Ok Young Park,Jung Hyun Shin,Yun Soo Choi 대한내과학회 2004 대한내과학회 추계학술대회 Vol.2004 No.1

성인에서 동시성 양측 서혜부 탈장과 이시성 반대측 서혜부 탈장에 대한 임상적 고찰

신선형(Sun Hyoung Shin),박찬용(Chan Yong Park),김정철(Jung Chul Kim),최수진나(Soo Jin Na Choi),김신곤(Shin Kon Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.1

Purpose: We are to describe the incidence and accordance rate of hernia type in synchronous bilateral and metachronous contralateral inguinal hernia. Methods: We retrospectively reviewed the medical records of 625 adult patients who underwent inguinal hernia repair by a single surgeon at our institute between November 2001 and October 2008. We divided the patients into 3 groups; Synchronous bilateral inguinal hernia group (SH), Metachronous contralateral inguinal hernia group (MH) and Unilateral inguinal hernia group (UH) and analyzed patients’ general clinical features and outcomes. Results: Male patients numbered 578 (92.5%) and female patients numbered 47 (7.5%), so the male to female ratio was 12.3:1. Each number of SH and MH were 49 (7.8%) and 59 (9.4%). In MH, the mean interval of counterlateral hernia development following ipsilateral hernia repair was 8.9 years and 20 (33.9%) were developed in a 3-year period. And the incidence of right hernia development after repair of left hernia predominated over left hernia development after repair of right hernia by a ratio of 1.27:1. Accordance rate of hernia type in both sides was 83.8% in SH and 91.2% in MH. Conclusion: The incidence of SH and MH were each 7.8% and 9.4% and accordance rate of hernia type is very high in SH and MH. In MH, many patients (33.9%) developed in 3 years after ipsilateral hernia repair. In this study, patients have high accordance rate of hernia type in both sides and indirect type is dominant, especially in MH.