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        • Glomerular Filtration Rate 검사방법 및 가이드라인

          박민호,이하영,류화진,유태민,노경운,Park, Min-Ho,Lee, Ha-Young,Ryu, Hwa-Jin,Yoo, Tae-Min,Noh, Gyeong-Woon 대한핵의학기술학회 2018 핵의학 기술 Vol.22 No.2

          Glomerular filtration rate (GFR)검사는 사구체의 여과기능을 나타내는 중요한 지표로서 신장기능과 그 기능의 정도를 검사하기 위하여 시행되고 있다. 사구체의 혈액 여과 작용은 신장의 중요한 기능 중 하나로 여과 장벽을 구성하여 체내에 필요한 혈구와 단백질은 빠져나가지 못하게 하고 크기가 작은 물질이나 수분, 노폐물은 자유롭게 통과시킨다. 하지만 사구체의 여과기능이 제대로 이루어 지지 않을 경우 혈뇨 및 단백뇨가 검출된다. 이와 같이 사구체의 기능에 문제가 있을 경우 급성 사구체 신염, 만성 사구체 신염 등 신장질환이 발생하게 되고 GFR검사를 통해 사구체 기능의 정도를 판단하고 있다. GFR검사는 $^{51}Cr$-EDTA으로 방사선의약품을 만들어 정맥주사를 하고 경과시간에 따라 EDTA Tube에 채혈하여 Plasma 내 방사능을 측정하여 결과 값을 도출해 낸다. 따라서 진료과 및 병동에 통보하여 동위원소를 사용하는 PET-CT, Bone Scan과 혈액에 영향을 주는 투석 및 수혈은 GFR검사와 병행하지 않도록 사전에 통보하고 있다. 검사방법으로는 먼저 $^{51}Cr$-EDTA 2 mL와 생리식염수 5 mL를 잘 혼합하고 혼합된 용액 중 5 mL로 환자에게 주입 할 방사성 의약품을 만든다. 먼저 주사 전 주사무게를 측정하고 환자의 정맥에 주사를 시행하고 난 뒤 주사 후 주사무게를 측정한다. 채혈은 총 2번 시행되고 성인의 경우에는 주입 후 3시간, 5시간 뒤, 소아의 경우 주입 후 2시간, 5시간 뒤 EDTA Tube에 5 mL채혈한다. 채혈 된 검체는 3300rpm에 5분간 원심분리 시키고 Plasma $500{\mu}L$를 Test tube에 분주하여 Sample rack에 준비해 둔다. Standard용액 제조방법은 200 mL Volumetric flask에 표시된 눈금까지 Diluent water를 채워주고 난 후 $500{\mu}L$을 버리고 $^{51}Cr$-EDTA $500{\mu}L$를 주입한 후 잘 혼합해준다. 제조 된 Standard 용액은 2개의 Test tube에 각각 $500{\mu}L$씩 분주하고 측정대상인 환자의 Plasma와 함께 Gamma Counter로 계측한다. 계측으로 얻은 CPM과 환자의 신장, 체중, 주사 전 후 무게 등을 GFR함수식에 입력하여 결과 값을 도출해 낸다. Reference range는 남성은 $119.5{\pm}30.3ml/min/1.73m^2$ 이고 여성은 $125.2{\pm}28.2ml/min/1.73m^2$ 설정되어 있지만 본원에서는 성별에 관계없이 $97.0ml/min/1.73m^2$ 이상일 경우 신장이식이 가능하다고 판단하고 있다. GFR검사 결과 값에 따라 신장기능의 정도가 반영 되기 때문에 병행하지 않아야 할 검사들과 주의사항을 준수한다면 보다 더 신뢰할 수 있는 결과 값을 얻을 수 있을 것이라 생각한다. Purpose The glomerular filtration rate (GFR) test is an important indicator of glomerular filtration and has been used to test renal function and the extent of its function. The GFR test is performed by intravenous injection of radioactive medicines made of $^{51}Cr$-EDTA, and blood concentration is measured by taking blood according to the elapsed time. also, PET-CT, bone scan, transfusion and so on will affect the outcome. Therefore, we will improve the quality of the test by providing guidelines for the GFR test for more accurate testing. Materials and Methods 5 mL of physiological saline solution and 2 mL of $^{51}Cr$-EDTA solution are used to make 5 mL of the radiopharmaceutical solution to be injected into the patient. First, the syringe weight is measured before the injection, and then the radioactive medicine is injected into the patient's vein and the syringe weight is measured after the injection. Blood sampling is performed twice in total. In adults, blood is collected 3 hours / 5 hours after injection and in children 2 hours / 5 hours after injection. The blood sample is centrifuged at 3300 rpm for 5 minutes. Standard solution is prepared by filling diluent water up to the scale indicated in the 200-mL volumetric flask, discarding $500{\mu}L$, injecting $500{\mu}L$ of GFR reagent and mixing well. $500{\mu}L$ each of the standard solution is dispensed into two test tubes, and $500{\mu}L$ of each of the plasma samples collected in time is dispensed into two test tubes and measured with a Cobra Counter. Results At present, the reference range applied in this study is $119.5{\pm}30.3ml/min/1.73m2$ for males and $125.2{\pm}28.2ml/min/1.73m^2$ for females. Conclusion The GFR test is conducted using radioactive medical products. GFR testing is performed as a scheduled test, but PET-CT, dialysis and transfusion, which may affect GFR testing, may be scheduled during GFR testing. Therefore, we could get accurate GFR test results by notifying the ward and department beforehand when booking.

        • KCI등재

          길이와 두께 비에 따른 두께 전단모드 압전소자의 공진 변위 및 압전특성

          박민호,류주현,홍재일,정영호,Park, Min-Ho,Yoo, Ju-Hyun,Hong, Jae-Il,Jeong, Yeong-Ho 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.6

          In this study, thickness shear mode piezoelectric devices for AE sensor with excellent displacement and sensitivity characteristics were simulated using ATILA FEM program, and then fabricated. Displacement and electro mechanical coupling factors of the piezoelectric devices were investigated. The simulation results showed that excellent displacement and electromechanical coupling factor was obtained when the ratio of Length/Thickness was 1. The piezoelectric device of L/T= 1 exhibited the optimum values of fr= 150 kHz, displacement= $6.23{\times}10^{-8}$[m], $k_{15}$= 0.598. The results show that the thickness shear mode piezoelectric device is a promising candidate for the application of AE sensor piezoelectric device.

        • 뇌척수액에서 항 Glutamic acid decarboxylase 항체검사의 참고치 설정

          박민호,신선영,윤태석,신희정,노경운,Park, Min-Ho,Shin, Sun-Young,Youn, Tae-Seok,Shin, Hi-Jung,Noh, Gyeong-Woon 대한핵의학기술학회 2017 핵의학 기술 Vol.21 No.2

          본 연구를 통해 항 GAD 항체검사에서 뇌척수액에 대한 정상치 범위를 추정하였다. 본원에서 211명을 대상으로 혈청과 뇌척수액에 대한 항 GAD 항체검사를 함께 의뢰받은 환자 데이터를 분석해 본 결과 혈청은 1.0 U/mL 이상의 값을 가진 환자가 약 5%를 차지하였고. 뇌척수액의 경우에는 1.0 U/mL이상의 값을 가진 환자는 약 98% 이상을 차지하였다. 혈청의 참고치 (1.0 U/mL 이상 양성)를 뇌척수액에 적용했을 경우에는 대부분의 환자들이 강직증후군 및 간질을 진단 받게 된다. 이에 혈청과 뇌척수액의 참고치를 병용해서 사용하는 것은 부적합하다고 판단하였고 뇌척수액에 대한 참고치를 본원에서 자체적으로 설정하고자 하였다. 실험 대상으로는 정상인의 뇌척수액을 채취하는 데는 어려움이 있어 이와 가장 유사한 생리식염수를 음성대조군으로 선정하였다. 총 70개의 생리식염수를 검사한 결과 Mean값이 1.97 U/mL, SD 값이 0.72 U/mL가 나왔다. 이 값들에 Hoffmann법으로 Mean값에서 ${\pm}2SD$를 정상범위로 하여 0.54 U/mL ~ 3.40 U/mL로 Expected reference range를 설정할 수 있었다. 본 실험에서 아쉬운 점은 참고치 설정에 있어 정상인의 뇌척수액으로 검사가 이루어지지 못한 부분이다. 앞으로 정상인의 뇌척수액으로 참고치 설정을 할 수 있다면 보다 더 정확하게 임상적으로 적용할 수 있을 것이라 생각 된다. Purpose Anti-Glutamic acid decarboxylase antibody test (GAD Ab) has been used as a predictor of type 1 diabetes. GAD Ab has also been shown to be highly potent in cerebrospinal fluid (CSF) of patients with suspected diabetic peripheral neuropathy. Recently, it has been known that clinical significance of GAD Ab using CSF is useful for the neurological disorders. However, the reference value of anti-GAD Ab has been provided only for serum. In this experiment, we estimated the reference value of anti-GAD antibody for CSF in neurological patients. Materials and Methods A total of 211 neurological patients were enrolled. Serum and CSF were analyzed by radioimmunoassay (RIA) using commercial RIA anti-GAD Ab kit (RSR, London, United Kingdom). Normal saline was used as the normal CSF control because CSF is most similar to 0.9% normal saline. Results The mean value of normal CSF control was 1.97 U/mL, and two standard deviations (2SD) was 1.44 U/mL. Based on this data, the expected reference range of CSF could be estimated from 0.54 U/mL to 3.40 U/mL Conclusion The reference range of normal CSF control using normal saline obtained with Hoffmann's method. However, there will be a need to validate the CSF reference values using human normal CSF.

        • 가변주파수에 있어서 유도잔동기특성의 도식산정법에 관한 연구 제3보

          박민호,Min Ho Park 대한전기학회 1969 전기의 세계 Vol.18 No.5

          The development of the frequency convertors using semiconductors devices makes it possible to control the speed of A.C. motors easily. It is now economically feasible to provide them with power at adjustable frequency using silicon-controlled rectifier (or thyristor) inverters. In such a case, in order to operate an induction motor efficiently over a wide speed range, it must be supplied from a variable frequency source of which frequency is adjustable over the speed range of the motor. It is desired to observe the changes in characteristics as primary current, torque-speed of induction motor etc. at any optional frequency. Although the characteristics can be obtained by means of the conventional methods, they require very complicated precedures of calculations. The Current Diagram Method in this paper suggests a new approach to simpler calculations of the characteristics, using the motor constants at reference frequency. The conclusions of this study are summarized as follows: 1) The equations of stator current at adjusted frequency were derived to construct graphical chart and the current circle required for the Current Diagram Method. 2) The radius, center of the current circle and the vector locus, the basis for calculating the characteristics, at any desired frequency could be easily determined with the aid of both the derived graphical chart and current circle at reference frequency. 3) The method was shown to be applicable to the various types of 3-phase induction motors and also dealt with its application to the split-phase, condenser motors.

        • KCI등재

          SrO의 첨가에 따른 [Li<sub>0.04</sub>(Na<sub>0.5</sub>K<sub>0.5</sub>)<sub>0.96</sub>](Nb<sub>0.86</sub>Ta<sub>0.10</sub>Sb<sub>0.04</sub>)O<sub>3</sub>세라믹스의 유전 및 압전 특성

          박민호,류주현,Park, Min-Ho,Yoo, Ju-Hyun 한국전기전자재료학회 2012 전기전자재료학회논문지 Vol.25 No.3

          In this study, $[Li_{0.04}(Na_{0.5}K_{0.5})_{0.96}](Nb_{0.86}Ta_{0.10}Sb_{0.04})O_3+xSrO$ (x=0, 0.0025, 0.005, 0.0075) ceramics were synthesized by the conventional mixed oxide method. The X-ray diffraction patterns demonstrated that ceramics possessed single perovskite structure. The SEM images indicate that microstructure can be obviously affected by a small amount of added SrO. The phase transition temperature tetragonal-cubic($T_c$) and orthorhombic-tetragonal($T_{o-t}$) shifts downward and upward with the increase of Sr addition, respectively. The excellent piezoelectric properties of $d_{33}=170[pC/N]$, $k_p=0.37$, $Q_m=64.12$, $T_{o-t}=153^{\circ}C$ and $T_c=370^{\circ}C$ were obtained from the 0.25 mol% Sr added ceramics sintered at $1,120^{\circ}C$ for 1 h.

        • 정준상관분류에 의한 하이퍼스펙트럴영상 분류에서 유효밴드 선정 및 추출에 관한 연구

          박민호,Park, Min-Ho 대한토목학회 2009 대한토목학회논문집 D Vol.29 No.3D

          본 연구의 핵심은 하이퍼스펙트럴영상에 정준상관분류기법을 적용할 때, 최적의 분광밴드를 찾아내는 유효밴드 선정 및 추출기법은 무엇인가를 알아내는 것이다. 본 연구에서는 미국의 Purdue University에서 개발된 Multispec$^{(C)}$ 소프트웨어를 사용하여 각각의 분리도 결정기법에 따른 최적의 유효밴드를 선정하였다. 사용된 분리도 결정기법은 Divergence, Transformed Divergence, Bhattacharyya, Mean Bhattacharyya, Covariance Bhattacharyya, Non Covariance Bhattacharyya로서 총 6가지이다. 특징추출을 위해 Erdas Imagine과 ENVI 소프트웨어를 사용하여 PCA 변환과 MNF 변환을 수행하였다. 유효밴드 선정 및 특징추출의 효과에 대한 비교평가를 위해, 정준상관분류기법에 의한 토지피복분류작업을 수행하였다. 1차 선별된 60개 밴드를 사용한 정준상관분류의 정확도는 71.8%이며, 정준상관분류를 사용하여 가장 높은 분류정확도를 얻은 방법은 Noncovariance Bhattacharyya 적용 후 정준상관분류를 수행한 경우로서 전체정확도 79.0% 이다. 결론적으로 정준상관분류에 의한 하이퍼스펙트럴영상 분류에서는 유효밴드선정기법으로 사실상 Noncovariance Bhattacharyya 기법만 유용하였으며, 나머지 유효밴드 선정기법(Divergence 제외)과 특징추출기법은 정준상관분류에서는 오히려 분류정확도가 하락함을 확인하였다. The core of this study is finding out the efficient band selection or extraction method discovering the optimal spectral bands when applying canonical correlation classifier (CCC) to hyperspectral data. The optimal efficient bands grounded on each separability decision technique are selected using Multispec$^{(C)}$ software developed by Purdue university of USA. Total 6 separability decision techniques are used, which are Divergence, Transformed Divergence, Bhattacharyya, Mean Bhattacharyya, Covariance Bhattacharyya, Noncovariance Bhattacharyya. For feature extraction, PCA transformation and MNF transformation are accomplished by ERDAS Imagine and ENVI software. For the comparison and assessment on the effect of feature selection and feature extraction, land cover classification is performed by CCC. The overall accuracy of CCC using the firstly selected 60 bands is 71.8%, the highest classification accuracy acquired by CCC is 79.0% as the case that executes CCC after appling Noncovariance Bhattacharyya. In conclusion, as a matter of fact, only Noncovariance Bhattacharyya separability decision method was valuable as feature selection algorithm for hyperspectral image classification depended on CCC. The lassification accuracy using other feature selection and extraction algorithms except Divergence rather declined in CCC.

        • KCI등재

          GTA 아래보기 자세 다층용접부의 비드형상 예측에 관한 실험적 연구

          박민호,김일수,이지혜,이종표,김영수,나상오,Park, Min-Ho,Kim, Ill-Soo,Lee, Ji-Hye,Lee, Jong-Pyo,Kim, Young-Su,Na, Sang-Oh 대한용접접합학회 2014 대한용접·접합학회지 Vol.32 No.1

          The automatic arc welding is generally accepted as the preferred joining technique and commonly chosen for assembly of large metal structures such as in areas of automotive, aircraft and shipbuilding due to its joint strength, reliability, and low cost compared to other joint processes. Recently, several mathematical models have been developed and studied for control and monitoring welding quality, productivity, microstructure and weld properties in arc welding processes. This study indicates the prediction of process parameters for the expected welding quality with accordance to the adaptive GTA welding process. Furthermore, the mathematical models is also develop to aid the selection of an optimal welding process as the generation of process controls to predict the bead geometry as a function output parameters in the GTA welding process. The developed models through this study showed comparatively excellent predicted results, and will extend to other welding processes to integrate an optimized system for the robotic welding process.

        • KCI등재

          하소온도 변화에 따른 0.95(Na<sub>0.5</sub>K<sub>0.5</sub>)<sub>0.04</sub>[(Nb<sub>0.8</sub>Ta<sub>0.20</sub>)<sub>0.994</sub>Co<sub>0.015</sub>]O<sub>3</sub>-0.05KNbO<sub>3</sub> 세라믹스의 유전 및 압전 특성

          박민호,이갑수,류주현,정회승,Park, Min-Ho,Lee, Kab-Soo,Yoo, Ju-Hyun,Jeong, Woy-Seung 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.2

          In this paper, the $0.95(Na_{0.5}K_{0.5})_{0.04}[(Nb_{0.8}Ta_{0.20})_{0.994}Co_{0.015}]O_3$(abbreviated as NKNT) + $0.05KNbO_3$ lead-free piezoelectric ceramics were synthesized by the conventional mixed oxide method route with normal sintering. And also, the effects of calcination temperature on the microstructure, dielectric properties, and piezoelectric properties were investigated. A polymorphic phase transition(PPT) between orthorhombic and tetragonal phases was observed in specimens calcined at $810^{\circ}C{\sim}850^{\circ}C$. The ceramics calcined at $830^{\circ}C$ showed excellent piezoelectric properties: $d_{33}$= 179 pC/N, $k_p$= 0.384, $Q_m$= 79.73). These results indicate that the ceramic is a promising candidate material for lead-free piezoelectric ceramics.

        • KCI등재

          디젤로 오염된 군부대 토양에 대하여 토착미생물 4종을 이용한 생분해법의 TPH 제거 효율 규명

          박민호,이민희,Park, Min-Ho,Lee, Min-Hee 한국지하수토양환경학회 2012 지하수토양환경 Vol.17 No.3

          Batch experiments using indigenous and commercialized adventive microorganisms were performed to investigate the feasibility of the biodegradation process for the diesel contaminated soil, which was taken in US Military Camp 'Hialeah', Korea. TPH concentration of the soil was determined as 3,819 mg/kg. Four indigenous microorganisms having high TPH degradation activity were isolated from the soil and by 16S rRNA gene sequence analysis, they were identified as Arthrobacter sp., Burkholderia sp., Cupriavidus sp. and Bacillus sp.. Two kinds of commercialized solutions cultured with adventive microorganisms were also used for the experiments. Various biodegradation conditions such as the amount of microorganism, water content and the temperature were applied to decide the optimal bioavailability condition in the experiments. In the case of soils without additional microorganisms (on the natural attenuation condition), 35% of initial TPH was removed from the soil by inhabitant microorganisms in soil for 30 days. When the commercialized microorganism cultured solutions were added into the soil, their average TPH removal efficiencies were 64%, and 54%, respectively, which were higher than that without additional microorganisms. When indigenous microorganisms isolated from the contaminated soil were added into the soil, TPH removal efficiency increased up to 95% (for Bacillus sp.). According to the calculation of the average biodegradation rates for Bacillus sp., the remediation goal (87% of the removal efficiency: 500 mg/kg) for the soil would reach within 24 days. Results suggested that TPH removal efficiency of biodegradation by injecting indigenous microorganisms is better than those by injecting commercialized adventive microorganisms and only by using the natural attenuation.

        • KCI등재후보

          봉약침과 자하거약침 시술로 호전된 횡단성척수염 환자에 대한 임상적 고찰

          박민호,임성택,최석우,Park, Min-Ho,Lim, Sung-Taek,Choi, Seok-Woo 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.2

          Objective : This study was performed to evaluate the treatment of acupuncture therapy including. Bee Venom and Hominis Placenta herbal acupuncture on the patient with Transverse myelitis. Methods : We treated the patient with Transverse myelitis by Bee Venom herbal acupuncture at beginning, since then we treated him adding to Hominis Placenta herbal acupuncture. Conclusions: The patient was effectively reduced symptoms with Bee Venom herbal acupuncture, since then he get more effective improvement of symptoms by adding Hominis Placenta herbal acupuncture. Therefore we are able to expect Bee Venom and Hominis Placenta herbal acupuncture will be more effective than simply acupuncture on the patient with Transverse myelitis.

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