전치부 개교를 동반한 골격성 Ⅲ급 부정교합 환자의 악교정 수술 후 교합평면의 변화와 안정성에 관한 연구

신수정,황병남,이정근,이승훈 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.1

악골의 골격적 부조화를 가진 환자의 교정치료는 악교정 수술을 필요로 하고, 악교정 수술에 의해 교합평면각은 변화된다. 특히 전치부 개교를 동반한 III급 부정교합 환자에서 치아안면 기형을 치료하기 위한 교합평면각의 변화에 대하여 많은 논란이 있어 왔다. 교합평면각을 증가시키는 하악골의 시계 방향 회전(clockwise rotation)은 전치부 개교에 대한 적절한 치료법으로 추천되어 왔고 하악골의 반시계 방향의 회전(counterclockwise rotation)은 하악지 고경을 증가시키는 방향으로 하악골을 회전시킨다는 개념으로 인해 재발(relapse)을 유발하는 불안정한 수술 방법으로 인식되어 왔다. 본 연구는 전치부 개교를 동반한 골격성 Ⅲ급 부정교합 환자에서 교합평면의 반시계 방향회전을 동반한 하악지시상분할 골절단술 시행 후 교합평면각의 변화와 술후 안정성과의 관계를 평가하고자 하였다. 하악지 시상분할 골절단술과 rigid fixation으로 치료받은 환자 25명(평균연령 20.6세)을 대상으로 하여 수술 작전(T1), 술후 2주내(T2), 그리고 술후 6개월 이후(T3)에 촬영한 측모 두부계측 방사선 사진을 통계분석한 결과 (Paired t-test, Pearson correlation analysis), 다음의 결론을 얻었다. 1. 악교정 수술 후 (T2) 하악평면각은 2.9° 감소하였고 SN평면에 대한 하악 교합평면의 각도는 2.7°감소하였다. 술후 6개월경과 후 (T3)후안면 고경의 감소로 인해(P<0.01) 하악 평면각은 1.0° 증가하였으나 하악 교합평면의 경사도는 변화되지 않았다. 2. 악교정 수술 후 시간 경과(T3)에 의해 발생한 수평적 개발은 하악골의 전방 이동량이 B점에서 1.6mm로 수술시 전체 후방 이동량의 약 22%였다. 전안면 고경에서는 수직적 재발이 발생하지 않았으나, 후안면 고경은 감소하였다(P<0.01). 3. 수평적 재발과 상관관계를 보이는 항목은 하악평면각 이었고(P<0.01) 수술 6개월경과 후 후안면 고경의 감소와 상관관계가 있는 요소로는 수술시 하악골의 후방 이동량(P<0.01), 하악지 고경의 증가량(P<0.01), 그리고 하악평면각의 감소량(P<0.01) 등이 있었다. 4. 수술시 하악 교합평면 경사도의 변화량과 술후 재발과는 상관관계가 없었다. The purpose of this study is to investigate the stability of counterclockwise rotation of mandible by sagittal split ramus osteotomy to correct the skeletal Class Ⅲ malocclusion with anterior open bite. Twenty five skeletal Class Ⅲ open bite patients(mean age 20.6 years) who were treated by the sagittal split ramus osteotomies with rigid fixation were examined in this study. Cephalometric radiographs were taken for each patients preoperative (T1), early postoperative(T2), and late postoperative period(T3). Mean postoperative period was 8.0 months. Cephalometric analysis was done and data from T1, T2, T3 were analyzed statistically by Paired t-test and Pearson correlation analysis. The following results were obtained. 1. Mandibular plane angle decreased 2.9° and mandibular occlusal plane angle related to SNplane decreased 2.7° after orthognathic surgery(T2). At 6 months after orthognathic surgery(T3), mandibular plane angle increased 1.0°, but mandibular occlusal plane angle did not changed. 2. The amount of horizontal relapse long time after orthognathic surgery(T3) was 1.6mm at B point and it was 22% of the total posterior movements. There was no vertical relapse in the anterior facial height. 3. The related factor with horizontal relapse at late postoperative period was mandibular plane angle(p<0.01). The related factors with decreasing posterior facial height were amount of mandibular setback(p<0.01), increasing of mandibular ramus height(p<0.01), and decrease of the mandibular plane angle during operation(p<0.01). 4. There was no relationship between the amount of changes in mandibular occlusal plan angle during operation and the amount of relapse after surgery.

재조합 Saccharomyces cerevisiae에서 Inulinase와 Invertase의 발현과 분비에 미치는 배양조건의 영향

남수완,신동하,김연희 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

The effects of medium pH and culture temperature on the expression and secretion and secretion of inulinase and invertase were investigated with recombinant Saccharomyces cerevisiae cells. These cells were obtained by transformation of 2μ-based plasmids pYI10 and pYS10 which contain Kluyveromyces marxianus inulinase gene (INU1A) and S. cerevisiae invertase gene (SUC2), respectively, in the downstream of GAL1 promoter. The expression level and localization of inulinase and invertase were not affected significantly by the initial medium pH: secretion efficiencies of inulinase and invertase into the medium were about 90% and 60%, respectively, in the pH ranges of 4.0 to 6.5. However, the expression and secretion of both enzymes were strongly dependent on the culture temperature. The highest expression (7.7 units/mL) and secretion (6.7 units/mL) of inulinase were observed at 28℃ and 30℃. As a consequence of decreased localization of inulinase in the periplasmic space, the secretion efficiency increased from 68% at 20℃ to 95% at 35℃. The total expression level and secretion efficiency of invertase increased from 19 units/mL and 55% at 20℃ to 25 units/mL and 68% at 35℃, respectively. Irrespective of the culture temperature, the invertase activity in the cellular fraction (periplasmic space and cytoplasmic fractions) was kept constant at around 33∼45%.

기관지천식 환자에서 유도객담을 이용한 기도 염증의 평가

남언정,이종명,김건우,김신우,김능수 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1

Objectives : This study was performed to investigate the relationship between cell counts, supernatant and lysate ECP levels in sputum, and physiologic markers in adult asthmatic. Methods : Twenty-two patients with mild to moderate persistent asthma, ten patients with acute exacerbated asthma and nine healthy subjects were enrolled. Sputum was induced by inhalation of hypertonic saline, and homogenized with 0.1% dithiothreitol. A total and differential cell was measured in supernatant fluid. Cell pellet was centrifuged, and ECP(supernatant ECP) was measured in supernatant fluid. Cell pellet was reacted with a cellular lysis buffer to release cell-associated ECP, and ECP(lysate ECP) was measured again in supernatant fluid. The ratio of supernatant to lysate ECP was calculated as an index of eosinophil degranulation. Spirometry and methacholine bronchial challenge tests were also performed as physiological markers of asthma. Results : The patients with acute exacerbated asthma showed significantly higher percentage of sputum neutrophil, eosinophil count, concentration of sputum supernatant ECP and ratio of supernatant to lysate ECP than those of normal controls and stable asthmatic patients(p<0.05, respectively). The level of sputum supernatant ECP, supernatant/lysate ECP ratio, and percentage of neutrophil showed negative correlations with pulmonary functions, but no correlations with a degree of bronchial hyperresponsiveness. There was no significant correlations between of serum ECP level and physiological parameters. Conclusion : These results suggest that both neutrophils and eosinophils play roles in the exacerbation of asthma. The sputum supernatant/lysate ECP ratio might be valuable in assessment of activation status of eosinophils in various hypereosinophilic conditions or diseases.

Saccharomyces cerevisiae에서 Trichoderma Endoglucanase의 발현과 분비

남수완,김병우,신동하,김재범,신지원,정대균,정춘수 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1

The endoglucanase gene, egl6, of Trichoderma sp. was connected with the yeast ADH1 promoter, and the resultant plasmid, pVT-C4, was introduced into three S. cerevisiae host strains (YNN27, 2805, and SEY2102). Among each 80 transformants, the cell growth and expression level of endoglucanase were compared in test-tube cultivation, and three respective transformants for each host cells showing the highest expression level and cell growth were selected. When three recombinant yeast cells were batchwise cultivated for 48 hr in flask, the total activities of endoglucanase expressed were about 1140 unit/1 with 2805/pVT-C4, 1020 unit/l with SEY2102/pVT-C4, and 590 unit/l with (YNN27/pVT-C4. Irrespective of host strain, about 80% of the expressed endoglucanase was detected in the extracellular medium. In addition, it was also found that the recombinant enzyme was secreted into the culture medium as two major forms of lightly and heavily glycosylated proteins.

어린이의 꿈, 공상 및 희마에 대한 경험적 연구(2) : 어머니의 양육 태도 및 아동 행동과의 연관성 고찰 In Relation to Maternal Behavior and Children's Behavioral Characteristics

金秀貞,申敏燮,南珉,洪剛義 서울醫大 1997 精神醫學 Vol.22 No.2

K대학 치위생과 재학생의 학과만족도 조사 연구

송윤신,권순복,안금선,김영남,김수화,차민주 경복대학 2003 京福論叢 Vol.7 No.-

경기 K대학 치위생과 재학생들의 대학 진학시 학과선택 요인을 알아보고, 학과 만족도를 분석하여 치위생과 학과 경쟁력을 높이고 학생지도의 기초자료를 제공하고자 한다. 치위생과 입학 결정시 영향을 준 요인으로는 전반적으로 본인이 가장 높게 나타났으나 학년별로는 2학년이 77.5%로 가장 높았으며, 치위생과 선택이유로는 취업보장, 주위권유, 적성·흥미 순으로 조사되었다. 치위생과 학과만족도에서 강의실환경에 대해서는 전체 조사대상자 중 9.4%가 만족하다고 응답했고, 실험·실습기자재는 36.0%가 만족한다고 응답하였으며, 학우관계에서는 74.0%, 학과지도방침 38.9%, 치과위생사 직업만족도는 79.4%가 만족하고 있었다. 특히 조사대상자 중 다른 학년보다 2학년 학생들에게서 직업만족도를 제외한 다른 항목의 만족도가 가장 높게 나타나고 있다. 직업만족도는 1학년이 85.4%로 가장 높게 조사되었다. 휴학·자퇴를 고려한 경험유무에 대한 질문에서는 있다고 응답한 학생이 47.8%이었으며, 그 이유로 1학년은 경제적이유를, 2, 3학년은 적성이라고 응답하였다. 입학결정요인과 만족도와의 관계에서는 본인이 입학을 결정했을 때 재학만족도, 직업만족도, 학과지도방침, 전임교수에 만족한다고 응답한 경우가 가장 많았으며 진로계획에서는 취업이 가장 높았다. 학우관계와 만족도와의 관계에서는 학우관계에 만족한다고 응답한 경우 재학만족도, 직업만족도, 학과지도방침에 대한 만족도가 높은 것으로 분석되었다. 구강보건교육이 치위생과 선택에 미친 영향력에 대한 조사에서는 학년별 유의성은 보이지 않았으나, 전체조사대상 중 89.5%가 영향력이 보통이상이라고 응답해 높은 비율을 차지하는 것으로 나타났다. The purpose of this study is to identify the factors affecting selection of a major and the department satisfaction for improving the competitiveness of the dental hygiene department and providing the data for students guidance. The most influential person and factor in selecting a major is the person oneself(77.5% of the second-year students responded to the question) and the percentage of employment. The reaction of satisfaction with the classroom and practice facility indicates 9.4% and 36.0% in favor. 74.0% of surveyees is satisfied with classmates. In satisfaction with a course of department and profession, 38.9% and 79.4% of respondents answer in the affirmative. The second-year students of the respondents shows higher rate than other grades in .satisfaction with items above, except the satisfaction with profession. It appears that the freshman answered the most in that question. From the survey related to the experience of thinking over temporary absence from school or voluntary resignation, 47.8% of surveyees responded they had experienced thinking about that. The freshman answered the reason is financial difficulty and the second- and third-year students selected an aptitude. In the correlation coefficient of determinants for selection of college with the department satisfaction, when the determinant is oneself, the satisfaction with being at college, profession, a course of department, and teaching staff is high. In the correlation coefficient of classmates with department satisfaction, the students responding in the affirmative on classmate satisfaction had a high degree of satisfaction with being at college, profession, and a course of department. The experience of oral health education is not statically significant by grades to select the major, but 89.5% of the students majoring dental hygiene at K-college responded over average.

Taxol합성에 관한 연구. Ⅱ : 3-(2-Hydroxyethyl)-2, 2, 4-trimethyl-3-cyclohexenone SEM ether의 합성

임남수,신동수,정윤성,김정주,박두천,주우홍 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-cyclohexenone SEM ether ??, an intermediate in the synthesis of taxol was provided in eight steps. The keto ketal ?? was obtained in three steps from 1,3-cyclohexanedione. Reaction of the potassium enolate of ?? with N-phenyltrifluoromethanesulfonimide provided triflate ?? in 84% yield. Thus palladium-mediated cross-coupling reaction of enol triflate ?? with vinyltributylstannane afforded diene ?? in a 89% yield. 3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-Cyclohexenone SEM ether was prepared from diene ?? by sequential hydroboration [9-BBN, THF, 89%], deprotection[pTsOH ·H₂O, THF-H₂O,~100%], and silyation [SEMC], iPr₂NEt, nBu₄NI, CH₂Cl₂, 94%]

어린이의 꿈, 공상 및 희망에 대한 경험적 연구(1) : 발달학적 관점에서 고찰 FROM DEVELOPMENTAL PERSPECTIVE

김수정,신민섭,남 민,홍강의 대한소아청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.1

저자들은 서울 시내에 위치한 2개 초등학교 1,3,5학년 학생 273명과 그들의 부모를 대상으로 하여 어린이의 꿈, 공상, 장래 희망 및 평소 상태를 경험적으로 조사하여, 발달학적 관점에서 이들의 특성 변화를 알아보고, 이들간의 상호 연관성을 살펴보았다. 그리고 이를 선행 연구와 비교하여 다음과 같은 결과를 얻었다. 1)어린이의 인지 발달 및 사회화와 더불어 꿈은 발달한다. 즉, 꿈에 동물, 가족 성원, 아는 사람의 출현은 줄고 나 자신, 동성 친구, 모르는 사람의 출현이 증가하며, 보다 현실적이고 정교한 내용으로 발달하였는데 이는 선행 연구에서와 비슷한 결과로 보여진다. 2)공상, 장래 희망, 그리고 평소 상태 역시 어린이의 학년에 따라 변화를 보였다. 즉 공상의 빈도는 학년에 따라 증가하였으며, 공상 내용 및 장래 희망도 보다 자기 중심적이고 현실적인 내용으로 변화하였다. 평소 상태 역시 학년에 따라 변화하였는데, 시험이나 공부에 대한 중압감이 심한 우리 나라의 현 실정을 반영하는 소견을 보였다. 3)꿈, 공상, 장래 희망, 그리고 평소 상태는 상호 연관성을 보였다. 즉, 기분 상태에서는 꿈과 공상, 공상과 평소 상태 사이에 유의한 연관성이 있었다. 또한 행복한 기분 및 무서운 기분은 각각의 기분과 합치되는 꿈, 공상, 장래 희망의 내용과 정적 연관성을 보였다. 내용에 있어서는 같은 내용의 꿈과 공상은 상당 부분 정적 연관성을 보였다. 본 연구는 정상 어린이들의 꿈, 공상, 장래 희망의 특성 변화를 발달학적 측면에서 살펴보고자 한 국내 최초의 시도로서 의의를 가지고 있다. 본 연구 결과를 통해 저자들은 꿈과 공상은 현실-모방-놀이-공상-꿈의 연속선상에 있으며 서로 밀접한 연관성을 가지고 나타남을 입증할 수 있었다. 마지막으로 앞에서 언급한 바와 같이 근래의 꿈 연구자들은 꿈의 심리적 의의에 대하여 서로 상반된 견해를 보이고 있으나, 본 연구 결과에서 꿈이 학년에 따라 특성이 변화한 점, 의미있는 감정 체험에 대한 반응성을 보인 점, 그리고 공상이나 장래 희망과 같은 각성 시의 사고 및 평소 상태와 밀접한 연관성을 보인 점 등은 꿈의 심리적 의의를 지지하는 소견으로 볼 수 있겠다. We examined the developmental characteristics of dream, daydream, and hope of elementary school students in their lst, 3rd, and 5th grades, and studied the correlation between three variables. We summarized the results of this study as follows. 1) The contents of dream developed with the cognitive development socialization process. In detail, appearance of animals, family members and known persons gradually decreased, and appearance of self, same-sex peers, and strangers gradually increased. These results are comparable with the previous studies of dream. 2) Daydream, hope, and current state also developed with age. In detail, frequency of daydream increased, and the contents of daydream and hope hanged toward more self-centered and more realistic. The changes of current state are thought to reflect the specific situation of Korea. 3) There are some correlation among dream, daydream, and hope. Especially happy mood and fearful mood had positive correlation with the relevant contents of dream, daydream, and hope. Also the contents of dream showed positive correlation with the same contents of daydream. This study is the first trial which investigate the developmental characteristics of dream, daydream, and hope of normal children in Korea. We verified that dream and daydream are on the continuous line of 'reality-imitation-play-daydream-dream'. Finally, considering the facts that dream developed with age ; responded to meaningful emotional experiences ; and had the correlation with daydream, hope and current state, the results of this study support the psychological meaning of dream.

하천제방 根固工크기에 관한 실험연구

文秀男,申文燮 群山大學校 1996 論文集 Vol.23 No.-

An experimental study on straight channel that belongs to steep slope at medium and upper stream solved tractive force from real gauged stage and velocity by hydraulic modeling test. And inducing genearlized Cross Type Flat Concrete Block Foot Protection Work Size in scouring point. The objectives of this experimental study is to provide Foot Protection Work Size for the sake of effective uses for the bank stabilization. And use for data of channel improvement some anticipated scale of foot protection work and so on.

봄철 익산지역 환경대기 중 수용성 이온성분의 일별 침적량

김남송,강공언,김정숙,김현아,신지혜,김병수,최석진 원광대학교 대학원 2008 論文集 Vol.40 No.-

Deposition samples were collected in wet gauge and dry gauge containers at downtown of Iksan city, located southwest of the Korean peninsula, from April 20 to May 1, 2004. The volume of 30-50㎖ deionized water was added for wet gauge before sampling, but dry gauge was installed in the dry state with no deionized water adding. These samples were collected twice a day during daytime and nighttime and were analyzed for anions(Cl^(-), NO^(3-), SO₄^(2-)) and cations (NH₄^(+), Na^(+), K^(+), Mg^(2+), Ca^(2+)) using ion chromatography. Data quality was checked by the data obtained from re-injection of standard solution, Dionex cross check standard solutions, and random several deposition samples, and measured data was estimated to be reliable. Considering the deposition sample volume, the sampling time, the surface area of sampling container, and the ion concentration measured, the deposition amounts were calculated in mg/㎡/day. The sum of ion dry deposition amounts for dry gauge and wet gauge was 9.1±6.7 mg/㎡/day and 26.5±9.1 mg/㎡/day, respectively. A significant increase in deposition amount during rainfall days and Asian yellow dust period was observed for both wet gauge and dry gauge, especially during rainfall days having no difference of deposition amount between in wet gauge and in dry gauge. The mean deposition of all ions measured in this study were higher in wet gauge than in dry gauge because of the surface difference of the sampling container. The mean deposition amount of NH₄^(+), SO₄^(2-), and NO^(3-) in wet gauge were found to be about 27.6 times, 5.5 times, and 3.4 times higher. than that in dry gauge, while the rest of the chemical species were equal or a little higher in wet gauge than in dry gauge. Dominant species in dry gauge were SO₄^(2-) and Ca^(2+), accounting for 14.7% and 47.3% of the total ion dry deposition, whereas those in wet gauge were SO₄^(2-) and NH₄^(+), accounting for 27.7% and 27.1% of the total ion dry deposition, respectively.