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KHFe(CO)_4-HCHO系를 利用한 Nitro 및 Nitroso化合物의 환원 N-메칠화 반응
沈相喆,閔庚隱,嚴在國,洪錫 경북대학교 1978 논문집 Vol.10 No.-
The reduction of nitro and nitroso compounds using tetracarbonylhydridoferrate-formaldehyde under mild conditions (at room temperature and then 60℃ under CO) gives the corresponding N, N-dimethylation via N-methylation in good to excellent yields. The reaction mechanism via immonium salt is assumed.
정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-
The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results
주상복합아파트 단지의 데크계획에 관한 연구 : 부산 L-project 계획안을 중심으로 focusing on plan of L-project in Pusan
박은주,심재현,김영욱,정성문 대한건축학회 2004 대한건축학회논문집 Vol.20 No.12
The purpose of this study is to analyze the planning and the design of public space at the street level of Mixed-use buildings This study is based on the spatial analysis with Space Syntax method and its outcome Example is plan of L-project in Pusan The results of this study were as follows, Drew design plan that consider link with surrounding environment, leading pedestrian and separation of vehicles for the convenience of pedestrian line, when deck planning for inside of Mixed-use buildings Also, categorizing various use of the deck will give more clear design guideline for future planning of similar
아동의 사회적 문제해결능력과 어머니의 대화형태와의 관계연구
김재림,백은주,신유림,심미경,이혜경 연세대학교 생활과학대학 1985 婦學 Vol.18 No.-
The present study investigated the relationship between the social problem solving ability of children and the language patterns of their mothers. The subjects included 193 nine yearolds (185 girls, 108 boys), and 230 twelve yearolds (115 girls, 115 boys). The instruments used were a language patterns test for the mother and IPA (Interpersonal Problem Solving Ability Test) for children. Major finding from this study were: ⑴ the correlation between the social problem solving ability of children and the language patterns of their mothers was not statistically significant, ⑵ the language patterns of the mothers were significantly different by child's sex; for boys, mother used more ordered language patterns and for girls, mothers used more ordered language patterns and for girls, mothers used more humanoriented language patterns, ⑶ the social problem solving ability of children were significantly different by child's age; 12yearolds exhibited higher ability than 9yearolds.
IntraCytoplasmic Sperm Injection(ICSI)치료의 임상적 유용성
양회생,이은주,심재철 동국대학교 경주대학 1998 東國論集 Vol.17 No.2
IntraCytoplasmic Sperm Injection(ICSI) as treatment for male-factor infertility has been introduced worldwide on the past few years in many laboratories using assisted reproduction techniques. In spite of much progress in in vitro fertilization and embryo transfer(IVF-ET) program, the pregnancy rate remains at 20-30% and the endometrial implantation rate per embryo transferred at 10%. Although IVF-ET is widely applied in the treatment of couples with male factor infertility, it may fail in many infertile couples with normal seman parameters, and certain couples cannot be accepted for standard IVF-ET due to unfertilization or extremely low fertilization rate of oocytes. Recently, several procedures of microassisted fertilization(MAF) using micromanipulation have been introduced, and pregnancies and births have been obtained after IntraCytoplasmic Sperm Injection(ICSI). In conclusion, MAF of human oocytes with ICSI is a promising fertilization method for IVF-ET patients, especially with few spermatozoa for the conventional methods of in vitro insemination and with the past history of failure in fertilization or low fertilization rate in the previous cycles, and ICSI using micromanipulation procedures applied to human oocytes will provide a range of novel technique which may dramatically improve the pregnancy rate in IVF-ET program and contribute much to the effective management of infertile couples.
이수진,송재철,장은철,이경영,심상효,박시복,박영재,김현주 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives: The effect of chronic exposure to low levels of n-hexane on peripheral nervous system and the relationship between duration of employment and impairment of peripheral nervous system was studied. Methods : In 21 workers at two shoe-maker factories and 21 unexposed controls, measurement of exposure of solvents, symptom Questionnaire, physical examination and electrophysiological study were conducted. Results : Mean ages of study subjects in the exposed and the unexposed were 39.9 and 40.1 years old. Mean durations of employment were 15.1 and 10.0 years, respectively. Mean concentrations of urinary 2.5-HD were 2.23 mg/g creatinine, 0.23 mg/g creatinine, respectively. Mean concentration of solvents in air were 21.1 ppm of n-hexane, 72.2 ppm of toluene and 0.5 ppm of MEK. There were no differences in the prevalence of subjective symptoms and abnormal neurological signs between the exposed and the unexposed. But vibration extinction time(VAT) of the exposed (8.8 second) was shorter than that of the unexposed (11.9 second) (p<0.05). Mean values of electrophysiological studies(EPS) of the two groups were within normal limit. However, mean conduction velocity of median motor nerve and median F wave(MMNCV and MFCV), mean amplitude of median sensory action potential(MSAP) were decreased in the exposed (p<0.05). Moreover, the rate of abnormal finding more than one in sensory nerves was increased in the exposed than those in the unexposed(p<0.05). Correlation coefficients between duration of employment and mean conduction velocity of median sensory nerve (MSNCV) and between duration of employment and MFCV were -0.57, -0.43, respectively (p<0.05). Conclusions : These results showed that chronic (mean 15 years) low level(mean 23 ppm) exposure to n-hexane cause subclinical impairment of peripheral nervous system. These results also suggest that the longer duration of employment, the shorter values of EPS and VAT.
Matrix Metalloproteinase-1 Inhibitory Activity of Kaempferia pandurata Roxb.
Shim, Jae-Seok,Choi, Eun-Jung,Lee, Chan-Woo,Kim, Han-Sung,Hwang, Jae-Kwan The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Matrix metalloproteinase (MMP)-1 is a superfamily of zinc-dependent endopeptidases that are capable of degrading all components of the extracellular matrix. Kaempferia pandurata extract ($0.01-0.5\;{\mu}g/mL$) significantly reduced the expression of MMP-1 and induced the expression of type 1 procollagen at the protein and mRNA levels in a dosedependent manner. Ultraviolet (UV)-induced MMP-1 initiates cleavage of fibrillar collagen. Once cleaved by MMP-1, collagen can be further degraded by elevated levels of MMP-3 and MMP-9. It was found that increased MMP-1 expression due to UV irradiation was mediated by activation of mitogen-activated protein kinases such as extracellular-regulated kinase (ERK), Jun N-terminal kinase ( JNK), and p38 kinase. Treatment of K. pandurata extract in the range of $0.01-0.5\;{\mu}g/mL$ inhibited the UV-induced phosphorylations of ERK, JNK, and p38, respectively. Moreover, inhibition of phosphorylated ERK, JNK, and p38 by K. pandurata extract resulted in decreased c-Fos expression and c-Jun phosphorylation induced by UV light. The results strongly suggest that K. pandurata is potentially useful for the prevention and treatment of skin aging.