응급실에 내원한 약물중독환자의 지역별 비교분석

임근우,박일영,유승진,나병호,오동렬,전해명,황주일,김세경 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

We reviewed retrospectively 230 patients who came to emergency room of Kang Nam St. Mary's Hospital and Uijongbu St. Mary's Hospital between 1. January and 31. December 1994. We classified them according to their age, sex, a sort of drug, the cause of poisoning, prehospital care, time-lapse to arrive at hospital after poisoning, psychiatric problem the status of patients. *We conclude as follows; 1. The male to female ratio was totally 1 : 1.98, 1 : 1.24 in a urban area, 1 : 2.43 in a rural area. 2. On age of the patients in this study, the peake incidence was between 20 and 39(55.2%). 3. On seasonal prevalence, the poisoning was most common in summer and spring, in urban area(35.7%) and rural area(37.0%) respectively. 4. The common drug were as follow; Doxylamine, Organophosphate, Acetaminophen in urban area, Paraquat, Organophospate, Doxylamine in rural area 5. The percentage of suicidal attempt were 81.8% and 87.7% in urban area and rural area respectively. 6. The poisoning patients had psychatric problem in 19.4% and 24.6%, in urban area and rural area respectively. 7. Before arrival to emergency room, 27.7% of patient was done prehospital care in rural area. 8. On arrival to emergency room, 95.1% and 73.8% of patients show stable vital sign in urban area and rural area respectively.

고리형 Melanotan Ⅱ 유사체의 합성과 생물활성

임세진 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

Melanotan-II analogs modified at D-Phe position were synthesized and evaluated against frog skin. Para-halogenation (F, Cl and I) resulted in 3-fold, 8-fold and 800-fold decrease in agonistic potency, respectively. Introduction of either D-Tyr, D-(3,5-diiodo)Phe or D-homoPhe resulted in up to 800-fold decrease in potency. D-(p-F)Phe-MT-II (1, EC50 = 0.33 nM) and D-(p-F)Phe-MT-II (2, EC50 = 1.0 nM) showed prolonged biological activity.

Determination of Kinetic Constants for Methionine Aminopeptidase

임세진 同德女子大學校 1997 同大論叢 Vol.27 No.1

대장균 아미노 펩티다제(MAP)의 최적 코발트(Co²+) 농도가 측정되었다. 코발트 포화곡선에 대한 메카니즘적 분석은 코발트가 필수적인 활성인자 보다는 오히려 조기질(cosubstrate)로서 작용할 수 있음을 보여주었다. 트리펩티드 기질의 기질특이성은 노루신(norleucine)이 기질의 P1이나 P2'위치에서 유의성 있는 활성의 손실없이 메치오닌을 대신할 수 있음을 나타내었다. H-Nle-Ala-NHNH-Dns를 기질로 사용하는 새로운 assay방법 (HPLC assay)이 MAP억제제의 효력을 측정하기 위하여 고안되었다. 기질의 시간별 가수분해는 1차불활성 단계를 포함한 Michaelis-Menten 메카니즘 모델에 적용되어 분석되었고 기질의 분해속도는 주어진 기질농도하에서 처음 15분이내에 거의 일정하였다. H-Nle-Ala-NHNH-Dns의 반응속도계수는 Km이 125±25μM이었고, kcat 6.0±0.2sec-¹이었다.

전환장애와 감별해야할 Meige 증후군 1예

임세원,김진세,정인과,박민규,이대희 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

Meige 증후군은 안검경련과 구-하악부의 근긴장이상을 특징적으로 보이는 신경학적 임상증후군이다. 발병원인은 아직 불분명하나 아세틸콜린과 도파민의 신경활성과다(excess neuronal activity)가 원인으로 여겨지고 있으며, 치료로는 향도파민성약물과 항콜린성약물, 그리고 보튤리듐독소 주사가 이용되고 있다. 그러나 증상양상이 다양하며 심리적 영향을 받으므로 전환장애 혹은 불안장애 등의 정신과적 문제로 오진되는 경우가 있다. 저자들은 49세 여자로 초기에 전환장애로 진단되었으나 Meige 증후군임이 밝혀져 성공적으로 치료되었던 환자 1례를 경험하여 문헌고찰과 함께 보고한다. A Meige's syndrome is a rare neurological syndrome characterized by blepharospam and oro-mandibular dystonia. Its pathophysiology is not clearly determined yet, but the hypothesis of dopaminergic and cholinergic hyperactivity is most widely accepted. Anticholinergic drugs, antidopaminergic drugs and botulism toxin injection are currently used for the treatment of Meige's syndrome. The Meige's syndrome could be misdiagnosed as a psychiatric disorder such as conversion disorder or anxiety disorder, because clinical features of the Meige's syndrome are very variable and affected by psychological factors. The authors experienced one case of a 49-year-old female patient who was initially misdiagnosed as conversion disorder but confirmed later as Meige's syndrome, and then successfully treated.

FEM을 이용한 선삭가공 절삭조건의 영향 분석

임세환,송춘삼,홍석관,강정진,김주현 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

A plane strain finite element model is developed to simulate turning with continuous chip formation using adaptive remeshing during the thermal-mechanical coupled analysis. Comparisons between the experimental and simulation results for cutting forces are performed to validate FE analysis results. Influences of machining parameters such as depth of cut, cutting speed and feed rate on cuting force and shear angle are analyzed by Taguchi method. The more depth of cut and feed rate result in the increase of cutting forces, but the rates of increase are decrease due to the larger shear angle. As the cutting speed increases, von Mises stress of workpiece near the tool tip decreases because the strength of specimen decreases at high temperature above 500℃. This thermal effect on cutting force is negligible because the affected area is very localized and the average values of von Mises stress in the shear plane are the same among the diverse cutting parameters.

Platinum sensitive 재발성 난소암에서 Carboplatin/Paclitaxel의 효과

장혜진,유희석,임윤경,문세희,장기홍,이정필 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 재발성 난소암에서 platinum 감수성을 기준으로 2차 항암요법으로 사용한 Carboplatin과 Paclitaxel의 효과를 알아보기 위하여 본 연구를 진행하였다. 연구방법 : 1998년 1월 1일부터 2003년 8월 31일까지 만 5년 8개월 간 아주대학교병원 산부인과에 재발성 난소암으로 입원한 환자 중에서 최초 수술로 난소암을 확진한 후 Cisplatin 또는 Carboplatin 등 platinum 제재가 포함된 항암치료를 받은 후 6개월 이후에 재발한 환자 29명을 대상으로 Carboplatin은 5 AUC를 그리고 Paclitaxel은 175 mg/m^(2)를 투여하였으며, 최소 3회에서 최고 16회까지 투여하였다. 치료효과의 판정은 CT, MRI, Ultrasonography등 영상진단상 암종괴의 크기가 완전히 소실되었을 경우를 완전반응(complete response)으로, 50%이상 감소되었을 경우를 부분반응(partial response)으로, 50% 미만으로 감소되었거나 20% 미만 증가하였을 경우를 불변(stable disease)으로, 그리고 20% 이상 증가되었을 경우를 진행(progressive disease)로 정의하였다. 결과 : 대상 환자에서 완전반응은 6명(21%), 부분반응은 11명(38%), 그리고 불변은 5명(17%)로 전체 반응율 (overall response rate)은 59% 그리고 임상적 유용성(clinical benefit=CR+PR+SD)은 76%이었다. 결론 : 재발성 난소암환자에서 기왕에 사용한 Platinum 제재에 민감한 환자에서는 Carboplatin과 Paclitaxel의 병행 투여가 효과적이었다. Objective : To ascertain the effect of Carboplatin and Paclitaxel combination as a second line regimen for recurrent ovarian carcinoma based on platinum sensitivity. Methods : From January 1st, 1998 through to August 31st, 2003, 29 patients were retrospectively reviewed who had previously underwent primary cytoreductive surgery and adjuvant chemotherapy with Cisplatin or Carboplatin for ovarian carcinoma, and who had later recurred during follow up. All 29 patients had recurred at least 6 months after therapy, and thereafter received second line chemotherapy consisting of Carboplatin (5 AUC) and Paclitaxel (175 mg/㎡) for a minimum of least 3 cycles and a maximum of 16 cycles. Treatment efficacy was assessed by imaging studies including Computerized tomography, Magnetic Resonance Imaging, or Ultrasonography. Complete response was determined as complete disappearance of tumor, partial response at least than 50% reduction in tumor volume, stable disease as less than 50% reduction or less than 20% increase in tumor volume, and progressive disease as more than 20% increase. Results : There was complete response in 6 (21%) patients, partial response in 11 (38%), stable disease in 5 (17%), showing an overall response rate of 59%. The clinical benefit (CR+PR+SD) was 76%. Conclusion : The combination of Carboplatin and Paclitaxel administration seems to be an effective mode of second line therapy in patients with recurrent ovarian carcinoma who had been sensitive to prior platinum based chemotherapy.

중소기업에 있어서 효과적인 ERP 패키지 선정을 위한 방법론과 Web-based DSS개발에 관한 연구

김진수,임세헌 중앙대학교 산업경영연구소 1999 산업경영연구 Vol.8 No.2

정보기술의 발달과 중요성이 증대됨에 따라 신속하게 정보시스템 구현이 가능한 ERP(Enterprise Resource Planning) 패키지 도입에 대한 관심이 증대되고 있다. 특히, 대기업에 비하여 자금력, 기술력, 전문인력 면에서 열세인 중소기업에서 ERP 패키지 도입에 많은 관심을 가지고 있다. 하지만, 체계적인 ERP 패키지 도입을 위한 효과적이고 구체적인 방법론이 부족하여 많은 중소기업들이 ERP 도입을 지원할 수 있는 보다 체계적인 ERP 패키지 평가요소와 방법론 개발이 시급한 실정이다. 따라서, 본 연구의 목적은 중소기업이 보다 쉽고 체계적으로 ERP 패키지를 평가할 수 있는 평가요소 및 방법론을 개발함으로써 중소기업의 성공적인 ERP 도입에 기여하고자 한다. 또한, 이를 웹에 기반을 둔 의사결정지원시스템의 기본설계를 제공함으로써 사용자들이 보다 쉽게 의사 결정을 할 수 있는 시스템 개발에 기여하고자 한다. Many enterprise are interested in building ERP (Enterprise Resource Planning) system because of its rapid development of management information systems. Especially, small and medium size enterprises are more concern about ERP package. Even though there are many successful cases of building ERP systems, however, many cases are also failed due to lack of a systematic evaluation methodology. Therefore, the purpose of this study is to develop a systematic evaluation methodology of ERP package and a framework of Web-based DSS (Decision Support Systems) for evaluation.

Terfenadine과 Ketoconazole 복용 후 발생된 Torsades de pointes 심실 빈맥증의 치험 1례

김세경,이기중,유승진,박일영,박승현,임근우,이원재,강동헌 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Torsades de pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval, characterized by QRS complexes of progressively changing amplitude and contour that seem to revolve around the isoelectric line. The most common cause of Torsades de pointes induced by antiarrhythmic agents, occupying in certain drugs or toxin, electrolyte disturbance, congenital QT prolongation syndrome. Cardiotoxicity terfenadine, in overdose a widely used, nonsedating antihistamine, has been reported. Case after administration of terfenadine and ketoconazole causing syncope and torsades de pointes have been reported in recommended dose. We report a case of QT prolongation with torsades de pointes after therapeutic administration of terfenadine, a long acting histamine H1 receptor antagonist, together with ketoconazole, an antifungal preparation. The patient is a 43-year-old female, who experienced palpitation, dizziness and syncopal episoders after coadministration of terfenadine and ketoconazole, for a fungal infection of the skin. The ECG showing typical episodes of torsades de pointes with QT prolongation. Magnesium sulfate was given, torsades de pointes did not recur. The patient was discharged with improved condition.

주의력결핍 과잉행동장애 아동에서 틱 장애 동반 여부에 따른 확산 텐서 영상 비교 연구

최지욱,임명호,이창화,박진균,손정우,심세훈,유인규,강현수,정범석 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : Diffuse tensor imaging (DTI) was applied to explore the difference in regional distribution and extent of white matter (WM) abnormalities in boys with Attention-deficit/hyperactivity disorder (ADHD) versus boys with comorbid ADHD and tic disorders. Methods : Fifteen boys with ADHD (mean age 9.3 +1.8), 24 ADHD boys with chronic tic disorder or Tourette's disorder(9.9 =b 1.2) and 9 age-, gender-matched controls (9.2 d= 1.8) received DTI assessments. Fractional Anisotropy (FA) maps of WM were compared between groups with a voxel-wise analysis after intersubject registration to MNI space. Results : Bo groups, ADHD group and ADHD with tic disorder group, commonly showed decreased FA than healthy control group in left cerebellar middle peduncle and right frontal lobe, increased FA in right middle occipital WM. In the common areas of left cerebellar middle peduncle and right middle occipital WM, comorbid group showed broader areas of significant FA. The comorbid group also showed increased FA in right cerebellar peduncle, additionally. Conclusion : The findings in ADHD group support previous ADHD hypothesis of the functional abnormalities in corticocerebellar circuit, and suggest that ADHD might have more complicated pathology of neuronal circuit including occipital visual system. The comorbid group showed common areas of overlapping but more extensive abnormalities and also had additional WM abnormalities. ADHD with chronic tic disorders may represent a severe form of ADHD with additional regions of abnormal connectivity.

Batimastat의 고체상 합성법에 관한 연구

김지연,임세진 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

The solid-phase approach to the facile synthesis of batimastat is described. Acid compound (5), prepared by solution-phase synthesis is loaded to a acid labile resin bearing a hydroxylamine linker and is subjected to a stereoselective Michael addition and subsequent acidic cleavage, affording batimastat in good yield and in short period of time.