외화부채와 외화자산의 상관관계: 통화매칭이론의 실증분석

임세원,권준엽,설윤 한국자료분석학회 2021 한국자료분석학회 학술대회자료집 Vol.2020 No.3

기분부전장애와 비전형우울증의 약물치료

임세원,오강섭,Lim, Se-Won,Oh, Kang-Seob 대한생물정신의학회 2007 생물정신의학 Vol.14 No.1

Objectives : The diagnosis of depression is based on a highly variable set of symptoms. Therefore, depression should not be viewed as a single disease, but a heterogenous syndrome comprised of different pathophysiologies. There are several subtypes of depression which were already incorporated in DSM-IV. This article provides a systematic review of pharmacological treatments of two recognized subtypes of depression-dysthymic disorder and atypical depression. Methods : Systematic search of relevant literatures on dysthymic disorder and atypical depression was performed by proposed search strategy of the Clinical Research Center for Depression of Korean Health 21 R&D Project. All identified literatures were carefully reviewed and classified according to SIGN grading system and summarized in a narrative manner. Results : For the treatment of dysthymic disorder and atypical depression, selective serotonin reuptake inhibitors( SSRIs) and moclobemide have more evidence than the other antidepressants. SSRIs and moclobemide showed superior tolerability than tricyclic antidepressants. Conclusions : The authors proposed treatment recommendations for dysthymic disorder and atypical depression by the methods of evidence-based medicine(EBM). However, guideline developing methods of EBM also have several inevitable limitations. Therefore, in the absence of clear and significant differences in efficacy, the choice of medication must be individualized for a particular patient based on psychiatrist's own clinical decision.

자살예방을 위한 교육적 접근

임세원,오강섭 대한의사협회 2012 대한의사협회지 Vol.55 No.4

The best and only solution for suicide is prevention. Suicidal behavior can be divided into 3phases: suicidal ideation, suicidal planning, and suicide attempt. To prevent suicide more effectively, it is better to intervene at an earlier phase of suicidal behavior before suicide attempts occur. It is essential to educate the public, gatekeepers, and mental health professionals about suicide prevention. The authors suggest that the role of the public and the gatekeepers-identifying signs of suicide earlier and referring to professionals-is very important because suicidal behavior is common in Korea. Although many public institutions or private organizations that are working for suicide prevention in Korea have made an effort to educate the public and the gatekeepers,the outcome has not yet been satisfactory due to a lack of structured programs for education. There are several kinds of well-made educational programs for gatekeepers. However,most of these programs were developed in foreign countries which have social and cultural backgrounds different from Korea. It is essential to develop a structured, systemized educational program that reflects the cultural and social characteristics of Korean society for the public and the gatekeepers.

이자 분할을 위한 노이즈 제거 알고리즘 기반 기존 임계값 기법 대비 U-Net 모델의 대체 가능성

임세원,이영진 한국방사선학회 2023 한국방사선학회 논문지 Vol.17 No.5

In this study, we aimed to perform a comparative evaluation using quantitative factors between a region-growing based segmentation with noise reduction algorithms and a U-Net based segmentation. Initially, we applied median filter, median modified Wiener filter, and fast non-local means algorithm to computed tomography (CT) images, followed by region-growing based segmentation. Additionally, we trained a U-Net based segmentation model to perform segmentation. Subsequently, to compare and evaluate the segmentation performance of cases with noise reduction algorithms and cases with U-Net, we measured root mean square error (RMSE) and peak signal to noise ratio (PSNR), universal quality image index (UQI), and dice similarity coefficient (DSC). The results showed that using U-Net for segmentation yielded the most improved performance. The values of RMSE, PSNR, UQI, and DSC were measured as 0.063, 72.11, 0.841, and 0.982 respectively, which indicated improvements of 1.97, 1.09, 5.30, and 1.99 times compared to noisy images. In conclusion, U-Net proved to be effective in enhancing segmentation performance compared to noise reduction algorithms in CT images.

함께하는 행정 : 공직자 힐링 ; 직장인의 번아웃

임세원 대한지방행정공제회 2016 地方行政 Vol.65 No.747

수면시작 기준의 차이에 의한 수면잠복기반복검사결과의 변화

임세원,복기남,이헌정,김린,Lim, Se-Won,Bok, Ki-Nam,Lee, Heon-Jeong,Kim, Leen 대한수면의학회 2004 수면·정신생리 Vol.11 No.2

목 적:수면잠복기 반복검사(Multiple sleep latency test, MSLT)는 주간 졸림증을 측정하는 객관적 방법으로 현재 가장 널리 쓰이고 있다. 미국 수면학회의 MSLT guideline에서는 수면의 시작을 최소 1개 epoch의 1단계 수면으로 정의하고 있으나 여전히 상당수의 수면센터에서는 수면의 시작을 위해 3개 epoch 이상의 1단계수면을 요구하고 있다. 본 연구는 두가지 다른 기준의 적용에 의해 수면잠복기반복검사의 결과에 어느 정도의 차이가 발생하는지를 확인하고 보다 타당한 수면시작기준을 알아보고자 한다. 방 법:1999년 4월부터 2004년 7월까지 고려대병원 수면다원검사실에서 시행한 수면잠복기 반복검사중 60건(300 nap)의 수면잠복기 반복검사기록을 후향적으로 조사하였다. 동일한 수면잠복기 반복검사기록을 각기 1개 epoch 기준과 3개 epoch 기준을 적용하여 수면잠복기를 기록후 이를 통계적 방법으로 비교하였다. 결 과:전체 60명의 MSLT 중 수면시작의 기준을 달리 적용했을때 평균 수면잠복기 결과가 달라진 경우는 20명으로 33.3%였으며 3개 epoch 기준에 비해 1개 epoch 기준을 적용시 단축되는 평균수면잠복기의 변화율은 최소 1.3%에서 최대 38.5%으로 평균값은 15.9%였지만 통계적으로 의미있는 차이는 아니였으며 수면잠복기가 상대적으로 긴비기면병군이 기면병군에 비해 변화가 발생하는 비율이 더 높았다. 결 론:다른 수면시작기준의 적용에 따라 수면잠복기결과의 변화가 나타났으나 졸림증의 정도가 중등도이상인 경우 그차이는 통계적으로 의미있는 것은 아니였다. 하지만 임상적으로 의미있는 졸리움을 보다 민감하게 측정할 수 있는 기준이라는 측면에서는 1개 이포크기준이 보다 타당할 수 있겠다. Objectives: The multiple sleep latency test (MSLT) is commonly used as a valid objective measure of sleepiness. The procedure of MSLT is well standardized but the sleep onset criterion is somewhat variable. One epoch of stage 1 sleep is the most commonly used criterion, and the criterion of three epochs of stage 1 sleep is also used. The purpose of this study was to compare the two criteria used to determine sleep onset. Methods: We retrospectively analyzed 60 consecutive MSLT that were performed according to a standaridized protocol. We scored each test using the two different criteria for sleep onset and then statistically analyed the results. Results: Using the different criteria, 20 patients among 60 showed changes in mean sleep latency (33.3%). The extent of change ranged from 1.3% to 38.5% (mean 15.9%). Non-narcoleptic patients showed a significantly higher incidence of change than other sleep disorder patients. Conclusion: Changes in mean sleep latency occurred according to the different criteria of sleep onset. But the difference arising from different criteria was statistically not significant in patients with moderate to severe sleepiness. Considering that 1 epoch criterion for sleep onset is more sensitive in detecting clinically significant sleepiness, the authors suggest that the 1 epoch criterion is more reliable than the 3 epochs criterion.

외상후 스트레스 장애의 수면

임세원,김린 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Sleep disturbance is a very common complaint among patients with posttraumatic stress disorder (PTSD). Recent studies suggest that sleep disturbances such as nightmare and insomnia are important in predicting later development of PTSD as well as diagnosing PTSD. Despite of its clinical significance and importance, consistent characterization of the neurophysiology underlying sleep symptoms in PTSD has been elusive. However, hyperarousal by increased noradrenergic activity in Sym-phathetic nervous system and/or dysregulation and fragmentation of REM sleep seem to have a significant role in mediating sleep disturbances of this disorder, In this article, the authors reviewed various literatures on sleep of PTSD and emphasized the importance of evaluating sleep disturbances in PTSD.

한국판 단축된 자기보고형 MINI (MINI 정신건강 평가)의 타당도 연구

임세원,송한수,오윤희,신호철,조광현,정상근,오강섭,Lim, Se-Won,Song, Han-Soo,Oh, Yun-Hee,Shin, Ho-Chul,Cho, Kwang-Hyun,Chung, Sang-Keun,Oh, Kang-Seob 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1

Objectives : To investigate the validity of an abbreviated self-rated Korean version of MINI (Mini International Neuropsychiatric Interview) patient health survey which screening social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder. Methods : 115 subjects completed MINI and MINI patient health survey. The validity of MINI patient health survey was assessed by whether the results from MINI patient health survey were compatible with the results from MINI or not. The Cohen's kappa value, specificity, sensitivity, positive predictive value, and negative predictive value was calculated for this purpose. Results : The Kappa values of social anxiety disorder (0.60), panic disorder (0.49), generalized anxiety disorder (0.60) and major depressive disorder without other co-morbid disorder (0.59) were at least moderate in strength of agreement. Conclusion : The abbreviated self-rated Korean version of MINI patient health survey has the moderate to good validity in social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder without other co-morbid disorders. Our result suggests that this instrument might be useful for screening above 4 disorders if it is used under careful supervision of experienced clinicians.

양극성장애 입원환자에서 항정신병약물치료와 관련된 임상요인 - 리스페리돈과 전형적 항정신병약물과의 비교를 중심으로 -

임세원,이민수,곽동일,정인과,Lim, Se-Won,Lee, Min Soo,Kwak, Dong-Il,Jung, In-Kwa 대한생물정신의학회 2000 생물정신의학 Vol.7 No.1

Background : In spite of relative high risk of extrapyramidal side effect and tardive dyskinesia, it is common clinical practice to use antipyschotics in treatment of bipolar I disorder. But in Korea, there has been few study about clinical factors related with antipsychotics treatment in bipolar disorder patients. So the author studied about the clinical factors related with antipsychotics treatment in bipolar inpatients focusing on the comparison of risperidone and classical antipsychotics. Method : By reviewing medical record retrospectively, datas about patient-related, illness-related, and treatment-related clinical factors on antipsychotics use were collected. Association between antipsychotics dose and duration and clinical factors were analysed by statistical method. Results : Aggressive behavior was only statistically significant factor associated with antipsychotics use. And in the case of aggression, maintenance dose of risperidone was not changed(p=0.84), but dose of classical antipsychotics was increased significantly(p=0.005). Total hospital days and antipsychotics treatment duration showed no difference between risperidone and classical antipsychotics treatment groups. Conclusion : Clinical factors associated with antipsychotics use was aggressive behavior. In the case of aggression, risperidone required lesser dose increment compared with classical antipsychotics.

내과적 질환에 동반된 불면증:이차성 불면증

임세원,김린,Lim, Se-Won,Kim, Leen 대한수면의학회 2005 수면·정신생리 Vol.12 No.1

Sleep can be easily disrupted by variety of conditions. Most of medical illnesses could be a primary condition causing secondary insomnia. The common underlying mechanism of secondary insomnia is presumed to be stress effects on sleep. The assessment and treatment of secondary insomnia are often complicated. Establishing an causal inference between primary condition and insomnia is the key to assessment. However, it can be difficult even for experienced clinicians due to diagnostic ambiguity of secondary insomnia. Therefore, through medical evaluation and integrative understanding of primary condition is essential to manage secondary insomnia properly. Although treatment have been usually focused on the primary medical illnesses per se, nonpharmacologic interventions, such as sleep hygiene, might be effective in many cases.