요관압 상승시 신혈류량 조절에 prostaglandin이 미치는 효과

민영기,양훈모,김종규,이석호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Higher ureteral pressure than in normal condition causes increase in renal blood flow (RBF) and partial impairment of the autoregulation of RBF. Higher ureteral pressure increased renal prostaglandin production, it is not clear whether or not it is also responsible for partial impairment of the autoregulation of RBF. Therefore, we investigated the role which prostaglandin play in the autoregulation of RBF, studying the interaction between ureteral pressure and RBF autoregulation may reveal the role of prostaglandin in tubuloglomerular feedback. For the purpose of this experiment, six anesthetized mongrel dogs were prepared for the measurements of RBF, mean systemic and renal arterial pressure (RAP) and the manipulation of ureteral pressure to 0 cmH20, 20 cmH20 and 40 cmH20. The autoregulation curves were determined during both control and elevation of the ureteral pressure, before and after the pretreatment with indomethacin, a cyclooxygenase inhibitor. The desired ureteral pressure was achieved by vertically elevating the water-filled reservoir connected to the ureteral catheter to 20 cm and 40 cm above the kidney level. In response to the elevation of the ureteral pressure, RBF increased from 167±11 ml/min to 185±8 ml/min, 204±11 ml/min respectively and the renal arterial pressure and the systemic arterial pressure didn't change significantly. During 0 mmHg of ureteral presure threshold pressure of RBF autoregulation was 59±3 mmHg. On the other hand, during 20 cmH20, 40 cmH20 of ureteral pressure, the autoregulation curves shifted upward and rightward from control, threshold pressure is elevated by 74±3 mmHg. The pretreatment of the dogs with indomethacin failed to affect the lower limit of RBF autoregulation during both control (63±5 mmHg) and the elevated ureteral pressure (77±5 mmHg). Since RBF failed to increase in response to the elevated ureteral pressure, RBF autoregulation curves obtained during the elevated ureteral pressure shifted only rightward from indomethacin control. The results indicate that the increased intrarenal level of prostaglandin by increased ureteral pressure or prostaglandin-induced vasodilation does not appear to bear any relation to the reduction in the autoregulatore capacity during elevated ureteral pressure. It seems that the partial impairment of the autoregulation during acute ureteral obstruction is due to the consumption of tubuloglomerular feedback mechanism at 0 mmHg of ureteral pressure and that prostaglandin is neither mediator nor effector of tubuloglomerular feedback mechanism.

가족성 아밀로이드성 말초신경병증 1예

양우석,서민정,권유석,유현정,노숙영,백소아 대한근전도전기진단의학회 2003 대한근전도 전기진단의학회지 Vol.5 No.2

L - NAME 주입시 신 교감신경이 신혈류량 변화에 미치는 영향

민영기,양훈모,이석호,김종규 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Recently it is known renal medullar will be play a important role of blood pressure control and pressure natriuresis. Renomedullary antihypertensive mechanism is activated by increasing perfusion pressure of kidney and can be inhibited by sympathetic nerve stimulation or blockade of nitric oxide(NO) formation. It is important to know what is affect on renal regional blood flow, especially renal medullary blood flow(MBF). For the purpose of investigating the effect of the renal sympathetic nerve on regional blood flow during infusion of blocking NO synthesis(by N^(ω)-nitro-L-arginine methylester:L-NAME) in spontaneous hypertensive rat(SHR) and Wistar rats normal control, Mean arterial pressure(MAP), total renal blood flow(TRBF), midcortical blood flow(CBF), inner medullary blood flow were measured in innervated or denervated renal sympathetic nerve group of SHR and Wister rats. All group that received the L-NAME were seen increasing MAP while TRBF, CBF and MBF decreased and the decrease of TRBF in SHR is more marked than in Wistar rat. In spite of increasing the MAP, MBF in all four group decreased, respectively C: 220 ± 3 U, 205 ± 2 U Wi : 215 ± 4 U, 165 ± 12 U Wd :218 ± 3 U, 170 ± 10 U Si :195 ± 4 U, 98 ± 15 U Sd : 200 ± 3 U, 120 ± 14 U, especially the most remarkable decrease about 50 % in SHR innervated group. Thus, according to these result, NO seems to maintain the MBF and the partial interaction between renal sympathetic nerve and NO in medullary blood flow can be suggested in innervated SHR.

고추 種子油中의 脂肪酸과 Sterol 組成에 關한 硏究

梁敏錫 慶尙大學校 1976 論文集 Vol.15 No.-

The unsaponifiables seperated from red pepper seed oil were divided into less polar compounds (hydrocarbon, etc., fraction 1), 4, 4-dimethyl sterol (fraction 2), 4-monomethyl sterol (fraction 3), and 4-desmethyl sterol (fraction 4) by preparative thin layer chraomatography and the sterol fractions, i.e., fraction 2,3,and 4, were further analyzed by gas liquid chromatography and combined gas liquid chromatography-mass spectrometry and also fatty acids were determined by gas liquid chromatography. The results obtained were summarized as follows; 1. From the analsis of fatty acid, it was found that palmitic acid and oleic acid were major fatty acid. 2. It was noted that 4-desmethyl sterol fraction from red pepper seed oil contained far more cholesterol (8%) than that from most of seed oils, and compesterol by gas liquid chromatography was identified to be mixed with 24-methylenecholesteral by combined gas liquied chromatography-mass spectrometry. 3. No seed oils have been repored to contain 4α-methylzymostenol. however, it were coourred in 4-mononomethyl strerol fraction from red pepper seed oil in the present study, and popheno was the major component(52%) of the faction. 4. Lanostenol was identified in 4,4-dimethyl sterol fraction but no detectable or trace amounts of lanotenol was reportd to present in most of seed oils.

만성 부비동염에서 섬모운동과 전산화 단층촬영에서의 상악동 점막비후의 상관관계

민양기,전상준,이재서,이철회,이강수,윤자복,이원진,박광석 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

생약성분 항암제 Tianxian의 흡수동태에 관한 연구

양은정,김원배,심창구,이민화,정석재 서울대학교 1995 藥學論文集 Vol.20 No.-

아시아문화콘텐츠에 나타난 민족주의와 여성재현의 탈식민적 독해

양민석 이화여자대학교 한국여성연구원 2007 여성학논집 Vol.24 No.2

현재 가속화되고 있는 문화콘텐츠산업과 함께 주목해야 할 것은 이 과정에서 여성들에 대한 문화적 상정폭력이 다양한 형태로 행사되고 있다는 것이다. 그럼에도 불구하고 경제적 이윤창출의 당면과제 앞에서 여성의 실제적 경험과 일상세계와 다른 여성의 모습과 특성들이 문화상품 또는 문화콘텐츠 개발을 통해서 재생산되고 있다. 본 연구에서는 아시아의 문화콘텐츠산업의 발전과 민족주의와의 연관성을 파악하고, 문화산업 또는 문화콘텐츠산업을 통해 재현된 여성표상에 민족주의가 어떻게 개입되고 있는지를 주요하게 고찰했다. 여기에서 민족주의는 정치기득권 세력의 이데올로기로 작용하는 ‘국가 민족주의’와, 지구화가 가속화 되고 있는 현 시점에서 새롭게 등장하는 ‘문화 민족주의’를 포함한다. 특히 아시아의 민족주의와 여성재현의 관계를 한국의 사회변동과 그에 따라 변화되는 여성표상의 사회사를 중심으로 살펴보았으며, 이러한 여성표상의 이미지가 문화콘텐츠화 하는 방식을 분석했다. 즉 ‘경험의 콘텐츠화’의 관점에서 여성들의 특수한 역사적 경험이 문화콘텐츠 개발을 통해 어떻게 재현되고 있는지 파악하였다, 이것은 사회발전기와 변동기에 특히 부각되는 민족주의가 여성의 문화표상에 개입해온 과정에 대한 추적이었으며, ‘우리’ 민족이라는 동일성의 범주 속에서 주류에 속하지 못하는 여성들의 또 다른 ‘타자화’에 대한 문제제기이기도 했다. 더불어 ‘심청’의 다양한 리메이크처럼 변형된 문화콘텐츠 속에 재현된 여성들의 문화혼종적 이미지를 포착하고, 점차 강한 위세를 드러내고 있는 문화 민족주의에 대한 논의를 진전시켜 전통문화콘텐츠와 대중문화콘텐츠에 나타난 여성재현의 양상을 ‘선화’와 ‘한류’를 중심으로 살펴보았다. Along with the development of technology typified by digital informationalization, the 'globalization of culture' became accelerated, and the interest in cultural contents has been increasing. The focus on the development of cultural contents was followed by the creation of cultural industry, which, focusing on maximizing the profit, reflects the general recognition that cultural contents will be the most important factor in strengthening a nation's competitiveness. In this process, it is remarkable that women's image and specific characters differed from women's actual experiences. Likewise, daily lives are reproduced through the development of cultural items and/or cultural contents in order to pursue economic profit in spite of the fact that cultural symbolic violence against women is exerted in various forms. The present study aims to understand the relationship between the development of cultural contents industry and nationalism in Asia and explores how nationalism is intervening on women's representation through cultural industry and/or cultural contents industry. Nationalism in this study includes the 'state's nationalism' working as a leading ideology of the political vested rights and 'cultural nationalism' which is newly emerged at the present time when globalization is enhanced. Especially, the relationship between nationalism in Asia and women's representation is examined centering on the social history of women's representation altered by social changes in Korea. Also, the way the images of women are transformed into cultural contents is analyzed. In other words, how women's specific historical experiences are represented through the development of cultural contents are examined from the viewpoint of 'making content of experiences'. It is an endeavor to trace the process of intervening on women's representation by nationalism which is especially highlighted in the periods of social development and/or social upheaval. It also poses the problem of 'the otherization' of women who are not involved in the main stream of the category of 'our' people. In addition, it explores problems of the cultural diaspora implied in the cultural contents industry focusing on the cultural hybrid images of women represented in the transformed cultural contents such as the example of varied remaking works of 'Shim-ch'ong'. It deals with the aspects of women's representation appearing in both contents of traditional culture and mass culture such as 'Mythology' and 'Han-Ryu' by unfolding discussions on cultural nationalism which has increased powerful influences.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

播種과 收穫時期에 따른 들깨(Perilla ocymoides)의 脂肪酸 組成變化

梁敏錫,全永式 慶尙大學校 1987 論文集 Vol.26 No.1

播種 및 收穫時期에 따른 들깨의 脂肪酸 組成 變化를 要約하면 다음과 같다. 1.油脂含量은 5月30日 播種區와 10月5日 收穫區에서 가장 높았다. 2.總 脂質의 主要脂酸은 palmitic, oleic, linoleic, linolenic acid로 이中linolenic acid의 含量이 가장 많았다. 3.不飽和度 및 C?/C? 比는 播種적기인 5月30日과 10月5日이 가장 높았다. 4.結合形態別 脂質은 植物脂質의 저장形態인 triglyceride의 含量이 가장 높았으며 主要脂?은 linolenic acid였는데 播種時期가 늦어질수록 增加하는 傾向이었다. 5.本 硏究의 結果로 南部地方의 播種 및 收穫 적기는 各各 5月30日과 10月5日로 생각된다. This experiments are carried out obtain the effects of different snowing and harvesting dates on the oil contents and fatty acids compositions of perlla cultivar. Total lipid was extracted from perilla seed with diethylether and sepsarated into glycolipid, sterylester, triglyceride, free fatty acid and phospholipid. Fatty acids compositions of each fraction of lipid were analyzed by gas chromatography(GLC). The results are summrized as follow: Oil contents were the highest at snowing treatment on May 30 and harvesting treatment on Oct, 5. Main fatty acid Compositions of total lipid were palmitic, oleic, linoleic and linolenic acid. Linolenic acid was the highest. Ratio of UFA/SFA and C?/C? were the highest at sowing date May 30 and harvesting date Oct.5. Trglyceride was predominant composition of total lipid and main fatty acid was linolenic acid as snowing dates delayed, its contents decreased. As a result of study, an opportunity of sowing and harvesting dates were regarded as on May 30 andOct. 5 in Southern District.

enalapril의 혈압하강효과에 대한 renomedullary depressor system의 역할

민영기,양훈모,김종규,이석호 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

It has long been recognised that renin-angiotensin system(RAS) takes part in blood pressure control. It was previously known that the physiological effects of the renomedullary depressor mechanism are in virtually all aspects the very opposite of those of RAS. Muirhead proposed that there was a negative-feedback interaction between two systems, RAS and renomedullary antihypertensive depressor system, and they balance each other. If true, as the suppression of angiotensin Ⅱ(ANG Ⅱ)by angiotensin converting enzyme(ACE) inhibitor activates the renomedullary antihypertensive function, we can assume the blood pressure lowering effects of ACE inhibitor due to an increased secretion of medullary depressor substance. After rats with intact and chemically destroyed renal medulla received either saline or the ACE inhibitor, mean arterial pressure(MAP) was clearly decreased after ACE inhibitor administration in controls with intact medulla, but MAP in rats with chemically destroyed renal medullar was not changed. According to these results, we can come to a conclusion that renomedullary depressor substance plays an important role to normal blood pressure control.