심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

PT조건하 V_2O_5에 의한 Alcohol의 산화

강선희,김미련,김선자,김현옥,노복자,이기화,이정숙 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

2, 3; 5,6-di-O-isopropylidene-α-D -mannofuranose(ManA) were oxidized to their cor-responding 2, 3;5,6-di-O-isoprolylidene-α-D-manno-1.4-lactone(ManB) using calcium chlorite as oxidant in a phase transfer catalysis system. But identified results were not obvious. V_2O_5 catalzed oxidation of primary and secondary alcohols to aldehydes and ketones respectively at alkali conditions under Solod-Liquid phase transfer conditions. This reaction affords good overall yields of products without formation of undersirable.

女性의 基本欲求와 衣裳價値觀間의 相關關係 硏究

姜京子,李貞淑,秋美先 慶尙大學校 1987 論文集 Vol.26 No.2

This was designed in order to find out the correlation between the basic needs and values on teh clothes of women, 358 women living in Taegu city and JinJu city were selected as sample for this study. The major findigs of this research were as followings. 1. Women have stronger needs for physiology, self-actualization belongness and affection self-esteem and safety. They regards economic, sensory values most important. 2. Young women tend to regard aesthetic values such as form,color, harmony important. Older women like to wear comfortable clothes. 3. Women having higher education have lower needs for physiology and safety, and they have strong need for self-actualization, And they tend to regard aesthetic values important, but they have lower religious values on the clothes. 4. There is difference of need and clothing values of women depending on the monthly income of the family. 5. Unemployed women have stronger need for self-actualization than the employed women. Ⅱ.Correlation between basic needs and values on clothes was investigated. 1. Married women who regard aethetic values important have stronger need for self-actualization. Single women who regard economic values important have lower needs for safety and self-actualization but married women have lower needs for belongingness and self-esteem. 2. There is a little difference of correltion between values and needs depending on the age and education of respondents. 3. There is a difference of correlation between values and needs depending on the monthly incomes of respondents.

뇌경색 환자에 있어 시간경과에 따른 영상변화

강경숙,양동선,김진미 국립서울정신병원 2000 臨床硏究論文集 Vol.2000 No.-

비결핵성 마이코박테리아 폐질환의 임상경과

최강현, 한혜숙, 정혜원, 안진영, 이기만, 김미경 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

-본문참고-

New Insight for Fluoroquinophenoxazine Derivatives as Possibly New Potent Topoisomerase Ⅰ Inhibitor

Kang, Da-Hye,Kim, Jung-Sook,Jung, Mi-Ja,Lee, Eung-Seok,Jahng, Yurngdong,Kwon, Youngjoo,Na, Younghwa 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18

Fluoroquinolones, represented by ciproxacin and norfloxacin, are well known clinical antimicrobial agents, and their phenyl ring expanded quinophenoxazines are reported as possible antitumor active compounds. These quinophenoxazines are known to inhibit DNA topoisomerase II essential for cell replication cycle. But there were no reports for topoisomerase I inhibition study for these compounds. In this report, we have prepared a few quinophenoxazine analogues and tested their topoisomerases I and II inhibitory activities and cytotoxicity. From the result, we found that qumophenoxazine analogues possessed strong topoisomerase I inhibitory capacity as well as topoisomerase II inhibition. Among the compounds prepared, A-62176 analogues showed strong topoisomerases I and II inhibitory activities. Interestingly, compound 8 missing the 3-aminopyrrolidine moiety at C2 position has similar potent inhibitory capacity against topoisomerases I & II at higher concentrations (20 and 10 uM, respectively). But compound 8 inhibited topoisomerase I function more selectively at lower concentration, 2 uM. Our observation mi&ht strongly implicate that fluoroquinophenoxazines can be developed as efficient topoisomerase I inhibitor with the elaborate modification.

학동기 손자녀에 대한 조모의 역할수행 : 취업모가족과 비취업모가족 비교

이미숙,조병은,강란혜 대한가정학회 2004 Family and Environment Research Vol.42 No.4

The purpose of this study was to compare the grandmothers role performance toward their grandchildren in the elementary school between working and nonworking mother families. The subjects were 274 grandparent-grandchild pairs. The sbuctured questionnaires, from both grandmothers and grandchildren were collected in 2001. Using statistical technique such as factor analysis, t-test, Pearson's correlation, and multiple regression analysis, the major findings were as follows: 1) The level of the grandmothers' role performance is moderate in general. However, the grandmothers in working mother families perform surrogate mother roles more strongly than the grandmothers in nonworking mother families. 2) While contact between grandmother and grandchild is associated with the grandmother's role performance in working mother families, the grandmother's age and the closeness between grandmother and mother are related to the level of the grandmother's role performance in nonworking mother families. In conclusion, the grandmothers' role performance in working mother families was found to be more important in the supporting system than in nonworking mother families.

麻黃의 사람 비점막 섬유아세포 monocyte chemotactic protein 중 MCP - 1 , MCP - 2 , 및 MCP - 3 분비에 대한 효과

김현미,이향숙,김정선,조정제,유영천,안현종,최훈,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).

혈액투석 환자의 가족지지, 무력감과 자가간호와의 관계 연구

이강오,이미숙,백영주 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

This study was designed to investigate the correlations between family support, Powerlessness. and self-care of hemodialysis patients. One hundred thirty seven hemodialysis patients with chronic renal failure from 2 university hospitals, 2 general hospitals, and 2 medical cilinics in Kwang-ju. were accidental sampled. The data were collected from September 16 to 30, 1995. by the questionnaire method. The instrment used for measuring family support was Kang's Family Support Scale, powerlessness was developed by the researcher from the literature review, and self-care was developed by Kim and Youm and was modified by the resecher. The data were analyzed by t-test, ANOVA, and Peatson's correlation coefficient. The results of the study were as follows: 1. Average family support score of subjects was 33.71. 2. Average powerlessness score of subjects was 70.03. 3. Average seof-care score of subjects was 63.28. 4. Relatinoships between general characteristics and variables were as follows 1) There was sighificant difference between family income and family support(F=6.90.p=.000). 2) Three were significant difference betweem present family income and family support(F=6.90, p=.000), 3) There was significant difference between medical insurance and self-care (t= 2.52, p=.013). 5. Correltions betweem family support, powerlessness, and self-care were as follows 1) The first hypothesis, "the higher the level of family support in patients on hemodialysis, the lower the level of powerlessness will be," was supported(r=-.233. p=.022). 2) the second hypothesis, "the higher the level of family support in patients on hemodialysis, the higher the level of self-cate will be." was supported(r=.235, p=.019). 3) The third hypothesis, "the lower the level of powerlessness in patients on hemodialysis, the higher the level of self-cate will be," was not supported(r=-.033. p=.740).

혈액투석환자의 혈액투석 관련지식과 환자역할행위 이행과의 관계

나덕미,이강오,송은숙 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

The purpose of this study was to clarify the relationship between the knowledge of hemodialysis and the compliance of patient role behavior in hemodialysis patients. This study was descriptive correlational study. Data were collected by questionnaire from 122 hemodialysis patients. Data were collected by questionnaire from 122 hemodialysis patients. In knowledge about hemodialysis, there were significant difference in age, education level, marital status, paying for the treatment and number of oral medication. In compliance of patient role behavior, there were significant difference in age, education level and paying for the treatment. The correlation between knowledge about hemodialysis and compliance of patient role behavior was statistically significant (r=.354, p=0.000). It is proved the research hypothesis, that is, 'statistically difference in the knowledge of hemodialysis and the compliance of patient role behaviour'. Based upon these findings, it was relevant that the knowledge of hemodialysis itself can promote the compliance of patient role behaviour in hemodialysis patients who are characterized by long time period treatment. As a result, it is very important to increase patients' knowledge of hemodialysis by learning in order to get a great treatment efficiency in case of hemodialysis patients.