조직학적 진단된 chronic necrotizing pulmonary aspergillosis 2예

김연숙,정숙인,기현균,김춘관,김신우,한정호,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

CNPA는 기존의 폐질환 및 폐절제술로 인해 국소방어기전에 저하가 있거나 비특이적 전신면역상태저하를 갖고 있는 환자들에게서 주로 발생하는 만성적인 공동성 폐질환이다. 현재까지 우리나라에서는 CNPA의 보고가 없는 상태이고, 저자들은 최근 조직학적으로 진단된 CNPA 2예를 경험하였기에 보고하는 바이다. 저자들이 경험한 CNPA 환자들은 만성알코올 중독 및 기관지확장증과 같은 기저질환과 폐절제술을 받은 병력이 있었다. Aspergillus가 폐실질을 침윤하고 있는 조직소견과 조직배양에서 Aspergillus가 검출되어 조직학적 진단이 가능하였고, amphotericin B의 정주요법 및 경구 itraconazole 투여와 폐절제술 등으로 성공적으로 치료되었다. 아직 많은 임상의들에게는 낯선 질환인 CNPA의 치료성적은 환자의 동반질환 및 CNPA 자체의 중증도, 진단과 치료 시작의 지연 등에 의해 크게 좌우되므로 만성적으로 진행하는 공동성 폐병변을 갖고 있는 환자에게서 CNPA를 감별하는 것이 중요하다. Chronic necrotizing pulmonary aspergillosis (CNPA) is a chronic cavitary form of pulmonary aspergillosis. Dozens of CNPA cases have been reported in patients with systemic immunologic dysfunction or altered local defense mechanism from preexisting pulmonary disease. Review of literatures revealed that no CNPA cases have been reported in Korea yet. We experienced two cases of CNPA proven by lung biopsy. A 53-year-old alcoholic male in poor nutritional state was admitted with generalized weakness and weight loss. Chest CT revealed a cavitary nodule surrounded with ground-glass attenuation. CT-guided fine needle aspiration and biopsy was done. The biopsy specimen demonstrated dichotomously branching septated hyphae consistent with those of Aspergillus sp. Another case was a 39-year-old man with bronchiectasis who was admitted with persistent hemoptysis. He had a past history of pulmonary tuberculosis. A parahilar lesion with intracavitary soft tissue mass was incidentally detected in high-resolution GT. Left lingular segmentectomy was done due to uncontrolled hemoptysis and CNPA was histologically diagnosed. Both patients were successfully treated with intravenous amphotericin B followed by oral itraconazole. Even though CNPA is unfamiliar to most clinicians, it should be included in differential diagnoses of chronic progressive cavitary pulmonary lesion, especially in patients with immunologic dysfunction.

무세포혈관과 자가 골수줄기세포를 이용한 조직공학적 인공혈관 제조

김동익,김병수,조승우,임정은,어현선,이민재,김종성,장인성 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

폐농양 및 복부농양을 일으킨 Eikenella corrodens 감염 2예 : Two Case Reports and Review

정용희,류미숙,김영식,이우인,이희주,서환조 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

Eikenella corrodens is a slowly growing, facultative anaerobic gram-negative bacillus. It is a normal inhabitant of the human upper respiratory tract, and it is recognized as an infrequent cause of invasive disease. To date, a few cases of E. corrodens infection were noted from all other organ. We report herein two cases of E. corrodens infection. In one case E. corrodens was isolated in the lung abscess and in the other case it was in the appendiceal abscess. The patients were treated empirically with penicillin G. The results of the bacterial culture and sensitivity test were available with it. The patients were discharged 15 days later with marked improvement after treatment. Our report clearly demonstrates that E. corrodens can be the pathogen of lung abscess and intraabdominal abscess. We reviewed descriptions from the literature of infections caused by E. corrodens.

녹차가루와 녹차물 추출액의 첨가수준에 따른 제주보리빵의 기호성 및 품질특성

김우실,이미정,박영선 제주한라대학 2000 論文集 Vol.24 No.-

At the production of 「Jejuborybbang」, the separate characteristic is duly reviewed by each addition of green tea powder in the ratio of 0%, 2.5%, 5%, 10% and water extract of green tea in of 50%, 70%, 100% as well. A unique difference in color and property has been come out in addition of green tea powder by chemical analysis and sensory evaluation, but not so much noticeable with the comparison of control in addition of water extract green tea. The conclusion is that it is most preferable to use control at making of 「Jejuborybbang」, but also preferable to add the ratio of 50%, 70%, 100% of water extract of green tea and 2.5% of green tea powder each into the making of 「Jejuborybbang」.

복합 적층판의 T-Joint에 대한 접착 강도 평가

김재훈,사정우 충남대학교 공업교육연구소 2000 論文集 Vol.23 No.1

The test specimen configuration of T-joint was proposed to evaluate the bond strength and damage mechanism between a skin and co-cured stringer or frame. When the static loading, such as monotonic loading, loading/unloading, the skin was bent along the edge of the frame. A test fixture which could change moment arm was designed for simply support condition. AE signal and optical crack propagation were monitored by AE measurement instrument and CCD camera in real-time during the test. The failure initiated and progressed on the noodle area. Results indicate that the failure initiation load was decreased by increasing distances between skin/flange termination point and support rod. Also it was shown that a significant amount of acoustic emission was suddenly generated by new damage.

신경망을 이용한 협력적 추천 시스템의 성능 향상

김종수,도영아,류정우,김명원 한국뇌학회 2001 한국뇌학회지 Vol.1 No.2

개인화 기술은 과다한 정보를 줄이기 위한 여과 기술로서 최근 인터넷 사용자들과 정보 제공자들로부터 관심의 대상이 되고 있다. 그 중 가장 많이 사용되고 있는 개인화 기술은 협력적 추천으로서, 이 방법은 사용자에게 어떤 항목(상품)을 추천해주는 데 있어서 그 사용자의 다른 항목들에 대한 선호도나 추천 항목에 대한 다른 사용자들의 선호도를 이용하여 추천해준다. 협력적 추천 방법 중 보편적으로 많이 사용되는 최근접 이웃 방법은 유사한 사용자들의 행위에 기반하여 항목들을 추천해 준다. 그러나 이 방법은 사용자들간의 단순한 유사도를 계산함으로써 성능이 떨어지는 문제점이 있다. 데이터마이닝 기법을 적용하여 사용자 선호도 데이터로부터 추천 규칙을 생성하여 추천을 해주는 연관규칙 방법 또한 사용자나 항목간의 내용적, 분류적인 공통성 또는 개념에 의한 연관성을 고려하지 못하고, 단지 단순하고 표면적인 연관성만을 고려하는 문제점을 가지고 있다. 본 논문에서는 추천의 정확도를 향상시키기 위한 신경망 추천 모델을 제안한다. 신경망으로는 다층 퍼셉트론을 사용하여 우선 학습변수들과 입력차원의 변화에 따른 신경망에 기반한 협력적 추천의 성능에 대해 조사하고, 순수한 협력적 추천에서의 문제점인 희소성(sparsity)문제를 해결하기 위해 내용기반 추천과 협력적 추천을 병합한 모델을 신경망에서 보인다. 마지막으로 다른 협력적 추천 방법과의 비교를 통하여 본 신경망 추천 방법의 장점과 성능의 우수함을 보인다. Personalization is a filtering technique to reduce information overload and it recently draws attention upon internet users and information providers. The collaborative recommendation is one of the widely used personalization methods. It recommends a user an article based on other users preferences for the target article or the preferences for other articles of the target user. The nearest neighbor method is one of the common collaborative recommendation methods, which recommends articles based on the behavior of the similar users. However, it suffers from poor performance mainly because it fails in properly computing similarity between users. The rule method extracts recommendation rules from the users preference data using data mining technique. It also suffers from simple and superficial association between users or articles without utilizing conceptual level of association such as commonality in contents and category. In this paper we propose neural networks model to improve the accuracy of recommendations. We investigate various aspects of collaborative recommendation based on multi-layer perceptrons by varying parameters and the dimension of input data. We also combine the collaborative recommendation and the content-based recommendation within a neural network model to solve sparsity problem in pure collaborative recommendation. We finally demonstrate through experiments that the neural network based collaborative recommendation outperforms the existing methods.

전단달변형을 고려한 단순지지된 비등방성 적층곡선판의 해석

김우중,이원홍 진주산업대학교 1993 論文集 Vol.32 No.-

In recent years the development of high modulus, high strength and low density boron and graphite fibers bonded together has brought a renewed interest in structural elements fabricated of layers, each layer possessing different mechanicla properties. Particularly laminaed composite plates exhibit properties considerably different from those of the single-layer plate. It results in the fact that the classical theory of plates, based on neglecting transverse shear deformation, is invalid for laminated composite plates. Thus, to obtain the more exact behavior of laminated composite plates, effects of shear strain should be considered in the analysis of them. This paper is composed of linear analysis of laminated composite plates that accout for the transverse shear strains. Some methods of analysis of generally anisotropic laminated composite curved plates with the effects of transverse shear deformation are given. The finite difference technique is used to analyze laminated composite curved plates in geometrical nonlinear problem as well as linear problem. Forward and backward finite difference at boundaries are used to exclude the pivotal points involved in each equation. Then this technique of analysis is shown reasonable results. From the numerical results, it is clarified that the effects of transverse shear strain is quite significant components for small ratio of side length ot thickness. Therefore when the more exact solution is required in the analysis of laminated composite plate, the present analytical technique in this study is used to obtain the more exact and the more rapid soution of them as some examples shown in this study.

탄성지반 강성행렬을 이용한 암거해석

김우중,이원홍,하대환 진주산업대학교 1994 論文集 Vol.33 No.-

Culvert is sometimes placed on elastic foundation at construction site. There are several methods to analyze a culvert, particularly finite element method used commonly. The stiffness matrix of finite element method does not include the character of the elastic foundation. When the elastic foundation stiffness matrix, which will be introduced in this study, add to the stiffness matrix, the combined matrix can be applicable to the bottom part of the culvert on elastic foundation. That could analyze the actual condition of the culvert, also predict the elastic displacements of the culvert.

말라리아 환자 32예의 임상적 고찰

정용희,백일현,김태형,김영식,이우인,서환조 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 삼일열 말라리아는 국내에서 1986년 이후에는 박멸된 것으로 알려졌으나 1993년 이후 증가하는 양상을 보이고 있다. 이에 말라리아의 임상적 고찰을 통하여 이 질환을 이해함에 있다. 방법 : 1991년 1월부터 1999년 10월까지 반복적 고열과 오한을 주소로 본 병원에 내원하여 말초혈액 도말검사에 의해 말라리아 감염으로 확진된 32예의 환자에 대해서 후향적으로 조사하였다. 결과 : 1991년부터 1999년 10월까지 총 32명의 환자의 연도별 발생빈도는 각각 1991년에 1명, 1996년에 1명, 1997년에 3명, 1998년에 13명, 1999년에 14명이었다. 월별발생빈도는 7월과 8월에 집중적으로 발생하였다.(46.9%) 환자의 거주지는 경기 연천과 파주에 주로 분포되었다(53.1%). 성별발생분포는 32예의 환자중에 여자가 5명, 남자가 27명으로 남자가 더 많았다. 발병연령은 22세에서 87세까지 분포되었고 20-30대에 많이 발생하였으며 20대가 가장 많았다. 군인 및 제대자가 17명(59.4%)에 해당하였으며, 제대자의 평균 제대후의 기간은 10개월 정도였다. 가장 흔한 임상증상은 발열 및 오한이었다.(100%) 비장종대 및 간장종대는 각각 26명(81.3%), 3명(9.4%)에서 관찰되었다. 검사실 소견은 평균적으로 WBC 5.317/㎕, 혈색소 12.5±7.1g/㎗, 혈소판 78,906.3±68391.4㎕, GOT/GPT 43.7±26.7/49.6±57.3 IU/ℓ, Total bilirubin 1.6±0.9㎎/㎗를 보였다. 말초혈액 도말검사상 모두 P. vivax였다. 치료는 hydroxychloroquine과 primaquine의 치료에 잘 반응하였다. 결론 : 말라리아는 7월과 8월에 한국에서 호발하는 중요한 급성 열성 질환으로 조기 진단 및 치료에 보다 관심을 기울여야 할 것이다. Background : In Korea malaria has been rare, but since reemergence of indigenous vivax malaria in 1993, the number of cases of malaria have recently increased. We analyzed the cases of malaria who were treated in Kyung-Hee University College of Medicine with regard to define the clinical characteristics of malaria. Methods : We retrospectively analyzed of 32 cases of malaria admitted to Kyung-Hee University Hospital between 1991 and 1999. Malaria was diagnosed by peripheral blood smear. Results : Among a total of 32 cases, the number of yearly incidence of 1991, 1996. 1997, 1998 and 1999 were 1,1,3,13,14 respectively. It demonstrated the high incidence especially between July and August. The most patients (53.1%) resided in Yeonchon and Pajoo. Among them, 5 cases were female and 27 cases were male. The age distribution ranged from 22 to 76 year old. The high incidence of age was between 20's and 30's. Military solidiers and ex-soldiers are 17 cases(59.4 %). The most frequent symptom was fever and chills (100%). Splenomegaly and hepatomegaly were also observed in 81.3 %(26 of 32) and 9.4 %(3 of 32) respectively. The laboratory findings were WBC 5.317/㎕. Hb 12.5±2.1 g/dl. platelet 78,906±68,391.4/㎕. GOT/GPT 43.7±26.7/49.6±57.3 IU/L. LD 678.3±50.1 IU/L. total bilirubin 1.6±0.9mg/dl- The all cases were treated suscessfully with hydroxychloroquine and primaquine. There were no central nervous system complications and pulmonary edema. Conclusion : Malaria is one of the important acute febrile illness with the high incidence between July and August.

산국 (Chrysanthemum boreale) 휘발성 추출액의 항균 및 항진균활성

차정단,김태영,우원홍,정규용,김강주,길봉섭 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1

To investigate the antimicrobial and antifungal activity of Chrysanthemum boreale(C. boreale) essential oil, the growth inhibition against Aspergillus nidulans, Fusarium oxysporum, Alternaria mali, Staphylococcus aureus, Streotococcus pyogenes, Streptococcus mutans and Escherichia coli in the presence of the essental oil was monitored by agar dilution method. The antifungal effect of C. boreale on Aspergillus nidulans, Fusarium oxysporum and Alternaria mali as affected at the concentration of 400 ppm. The antibacterial effect of C. boreale on staphylococcus aureus, streptococcus pyogenes and Streptococcus mutans was affected at the concentration of 0.4 μl, while growth of E. coli was not inhibited at the concentration of essential oil. The results of this experiment on microorganisms indicated that naturally occuring chemical substances from C. boreale might have biologically toxic activities, that is, allelopathic potentials to the microorganisms.