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골프장의 잔디 토양에서 살균제 Tolclofosmethyl의 분해
정근욱,우선희,김흥태,사동민,김영기,홍순달,김재정,이재구 한국환경농학회 2004 한국환경농학회지 Vol.23 No.3
Tolclofosmethyl (TCFM) is heavily and annually applied to the turf soils of most golf courses in Gyeongju to control the fungi known to cause the disease brown patch. The soil samples used for the experiment was collected three weeks after the annual application at the end of May in the year 2002. The preliminary results obtained from this study demonstrated that the repeated field annual applications of TCFM to the turf soils of a golf course located in Gyeongju city in the southern area of Korea showed the enhanced degradation of the parent compound TCFM, especially in the surface (0~15 cm) soil rather than the shallow subsurface (15~30 cm) and deep subsurface (30~45 cm) soils, compared to the corresponding surface (0~15 cm) and shallow and deep subsurface (15~30 cm and 30~45 cm) soils of the untreated plot. It appears that microorganisms in the soil may be involved in the enhanced degradation of TCFM.
구흥회,정수현 한국식품영양학회 1994 韓國食品營養學會誌 Vol.7 No.1
인삼의 ehtanol 추출물과 영지 열수추출물 및 영지 crude polysaccharide가 유산균 생육에 미치는 효과를 L. casei IAM 1643과 S. thermophilus KCTC 2185를 대상으로 하여 조사하였다. 인삼추출물에는 탄수화물 60.7%, 단백질 27.5%, 영지추출물에는 단백질 46.4%, 탄수화물 35.9%가 함유되어 탄수화물과 단백질이 일반성분의 대부분을 나타내었으며, 영지 crude polysaccharide의 총당함량과 총단백질함량은 각각 47.2%와 15.2%이었다. 인삼 추출물에는 arginine과 tryptophan의 2종의 아미노산이 함유된 것으로, 영지추출물에는 이들 외에도 alanine, lysine, serine 등 모두 11종의 아미노산이 함유된 것으로 확인되었다. 인삼추출물과 영지추출물 및 영지 crude polysaccharide를 0.1%, 0.2%, 0.4%씩 TG배지에 첨가하여 유산균을 배양하였을 때 이들을 첨가하지 않은 대조구에 비하여 모두 뚜렷한 생육증진 효과를 나타내었다. 특히 그 효과는 인삼추출물은 L. casei의 경우에, 영지추출물은 S. thermophilus의 경우에 더욱 뚜렷하게 나타났으며 첨가량이 증가할수록 그 효과도 증가하였다. 인삼 및 영지추출물에서 분석된 유리 아미노산중 arginine, lysine 등은 L. casei의 경우에 생육증진 효과를 나타내었으며, lysine, serine, arginine, glutamic acid 등은 S. thermophilus의 경우에 효과를 나타내었다. This study was carried out to investigate the effects of Panax ginseng, Ganoderma lucidum extract and crude polysaccharide of G. lucidum on the growth of lactic acid bacteria. P. ginseng extract contained 60.7% carbohydrate and 27.5% protein, whereas G. lucidum contained 35.9% carbohydrate and 46.3% protein. The total sugar and protein content of crude polysaccharide of G. lucidum were 47.2% and 15.2%, respectively. Two amino acids(Arg, Trp) were detected in P. ginseng extract and 11 amino acids(Arg, Trp, Ala, Lys, Ser, etc. ) in G. lucidum extract. By the addition of P. ginseng, G. lucidum extract and crude polysaccharide, the growth of lactic acid bacteria was increased obviously in comparison to that in Tryptone-glucose control media. P. ginseng was more effective on the growth of L. casei and C. lucidum was more effective on that of S. thermophilus. The effect of free amino acids on the growth of lactic acid bacteria was also examined. Argi-nine and lysine stimulated the growth of L. casei, whereas lysine, serine, arginine, and glutamic acid stimulated the growth of S. thermophilus.
Chung Mo Koo,Se Hee Kim,Heung Dong Kim,Joon Soo Lee,Jong Rak Choi,Seung-Tae Lee,Hoon-Chul Kang 대한소아신경학회 2019 대한소아신경학회지 Vol.27 No.2
Purpose: Mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene are associated with epileptic encephalopathy and severe cognitive impairment. We aim to characterize the association between this gene and treatment efficacy. Methods: We retrospectively analyzed 10 patients who were treated at Severance Children s Hospital for epileptic encephalopathy who were subsequently diagnosed with a CDKL5 mutation using next-generation sequencing. Results: Electroencephalography (EEG) results showed generalized pattern abnormalities in 60% (6/10) of patients with CDKL5 mutations. We analyzed the effects of three treatments, namely antiepileptic drugs (AEDs), ketogenic diet (KD), and steroids. A more than 50% reduction in seizures was observed in 12% (1/8) of patients treated with clobazam. KD treatment proved ineffective in most cases. In addition, a more than 50% reduction in seizures was observed in 57% (4/7) of patients treated with steroids. EEG analysis of patients treated effectively with steroids revealed that 75% (3/4) showed hypsarrhythmia and 25% (1/4) showed focal epileptiform. Conclusion: In this study, as in other studies, AEDs and KD did not effectively control seizures in most patients with a CDKL5 mutation. However, steroid therapy reduced the frequency of seizures in patients who also exhibited hypsarrhythmia. This suggests that steroid treatment is helpful in cases of hypsarrhythmia with CDKL5 mutations.
Chung Mo Koo,Se Hee Kim,Heung Dong Kim,Joon Soo Lee,Hoon-Chul Kang 대한소아신경학회 2019 대한소아신경학회지 Vol.27 No.2
Purpose: Acquired epileptic aphasia (AEA) accompanied by electroencephalogram (EEG) abnormality is a rare disease; therefore, there are few studies investigating the prognostic factors and treatment efficacy. We aimed to determine the therapeutic effects and prognostic factors for clinical seizure and neuropsychological function in acquired aphasia patients. Methods: We retrospectively studied cases of AEA diagnosed at Severance Children’s Hospital from January 2013 to October 2017. We evaluated the efficacy of antiepileptic drugs, steroids, and ketogenic diets (KD) in treating acquired aphasia. The EEG patterns and prognostic factors were predicted by the background EEG and frequency of spike and wave during sleep (SWS). Results: The study analyzed 20 patients, 11 male and 9 female, with AEA. Aphasia most commonly occurred at 4 years of age, and clinical seizure was most likely to occur between 2 and 4 years of age and focal seizures were the most common seizure type. KD was shown to be the best treatment for clinical seizure in AEA patients. Patients with normal EEG background showed better responses to clinical seizure treatment and improvements in neuropsychological function. Conclusion: KD and steroids generate the best therapeutic effects for clinical seizure in AEA patients. Improvements in neuropsychological function in AEA patients may be related to the EEG background and the SWS patterns. Additionally, the results suggest that the response of clinical seizure to antiepileptic drugs may also be related to the EEG background. However, the current study had some limitations and further research is needed.
Chung-Tack Han,Du-Yeol Kim,Chunja Nam,Seol-Hee Moon,Sun-Hee Park,Kyoung-Goo Han,Hye-Yeong Lee,Heung-Mo Bae,Cheol-Beom Park,Jai-Hyun So,Sukmo Kang,Jong Koo Kang 한국독성학회 2020 Toxicological Research Vol.36 No.1
Cynanchi wilfordii Radix (CWR) is a herbal medicinal plant that is well-known and used in Asian countries as a health food. In this study, acute and 13-week subchronic oral toxicity studies of hot-water extract of CWR (CWR-WE) were performed in Sprague-Dawley rats. For the acute toxicity study, CWR-WE was administered once orally to five male and five female rats at doses of 800, 2000, and 5000 mg/kg. Mortality, clinical signs, and body weight changes were monitored over 14 days. There were no treatment-related changes in these parameters and the approximate lethal dose of CWR-WE in male and female rats was determined to be > 5000 mg/kg. For the subchronic toxicity study, CWR-WE was administered orally once daily to male and female rats for 13 consecutive weeks at doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg/day (n = 10 rats/sex/group). There were no toxicologically significant changes with regard to clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, clinical chemistry, organ weights, necropsy findings, and histopathological findings. These results suggest that the oral no observed adverse-effect level of CWR-WE is > 2000 mg/kg/day for both sexes, although target organs were not identified.
최흥재(Heung Jai Choi),문영명(Young Myoung Moon),정재복(Jae Bock Chung),이상인(Sang In Lee),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),김상애(Sang Ae Kim),조준구(Jun Koo Cho) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2
N/A We assessed predicting factors of fafality in 42 patients with fulminant hepatitis such as age, sex, etiology, serurn levels of albumin, total bilirubin, SGOT, SGPT and alpha-fetoprotein, SGOT/SGPT ratio, plasma level of ammonia, prothrombin time, degree of encephalopathy and complication. Singificant differences were observed between the survivors (14 patients) and the non-survivors (28 patient.) by plasma level of ammonia and serum level of alpha-fetoprotein. Mortality tended to be increased by decreasing serum level of albumin and alpha-fetoprotein, prolonging prothrombin time, increasing plasma level of ammonia, a SGOT/SGPT ratio above than 1.0, deepening of encephalopathy and developing complication such as respiratory failure, cardiac dysfunction, cerebral edema or renal dysfunction. In patients with fulminant hepatitis B, the absence of HBsAg in serum had favorable prognostic value. In conclusion, the serum level of alpha-fetoprotein, plasma level of ammonia, prothrombin time, SGOT/SGPT ratio, degree of encephalopathy, and complication such as respiratorv failure, cardiac dysfunction. Cerebral edema and renal dysfunction may be used as predicting factors of fatality in fulminant hepatitis.
최흥재 ( Heung Jai Choi ),허갑범 ( Kap Bum Huh ),정진각 ( Chin Kak Chung ),박정호 ( Jung Ho Park ),박봉구 ( Bong Koo Park ) 대한내과학회 1969 대한내과학회지 Vol.12 No.4
A case of choleduodenal fistula caused by duodenal ulcer is reported. A 19 year-old high school boy was hospitalized because of 2 months intermittent postprandial epigastric pain and vomiting which became more severe 1 week prior to the admission. Physical
Computer Assisted Learning (CAL) 프로그램의 작성
한만청(Man Chung Han),강흥식(Heung Sik Kang),한준구(Joon Koo Han),임정기(Jung Gi Im),최병인(Byung Ihn Choi) 한국의학교육학회 1989 Korean journal of medical education Vol.1 No.1
Recently, computers are more and more widely used in many aspects of medicine, including education, and using computers to assist in traditional learning has many advantages. Authors developed Computer Assisted Learning (CAL) systems, which were consisted of Apple II computer and VTR controlled by the computer to present X-ray images and meticulously designed questions with computer aided feed back alternately to facilitate the understanding of the students. So authors present the one of the CAL program. Bone and Joint Radiology , in detail to introduce the perspective of the system and discuss the benefit of the CAL system and the advantage and disadvantage of the image presentation by the VTR. With recent advance in computer technology, presentation of the better quality images and random access to the image files are enabled that CAL system vill give greater benefit to the traditional education and the development of the better designed CAL system and program is expected.