간경변증 환자에서 Escherichia coli 균혈증 합병 시 간기능 장애에 따른 C-reactive protein 생성 능력에의 영향

박완범,강철인,김동민,이기덕,장희창,김홍빈,오명돈,이효석,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : C-reactive protein(CRP)은 간에서 생성되는 급성 반응물질이다. 하지만 간부전증 환자에서 CRP의 반응이 간기능에 따라 어느 정도 영향을 받는지는 별로 알려진 바가 없다. 본 연구에서는 간기능에 따른 CRP 생성 능력을 평가하고자 하였다. 방법 : E. coli 균혈증이 있는 간경변증 환자 30명을 대상으로 하였고 간기능은 균혈증이 발생하기 전 2개월 이내에 측정된 혈청 빌리루빈, 혈청 알부민, 프로트롬빈시간, Child-Pugh 점수로 평가하였다. 대조군 A는 간질환이 없으면서 E. coli 균혈증이 발생한 환자 30명으로 하였고 대조군 B는 간경변증이 있으면서 급성 감염의 증거가 없는 환자 30명으로 하였다. 환자군과 대조군 간에 CRP의 최대값을 비교하였다. 결과 : CRP의 최대값은 환자군에서 7.3±5.0㎎/dL, 대조군 A에서 17.9±8.3㎎/dL로 환자군에서 유의하게 낮았다.(P<0.001). 간경변증 환자에서 CRP의 생성은 Child-Pugh 점수에 비례하여 감소하였으나(P=0.004) Child=Pugh class C의 간기능을 가진 환자군에서도 대조군 B와 비교하여 의미있는 CRP의 생성을 보였다(5.3±3.2 vs. 0.5±0.4㎎/dL, P<0.001). 결론 : 간기능부전 환자에서 CRP 반응은 간기능 저하 정도에 따라 둔화되지만 심한 간기능 장애를 가진 환자에서도 CRP의 생성은 유지된다. Background : C-reactive protein (CRP) is an acute phase reactant produced in the liver. To assess the influence of liver dysfunction on the production of CRP, we evaluated CRP response to E. coli bacteremia in patients with or without liver cirrhosis (LC). Methods : 30 LC patients who developed spontaneous peritonitis with E. coli bacteremia were enrolled in the study. Baseline values of total bilirubin, serum albumin, and prothrombin time were obtained within 2 months prior to infection. Liver dysfunction was categorized according to the Child-Pugh score. 30 patients with E. coli bacteremia who had no underlying liver dysfunction were included as a control group. Matched-control of 30 LC patients without evidence of acute infection was also included. The peak CRP values were compared among the groups. Results : In the patients with E. coli bacteremia, the mean value of peak CRP was 7.3 (+/- 5.0) ㎎/dL in LC patients, 17.9 (+/- 8.3) mg/dL in patients without liver dysfunction (p<0.001). In the advanced LC patients with Child-Pugh class C, the level of CRP was 5.2 (+/- 3.3) ㎎/dL in patients with E. coli bacteremia, 0.5 (+/- 0.4) ㎎/dL in patients without acute infection (P<0.001). Child-Pugh score had correlation with decrease of CRP (linear regression test, P=0.004). Conclusion : CRP response during E. coli bacteremia was attenuated but maintained even in patients with advanced liver dysfunction.

접착제 미 사용시 치면열구전색제로서의 유동성 복합레진 평가

권호범,김명진,신철환,김지연,박기태 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

본 연구의 목적은 유동성 복합레진을 치면열구전색제로 사용할 수 있는지 여부를 평가하는 것이다. 세 종류의 유동성 복합레진(Filtek Flow, Tetric Flow, Charmfil Flow)과 한 종류의 filled sealant(Ultraseal XT plus)가 사용되었다. 주사전자 현미경을 이용하여 세 종류의 유동성 복합레진 및 filled sealant의 resin tag 형성 양상을 비교하였다. 미세누출 평가를 위해 발거된 사람의 소구치 54개를 각각 18개씩 무작위로 세 군으로 배분하였다. 각 군마다 통상의 filled sealant 와 한 가지씩의 유동성 복합레진을 교합면 열구에 도포하였다. 치아들은 thermocycling(5˚ ± 2℃와 55˚ ± 2℃ 사이에서 30초씩 1200회 시행) 후 48시간 동안 1% methylene blue 용액에 보관하였다. 각각의 치아를 절단하여 미세누출 정도를 관찰하였다. 세 종류의 유동성 복합레진 및 filled sealant는 유사한 resin tag 형성양상을 보였다. 세 종류의 유동성 복합레진은 각각 filled sealant보다 현저히 더 많은 미세누출을 보였다. 세 종류의 유동성 복합레진 간의 미세누출 정도는 유사하였다. 유동성 복합레진은 통상의 filled sealant와 비교해볼 때 보다 많은 미세누출을 야기할 수 있으므로 치면열구전색제로 적절하지 않다. The aims of this study were to determine if flowable composites can be used as pit and fissure sealants without bonding agents. Three flowable composites(Filtek Flow, Tetric Flow, Charmfil Flow) and a filled sealant (Ultraseal XT plus) were used. The pattern of resin tag formation in the four sealant meterials were compared using SEM. For the microleakage assessment, 54 extracted human premolar teeth were randomly divided into 3 groups containing 18 premolars each. In each group, a conventional filled sealant and one of the three flowable composites were applied to occlusal fissures. The teeth were thermocycled(1200 cycles between 5˚± 2℃ and 55˚± 2℃ with a dwell time of 30 seconds) and immersed in a 1% methylene blue solution for 48 hours. Each tooth was sectioned and examined to determine the extent of dye penetration. Three flowable composites and a filled sealant showed a similar resin tag formation pattern. The three flowable composites showed significantly more microleakage in each group than the filled sealant. The level of microleakage was similar in the three flowable composites. Flowable composites are not recommended as pit and fissure sealants because more microleakage can occur even when occlural fissures are mechanically widened.

N-아세틸시스테인 투여후 발생한 급성 무기폐 : 증례보고

이광범,안용미,이철승,최준석,박천희 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

Causes of atelectasis under general anesthesia are tracheal foreign body, blood clot, aspiration of bronchial secretion, one-lung ventilation and relative predominance of parasympathetic system. N-acetylcysteine is mucolytic agent which improves the capability of sputum drainage. After administration of N-acetylcysteine, an increased volume of liquified bronchial secretions may occur. When cough is inadequate, the airway must be maintained open by mechanical suction. In case that is a mechanical block due to local accumulation, the airway should be cleared by endotracheal aspiration. A 49-year-old female was admitted for bilateral laparoscopic oophorectomy due to ovarian tumors. There was not any problem during a general anesthesia induction. After instillation of N-acetylcysteine into endotracheal tube, acute atelectasis was developed in right lower lung.

에이즈 환자에서 발생한 조류형결핵균 뇌수막염 1예

이기덕,박완범,정혜승,강철인,김동민,김홍빈,오명돈,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

에이즈 환자의 중추신경계 합병증으로 에이즈 바이러스 자체에 의한 합병증, 기회감염, 종양 등이 있다. 저자들은 전신긴장간대발작을 일으킨 31세 남자 에이즈 환자에 발생한 조류형결핵균 뇌수막염을 조직학적 및 미생물학적으로 증명하고, 항비결핵미코박테리아 약제를 고농도로 투여하여 치료하였다. 조류형결핵균 뇌수막염은 결핵성 뇌수막염으로 잘못 진단되면 치명적인 결과를 초래할 수 있으므로, 조직검사를 포함한 적극적인 검사가 필요하다. We report a case of Mycobacterium avium-intraceliuiarae meningoencephalitis found in a 31-year-old patient with AIDS and preexisting disseminated Mycobacterium avium-intracellularae infection. He had been taking highly active antiretroviral therapy and antimycobacterial medications when he developed generalized tonic-clonic seizure. Repeated workups including blood and cerebrospinal fluid examinations and magnetic resonance image (MRI) of the brain revealed nondiagnostic. The diagnosis was made by stereotactic brain biopsy of the nodule, which was detected 9 month after the first seizure attack in brain MRI. Acid-fast bacilli were observed on microscopic exam. Mycobacterium avium-intracellularae was isolated from the biopsy specimen.

Laser Diode Tester 개발과 비젼 피드백을 이용한 위치 보정

김재희,유철우,박상민,유범상 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4

The development of LD(Laser Diode) tester and its control system based on the graphical programming language(LabVIEV) is addressed. The LD tester is used to check the optic power and the optic spectrum of the LD Chip. The emitter size of LD chip and the diameter of the Detector(optic fiber and photo diode) are very small, therefore the test device needs high accuracy. But each motion part of the test device could not accomplish high accuracy due to the limit of the mechanical performance. So, an image processing with machine vision is proposed to compensate for the error. By adopting our method we can reduce the error of position within ±5μm.

Human Papillomavirus에 감염된 에이즈 환자에게 발생한 항문암 2예

이창섭,박완범,이기덕,장희창,강철인,박소연,김지현,김홍빈,오명돈,최강원 대한감염학회 2005 감염과 화학요법 Vol.37 No.1

We report two cases of anal cancer in patient with acquired immunodeficiency syndrome infected by human papillomavirus (HPV). One patient presented with huge anal abscess of long duration which developed after incomplete resection of anal warts 2 years ago and the other patient presented with anal bleeding. They were diagnosed as having anal squamous cell carcinoma. Highly oncogenic HPV 69 and 16 were detected by HPV-DNA chip on the previous specimen of warts and anal cancer tissue, respectively. The possibility of anal cancer should be considered in patients infected with human immunodeficiency virus who present anal problems such as anal abscess, anal bleeding, or condyloma accuminatum in anus. 항문암은 HIV 감염자에게 발생하는 빈도가 비감염자에 비해 더 높다. HIV 감염자에게 항문암의 발생 빈도가더 높은 까닭은 항문 성교와 이로 인해서 발생하는 human papillomavirus (HPV) 감염이 이들 환자에게 더 흔하기 때문이라고 생각한다. 항문의 농양, 첨규 콘딜로마로 내원한 HIV 감염자에게서 항문암을 진단하였으며, 이환자로부터 2년 전에 수술로 떼어낸 첨규 콘딜로마 조직에서 HPV 유전형 69를 발견하였다. 또한, 항문 출혈로병원을 방문한 HIV 감염자에게서 항문암을 진단하였으며, 조직 생검으로 얻은 종양 조직에서 HPV 유전형 16를발견하였다. HIV 감염자에게 항문의 농양, 첨규 콘딜로마, 항문 출혈 등의 임상 증상이 발생하면 HPV와 관련된항문암을 감별해야 하겠다.

Inter-Laboratory validation of alternative methods of KeraSkin model for the assessment of skin irritation

( Cheol Beom Park ) 한국동물실험대체법학회 2009 한국동물실험대체법학회 학술대회집 Vol.2009 No.1

Various industrial companies and industry associations, scientists and animal welfare groups have been concerned that relevant and reliable in vitro alternatives methods should replace the Draize eye irritation test and skin test. Numerous in vitro assay have been developed over the last twenty years in response to this need. Alternative skin irritation test was performed using 9 irritant and 9 non-irritant chemicals(ECVAM SIVS, May 2007) for KeraSkin(TM). The two main endpoint measured for KeraSkin(TM) was cell viability via MTT and Interleukin-1alpha release. Three laboratories in Korea were participated in the inter-laboratory validation. In the inter-laboratory validation study for KeraSkin(TM), sensitivity, specificity and accuracy of KeraSkin(TM) were 88.9%, 59.3% and 74.1%, respectively. Based on these results, It is suggested that this Kearskin(TM)model is very useful for alternative skin irritation test.

MODAL CHARACTERISTIC ANALYSIS OF THE APR1400 NUCLEAR REACTOR INTERNALS FOR SEISMIC ANALYSIS

Park, Jong-Beom,Choi, Youngin,Lee, Sang-Jeong,Park, No-Cheol,Park, Kyoung-Su,Park, Young-Pil,Park, Chan-Il Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.5

Reactor internals are sensitive to dynamic loads such as earthquakes and flow induced vibration. Thus, it is essential to identify the dynamic characteristics to evaluate the seismic integrity of the structures. However, a full-sized system is too large to perform modal experiments, making it difficult to extract data on its modal characteristics. In this research, we constructed a finite element model of the APR1400 reactor internals to identify their modal characteristics. The commercial reactor was selected to reflect the actual boundary conditions. Our FE model was constructed based on scale-similarity analysis and fluid-structure interaction investigations using a fabricated scaled-down model.

Osteopromotion With Synthetic Oligopeptide-Coated Bovine Bone Mineral In Vivo

Park, Jun-Beom,Lee, Jue-Yeon,Park, Ho-Nam,Seol, Yang-Jo,Park, Yoon-Jeong,Rhee, Sang-Hoon,Lee, Sang-Cheol,Kim, Kyoung-Hwa,Kim, Tae-Il,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Chung, Chong-Pyo Wiley (John WileySons) 2007 Journal of periodontology Vol.78 No.1

Enhanced Bone Regeneration in Beagle Dogs With Bovine Bone Mineral Coated With a Synthetic Oligopeptide

Park, Jun-Beom,Lee, Jue-Yeon,Park, Yoon-Jeong,Rhee, Sang-Hoon,Lee, Sang-Cheol,Kim, Tae-Il,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Chung, Chong-Pyoung Wiley (John WileySons) 2007 Journal of periodontology Vol.78 No.11

<P>BACKGROUND: Recombinant human bone morphogenic protein-2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3-wall defect model and the clinical implications. METHODS: The second and fourth mandibular premolars of four adult beagle dogs were extracted bilaterally, and the extraction sites were allowed to heal for 2 months. An L-shaped defect was prepared at the central part of the extraction site with a round bur on a low-speed motor. Peptide-coated bone mineral was implanted on one side, and uncoated bone mineral was implanted on the other side. The membrane was tucked underneath the mobilized lingual flap. New bone formation at the test and control sites was determined at 4 weeks. RESULTS: No specimen revealed any evidence of infection or foreign body reaction, and all wounds showed a good healing response. Sites augmented with peptide-coated bone mineral and uncoated mineral exhibited excellent maintenance of the ridge contour. There was more new bone at sites with peptide-coated bone mineral than at control sites. The new bone in sites with peptide-coated bone mineral was deposited evenly around the graft material, and bone mineral was integrated fully into the new bone. CONCLUSION: Deproteinized cancellous bovine bone coated with synthetic oligopeptides enhanced new bone formation, and it seemed to be a better material for guided bone regeneration in the beagle L-shaped defect model.</P>