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Bae, Gi-Sang,Kim, Dong-Goo,Jo, Il-Joo,Choi, Sun-Bok,Kim, Myoung-Jin,Shin, Joon Yeon,Kim, Dong-Uk,Song, Ho-Joon,Joo, Myungsoo,Park, Sung-Joo ELSEVIER 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.69 No.-
<P><B>Abstract</B></P> <P>Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Female C57/BL6 Mice were intraperitoneally injected with supramaximal concentrations of cerulein (50 μg/kg) hourly for 6 h to induce AP. DMSO or DN was administered intraperitoneally, then mice were sacrificed 6 h after the final cerulein injection. Administration of DN increased pancreatic HO-1 expression through activation of activating protein-1, mediated by mitogen-activated protein kinases. Furthermore, DN treatment reduced the pancreatic weight-to-body weight ratio as well as production of digestive enzymes and pro-inflammatory cytokines. Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage. Additionally, DN treatment inhibited neutrophil infiltration into the pancreas via regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) by HO-1. Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Desoxo-narchinol-A (DN) is a natural compound of HO-1 inducer in pancreas. </LI> <LI> Mechanism of DN-induced HO-1 is mediated by MAPK/Activator Protein-1/HO-1 signaling. </LI> <LI> DN-induced HO-1 blocks neutrophil infiltration into pancreas via inhibition of CXCL2. </LI> <LI> DN inhibits cerulein-induced acute pancreatitis (AP) and AP-associated lung injury. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
宋昊埈 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2
This study was investigated the inhibitory activity of RADIX ASARI (RA) on type I immediate hypersensitivity of the anaphylactic type. RA inhibited compound 48/80-induced anaphylaxis 100% with a dose of 0.5 g/㎏ body weigh at 1 h before or 5 and 10 min after injection of compound 48/80. RA also exhibited the dose-dependent inhibitory effect on compound 48/80-induced, Substance P-induced and anti-DNP IgE-induced histamine release from rat peritoneal mast cells. These results suggest the possibility that RA induced inhibition of type I allergic reaction is regulated by histamine.
백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.
건설 PMIS 실태와 건설 CALS 연계 및 확산방안에 관한 연구
송병관,박영호,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
This study has aimed for wide spreading of CALS in Construction Industry. The PMIS produce original information of construction project linked to CALS. So, this study have investigated present state of PMIS in construction industry, and reviewed the interface to construction CALS. And, key issues of adopting PMIS & CALS to whole construction and its related industry have been found. Additionally, it has also found improvement issues of construction system and political supports for PMIS adoption.
Song,Won-Seob,Chi,Hyung-Joon,Rim,Yo-Sup,Yoon,Jae-Ho 한국자원식물학회 2002 Plant Resources Vol.5 No.1
The material of Rhodiola sachatinensis collected from an alpine region of the west-northern China. For analysing the effect, 1 used Rhodiola sachatinensis s rhizome and cultivated callus. In EtOAc, BuOH, H₂0separation the plant showed strong antioxidative activity, but not in Hexane. The radical scavenging effect of EtOAc(RC50, 35(g), BuOH(RC50, 43(g), H₂0(RC50, 50(g) fraction and MeOH extract(RC50, 50(g) of the Rhodiola sachatinensis was comparable to that of synthetic antioxidant BHA(RC50, 14(g) and α-Tocopherol(RC50, 12(g). Total amino acid concentration of plant of In nature condition were 18,009ppm, and major components were arginine, glutamic acid, aspartic acid and valine. The ratio of essential/total amino acid on plant of In nature condition was 46.93%. Total amino acid concentration of callus of In vitro condition were 32,435ppm, and major components were valine, histidine, lysine and leucine. The ratio of essential/total amino acid on callus of In vitro condition was 56.07%. was 56.07%.
宋昊埈,河顯秀,金台現,辛民敎 대한본초학회 1998 大韓本草學會誌 Vol.13 No.2
We studies inhibitation effect of IgE release in the human B cell line(U266B1) and in the serum and spleen cell of mouse that has been immunized by antigen in order to find antiallergic effect of Fructus Xanthii (FX). We have some findings as below. 1. IgE release in serum was inhibited dose dependently in case of administering FX orally in the mouse immunized. 2. IgE release in serum was inhibited dose dependently in case of injecting FX into abdomen in the mouse immunized. 3. When we take LPS+IL-4 way in the mouse spleen cell, IgE release was less than LPS way. 4. When we take LPS+IL-4 way in the human B cell line (U266B1), IgE release was less than LPS way.
Hydroxy Apatite가 피복된 치과매식체의 주위골조직 반응에 관한 조직학적 연구
송준기,허성주,조인호 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-
Even if we can recover the function of mastication, pronunciation and esthetic using the fixed or removable prosthesis in the loss of teeth or hard tissue in the oral cavity, we use several kinds of implants in order to solve the problem which can be occured when we can't install the denture because of excessive bone resorption or psychlogical affairs. At present Titanium implant plays a major role in this field and has osseointegrated. And the study on the modern material is going on, that result in developing and using the implant which is coated with HA, bone induced material. In this, I studied histologically the change of the bone tissue which is occured when three kinds of HA coated implants. Such as Integral, Sustain, Biovent implanted into mandible of dog and got a 8-weeks healing period. I got the conclusion as follows : 1. Most of the implant which is covered with serveral kinds of HA coating implant in bone affter 8 weeks being implanted and has osseointegrated, partially converted into the connective tissue. 2. Biovent formed the connective tissue in the perforated area of inferior alveolar canal and has osseointegrated.
宋昊埈,金裕鎭 대한본초학회 1996 大韓本草學會誌 Vol.11 No.1
This study aims to survey through literature the origin of Celastraceae (belonging to the class of wild spimach) which grow in nature or are cultivated in Korea. The results of survey can be summarized as follows; 1. The total 40species of wild spinach surveyed consisted of 7 Celastrus, 32 Euonymus, 1 Tripterygium; Euonymus occupies 80% of these species. 2. The wild spinaches of the Korean origin were found to be 3genuses, 40species, among which the herb species occupied about 56% 3. The herb species out of the wild spinaches were 7 ones according to the nomenclature of Korean oriental medicine. They were 24 root species, 20 leaf species. 3 seed species, 20 cortex species, 9 fruit species, 6 exocarpium species, I flora species. Thus it was noticed that radix was the main kind. 4. In view of their traits, they were 10 antife brile species, 5 neutral in nature species and 12 hot-natured species. 5. In view of their dfficacy and following for duplicate nomenclature, they can be classified into 6 heat-clearing and detoxifying herbs, 6 insecticides, 16 expel wind alleviate itching herbs, 8 promote blood circulation hemostatic herbs, I gastrotomic herbs 9 promote diuresis to reduce edema herbs and 1 invigratic herbs. 6. The toxic herbs were lekondung, kijunyu, etc. However, expect lekondung, their toxity was weak and they accounted of 48% of the total herb plants. As discussed above the herb plants account for 56% of the total wild sponaches. Among them the root species are ranked atop. It is conceived that these herb plants should be surveyed more for their clinical efficacy.