유아 사회지능에 나타나는 유동적 사회지능과 결정적 사회지능의 발달 경향에 관한 연구

양승희,임명희 한국보육학회 2012 한국보육학회지 Vol.12 No.1

The purpose of this study was to measure how the social intelligence of the young children is developing in proportion to their ages, gender. Both Fluid Social Intelligence and Crystallized Social Intelligence was the children's social intelligence was checked by their classroom teachers using the Teacher Rating Scale of Social Intelligence for Young Children(Yang, & Park, 2005), and then Fluid Social Intelligence by social sensitivity, social expressivity, and social fluidity, Crystallized Social Intelligence by social knowledge one respectively. Social intelligence scale developed were examined with the use of a nation-wide kindergarden and childcare center sample of 1,238 young children from classes of 3-, 4- and 5-year-olds. The results of this study are as follows; First, there has been a significant difference between Fluid Social Intelligence and Crystallized Social Intelligence in proportion to their ages. Second, Fluid Social Intelligence and Crystallized Social Intelligence have statistically significant in proportion to their gender. 본 연구는 유아 사회지능이 연령, 성별에 따라서 어떻게 발달하는가를 양승희, 박낭자(2005)의 교사 평정용 사회지능 평가도구로 유동적 사회지능(Fluid Social Intelligence)과 결정적 사회지능(Crystallized Social Intelligence)을 측정하였다. 유동적 사회지능 검사는 사회지능 검사도구의 사회적 민감성(social sensitivity)・사회적 표현성(social expressivity)・사회적 유연성(social fluidity) 검사로, 결정적 사회지능 검사는 사회지능 검사도구의 사회적 지식(social knowledge) 검사로 측정하였다. 연구대상은 유치원과 어린이집에서 표집된 1,238명의 만 3세, 만 4세, 만 5세 학급 유아를 대상으로 유아 사회지능 발달 경향을 분석하였으며, 결과는 다음과 같다. 첫째, 유아의 연령이 증가함에 따라 사회지능의 유동적 사회지능과 결정적 사회지능은 유의미한 차이가 있었다. 둘째, 유아의 성별에 따라 유아 사회지능의 유동적 사회지능과 결정적 사회지능은 유의미한 차이가 있었다.

공여자 기원 미성숙 수지상세포의 투여와 CD40/CD154 경로차단이 이식장기의 장기 생존에 미치는 영향

양승희,성은영,이정은,신재현,Jin Ji Zhe,Odongua Sangidorj,김연수 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.2

Background:Dendritic cells (DC) are pivotal antigen presenting cells and serve a unique role in initiating immunity. To test the hypothesis that pre- immunization of recipient with certain DC subsets of donor origin can influence graft outcome. Methods:We have studied the effects of immunization with allogeneic CD4+CD11c+ (MDC) and CD8+CD11c+ (LDC) DCs on the allograft response. Results:Both immature MDC and LDC subsets from DBA/2 were able to prime naïve allogeneic C57BL/6 (B6) T cells in MLR. In vitro allogeneic T cell responses were attenuated by the addition of anti-CD154 mAb into the culture. T cells from B6 mice that received DBA/2 MDC intravenously 4 weeks before testing mounted weaker MLR driven cell proliferation than T cells from LDC pretreated B6 mice. Consistent with the MLR results, combined pretreatment with MDC, but not LDC, plus anti- CD154 mAb produced donor-strain specific long- term graft survival and induced tolerance while treatment with LDC plus anti-CD154 mAb created minimal prolongation of allograft survival in a pancreas islet transplant model (DBA/2→B6). The beneficial effects exerted by MDC and anti-CD154 mAb pretreatment were correlated with TH1 to TH2 immune deviation and with the amplified donor-specific suppressive capacity by recipient CD4+CD25+T cells. Conclusion:These findings highlight the capacity of MDC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor specific tolerance. 목 적:수지상세포 (DC)는 체내의 가장 중요한 항원제공세포이며 동종이식 면역반응의 활성화에 직접적인 역할을 한다. 본 연구에서는 공여자 기원의 특이 DC군의 수혜자에 대한 전처치가 이식장기의 장기생존에 영향을 미친다는 가정을 증명하고자 하였다. 방 법:실험생쥐의 골수에서 추출한 미성숙 수지상 세포를 동종항원에 반응하는 CD4+CD11c+ (MDC)와 CD8+CD11c+ (LDC) DC를 수혜자에게 전처치하고 피부와 췌장도세포 이식을 수행하였다. 결 과:DBA/2의 비장에서 분리한 MDC와 LDC는 미성숙 상태였으며 혼합 배양검사에서 C57BL/6 (B6) 기원의 동종항원 반응성 T 림프구를 증식시켰으며 anti-CD154 mAb의 투여로 그 증식 정도를 억제할 수 있었다. B6 생쥐에 DBA/2의 MDC나 LDC를 전처치한 후 DBA/2 기원의 췌장도세포를 이식하였을 때 이식장기의 생존에는 영향을 미치지 않았다. DC 전처치시 anti-CD154 mAb를 이용하여 CD40/CD154의 경로를 차단하였을 경우에 MDC와의 병용 치료시 이식장기의 장기 생존과 공여자 특이 면역관용이 유도됨을 확인할 수 있었으나 LDC와의 병용치료시에는 이식장기의 장기 생존이 유도되지 않았다. 이러한 MDC와 anti-CD154 mAb의 병용치료 효과는 동종면역 반응의 TH1에서 TH2로의 T 림프구 반응성 변화와 CD4+CD25+T 림프구의 공여자 특이 면역조절능의 활동성 증가에서 기인하였음을 확인하였다.

Active maintenance of endothelial cells prevents kidney fibrosis

양승희,김용철,안정남,김진혁,이주호,이희윤,조주연,백진호,오윤규,임춘수,김연수,이정표 대한신장학회 2017 Kidney Research and Clinical Practice Vol.36 No.4

Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.Methods: We used a unilateral ureteral obstruction mouse model of kidney fibrosis to determine whether inhibition of sEH activity reduces fibrosis, the final common pathway for chronic kidney disease. Results: sEH activity was inhibited by continuous release of the inhibitor 12-(3-adamantan-1-ylureido)-dodecanoic acid (AUDA) for 1 or 2 weeks. Treatment with AUDA significantly ameliorated tubulointerstitial fibrosis by reducing fibroblast mobilization and enhancing endothelial cell activity. In an in vitro model of endothelial-to-mesenchymal transition (EndMT) using human vascular endothelial cells (HUVECs), AUDA prevented the morphologic changes associated with EndMT and reduced expression of fibroblast-specific protein 1. Furthermore, HUVECs activated by AUDA prevented the epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells in a co-culture system.Conclusion: Our findings suggest that regulation of sEH is a potential target for therapies aimed at delaying the progression of kidney fibrosis by inhibiting EndMT and EMT.

Flame retardancy polyurethane foam prepared from polyurethane depolymerization polyol

양승희,정문근 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

肝性氏睡의 臨床的 觀察 및 看護

梁承姬,趙敬順 中央醫學社 1971 中央醫學 Vol.21 No.6

Hepatic coma is not rare seen in Korea due to increase of tendency of acute and chronic hepatopathy which it may be developed from to take a her's medicine and hepatotoxic drugs recently. For 3 years, from 1968 to 1970. 30 cases of hepatic coma hospitalized in Pep. of Int. Med. Chung nam Medical Center were clinically and nurselly studied. a. Radio of developing of hepatic coma among the admitted patients of G-1 cases was about 13%. b. In sex radio, the man and female is 3 : 1. c. The underlying disease of the hepatic coma included cirrhosis of the liver 23 patients(76. 7%, hepatoma 2 patients (6.7%), drug induced hepatitis 2 patients (6.7%), fluminating hepatitis 2 patients (6.7%), acute hepatitis 1 patient (3.3%), The precipitaing factors of hepatic coma were 17 cases of upper G-I bleeding, abdominal synthesis 2 cases, infection 2 cases, 2 cases of sedation and analgesic among the 23 cases or chronic hepatopathy. d. There were, fever history more than 38°C in half cases and leucocytosis (more than 10, 000mm3) and shift to in 60% each. Urine albumin was detected in all cases except 2 cases. e. Liver function tests revealed diffuse hepatocellur damage but it may be helpful to diagnosis that acute elevation of serum bilirubin, lowering of serum cholesterol, marked prolongation of prothrombin time. f. Mortality was very high but may depend upon underling disease and the causes of precipitating factors.

Different Target Vessel May Have Different Prognosis following Chronic Total Occlusion Intervention

양승희,박지영,최재웅,유승기,박성훈 대한내과학회 2018 대한내과학회 추계학술발표논문집 Vol.2018 No.1

농어촌지역 직장인의 음주실태

양승희,김지희 한국디지털정책학회 2012 디지털융복합연구 Vol.10 No.10

중소병원 간호사의 긍정심리자본, 의사소통능력이 임상수행능력에 미치는 영향

양승희 융복합지식학회 2025 융복합지식학회논문지 Vol.13 No.3

본 연구는 중소병원 간호사의 긍정심리자본, 의사소통능력이 임상수행능력에 미치는 영향을 주는 요인을 알아보기 위한 서술적 조사연구이다. 일반적 특성 및 임상수행능력의 차이를 검증한 결과 연령, 교육수준, 결혼상태, 종교, 직위, 급여, 현 부서 근무경력, 총 임상경력에서 유의한 차이가 있었다. 대상자의 긍정심리자본, 의사소통능력, 임상수행능력 간의 상관관계를 분석한 결과 긍정심리자본은 의사소통능력, 임상수행능력과 통계적으로 유의미한 양의 상관관계를 보였고, 의사소통능력은 임상수행능력과 통계적으로 유의미한 양의 상관관계를 보였다. 즉, 긍정심리자본과 의사소통능력이 높아지면 임상수행능력도 커지는 것을 알 수 있었다. 중소병원 간호사의 임상수행능력에 영향을 주는 요인을 파악하고자 위계적 다중회귀분석을 실시한 결과 긍정심리자본과 의사소통능력이 임상수행능력에 유의하게 높은 것으로 조사되었다. 즉, 긍정심리자본과 의사소통능력이 높을수록 임상수행능력이 커지는 것으로 나타났고, 의사소통능력이 더욱더 큰 영향을 미치는 것으로 나타났으며, 57.3% 설명력을 나타냈다. This study is a descriptive research study to find out the factors that affect the clinical competence ability of nurses in small and medium-sized hospitals. As a result of verifying the difference between general characteristics and clinical competence ability, there were significant differences in age, education level, marital status, religion, position, salary, current department work experience, and total clinical experience. As a result of analyzing the correlation between positive psychological capital, communication ability, and clinical competence ability of the subject, positive psychological capital showed a statistically significant positive correlation with communication ability and clinical competence ability, and communication ability showed a statistically significant positive correlation with clinical competence ability. In other words, it was found that the higher the positive psychological capital and communication ability, the greater the Clinical competence ability. As a result of conducting hierarchical multiple regression analysis to identify the factors affecting the clinical competence ability of small and medium-sized hospital nurses, it was found that positive psychological capital and communication ability were significantly higher in clinical competence ability. In other words, the higher the positive psychological capital and communication ability, the greater the clinical competence ability, the greater the communication ability, and the 57.3% explanatory power.

실험적 항기저막 사구체신염에재조합 Uteroglobin 투여가 미치는 영향

양승희,김유영,정현주,이상구,이세한,김성균,김연수,정남현,김현리 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4

Glomerulonephritis(GN) is characterized by cognate immune responses against self or non-self antigen. It is suggested that the crescentic GN is a manifestation of cell-mediated immune response akin to delayed type hypersensitivity. Uteroglobin(UG) is a steroid-dependent, immunomodulatory, and cytokine-like protein. It was reported that UG prevented fibronectin(Fn) deposition in the glomeruli of normal mice to form Fn-UG heterodimers that competed with Fn self-aggregation. We hypothesized that UG would prevent the development of experimental GN induced by anti-glomerular basement membrane globulin(anti-GBM Ab) in mice through immunomodulatory properties. GN was induced by intravenous injection of 4.5 mg rabbit anti-GBM Ab to mice(C57BL/6). Renal injury was evaluated at 7, 14, and 21 days thereafter. UG-treated mice(n=10) were received for 3 days(0.5 mg/mouse/day) beginning 1 hour after anti-GBM Ab injection. Also, disease-control mice(n=10) were received PBS for 3 days after anti-GBM Ab. Proteinuria was significantly reduced in the mice treated with UG when compared with the disease-control mice after 7 and 14 days of anti-GBM Ab injection. The amount of proteinuria was similar between UG treated and normal control mice. The mesangial matrix expansion and cellular crescent were markedly attenuated by the injection of UG. The proliferative responses of mesangial cells(C57BL/6) to LPS were blunted with the addition of UG in dose-dependent manner. In this study, we revealed the preventive effects of UG in the experimental model of glomerulonephritis. This result in turn could provide the basis for the treatment of human disease such as chronic glomerulonephritis. 목 적:면역복합체 침착으로 인한 사구체신염은 우리나라 말기신부전의 중요한 원인이다. 최근 면역조절기능을 가진 uteroglobin(UG)을 유전적으로 결핍시킨 동물모델에서 인체의 IgA 신염과 같은 사구체신염의 발생이 보고된 바 있다. 저자들은 생쥐에서 항기저막 사구체신염(aGBM- GN)을 발생시키고 인체 재조합 UG를 이용하여 신염의 발생에 UG가 미치는 영향을 확인하고 신염 억제기전을 파악하고자 하였다. 방 법:토끼에서 생산한 Anti-GBM Ab 4.5 mg을 8주령의 생쥐(C57BL/6)에 정맥주사하여 aGBM-GN을 유발시킨 후, UG를 투여한 치료군, 질환대조군, 정상대조군에서 신염의 정도를 비교하였다. 또한 생쥐의 메산지움세포를 LPS로 자극한 후 UG에 의한 세포증식의 저해정도를 비교하였다. 결 과:신염 유도 후 7일째 치료군은 정상대조군에 비해 요단백량/creatinine 값은 차이를 나타내지 않았지만, 질환대조군에 비해서는 유의한 감소를 나타내었다. 이러한 UG의 효과는 사구체신염이 유도된 14일째까지 유지되었으며, 21일째에는 치료군과 질환대조군에서의 요단백/creatinine 값이 정상대조군에 비해 감소하였다. 조직학적으로 신염이 유도된 7일째, 질환대조군에서는 메산지움세포의 증식과 사구체의 50% 이상에서 세포성 반월상이 관찰되었으나, 치료군은 정상대조군과 유사한 조직학적 소견을 보였다. 생쥐 메산지움세포를 LPS로 자극한 후 UG를 투여하였을 경우 LPS에 의한 세포 증식효과는 유의한 감소를 보였다. 결 론:실험적으로 유도된 항기저막 사구체신염에 인체 재조합 UG를 투여함으로써 항기저막 사구체신염의 발생을 억제하였으며, 그 기전으로 메산지움세포 활성화 억제 가능성을 제시하였다. 이러한 결과는 신질환 진행 고위험군 집단의 유전자치료에도 이용될 수 있는 근거를 제시하였다고 할 수 있다.

포스트모더니즘 시대의 유아교육

양승희 한국보육학회 2002 한국보육학회지 Vol.2 No.2

Early childhood education is now at the turning point to be changed entirely. As if our society change has continued, early childhood education should be changed. Early childhood education needs to be changed more because these days our society has altered to postmodern society that has the importance of the knowledge and information in the industrial society based on labor values. Therefore, early childhood education must immediately be changed by coming postmodern society. As, especially, postmodern society is necessary for creative persons being able to have various and logical thoughts and independent persons being able to enjoy the meanings of their life, the practice of education should be accomplished in the aspects of understanding about the life of young children. Then, the whole changes of education may make the life of young children be more affluent and valuable.