당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

최우정,김동웅,신선호,이언정,최진영,신학수,조권일,이광석 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the "Deficiency in Origin and Excess in Superficiality(本虛表實)“points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis

Jung, Gwon-Soo,Kim, Mi-Kyung,Choe, Mi Sun,Lee, Kyeong-Min,Kim, Hye-Soon,Park, Young Joo,Choi, Hueng-Sik,Lee, Ki-Up,Park, Keun-Gyu,Lee, In-Kyu American Society of Nephrology 2009 Journal of the American Society of Nephrology Vol.20 No.10

<P>The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by stimulating the generation and inhibiting the removal of matrix proteins. The small heterodimer partner (SHP) represses PAI-1 expression in the liver by inhibiting TGF-beta signaling, but whether SHP inhibits renal fibrosis is unknown. Here, unilateral ureteral obstruction (UUO) markedly increased the expression of PAI-1, type I collagen, and fibronectin but decreased SHP gene expression. Moreover, in kidneys of SHP-/- mice, the expression of PAI-1, type I collagen, fibronectin and alpha-smooth muscle actin (alpha-SMA) were higher compared with those in kidneys of wild-type mice. In addition, loss of SHP accelerated renal fibrosis after UUO. Adenovirus-mediated overexpression of SHP in cultured rat mesangial cells and renal tubular epithelial cells inhibited TGF-beta-stimulated expression of PAI-1, type I collagen, and fibronectin. SHP inhibited TGF-beta- and Smad3-stimulated PAI-1 promoter activities as well as TGF-beta-stimulated binding of Smad3 to its consensus response element on the PAI-1 promoter. Similarly, in vivo, adenovirus-mediated overexpression of SHP in the kidney inhibited the expression of UUO-induced PAI-1, type I collagen, fibronectin, and alpha-SMA. In summary, SHP attenuates renal fibrosis in obstructive nephropathy, making its pathway a possible therapeutic target for chronic kidney disease.</P>

Morphogenetic and neuronal characterization of human neuroblastoma multicellular spheroids cultured under undifferentiated and all-trans-retinoic acid-differentiated conditions

Gwon Soo Jung,Kyeong Min Lee,Jin Kyu Park,Seong Kyoon Choi,Won Bae Jeon 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.5

폐마스크 열분해 시 발생하는 유해 화학 물질 분석

유수진(Soo-Jin Yoo),권윤경(Yun-Gyeong Gwon),배수현(Soo-Hyeon Bae),이한별(Han-Byeol Lee),이정훈(Jung-Hun Lee),장효정(Hyo-Jung Jang),김동현(Dong-Hyun Kim) 호서대학교 공업기술연구소 2023 공업기술연구 논문집 Vol.42 No.1

본 연구에서는 폐마스크의 열분해 과정에서 발생하는 유해화학물질을 측정 및 분석하기 위해 2022년 3월 20일부터 2022년 10월 31일 까지 마스크 제조사 6종을 선정하여 GC를 이용하여 분석하였다. 덴탈 마스크 3종에서 총 10종의 화학물질이 검출됐다. 열분해시 발생되는 물질을 살펴보면 비말차단용 마스크(KF-AD) 분석결과 TCE 13,840ppm, 1,1,1-TCE 4,700~61,170ppm, MIBK 5,570~28,420ppm, Cyclohexanone 420~4750ppm, m-Xylene 16,250ppm, p-Xylene 99,450ppm, Acetone 47,790ppm, Methyl acetate 6,350ppm, n-propyl acetate 77,780ppm, EB 35,480ppm 이었다. KF-94 마스크 3종에서는 총 10종의 화학물질이 검출됐다. KF-94 마스크의 열분해 시 발생되는 물질 분석결과 TCE 23,940ppm, MIBK 4,630~42,800ppm, Cyclohexanone 6,780~8,860ppm, o-Xylene 17,000ppm, m-Xylene 28,730ppm, p-Xylene 17,220ppm, Acetone 29,410~51,940ppm, Methyl acetate 5,230~6,430ppm, n-propyl acetate 107,390ppm, EB 32,570~53,590ppm 검출되었다. 폐마스크의 열분해 과정에서 발생하는 물질을 분석한 결과, 인체에 유해한 영향을 미칠 수 있는 유해화학물질이 포함되어 있는 것을 확인하였다. In this study, six types of masks were selected from mask manufacturers and analyzed using GC to measure and analyze hazardous chemicals generated during the thermal decomposition process of respirators. A total of 10 types of chemicals were detected in three types of dental masks. Upon examining the substances generated during thermal decomposition, the results of the dental mask analysis were TCE 13,840 ppm, 1,1,1-TCE 4,700-61,170 ppm, MIBK 5,570-28,420 ppm, Cyclohexanone 420-4,750 ppm, m-Xylene 16,250 ppm, p-Xylene 99,450 ppm, Acetone 47,790 ppm, Methyl acetate 6,350 ppm, n-propyl acetate 77,780 ppm, and EB 35,480 ppm. A total of 10 types of chemicals were detected in three types of KF-94 masks. Results fromthe analysis of substances generated during the thermal decomposition of KF-94 masks showed TCE 23,940 ppm, MIBK 4,630-42,800 ppm, Cyclohexanone 6,780-8,860 ppm, o-Xylene 17,000 ppm, m-Xylene 28,730 ppm, p-Xylene 17,220 ppm, Acetone 29,410-51,940 ppm, Methyl acetate 5,230-6,430 ppm, n-propyl acetate 107,390 ppm, and EB 32,570-53,590 ppm. The results of the analysis of the substances generated during thermal decomposition of respirators revealed that they contained hazardous chemicals that could have harmful effects on the human body.

국내 Bi-modular charge system 개발현황

손수정(Soo-Jung Son),이원민(Won-Min Lee),권순길(Soon-Gil Gwon),정진영(Jin-Young Jung) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.5

지속성 외래 복막투석 환자에서 영양상태와 투석의 적절도

박미정(Mi Jung Park),이균상(Kyun Sang Lee),조민석(Min Seok Cho),김정기(Jeong Ki Kim),박병석(Byoung Seok Park),마성권(Seong Kwon Ma),고정희(Jung Hee Ko),나명윤(Myong Yun Nah),염충호(chung Ho Yeum),정권(Jung Gwon),김수완(Soo Wan Kim) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4

Purpose - Malnutrition is common in CAPD patients and depends on many factors such as dialysis-related and nondialysis-related factors. The present study aimed to assess nutritional status, dialysis adequacy and their relationships with overall mortality and morbidity. Methods - We studied 102 patients who had been receiving CAPD for at least 6 months. Dialysis adequacy was assessed by parameters derived from urea kinetic modeling(UKM) and nutritional status was assessed by serum biochemical measurement, normalized protein catabolic rate(nPCR), normalized protein equvalent of total nitrogen appearance(nPNA) and urea kinetic studies. Spearman's simple correlation and multiple linear stepwise regression analysis were used to assess correlation between dialysis adequacy and nutritional status in CAPD patients. We compared the differences between patients who suffered morbid events, defined as either an infectious complication or hospitalization, and patients who remained well. Results : The results showed that the total dialysis dose(total weekly Kt/Vurea ) has statistically significant correlation with nPCR(r=0.234, p=0.028), nPNA (r=0.246, p=0.021), total weekly creatinine clearance (WCC)(r=0.479, p=0.0001), serum albumin levels(r= 0.233, p=0.029), serum cholesterol(r=0.266, p=0.013), serum BUN(r=-0.290, p=0.006) and serum creatinine levels(r=-0408, p-0.0001). nPNA was positively correlated with serum cholesterol(r=0.217, p=0.045), serum transferrin(r=0.218, p=0.042) and serum ferritin levels(r=0.220, p=0.043). Patients who suffered morbid events had an old age(p=0.001), long duration of CAPD(p=0.0001), higher CRP(p=0.021), lower serum albumin level(p=0.020), lower hematocrit(p=0.049) and lower WCC(p=0.017). Conclusions: These results indicate that adequate dialysis is very important for the maintenance of adequant nutrition because nutritional status positively correlated with dialysis dose, which is best assessed by UKM. In addition, assessment of nutritional status and dialysis adequacy are important in predicting clinical outcomes in CAPD patients.

태양광발전 시스템용 인버터의 계통연계 제어

정영석(Young-Seok Jung),이정태(Jung-Thae Lee),정명웅(Myung-Woong Jung),유권종(Gwon-Jong Yu),송진수(Jin-Soo Song),최재호(Jae-ho Choi) 대한전기학회 1996 대한전기학회 학술대회 논문집 Vol.1996 No.7

신경아세포종을 동반한 비면역성 태아수종 1예

정대영,유영옥,황대진,김수평,박동춘,김대훈,남궁성은,이형근,조형권 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.1

Hydrops fetalis is diagnosed when abnormal fluid collections are manifest in two or more fetal compartmnets including abdominal ascite, pleural effusion, percardial effusion, skin edema, polyhydroamniosis and placental edema. Although fetal hydrops was historically most commonly associated with Rh blood group isoimmunization, the availability of Rh immunoglobulin has increased the proportion of fetuses affected due to nonimmune etiologies. Neuroblastoma is a malignant tumor which originates in the autonomous nervous system. Congenital neuroblastoma is the most common solid malignant tumor of the neonatal period, incidence ranges 1:10,000 of all live births, retroperitoneal space being the most frequent localization. We have experienced a case of nonimmune hydrops fetalis with neuroblastoma at 32 weeks of gestation in 39 year old woman and reported that with brief review of related literatures.

Simultaneous hemagglutinin subtyping andpathotyping of influenza A (H5N8) virus directly from clinical samples using adiagnostic microarray

Jung Hoon Kwon,Ji hoon Kim,Seung Yong Hwang,Seong Su Yuk,Erdene Ochir Tseren Ochir,Jin Yong Noh,Woo Tack Hong,Jei Hyun Jeong,Sol Jeong,Gyeong Bin Gwon,In Soo Choi,Chang Seon Song 대한수의학회 2015 대한수의학회 학술대회발표집 Vol.2015 No.-