Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

계단 오르기 동작시 계단 높이에 따른 하지 관절 모멘트의 변화 분석

은선덕 한국운동역학회 2003 한국운동역학회지 Vol.13 No.1

Eun, S-D. The effect of the stair heights on lower extremity joint moment in stair-ascent activity. Korean Journal of Sport Biomechanics, Vol. 13, No. 1, pp. 121-138. The purpose of this study was to investigate the effect of the stair heights on lower extremity joint moment in stair-ascent activity. Data were collected by 3-D cinematography, force platform. six normal males were participated in this experiment. All subjects performed a stair-ascent in four different heights of stairs (10, 14, 18, 22cm) having a 5 step staircase. The moment of lower extremity joint was analyzed during stance phase. The results were as follows: First, the second increase of plantar flexion moment of ankle joint in the 'forward continuance' phase was not occurred for stair A and B. But it occurred for stair C and D. And the maximum plantar flexion moment increased as the stair height become higher. Second, it was shown that the maximum inversion moment of the ankle joint was the smallest at stair B and it increased significantly at stair C. Third, maximum extension moment appeared in the 'pull-up' phase. And it increased as the stair height become higher. Fourth, it was shown that the maximum abduction moment of the knee joint was the smallest at stair C and it increased significantly at stair C. Fifth, maximum extension moment of hip joint increased significantly at stair C. Sixth, remarkable value of adduction moment occurred at hip joints and maximum adduction moment increased at stair D.

국내외 저명학술지에 발표된 무작위대조연구 초록의 질적 연구

김효선,김은영 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

In this study, the quality of reporting the Randomized Controlled Trial (RCT) abstracts was investigated. It was compared between abstracts in four major Korean medical journals, covered by SCI(E), and in the New England Journal of Medicine (NEJM), the most cited medical journal in 2010 (IF=53.484), published from 2007/01 to 2011/06. There were 57 abstracts in Korean SCIs and 50 in NEJM included in the investigation; among them, three from Korean SCIs and one from NEJM were excluded. A modification of CONSORT for abstract was used as criteria, including 16 checklist items. The conformity of the abstracts to each item was assessed, and the χ2 (chi-square) analysis was used to analyze the significance of difference between the two. As a result, the two groups of journals were statistically equivalent in six items; Korean journals were significantly better in two items, and NEJM were in eight. In conclusion, the quality of reporting of RCT abstracts was better in general in NEJM than in Korean SCIs. This does not mean the full RCT reports of NEJM are superior to that of Korean SCI; rather, it highlights the need for Korean journals to adopt the CONSORT for abstracts in reporting of RCT in abstracts.

트레드밀의 속도 변화에 따른 노년기 성인의 보행패턴 연구

은선덕 서울대학교 체육연구소 2001 서울大學校 體育硏究所論集 Vol.22 No.1

The purpose of this study was to investigate the effect of speed conditions on the gait pattern in old age. Data were collected using video camera and video analyzing system. Six males in their sixty to seventies were tested during slow(3.5km/h), moderate(4.0km/h), fast(4.5km/h) speed on treadmill wish 10% grade. They were videotaped using a high speed video camera with the frame rate being 60Hz, Variables computated using the method of two-dimensional video analysis. One-way ANOVA was used to evaluating the statistical significance. The results obtained from this study were as follows: The stance phase was increased and swing phase was decreased as the speed uras increased in all subjects. But there was no significant difference statistically. All subjects did not show a significant difference in speed conditions at major events jn mean ankle angle. However, max. ankle angle and ROM(range of motion) during stance phase was augmented as the speed was increased(P<.05). All subjects did not show a significant difference in speed conditions at major event in mean knee angle. However min. ankle angle during stance phase and ROM during swing phase was augmented as the speed was increased(P<.05).

100m 달리기시 최고 속도 구간과 감속 구간의 동작 비교 연구

은선덕,정철수,배성제 한국운동역학회 1996 한국운동역학회지 Vol.6 No.1

본 연구의 목적은 100m 달리기에서 최고 속도 구간과 감속 구간에서의 동작을 비교하여 감속의 원인을 규명하는 데 있다. 두 구간에 대한 주요 운동학적 변인인 신체 중심의 속도와 변위, 보속과 보폭, 상체의 전경각, 관절각, 각속도를 분석하여 다음과 같은 결론은 얻었다. 감속 구간에서의 지면 접촉 기간 동안과 체공 기간 동안의 신체 중심의 수평 속도는 최고 속도 구간에 비해 느린 것으로 나타났다. 보속은 최고 속도 구간에 비해 느린 것으로 나타났고, 지지 시간은 긴 것으로 나타났으며, 체공 시간은 차이가 나타나지 않았다. 보폭은 최고 속도 구간에 비해 짧은 것으로 나타났고, 착지시 신체 중심과 발끝의 수평 거리는 최고 속도 구간에 비해 긴 것으로 나타났다. 또한 상체의 전경각은 착지시에만 차이가 있었으며 최고 속도 구간에 비해 작고, 무릎 관절각은 착지시와 이지시에 있어서 최고 속도 구간에 비해 작았다. 그리고 고관절각은 반대발의 이지시와 착지시, 그리고 최소값에 있어서 최고 속도 구간에 비해 크고, 운동 범위에 있어서는 작은 것으로 나타났다. 또한 무릎 관절 각속도는 최고 속도 구간과의 비교에서 차이가 나타나지 않았다. The study was conducted to make a comparative analysis of running motion and to examine the difference in the deceleration phase(80∼90m) and the Max-speed phase(30∼40m) during the 100-meter Sprint. In this study, data was analyzed with variables including velocity and displacement of center of gravity, stride frequency, stride length, foward angle of upper body, joint angle, angular velocity in the deceleration phase and the max-speed phase. The conclusions of the study were as follows ; 1. Horizontal velocity of the center of gravity in the deceleration phase was found to be slower than that in the max-speed phase in the supporting period and non-supporting period. 2. Stride frequency in the deceleration phase was found to be slower than that in the max-speed phase, and supporting time n the deceleration phase was longer than that in the max-speed phase, also there was no difference between each phase in nonsupporting time. 3. Stride length in the deceleration phase was to be found shorter than that in the max-speed phase. 4. Horizontal distance between the center of gravity and toe in the deceleration phase was to be found longer than that in the max-speed phase. 5. Forward angle of upper body at the moment of touch down in the deceleration phase was found to be smaller than that in the max-speed phase. 6. Knee angle at the moment of touch down and take off in the deceleration phase were found to be smaller than in the max-speed phase. 7. Hip angle at the moment of touch down and take off of the other foot, and minimum hip angle in the deceleration phase were found to be larger than that in the max-speed phase, and range of, motion in the deceleration phase was smaller than that in the max-speed phase. 8. Knee angular velocity at the moment of touch down of the other foot toward flection in the deceleration phase was found to be larger than that in the max-speed phase.

지역별 시판 포기배추김치의 이용실태 및 기호도 조사

이인선,김혜영B,김은정 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.4

Survey on the usage of commercial poggi Kimchi was run and consumer's acceptance test of the Kimchi in the various regions of Korea including Seoul(SE), Kyonggi Province(KG), Kangwon Province(KW), Kyungsang Province(KS), and Jeonla Province(JL) were investigated. Survey result of 34% of consumer showed that they eat Kimchi very much, and 19% answered they ate Kimchi whenever they had chance to eat. The most desired points of improvement in commercial poggi Kimchi were as following; Taste and degree of fermentation should be standardized. Order of preferences of minor ingredients of Kimchi were radish, hot pepper, welsh onion, and leek, respectively. Consumer acceptance test of KS sample group showed higher preference in whole color, salted condition, spicy hot flavor and crispness than the others. In whole color and pickled seafood properties, KG sample group showed significantly higher values than the others. In salty flavor, SE sample group showed lower preference than the others.

인삼, 식이섬유, DHA를 첨가한 기능성 두부의 특성

백은경,구혜진,김경선,김동섭,백무열 경희대학교 생명자원과학연구원 2004 硏究論文集 Vol.23 No.-

두부의 기능성과 고급화 및 다양화를 하기 위하여 식이 섬유, 인삼, DHA를 첨가하여 기능성 두부를 제조함에 있어 이들 첨가량이 품질에 미치는 영향을 조사하였다. 식이 섬유 첨가 두부는 첨가량이 증가함에 따라 수율이 증가하여 경도, 응집성 및 껌성이 감소하는 경향을 나타내었으며 탄성은 첨가량에 따라 큰 차이를 나타레지 않았다. 관능검사 결과 또한 첨가량이 증가함에 따라 경도, 응집성, 탄성 등의 감소와 쓴맛, 떫은맛의 증가로 인하여 전반적인 기호도가 첨가량이 증가함에 따라 감소하였다. DHA 첨가 두부는 경도와 껌성이 기계적 특성치와 관능검사 결과에서 모두 첨가량의 증가에 따라 증가하였으며, 이외의 특성들은 대조구와 큰 차이를 나타내지 않아 첨가량에 관계없이 전반적인 기호도에서 대조구와 크게 차이를 나타내지 않았다. 인삼분말과 extract 첨가 두부는 첨가 방법에 상관없이 수율과 기계적 특성치인 탄성과 응집성에서 대조구와 큰 차이를 나타내지 않았으며, 인삼 고유의 성질 때문에 첨가량이 증가함에 따라 L값은 감소하고 a값은 증가하였으며 쓴맛과 떫은맛이증가하여 전반적인 기호도가 분말과 extract 모두 첨가량이 증가하면서 낮아졌으며 최소 첨가량인 0.05%를 첨가하는 것이 경도. 탄성, 껌성 , 응집성에서 대조구와 가장 유사한 것으로 나타나 전반적인 기호도가 0.05%에서 우수하게 평가되었다. 따라서본 실험을 바탕으로 하여 앞으로 식이 섬유와 인삼, 식이 섬유와 DHA. 인삼과 D보A, 마지막으로 이 세 가지를 모두 섞어서 첨가하여 더 기능적이고 다양한 기능성 두부에 대한 실험을 수행해야 할 것이다. The quality characteristics of functional soybean curd with polydextrose, ginseng and DHA (docosahexaenoic acid) were investigated. As the concentration of polydextrose increased, the yield increased but hardness, cohesiveness and gumminess decreased. In sensory evaluation, the overall preference decreased with increasing polydextrose concentration possibly due to decrease of hardness, cohesiveness and springiness, as well as increase of bitter and puckery tastes. Soybean curd with DHA showed no differences in all properties except hardness and gumminess. Soybean curd with ginseng extract and ginseng powder showed no difference in the yield and the textural properties. But the L value decreased, and a value, bitter taste and puckery taste increased with increasing ginseng concentration. Although the overall preference was decreased with increasing ginseng concentration in both powder and extract, addition of minimum concentration (0.05%) showed similar characteristic with control.

물/극성유기용매 혼합욕에서 폴리에스테르의 염색

유효선,김은아 한국의류학회 1998 한국의류학회지 Vol.22 No.1

Polyester filaments were dyed with disperse dye in dyebath containing water and water miscible organic solvents : acetone, 1,4-dioxane, DMF. In case of Acetone and 1,4-dioxane, the equilibrium dyeuptake was maximun at the volume fraction 0.05. The equilibrium dye uptakes were decreased as volume fraction of organic solvents were increased. When the volume fractions of water miscible organic solvents were varied, dye uptake was increased constantly with dyeing time. In dyebath containing water and water miscible organicsolvent, the dyeuptake was increased quickly during initial 40∼60 min. and slowly increased there after. The slope of C_t/C_∞ to √t was greater in dyebath containing water and water miscible organic solvents than dyebath containing water. The differences of the slope with volume fractions of water miscible organic solvent were not shown big.

수업용 CD-ROM 제작 및 이를 적용시킨 효과적인 학습지도안 개발 : 중학교 1학년 가정 한복 입기를 중심으로 In the Point of Wearing Korean Traditional Costume for First Grade of Junior Middle School Students in Home Economics Teaching

이은선,김병미 한국 가정과 교육 학회 1999 한국가정과교육학회지 Vol.11 No.2

The goals of the research are for producing and optimizing the CD-ROM effective and practical Teaching-Learning method. It consists of Wearing Korean Tradition Costume for the First Grade of Middle School Students in Home Economics Teaching. This research's summarization in following. First, the multi- media material, CD-ROM making use of Powerpoint. Wearing Korean Traditional Costume is produced to help the students learn the difficult contents in terms of video and audio. Second, It is introduced the model of "Open Education for increasing the efficiency f class. Third, it is developed to proceed the class with the CD-ROM and small group study of place activity. Fourth, it helps students concentrate on the class with proper sound effect whenever the slide films are changed. And it helps to link the web sited related to Korean Traditional Costume. Finally, another kinds of suggestions are following. The effective verification of this software that is tested and applied at the field for a given period willbe necessary. And, it is necessary to upgrade for the CD-ROM and the supplementary teaching materials in Korean Traditional Costume education.