5~6세기 백제의 지배세력 연구

문동석 한국역사연구회 2005 역사와 현실 Vol.- No.55

Though Baekje transferred unpreparedly its captial to Ueong-Chin of Baek-Che and the loyal family of Baek-Che related local powers unexpectedly in order to accept their new powers, how the local powers acquired the strong power abruptly from the rein of government of Baekje? The King of Dongseong ascend the throne of Baekje paved the way of new development and save the political unrest situation being brought by The Kings of Munchu and Samkeung. Baekje in which the political situation is stabled by ascending the throne of Dongseong, extended its power to southern province in order to heighten its power caused by loss of the area around Han river which is important advanced base to be provided with materials and human resources Baekje, furthermore, began to hold Kaya in check which is intended to escape its influence after Baekje transferring its capital to Ungchin. The upper change of foreign situations had a chance to the king of Dongseong to assume the reins of the government. Especially, The local powers from Kaya reinforced and assumed their helm to the government of Baekje. But they who related already to the loyal families, regained their power according to political and power situation's change after transferring its capital to Ungchin. As the area of Kaya became important base after transferring Baeke's capital to Ungchin, The power who could made an influence of the area was appointed with higher position. The King of Dongseong completed to set up the classs of power and use the system of Hwangho, develop bureaucratized system through specializing the function of Jwapyung system. The era of the King of Murjung drived forward continuously to specialize the function of Chwaphjung system

진화전략과 상태 관측기에 의한 영구자석 동기전동기의 센서리스 속도제어기 설계에 관한 연구

손문경,이동희,오석규 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

Permanent magnet synchronous motor is widely applied for the industrial and home appliance because of it`s high power density and easy control. Recently sensorless speed control of PMSM is much studied because a mechanical sensor reduces reliability and increases cost. This paper investigates sensorless controller design of PMSM. Angular speed and position are estimated with observer. In order to reduce variation effect of mechanical parameters and calculation delay, reduced order state observer is designed with electrical parameters. Evolution strategy is used to optimize controller gains and observer eigenvalue. In the sensorless control of PMSM with state observer, eigenvalue affect stability and dynamic response of system,. The simulation and experimental results indicate good performances.

시험관내 심내막염 모델에서 Methicillin 내성 포도구균에 대한 Vancomycin, Arbekacin, Gentamicin 단독 혹은 병합효과

이동건,전혜선,임동석,최수미,최정현,유진홍,신완식,강문원 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : Methicillin 내성 포도구균(methicillin resistant Staphylococcus aureus, MRSA)은 병원감염의 중요한 원인균으로 vancomycin이 선택약제이다. 그러나 심내막염 등의 중증감염에서는 vancomycin의 치료실패와 함께 최근 내성균도 증가하고 있어 vancomycin을 대체할 수 있는 항균제와 보다 효과적인 항균요법의 개발이 필요하다. 본 연구에서는 사람의 환경과 유사한 시험관내 감염 모델을 적용하여 MRSA 치료를 위한 vancomycin, arbekacin, gentamicin의 단독 및 병합효과를 비교하였다. 방법 : 임상에서 분리된 MRSA 2균주(GRI 53, gentamicin 내성 : GS171, gentamicin 감수성)로 fibrin clot을 제작하여 시험관내 심내막염 모델을 만들어 vancomycin, arbekacin, gentamicin을 단독 혹은 병합주입하였다. 반감기와 최고 및 최저농도는 사람의 약동학을 기준으로 하였다. Vancomycin은 6, 12, 24시간마다 주입하거나 24시간 연속주입하였고 arbekacin은 12, 24시간마다, gentamicin은 8, 24시간마다 주입하였다. 병합주입의 경우 vancomycin은 12시간마다, gentamicin, arbekacin은 24시간마다 투여하였다. 각 투여군의 살균효과는 0, 8, 24, 32, 48, 72시간째의 fibrin clot내 집락수로 측정하였다. 결과 : GRI153에 gentamicin을 주입한 군 이외의 모든 실험군에서 대조군에 비해 의미있게 fibrin clot내 집락수가 감소하였다(P<0.001). Vancomycin과 arbekacin 단독주입군내서 8시간째의 집락수는 GRI153보다 GS171에서 의미있게 낮았고(P=0.02), GS171에 arbekacin 12시간마다 투여한 군의 집락수가 가장 낮았다(P=0.01). 72시간째 집락수는 균주의 종류나 vancomycin 혹은 arbekacin의 투여간격에 따른 차이가 없었다. GRI153에서 vancomycin과 arbekacin의 병합주입군은 24시간까지 상가작용이 있었으나 vancomycin과 gentamicin 병합주입에서는 무관작용이었고 GS171에서도 72시간 동안 무관작용을 보였다. 또한 전 실험기간 동안 내성균은 발현되지 않았다. 결론 : 시험관내 심내막염 모델에서 MRSA에 대한 arbekacin의 항균력은 vancomycin과 유사하여 단독주입이 가능함을 시사한다. Gentamicin 내성균주의 경우 두가지 항균제의 병합주입으로 24시간까지 상가작용을 보이고 있으나 임상에 적용하기 위해서는 추가연구가 필요할 것으로 생각된다. Background : Glycopeptide has been used for the one-and-only treatment of choice in methicillin resistant Staphylococcus aureus (MRSA) infection, but its exclusive use for the MRSA infection has led to the increased risk of glycopeptide-resistance. To find an alternative (s), we employed an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VCM). arbekacin (ABK), and gentamicin (GM) alone or in combination. Methods : Using two strains of clinically isolated MRSA, one GM susceptible (GS171) and the other GM resistant (GR153), fibrin clots were prepared and suspended in IVIEM. Antibiotics were added as a bolus to simulate human pharmacokinetics of regimens, including q 6 h, q 12 h, q 24 h, or continuous infusion with VCM, q 12h or q 24 h with ABK, and q 8 h or q 24 h with GM. In cases of combination, regimens were VCM q 12 h plus ABK q 24 h, and VCM q 12 h plus GM q 24 h. Fibrin clots were removed from each model at 0, 8, 24, 32, 48. and 72 h, and the bacterial densities (in CFU/g) were determined. Results : At 8 hour, the colony counts of GS171 were lower than those of GR153 (P=0.02), and the lowest with the ABK q12h against GS171 (P=0.01). At 72 hour, monotherapy with ABK or VCM produced same degree of bacterial reductions in IVIEM, regardless of dosing frequency or GM-resistance. In the case of GM-resistance, combination of VCM and ABK did show additive effect until 24 hours, although VCM and GM showed no indifference during all the experiments. Development of resistance during experiment was not observed with any regimens. Conclusions : Our data suggest that ABK monotherapy could be used as an alternative to VCM even in the treatment of GM-resistant staphylococcal endocarditis. Further studies will clinical trials are warranted to evaluate the additive effect of VCM and ABK.

저선량 감마선 조사가 왕겨의 항산화능에 미치는 영향

정석문,김정한,김동열,육홍선,변명우,이승철 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

왕겨에 200, 400, 600, 800 및 1000 Gy의 저선량의 감마선을 조사하여 항산화능의 변화를 관찰하였다. 총 페놀 화합물의 양은 무처리구의 경우 0.184 mM를 나타내었고, 200 Gy로 감마선을 조사하였을 때는 0.215 mM로 약간 증가함을 보였으나 이후 차츰 감소하였다. 전자 공여능은 무처리구에 비해 처리구의 경우 조사 선량별로 조금씩의 차이만 있을 뿐, 조사 선량에 대한 왕겨의 전자 공여능은 유의적인 큰 변화 없이 비슷한 활성을 보였다. Fe^2+-ions 킬레이팅 활성은 무처리구의 경우 68.25%를 나타내었으며, 200, 400, 600 및 800 Cy 에서는 각각 86.45, 85.61, 86.65 및 82.84%로서 무처리구보다는 증가함을 보였으나, 1000 Gy에서는 74.67%로 감소하였다. 지질 과산화 억제능은 무처리구에 비해 처리구는 약간의 증가를 보였으나 효과는 미비하였다. We studied the effect of small-dose of γ-irradiation to rice hull(RH) for its antioxidant ability. The RH was treated with 200, 400, 600, 800, and 1000 Gy of γ-ray at 70 Gy/min. Total phenol amount of unirradiated RH was 0,184 mM, after irradiation at 200 Gy it increased to 0,215 mM, while irradiation above 400 Gy up to 1000 Gy decreased that to unirradiated level. The electron donating ability of RH did not show significant change depend on irradiation. The chelating ability for Fe^2+ of unirradiated RH was 68.25 %, while that of 200, 400, 600 and 800 Gy irradiated RH showed 86.45, 85.61, 86.65 and 82.84 % respectively, but, 1000 Gy was decreased to 74.67 %. According to TBARS analyses, inhibition ability of lipid peroxidation by RH was not affected by γ-irradiation.

상태관측기를 이용한 영구자석 동기전동기의 센서리스 속도제어

손문경,이동희,오석규 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

Sensorless PMSM is much studied for the industrial applications and home appliances because a mechanical sensor reduces reliability and increases cost. This paper investigates a field oriented control method without speed and rotor position sensor using the state observer. The observer is based on the model of the motor represented in the stationary two-axes coordinates. The control strategy is to estimate back-EMF by the state observer and to estimate the rotor speed and the rotor position angle from the estimated back-EMF. And we construct back-EMF constant compensator to compensate estimated speed error due to detuned electrical parameter. The observer is tested by simulation and experiment. The results show that the observer gives a good estimation of speed and rotor position, compensated parameter constants. The simulation and experimental results indicate good performances.

Metoclopramide가 휜쥐의 血壓에 미치는 影響

임동윤,최동준,김규형,최철희,박재윤,문재규,김문석,황두환 中央醫學社 1988 中央醫學 Vol.53 No.9

Influences of metocopramide (MCP), which is a seletive dopaminergic antagonist, on blood pressure of the rat and its mechanism of action were investigated in the present study. MCP administered into a femoral vein of the rat caused markedly a dose-related fall in blood pressure followed by secondary transient pressor response. The depressor action evoked by MCP was not blocked by pretreatment of atropine or chlorisondamine, while the pressor action was inhibited significantly. Prazosin treatment reduced markedly both of depressor and pressor induced by MCP. MCP-evoked pressor action was not affected by clonidine, but the depressor response was attenuated significantly. Debrisoquin treatment made the inhibited response to MCP-induced pressor response, while did not affect the depressor action. Both of pressor and depressor responses evoked by MCP were not influenced by cyproheptadine. The hypertensive activity induced by nor epinephrine was weakened markedly by the infusion of MCP (1.50 mg/kg/30min.), but the pressor action evoked by dopamine not affected. These experimental data suggest that MCP produces biphasic responses (depressor and pressor) in blood pressure of the rat, and that the hypotensive activity is due to adrenergic alpha-receptors blockade, and that pressor activity is exerted through stimulation of cholinergic nicotinic receptors in autonmic ganglia.

유도 맞잡기 타입과 받기의 신장에 따른 허벅다리걸기의 Kinematic 분석[2]

권문석,김의환,조동희 한국운동역학회 2002 한국운동역학회지 Vol.12 No.2

본 연구는 6년 이상의 유도경력 소유자인 Y.대학교 유도전공자를 대상으로 맞잡기 타입과 받기신장에 따른 허벅다리걸기 동작시 3차원 영상분석법을 이용하여 운동학적 변인의 특성을 분석하는데 그 목적이 있다. 유도 맞잡기 타입과 받기신장에 따른 허벅다리걸기 동작은 비디오카메라 2대를 사용하여 촬영(30frame/sec.)하였으며, 분석을 위한 운동학적 변인들은 시간, 자세, 중심변인이며, 실험 결과에 대한 분석과 논의를 통하여 다음과 같은 결론 및 제언을 얻을 수 있었다. 허벅다리걸기 동작의 맞잡기 타입에 따른 유의한 차이는 3국면 소요시간, 걸기1단계 공격둔부각, 걸기1단계 공격무릎각, 걸기2단계 공격무릎각, 걸기2단계 지지무릎각, 걸기1단계 공격발목각, 걸기2단계 지지발목각에서 유의한 차이(p<.05)를 보였다. 종합해보면, 허벅다리걸기를 수행할 때 맞잡기와 상대신장이 허벅다리걸기 기술에 영향을 미친다는 것을 알 수 있었으며, 상대의 신장이 작을 경우 목 뒤를 잡는 타입 A가 시간이 단축(<.05)되었다. 따라서 경기 중 상대의 신장이 작다면 목 뒤를 잡는 것이 유리하다.이러한 사실들을 종합해 볼 때, 유도 경기 중 허벅다리걸기를 수행할 대 맞잡기가 많은 영향을 주었다. 또한 기술의 핵심단계인 3(걸기)국면에서도 받기신장에 의한 차가 더 크게 나타나 받기신장 역시 많은 영향을 주었다. 단계별 변인들의 변화량에 있어서는 전체적으로 모든 변인들이 변화량에서 큰 차이를 나타내지는 않았다고 할 수 있다. 따라서 맞잡기와 받기신장은 상당한 관계가 있음을 알 수 있었으며 유도 경기 중 상대에 따른 다양한 잡기와 신장을 고려한 기술이 요구된다. This study was to analyze the kinematic variables when the subjects performing Uchi-mata(inner thigh reaping throw) by Kumi-kata types((How to grasp A or B?) and two different opponent's height in Judo. Kinematic variables were temporal, posture. Data analysis was collective comparison of two-way ANOVA, t-test by type A&B and two different opponent's height. There were significant difference of Kumi-kata types(p<.05) in the time elapsed on Kake phase(KP : throwing phase) and hip, knee, ankle-angle of the attacking foot in the 1st stage of KP and knee, ankle-angle of the attacking foot and hip, knee ankle-angle of the supporting foot in the 2nd stage of KP. There were significant difference of two opponent's(p<.05) in the time elapsed on KP and hip-angle of the supporting foot in 1st stage of KP. Therefore, the interaction effect(p<.05) were in the time elapsed on KP and hip-angle of the supporting foot in the 2nd stage of KP. So, It could be suggested that Judoka hold on the part-behind neck lapel(type A) at the sleeve with the other of Judogi jacked when opponent's height was short. Because the time elapsed on KP of type B was not so fast as type A(p<.05) during performed Uchi-mata, and also the bigger hip-angle of the supporting foot in the 2nd stage of KP grew, the faster the time elapsed on KP became.

대구·경북지역 전기통신의 수요예측 및 중장기계획 연구

이동만,문석환 경북대학교 경제경영연구소 1991 經商論集 Vol.19 No.3

Virus Associated Hemophagocytic Syndrome 3례

전동석,황종문,김준식,서은숙,강진무 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

Virus associated hemophagocytic syndrome is characterized by a benign generalized histiocytic proliferation with marked hemophagocytosis associated with systemic viral infectioin. The syndrome is a non-neoplastic, potentially reversible process and manifested fever, severe constitutional symptoms, hepatosplenomegaly, and lymphadenopathy, and characterized by laboratory findings of pancytopenia, hemophagocytosis and abnormal liver function test and coagulopathy. Immunosuppressive and cytotoxic therapy are contraindicated because of increasing risk of fatal outcome. The authors experienced three cases of virus associated hemophagocytic syndrome diagnosed by clinical features, bone marrow aspiration and lymph node biopsy. All cases had higt fever, hepatosplenomegaly and lymphoadenopathy and showed granulocytopenia in peripheral blood and phagocytized histiocytes in bone marrow. The brief review of the literatures was made.

마취흰쥐에서 天麻鉤藤飮의 心血管作用에 對한 硏究

배남규,문석재,임동윤,권오성 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2

The present study was attempted to investigate the cardiovascular effects of Cheonmagudeumg-Eum (CMGDE), which is known to be one of chinese medical prescriptions used in treatment of hypertension, in the anesthetized rats and to clarify the mechanism of its pharmacological action, making use of its water extract. 1. CMGDE (5-45 ㎎/㎏), given into a femoral vein of the rat, produced a dose-dependent hypotensive and bradycardic responses while even much larger doses of it (10-90 ㎎/㎏), given into the rectum, did induced negligible hypotensive responses. 2. CMGDE-induced depressor responses were inhibited greatly by pretreatment with phentolamine (an adrenergic α-receptor antagonist), but not by pretreatment with atropine (an antimuscarinic agent) and chlorisondamine (an autonomic ganglionic blocker). 3. Pressor responses evoked by intravenous norepinephrine were attenuated significantly by pretreatment of CMGDE-infusion with a rate of 45㎎/㎏/20min. 4. In the rat aortic strips, phenylephrine (an adrenergic α1-receptor agonist) and high potassium (a membrane depolarizing agent) caused potent contractile responses, respectively. However, in the presence of CMGDE (2㎎/㎖), the contractile responses of phenylephrine (10-5M) and high potassium (5.6×10 exp (-2)M) were markedly inhibited. Taken together, these experimental results suggest strongly that Cheonmagudeung-Eum may cause the hypotensive responses in the anesthetized normotensive rat, indicating that this cardiovascular effects of CMGDE is likely due to the blockade of adrenergic α-receptors without cholinergic effects.